ATE356130T1 - Inhibitoren von cruzipain und anderen cysteinproteasen - Google Patents
Inhibitoren von cruzipain und anderen cysteinproteasenInfo
- Publication number
- ATE356130T1 ATE356130T1 AT02732145T AT02732145T ATE356130T1 AT E356130 T1 ATE356130 T1 AT E356130T1 AT 02732145 T AT02732145 T AT 02732145T AT 02732145 T AT02732145 T AT 02732145T AT E356130 T1 ATE356130 T1 AT E356130T1
- Authority
- AT
- Austria
- Prior art keywords
- inhibitors
- cruzipain
- cysteine proteases
- general formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB0101179A GB0101179D0 (en) | 2001-01-17 | 2001-01-17 | Biologically active compounds |
US27535901P | 2001-03-13 | 2001-03-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE356130T1 true ATE356130T1 (de) | 2007-03-15 |
Family
ID=26245571
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02732145T ATE356130T1 (de) | 2001-01-17 | 2002-01-17 | Inhibitoren von cruzipain und anderen cysteinproteasen |
Country Status (21)
Country | Link |
---|---|
US (2) | US7425562B2 (de) |
EP (1) | EP1362052B1 (de) |
JP (1) | JP4608183B2 (de) |
KR (1) | KR100860067B1 (de) |
CN (1) | CN1269822C (de) |
AT (1) | ATE356130T1 (de) |
AU (1) | AU2002219397B2 (de) |
BR (1) | BR0206501A (de) |
CA (1) | CA2436462C (de) |
CY (1) | CY1106640T1 (de) |
DE (1) | DE60218633T2 (de) |
DK (1) | DK1362052T3 (de) |
ES (1) | ES2281516T3 (de) |
HK (1) | HK1060729A1 (de) |
IL (2) | IL156774A0 (de) |
MX (1) | MXPA03006224A (de) |
NO (1) | NO328208B1 (de) |
NZ (1) | NZ526913A (de) |
PT (1) | PT1362052E (de) |
RU (1) | RU2329266C2 (de) |
WO (1) | WO2002057270A1 (de) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
US7064123B1 (en) | 2000-12-22 | 2006-06-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
IL160819A0 (en) | 2001-09-14 | 2004-08-31 | Aventis Pharma Inc | Novel compounds and compositions as cathepsin inhibitors |
CN1324018C (zh) | 2001-11-14 | 2007-07-04 | 安万特药物公司 | 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物 |
DE60326473D1 (en) * | 2002-07-16 | 2009-04-16 | Amura Therapeutics Ltd | Pyrrolderivate als hemmstoffe von cystein proteasen |
US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
CA2552739A1 (en) | 2004-01-08 | 2005-07-21 | Medivir Ab | Cysteine protease inhibitors |
JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
KR101447897B1 (ko) * | 2005-03-21 | 2014-10-07 | 비로베이, 인코포레이티드 | 시스테인 단백질분해효소 억제제로서의 알파 케토아미드화합물 |
GB0513839D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
GB0513840D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
GB0614044D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614052D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614053D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614037D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614046D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
GB0614073D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
WO2008114054A1 (en) * | 2007-03-19 | 2008-09-25 | Medivir Ab | Protease inhibitors |
US7893067B2 (en) * | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
EP2240491B1 (de) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ON DERIVATE ALS INHIBITOREN VON CYSTEIN PROTEINASEN |
GB0804702D0 (en) | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
GB0804701D0 (en) * | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
US9409880B2 (en) | 2011-01-20 | 2016-08-09 | The Regents Of The University Of Colorado, A Body Corporate | Modulators of TLR3/dsRNA complex and uses thereof |
IN2015MN00405A (de) * | 2012-08-30 | 2015-09-04 | Univ Tokyo | |
CN106279188A (zh) * | 2016-07-21 | 2017-01-04 | 青岛科技大学 | 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3652574A (en) | 1970-04-01 | 1972-03-28 | Abbott Lab | Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof |
DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
WO1998008802A1 (en) | 1996-08-28 | 1998-03-05 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
EA002100B1 (ru) | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
AR013079A1 (es) * | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
CO5150165A1 (es) | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
GB9911417D0 (en) | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
EP1345931A2 (de) | 2000-11-17 | 2003-09-24 | Medivir UK Ltd | Cystein protease inhibitoren |
US7064123B1 (en) | 2000-12-22 | 2006-06-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
-
2002
- 2002-01-17 AT AT02732145T patent/ATE356130T1/de active
- 2002-01-17 PT PT02732145T patent/PT1362052E/pt unknown
- 2002-01-17 IL IL15677402A patent/IL156774A0/xx active IP Right Grant
- 2002-01-17 RU RU2003125270/04A patent/RU2329266C2/ru not_active IP Right Cessation
- 2002-01-17 WO PCT/GB2002/000184 patent/WO2002057270A1/en active IP Right Grant
- 2002-01-17 MX MXPA03006224A patent/MXPA03006224A/es active IP Right Grant
- 2002-01-17 US US10/466,384 patent/US7425562B2/en not_active Expired - Fee Related
- 2002-01-17 BR BR0206501-0A patent/BR0206501A/pt not_active IP Right Cessation
- 2002-01-17 DK DK02732145T patent/DK1362052T3/da active
- 2002-01-17 CA CA2436462A patent/CA2436462C/en not_active Expired - Fee Related
- 2002-01-17 CN CNB028038142A patent/CN1269822C/zh not_active Expired - Fee Related
- 2002-01-17 KR KR1020037009524A patent/KR100860067B1/ko not_active IP Right Cessation
- 2002-01-17 ES ES02732145T patent/ES2281516T3/es not_active Expired - Lifetime
- 2002-01-17 NZ NZ526913A patent/NZ526913A/xx not_active IP Right Cessation
- 2002-01-17 DE DE60218633T patent/DE60218633T2/de not_active Expired - Lifetime
- 2002-01-17 AU AU2002219397A patent/AU2002219397B2/en not_active Ceased
- 2002-01-17 EP EP02732145A patent/EP1362052B1/de not_active Expired - Lifetime
- 2002-01-17 JP JP2002557947A patent/JP4608183B2/ja not_active Expired - Fee Related
-
2003
- 2003-07-03 IL IL156774A patent/IL156774A/en not_active IP Right Cessation
- 2003-07-16 NO NO20033220A patent/NO328208B1/no not_active IP Right Cessation
-
2004
- 2004-05-14 HK HK04103421A patent/HK1060729A1/xx not_active IP Right Cessation
-
2007
- 2007-06-04 CY CY20071100742T patent/CY1106640T1/el unknown
-
2008
- 2008-09-15 US US12/211,069 patent/US20090247471A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP4608183B2 (ja) | 2011-01-05 |
NO328208B1 (no) | 2010-01-11 |
HK1060729A1 (en) | 2004-08-20 |
NO20033220D0 (no) | 2003-07-16 |
AU2002219397B2 (en) | 2008-02-14 |
US20090247471A1 (en) | 2009-10-01 |
ES2281516T3 (es) | 2007-10-01 |
KR20030075161A (ko) | 2003-09-22 |
RU2003125270A (ru) | 2005-02-20 |
CA2436462A1 (en) | 2002-07-25 |
PT1362052E (pt) | 2007-04-30 |
US7425562B2 (en) | 2008-09-16 |
DE60218633T2 (de) | 2008-02-21 |
IL156774A (en) | 2008-08-07 |
RU2329266C2 (ru) | 2008-07-20 |
DE60218633D1 (de) | 2007-04-19 |
CN1486320A (zh) | 2004-03-31 |
IL156774A0 (en) | 2004-02-08 |
DK1362052T3 (da) | 2007-07-09 |
MXPA03006224A (es) | 2004-10-15 |
NZ526913A (en) | 2004-12-24 |
US20040138250A1 (en) | 2004-07-15 |
CA2436462C (en) | 2011-07-05 |
CY1106640T1 (el) | 2012-01-25 |
BR0206501A (pt) | 2004-01-13 |
WO2002057270A1 (en) | 2002-07-25 |
EP1362052B1 (de) | 2007-03-07 |
JP2004518674A (ja) | 2004-06-24 |
KR100860067B1 (ko) | 2008-09-24 |
NO20033220L (no) | 2003-09-17 |
EP1362052A1 (de) | 2003-11-19 |
CN1269822C (zh) | 2006-08-16 |
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Legal Events
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UEP | Publication of translation of european patent specification |
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