NO20033220D0 - Inhibitorer for cruzipain og andre cysteinproteaser - Google Patents

Inhibitorer for cruzipain og andre cysteinproteaser

Info

Publication number
NO20033220D0
NO20033220D0 NO20033220A NO20033220A NO20033220D0 NO 20033220 D0 NO20033220 D0 NO 20033220D0 NO 20033220 A NO20033220 A NO 20033220A NO 20033220 A NO20033220 A NO 20033220A NO 20033220 D0 NO20033220 D0 NO 20033220D0
Authority
NO
Norway
Prior art keywords
inhibitors
cruzipain
cysteine proteases
general formula
compounds
Prior art date
Application number
NO20033220A
Other languages
English (en)
Other versions
NO20033220L (no
NO328208B1 (no
Inventor
Martin Quibell
Original Assignee
Amura Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0101179A external-priority patent/GB0101179D0/en
Application filed by Amura Therapeutics Ltd filed Critical Amura Therapeutics Ltd
Publication of NO20033220D0 publication Critical patent/NO20033220D0/no
Publication of NO20033220L publication Critical patent/NO20033220L/no
Publication of NO328208B1 publication Critical patent/NO328208B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
NO20033220A 2001-01-17 2003-07-16 Inhibitorer for cruzipain og andre cysteinproteaser, fremgangsmate for validering av en kjent eller antatt cysteinproteaseinhibitor som et terapeutisk mal, anvendelser av forbindelsene i fremgangsmaten og ved fremstilling av medikamenter, samt farmasoytiske eller veterinaermedisinske preparater og fremgangsmate for fremstilling derav NO328208B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0101179A GB0101179D0 (en) 2001-01-17 2001-01-17 Biologically active compounds
US27535901P 2001-03-13 2001-03-13
PCT/GB2002/000184 WO2002057270A1 (en) 2001-01-17 2002-01-17 Inhibitors of cruzipain and other cysteine proteases

Publications (3)

Publication Number Publication Date
NO20033220D0 true NO20033220D0 (no) 2003-07-16
NO20033220L NO20033220L (no) 2003-09-17
NO328208B1 NO328208B1 (no) 2010-01-11

Family

ID=26245571

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20033220A NO328208B1 (no) 2001-01-17 2003-07-16 Inhibitorer for cruzipain og andre cysteinproteaser, fremgangsmate for validering av en kjent eller antatt cysteinproteaseinhibitor som et terapeutisk mal, anvendelser av forbindelsene i fremgangsmaten og ved fremstilling av medikamenter, samt farmasoytiske eller veterinaermedisinske preparater og fremgangsmate for fremstilling derav

Country Status (21)

Country Link
US (2) US7425562B2 (no)
EP (1) EP1362052B1 (no)
JP (1) JP4608183B2 (no)
KR (1) KR100860067B1 (no)
CN (1) CN1269822C (no)
AT (1) ATE356130T1 (no)
AU (1) AU2002219397B2 (no)
BR (1) BR0206501A (no)
CA (1) CA2436462C (no)
CY (1) CY1106640T1 (no)
DE (1) DE60218633T2 (no)
DK (1) DK1362052T3 (no)
ES (1) ES2281516T3 (no)
HK (1) HK1060729A1 (no)
IL (2) IL156774A0 (no)
MX (1) MXPA03006224A (no)
NO (1) NO328208B1 (no)
NZ (1) NZ526913A (no)
PT (1) PT1362052E (no)
RU (1) RU2329266C2 (no)
WO (1) WO2002057270A1 (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1383748A2 (en) 2000-12-22 2004-01-28 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2005504078A (ja) 2001-09-14 2005-02-10 アベンティス・ファーマスーティカルズ・インコーポレイテツド カテプシン阻害剤としての新規化合物および組成物
EP1446392A1 (en) 2001-11-14 2004-08-18 Aventis Pharmaceuticals, Inc. Oligopeptides and compositions containing them as cathepsin s inhibitors
ATE424401T1 (de) * 2002-07-16 2009-03-15 Amura Therapeutics Ltd Pyrrolderivate als hemmstoffe von cystein proteasen
US7399765B2 (en) * 2003-09-19 2008-07-15 Abbott Laboratories Substituted diazabicycloalkane derivatives
ATE461200T1 (de) * 2004-01-08 2010-04-15 Medivir Ab Inhibitoren von cysteinprotease
JP2005350417A (ja) * 2004-06-11 2005-12-22 Dai Ichi Seiyaku Co Ltd 還元的エーテル化法を用いたピロリジン誘導体の製造法
MX2007011617A (es) * 2005-03-21 2008-03-13 Applera Corp Compuestos de alfa-cetoamida como inhibidores de la cisteina proteasa.
GB0513840D0 (en) * 2005-07-07 2005-08-10 Medivir Ab Cysteine protease inhibitors
GB0513839D0 (en) * 2005-07-07 2005-08-10 Medivir Ab Cysteine protease inhibitors
GB0614052D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614037D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614046D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614053D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614042D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614044D0 (en) * 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
GB0614073D0 (en) 2006-07-14 2006-08-23 Amura Therapeutics Ltd Compounds
WO2008114054A1 (en) * 2007-03-19 2008-09-25 Medivir Ab Protease inhibitors
US7893067B2 (en) 2007-06-27 2011-02-22 Medivir Ab Cysteine protease inhibitors
JP5587790B2 (ja) * 2008-01-09 2014-09-10 アミュラ セラピューティクス リミティド 化合物
GB0804701D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
GB0804702D0 (en) 2008-03-13 2008-04-16 Amura Therapeutics Ltd Compounds
WO2012099785A2 (en) * 2011-01-20 2012-07-26 The Regents Of The University Of Colorado, A Body Corporate Modulators of tlr3/dsrna complex and uses thereof
DK2891492T3 (da) 2012-08-30 2022-11-21 Univ Tokyo Endoparasit kontrol middel
CN106279188A (zh) * 2016-07-21 2017-01-04 青岛科技大学 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3652574A (en) * 1970-04-01 1972-03-28 Abbott Lab Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof
DZ2285A1 (fr) 1996-08-08 2002-12-25 Smithkline Beecham Corp Inhibiteurs de protéase de la cystéine.
EP0923535A4 (en) 1996-08-28 2001-01-10 Smithkline Beecham Corp CYSTEINE PROTEASE INHIBITORS
CN1171878C (zh) 1996-12-23 2004-10-20 伊兰药品公司 化合物、其用途以及含有所述化合物的药物组合物
AR013079A1 (es) * 1997-05-06 2000-12-13 Smithkline Beecham Corp Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios
MA26618A1 (fr) 1998-04-09 2004-12-20 Smithkline Beecham Corp Composes et compositions pharmaceutiques pour le traitement du paludisme
CO5150165A1 (es) 1998-11-13 2002-04-29 Smithkline Beecham Plc Inhibidores de proteasa: tipo catepsina k
GB9911417D0 (en) 1999-05-18 1999-07-14 Peptide Therapeutics Ltd Furanone derivatives as inhibitors of cathepsin s
AU2002227222A1 (en) 2000-11-17 2002-05-27 Genzyme Corporation Cysteine protease inhibitors
EP1383748A2 (en) 2000-12-22 2004-01-28 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors

Also Published As

Publication number Publication date
US20090247471A1 (en) 2009-10-01
PT1362052E (pt) 2007-04-30
CA2436462A1 (en) 2002-07-25
CN1486320A (zh) 2004-03-31
AU2002219397B2 (en) 2008-02-14
MXPA03006224A (es) 2004-10-15
US7425562B2 (en) 2008-09-16
KR100860067B1 (ko) 2008-09-24
CY1106640T1 (el) 2012-01-25
BR0206501A (pt) 2004-01-13
DK1362052T3 (da) 2007-07-09
IL156774A0 (en) 2004-02-08
NO20033220L (no) 2003-09-17
RU2003125270A (ru) 2005-02-20
NO328208B1 (no) 2010-01-11
WO2002057270A1 (en) 2002-07-25
DE60218633D1 (de) 2007-04-19
RU2329266C2 (ru) 2008-07-20
IL156774A (en) 2008-08-07
NZ526913A (en) 2004-12-24
EP1362052A1 (en) 2003-11-19
ES2281516T3 (es) 2007-10-01
HK1060729A1 (en) 2004-08-20
JP4608183B2 (ja) 2011-01-05
EP1362052B1 (en) 2007-03-07
JP2004518674A (ja) 2004-06-24
ATE356130T1 (de) 2007-03-15
US20040138250A1 (en) 2004-07-15
KR20030075161A (ko) 2003-09-22
DE60218633T2 (de) 2008-02-21
CN1269822C (zh) 2006-08-16
CA2436462C (en) 2011-07-05

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