EP0923535A4 - Inhibitors of cysteine protease - Google Patents

Inhibitors of cysteine protease

Info

Publication number
EP0923535A4
EP0923535A4 EP97938632A EP97938632A EP0923535A4 EP 0923535 A4 EP0923535 A4 EP 0923535A4 EP 97938632 A EP97938632 A EP 97938632A EP 97938632 A EP97938632 A EP 97938632A EP 0923535 A4 EP0923535 A4 EP 0923535A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
cysteine protease
cysteine
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938632A
Other languages
German (de)
French (fr)
Other versions
EP0923535A1 (en
Inventor
Dennis S Yamashita
Renee L Desjarlais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0923535A1 publication Critical patent/EP0923535A1/en
Publication of EP0923535A4 publication Critical patent/EP0923535A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
EP97938632A 1996-08-28 1997-08-26 Inhibitors of cysteine protease Withdrawn EP0923535A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2484896P 1996-08-28 1996-08-28
US24848P 1996-08-28
PCT/US1997/015029 WO1998008802A1 (en) 1996-08-28 1997-08-26 Inhibitors of cysteine protease

Publications (2)

Publication Number Publication Date
EP0923535A1 EP0923535A1 (en) 1999-06-23
EP0923535A4 true EP0923535A4 (en) 2001-01-10

Family

ID=21822708

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938632A Withdrawn EP0923535A4 (en) 1996-08-28 1997-08-26 Inhibitors of cysteine protease

Country Status (3)

Country Link
EP (1) EP0923535A4 (en)
JP (1) JP2000517319A (en)
WO (1) WO1998008802A1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
AP9801222A0 (en) 1995-10-30 1998-06-30 Smithkline Beecham Corp Proatease inhibitors.
DE19817461A1 (en) * 1998-04-20 1999-10-21 Basf Ag New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc.
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
JP2003513972A (en) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション Protease inhibitor
AU1474801A (en) 1999-11-10 2001-06-06 Smithkline Beecham Corporation Protease inhibitors
SK13632002A3 (en) 2000-03-21 2003-02-04 Smithkline Beecham Corporation C1-6-alkyl-4-amino-azepan-3-one compounds, process for the preparation thereof, pharmaceutical composition comprising the same and intermediates
CA2433520A1 (en) 2000-12-22 2002-07-04 Axys Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2004520365A (en) 2001-01-17 2004-07-08 アミュラ テラピューティクス リミテッド Inhibitors of cruzipain and other cysteine proteases
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
EP1362052B1 (en) 2001-01-17 2007-03-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
EP1362042A1 (en) * 2001-01-17 2003-11-19 Amura Therapeutics Limited Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases
EP1436255A1 (en) 2001-09-14 2004-07-14 Aventis Pharmaceuticals, Inc. Novel compounds and compositions as cathepsin inhibitors
KR20050044497A (en) 2001-11-14 2005-05-12 아벤티스 파마슈티칼스 인크. Oligopeptides and compositions containing them as cathepsin s inhibitors
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
EP1483241A4 (en) 2002-03-08 2006-12-13 Bristol Myers Squibb Co Cyclic derivatives as modulators of chemokine receptor activity
KR100962972B1 (en) 2002-07-26 2010-06-09 주식회사유한양행 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof
DE202014101592U1 (en) 2014-04-04 2014-06-30 Wilkhahn Wilkening + Hahne Gmbh + Co. chair
CN114981251B (en) * 2020-01-21 2023-11-21 深圳信立泰药业股份有限公司 Dibenzofuran derivative cathepsin K inhibitor and preparation method and medical application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (en) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
EP0603873A1 (en) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Aminoketone derivatives
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5668128A (en) * 1994-04-13 1997-09-16 Takeda Chemical Industries, Ltd. Aziridine derivatives, their production and use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (en) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy and arylacyloxy methyl ketones as thiol protease inhibitors
EP0603873A1 (en) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Aminoketone derivatives
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9808802A1 *

Also Published As

Publication number Publication date
EP0923535A1 (en) 1999-06-23
JP2000517319A (en) 2000-12-26
WO1998008802A1 (en) 1998-03-05

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