EP0923535A4 - Inhibiteurs de cysteine protease - Google Patents

Inhibiteurs de cysteine protease

Info

Publication number
EP0923535A4
EP0923535A4 EP97938632A EP97938632A EP0923535A4 EP 0923535 A4 EP0923535 A4 EP 0923535A4 EP 97938632 A EP97938632 A EP 97938632A EP 97938632 A EP97938632 A EP 97938632A EP 0923535 A4 EP0923535 A4 EP 0923535A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
cysteine protease
cysteine
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938632A
Other languages
German (de)
English (en)
Other versions
EP0923535A1 (fr
Inventor
Dennis S Yamashita
Renee L Desjarlais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0923535A1 publication Critical patent/EP0923535A1/fr
Publication of EP0923535A4 publication Critical patent/EP0923535A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
EP97938632A 1996-08-28 1997-08-26 Inhibiteurs de cysteine protease Withdrawn EP0923535A4 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2484896P 1996-08-28 1996-08-28
US24848P 1996-08-28
PCT/US1997/015029 WO1998008802A1 (fr) 1996-08-28 1997-08-26 Inhibiteurs de cysteine protease

Publications (2)

Publication Number Publication Date
EP0923535A1 EP0923535A1 (fr) 1999-06-23
EP0923535A4 true EP0923535A4 (fr) 2001-01-10

Family

ID=21822708

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938632A Withdrawn EP0923535A4 (fr) 1996-08-28 1997-08-26 Inhibiteurs de cysteine protease

Country Status (3)

Country Link
EP (1) EP0923535A4 (fr)
JP (1) JP2000517319A (fr)
WO (1) WO1998008802A1 (fr)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR19990067184A (ko) 1995-10-30 1999-08-16 스튜어트 알. 수터, 스티븐 베네티아너, 피터 존 기딩스 프로테아제 억제제
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
DE19817461A1 (de) 1998-04-20 1999-10-21 Basf Ag Neue substituierte Benzamide, deren Herstellung und Anwendung
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
US6583137B1 (en) 1999-11-10 2003-06-24 Smithkline Beecham Corporation Protease inhibitors
EP1232155A4 (fr) 1999-11-10 2002-11-20 Smithkline Beecham Corp Inhibiteurs de protease
JP2003513924A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
NZ520588A (en) 2000-03-21 2004-06-25 Smithkline Beecham Corp Protease inhibitors
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
EP1383748A2 (fr) 2000-12-22 2004-01-28 Axys Pharmaceuticals, Inc. Composes et compositions en tant qu'inhibiteurs de cathepsine
CA2434068A1 (fr) 2001-01-17 2002-07-25 Amura Therapeutics Limited Inhibiteurs de la cruzipaine et d'autres cysteines proteases
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
CA2435117A1 (fr) * 2001-01-17 2002-07-25 Amura Therapeutics Limited 2-carbonylaminocetones cycliques, inhibiteurs de la cruzipain et autres cysteine proteases
US7425562B2 (en) 2001-01-17 2008-09-16 Amura Therapeutics Ltd. Inhibitors of cruzipain and other cysteine proteases
JP2005504078A (ja) 2001-09-14 2005-02-10 アベンティス・ファーマスーティカルズ・インコーポレイテツド カテプシン阻害剤としての新規化合物および組成物
EP1446392A1 (fr) 2001-11-14 2004-08-18 Aventis Pharmaceuticals, Inc. Nouveaux composes et compositions jouant le role d'inhibiteurs de cathepsine s
EP1465862A1 (fr) 2002-01-17 2004-10-13 SmithKline Beecham Corporation Derives de cetoamides a substitution cycloalkyle, utiles comme inhibiteurs de cathepsine k
US7087604B2 (en) 2002-03-08 2006-08-08 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
KR100962972B1 (ko) * 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
DE202014101592U1 (de) 2014-04-04 2014-06-30 Wilkhahn Wilkening + Hahne Gmbh + Co. Stuhl
WO2021147882A1 (fr) * 2020-01-21 2021-07-29 深圳信立泰药业股份有限公司 Inhibiteur de la cathepsine k dérivé du dibenzofurane, son procédé de préparation et son utilisation médicale

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (fr) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy et arylacyloxy méthyl cétones comme inhibiteurs de thiol protéase
EP0603873A1 (fr) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Dérivés d'aminocétone
WO1997016433A1 (fr) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Inhibiteurs de proteases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69510338T2 (de) * 1994-04-13 1999-10-14 Takeda Chemical Industries Ltd Azirdin-derivate, deren herstellung und verwendung

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (fr) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy et arylacyloxy méthyl cétones comme inhibiteurs de thiol protéase
EP0603873A1 (fr) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Dérivés d'aminocétone
WO1997016433A1 (fr) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Inhibiteurs de proteases

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9808802A1 *

Also Published As

Publication number Publication date
WO1998008802A1 (fr) 1998-03-05
JP2000517319A (ja) 2000-12-26
EP0923535A1 (fr) 1999-06-23

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