EP0923535A4 - Inhibitoren der cystein-protease - Google Patents

Inhibitoren der cystein-protease

Info

Publication number
EP0923535A4
EP0923535A4 EP97938632A EP97938632A EP0923535A4 EP 0923535 A4 EP0923535 A4 EP 0923535A4 EP 97938632 A EP97938632 A EP 97938632A EP 97938632 A EP97938632 A EP 97938632A EP 0923535 A4 EP0923535 A4 EP 0923535A4
Authority
EP
European Patent Office
Prior art keywords
inhibitors
cysteine protease
cysteine
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP97938632A
Other languages
English (en)
French (fr)
Other versions
EP0923535A1 (de
Inventor
Dennis S Yamashita
Renee L Desjarlais
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of EP0923535A1 publication Critical patent/EP0923535A1/de
Publication of EP0923535A4 publication Critical patent/EP0923535A4/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
EP97938632A 1996-08-28 1997-08-26 Inhibitoren der cystein-protease Withdrawn EP0923535A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2484896P 1996-08-28 1996-08-28
US24848P 1996-08-28
PCT/US1997/015029 WO1998008802A1 (en) 1996-08-28 1997-08-26 Inhibitors of cysteine protease

Publications (2)

Publication Number Publication Date
EP0923535A1 EP0923535A1 (de) 1999-06-23
EP0923535A4 true EP0923535A4 (de) 2001-01-10

Family

ID=21822708

Family Applications (1)

Application Number Title Priority Date Filing Date
EP97938632A Withdrawn EP0923535A4 (de) 1996-08-28 1997-08-26 Inhibitoren der cystein-protease

Country Status (3)

Country Link
EP (1) EP0923535A4 (de)
JP (1) JP2000517319A (de)
WO (1) WO1998008802A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6586466B2 (en) 1995-10-30 2003-07-01 Smithkline Beecham Corporation Carbohydrazide-protease inhibitors
HUP9900964A3 (en) 1995-10-30 2001-02-28 Smithkline Beecham Corp Protease inhibitors and pharmaceutical compositions containing these compounds
DE19817461A1 (de) * 1998-04-20 1999-10-21 Basf Ag Neue substituierte Benzamide, deren Herstellung und Anwendung
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
TW200404789A (en) 1999-03-15 2004-04-01 Axys Pharm Inc Novel compounds and compositions as protease inhibitors
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1232155A4 (de) 1999-11-10 2002-11-20 Smithkline Beecham Corp Protease inhibitoren
JP2003513924A (ja) 1999-11-10 2003-04-15 スミスクライン・ビーチャム・コーポレイション プロテア−ゼ阻害剤
SK13632002A3 (sk) 2000-03-21 2003-02-04 Smithkline Beecham Corporation C1-6-alkyl-4-amino-azepán-3-ónové zlúčeniny, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom, ich použitie a medziprodukty
IL156577A0 (en) 2000-12-22 2004-01-04 Axys Pharm Inc Selective cathepsin s inhibitors and pharmaceutical compositions containing the same
US7030116B2 (en) 2000-12-22 2006-04-18 Aventis Pharmaceuticals Inc. Compounds and compositions as cathepsin inhibitors
JP2004520365A (ja) 2001-01-17 2004-07-08 アミュラ テラピューティクス リミテッド クルジパインおよび他のシステインプロテアーゼの阻害剤
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
CA2435117A1 (en) * 2001-01-17 2002-07-25 Amura Therapeutics Limited Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases
PT1362052E (pt) 2001-01-17 2007-04-30 Amura Therapeutics Ltd Inibidores de cruzipaína e de outras proteases de cisteína
BR0212535A (pt) 2001-09-14 2004-10-19 Aventis Pharma Inc Compostos e composições como inibidores de catepsina
CN1324018C (zh) 2001-11-14 2007-07-04 安万特药物公司 作为组织蛋白酶s抑制剂的寡肽以及含有它们的组合物
US7282512B2 (en) 2002-01-17 2007-10-16 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin K inhibitors
WO2003075853A2 (en) 2002-03-08 2003-09-18 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
KR100962972B1 (ko) 2002-07-26 2010-06-09 주식회사유한양행 1-페닐피페리딘-3-온 유도체 및 그의 제조방법
DE202014101592U1 (de) 2014-04-04 2014-06-30 Wilkhahn Wilkening + Hahne Gmbh + Co. Stuhl
CN114981251B (zh) * 2020-01-21 2023-11-21 深圳信立泰药业股份有限公司 一种二苯并呋喃类衍生物组织蛋白酶k抑制剂及其制备方法和医药用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (de) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy- und Arylacyloxymethyl-Ketone als Thiolprotease-Hemmungsstoffe
EP0603873A1 (de) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Aminoketonderivate
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2223595A (en) * 1994-04-13 1995-11-10 Takeda Chemical Industries Ltd. Aziridine derivatives, their production and use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0272671A2 (de) * 1986-12-22 1988-06-29 Sandoz Ltd. Aryloxy- und Arylacyloxymethyl-Ketone als Thiolprotease-Hemmungsstoffe
EP0603873A1 (de) * 1992-12-25 1994-06-29 Mitsubishi Chemical Corporation Aminoketonderivate
WO1997016433A1 (en) * 1995-10-30 1997-05-09 Smithkline Beecham Corporation Protease inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of WO9808802A1 *

Also Published As

Publication number Publication date
JP2000517319A (ja) 2000-12-26
WO1998008802A1 (en) 1998-03-05
EP0923535A1 (de) 1999-06-23

Similar Documents

Publication Publication Date Title
CY2528B1 (en) Inhibitors of cysteine protease
ZA951573B (en) Cysteine protease inhibitors
IL129603A0 (en) Benzamidoaldehydes and their use as cysteine protease inhibitors
AU4236796A (en) Cysteine protease and serine protease inhibitors
EP0923535A4 (de) Inhibitoren der cystein-protease
ZA964751B (en) Reversible cysteine protease inhibitors
PL336625A1 (en) Protease inhibitors
PL336589A1 (en) Serinic protease inhibitors
PL328307A1 (en) Serinic protease inhibitors
PL328665A1 (en) Inhibitors of serinic protease
PL336856A1 (en) Protease inhibitors
PL337725A1 (en) Inhibitors of proteases
PL337755A1 (en) Protease inhibitors
PL328875A1 (en) Serinic protease inhibitors
PL328223A1 (en) Aspartil protease inhibitors
IL139187A0 (en) Cysteine protease inhibitors
HK1039276A1 (en) Hydroxamate-containing cysteine and serine protease inhibitors
EP1015438A4 (de) Protease inhibitoren
EP0975612A4 (de) Proteaseinhibitoren
SI0936912T1 (en) Inhibitors of cysteine protease
GB9613719D0 (en) Serine protease inhibitors
ZA969078B (en) Inhibitors of cysteine protease.
ZA977032B (en) Protease inhibitors
ZA983097B (en) Protease inhibitors

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19990305

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): BE CH DE DK FR GB IT LI NL

A4 Supplementary search report drawn up and despatched

Effective date: 20001124

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): BE CH DE DK FR GB IT LI NL

RIC1 Information provided on ipc code assigned before grant

Free format text: 7C 07C 211/00 A, 7A 61K 31/13 B, 7C 07C 271/22 B, 7C 07C 237/04 B

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20010627

REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1020939

Country of ref document: HK