PL336856A1 - Protease inhibitors - Google Patents
Protease inhibitorsInfo
- Publication number
- PL336856A1 PL336856A1 PL98336856A PL33685698A PL336856A1 PL 336856 A1 PL336856 A1 PL 336856A1 PL 98336856 A PL98336856 A PL 98336856A PL 33685698 A PL33685698 A PL 33685698A PL 336856 A1 PL336856 A1 PL 336856A1
- Authority
- PL
- Poland
- Prior art keywords
- protease inhibitors
- protease
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4575897P | 1997-05-06 | 1997-05-06 | |
| PCT/US1998/003200 WO1998050533A1 (en) | 1997-05-06 | 1998-05-06 | Protease inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL336856A1 true PL336856A1 (en) | 2000-07-17 |
Family
ID=21939723
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL98336856A PL336856A1 (en) | 1997-05-06 | 1998-05-06 | Protease inhibitors |
Country Status (19)
| Country | Link |
|---|---|
| EP (1) | EP1003846A4 (en) |
| JP (1) | JP2001525804A (en) |
| KR (1) | KR20010012256A (en) |
| CN (1) | CN1255161A (en) |
| AR (1) | AR013079A1 (en) |
| AU (1) | AU7562598A (en) |
| BR (1) | BR9809306A (en) |
| CA (1) | CA2288868A1 (en) |
| CO (1) | CO4950618A1 (en) |
| HU (1) | HUP0002247A3 (en) |
| IL (1) | IL132088A0 (en) |
| NO (1) | NO995434L (en) |
| NZ (1) | NZ337889A (en) |
| PE (1) | PE71599A1 (en) |
| PL (1) | PL336856A1 (en) |
| TR (1) | TR199902766T2 (en) |
| UY (1) | UY25143A1 (en) |
| WO (1) | WO1998050533A1 (en) |
| ZA (1) | ZA983762B (en) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CO5150165A1 (en) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | PROTEASE INHIBITORS: KATEPSIN K TYPE |
| DZ3083A1 (en) * | 1999-02-19 | 2004-06-02 | Smithkline Beecham Corp | New protease inhibitor compounds, process for their preparation and pharmaceutical compositions containing them |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| WO2001034599A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
| CA2426271A1 (en) * | 2000-10-19 | 2002-04-25 | Naeja Pharmaceutical Inc. | Dihydropyrimidine derivatives as cysteine protease inhibitors |
| EP1345931A2 (en) * | 2000-11-17 | 2003-09-24 | Medivir UK Ltd | Cysteine protease inhibitors |
| ATE323083T1 (en) * | 2000-11-17 | 2006-04-15 | Medivir Ab | CYSTEIN PROTEASE INHIBITORS |
| JP2004520365A (en) * | 2001-01-17 | 2004-07-08 | アミュラ テラピューティクス リミテッド | Inhibitors of cruzipain and other cysteine proteases |
| EP1362052B1 (en) * | 2001-01-17 | 2007-03-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| EP1362042A1 (en) * | 2001-01-17 | 2003-11-19 | Amura Therapeutics Limited | Cyclic 2-carbonylaminoketones as inhibitors of cruzipain and other cysteine proteases |
| US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
| WO2003037892A1 (en) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
| BR0312662A (en) * | 2002-07-16 | 2005-05-03 | Amura Therapeutics Ltd | Biologically Active Compounds |
| KR100962972B1 (en) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof |
| AU2016206281B2 (en) * | 2003-08-06 | 2017-11-30 | Senomyx, Inc. | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| NZ619746A (en) | 2003-08-06 | 2014-05-30 | Senomyx Inc | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
| EP1701960B1 (en) * | 2004-01-08 | 2010-03-17 | Medivir Aktiebolag | Cysteine protease inhibitors |
| EP1931657B1 (en) * | 2005-08-17 | 2013-12-25 | Merck Sharp & Dohme Corp. | Novel high affinity quinoline-based kinase ligands |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| EP2152664B1 (en) * | 2007-06-13 | 2014-09-03 | Bristol-Myers Squibb Company | Dipeptide analogs as coagulation factor inhibitors |
| US7893067B2 (en) | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
| EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
| GB0817424D0 (en) | 2008-09-24 | 2008-10-29 | Medivir Ab | Protease inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3190431B2 (en) * | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | Ketone derivatives |
| JPH05140063A (en) * | 1991-11-19 | 1993-06-08 | Suntory Ltd | Dipeptide derivative and medicine for preventing and improving osteopathy, containing the same compound as active component |
| CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
| JP2848232B2 (en) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | Aldehyde derivatives |
| JP3599287B2 (en) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | Sulfonamide derivative |
| US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
| EA199700087A1 (en) * | 1995-10-30 | 1998-04-30 | Смитклайн Бичам Корпорейшн | METHOD OF INHIBITING KATEPSIN K |
| TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
| WO1998004539A1 (en) * | 1996-07-29 | 1998-02-05 | Mitsubishi Chemical Corporation | Oxygenic heterocyclic derivatives |
-
1998
- 1998-05-04 AR ARP980102069A patent/AR013079A1/en unknown
- 1998-05-05 PE PE1998000336A patent/PE71599A1/en not_active Application Discontinuation
- 1998-05-05 ZA ZA983762A patent/ZA983762B/en unknown
- 1998-05-06 EP EP98923299A patent/EP1003846A4/en not_active Withdrawn
- 1998-05-06 BR BR9809306-1A patent/BR9809306A/en not_active Application Discontinuation
- 1998-05-06 IL IL13208898A patent/IL132088A0/en unknown
- 1998-05-06 NZ NZ337889A patent/NZ337889A/en unknown
- 1998-05-06 JP JP54804998A patent/JP2001525804A/en active Pending
- 1998-05-06 WO PCT/US1998/003200 patent/WO1998050533A1/en not_active Application Discontinuation
- 1998-05-06 PL PL98336856A patent/PL336856A1/en unknown
- 1998-05-06 CA CA002288868A patent/CA2288868A1/en not_active Abandoned
- 1998-05-06 AU AU75625/98A patent/AU7562598A/en not_active Abandoned
- 1998-05-06 CO CO98024945A patent/CO4950618A1/en unknown
- 1998-05-06 KR KR1019997010207A patent/KR20010012256A/en not_active Application Discontinuation
- 1998-05-06 TR TR1999/02766T patent/TR199902766T2/en unknown
- 1998-05-06 CN CN98804791A patent/CN1255161A/en active Pending
- 1998-05-06 HU HU0002247A patent/HUP0002247A3/en unknown
- 1998-08-17 UY UY25143A patent/UY25143A1/en unknown
-
1999
- 1999-11-05 NO NO995434A patent/NO995434L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2001525804A (en) | 2001-12-11 |
| HUP0002247A3 (en) | 2003-01-28 |
| IL132088A0 (en) | 2001-03-19 |
| EP1003846A1 (en) | 2000-05-31 |
| CN1255161A (en) | 2000-05-31 |
| WO1998050533A1 (en) | 1998-11-12 |
| PE71599A1 (en) | 1999-09-15 |
| BR9809306A (en) | 2000-07-04 |
| EP1003846A4 (en) | 2002-11-13 |
| NO995434D0 (en) | 1999-11-05 |
| KR20010012256A (en) | 2001-02-15 |
| ZA983762B (en) | 1998-11-06 |
| TR199902766T2 (en) | 2000-02-21 |
| CO4950618A1 (en) | 2000-09-01 |
| CA2288868A1 (en) | 1998-11-12 |
| AR013079A1 (en) | 2000-12-13 |
| HUP0002247A2 (en) | 2001-05-28 |
| AU7562598A (en) | 1998-11-27 |
| NZ337889A (en) | 2001-09-28 |
| UY25143A1 (en) | 1998-11-27 |
| NO995434L (en) | 1999-11-05 |
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