PE71599A1 - PROTEASE INHIBITORS - Google Patents
PROTEASE INHIBITORSInfo
- Publication number
- PE71599A1 PE71599A1 PE1998000336A PE00033698A PE71599A1 PE 71599 A1 PE71599 A1 PE 71599A1 PE 1998000336 A PE1998000336 A PE 1998000336A PE 00033698 A PE00033698 A PE 00033698A PE 71599 A1 PE71599 A1 PE 71599A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- alkyll
- ccero
- alkylll
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/99—Enzyme inactivation by chemical treatment
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/32—Oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/06—Anabolic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/22—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
- C07D307/83—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/86—Benzo [b] furans; Hydrogenated benzo [b] furans with an oxygen atom directly attached in position 7
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/30—Oxygen atoms, e.g. delta-lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Pyrane Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA (I) O SU SAL, DONDE: R1 ES R", R"C(O), R"R`NC(O), ENTRE OTROS; R2 Y R4 SON H, ALQUILO C1-C6, ALQUENILO C2-C6, Ar-ALQUILO Ccero-C6, Het-ALQUILO Ccero-C6; R3 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ALQUINILO C2-C6, ENTRE OTROS; R5 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R' ES H, ALQUILO C1-C6, ALQUENILO C2-C6, ENTRE OTROS; R" ES ALQUILO C1-C6, Ar-ALQUILO C CERO-C6, ENTRE OTROS; X ES O o S; n ES 1-3. SON COMPUESTOS PREFERIDOS 4-(R,S)-AMINO-N-[(3,4-METILENDIOXIBENZOIL)-S-LEUCINA]-TETRAHIDROFURAN-3-ONA, TRANS-4-(R,S)-AMINO-N-[BENCILOXICARBONIL)-S-LEUCINA]-3-HIDROXITETRAHIDROFURANO, ENTRE OTROS. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO (I) INHIBE LA ENZIMA CISTEINA PROTEASA EN PARTICULAR LA CATEPSINA K, POR LO QUE PUEDE SER UTIL PARA INHIBIR PERDIDA OSEA, OSTEOPOROSIS, ENFERMEDAD GINGIVAL O PERIODONTAL; TRATAR UNA ENFERMEDAD CARACTERIZADA POR UNA DEGRADACION EXCESIVA DE CARTILAGO O MATRIZ COMO LA OSTEOARTRITIS O ARTRITIS REUMATOIDEREFERS TO A COMPOUND OF FORMULA (I) OR ITS SALT, WHERE: R1 IS R ", R" C (O), R "R`NC (O), AMONG OTHERS; R2 AND R4 ARE H, RENT C1-C6 , C2-C6 ALKYYL, Ar-Ccero-C6 ALKYL, Het-Ccero-C6 ALKYL; R3 ES H, C1-C6 ALKYL, C2-C6 ALKYLL, AMONG OTHERS; R5 IS H, C1-C6 ALKYL , C2-C6 ALKYLLL, AMONG OTHERS; R6 IS H, C1-C6 ALKYLL, C2-C6 ALKYLL, AMONG OTHERS; R 'ES H, C1-C6 ALKYLL, C2-C6 ALKYLLL, R1 IS C1- C6, Ar-ALKYL C ZERO-C6, AMONG OTHERS; X IS O or S; n IS 1-3. THEY ARE PREFERRED COMPOUNDS 4- (R, S) -AMINO-N - [(3,4-METHYLENDIOXIBENZOIL) -S-LEUCINE] -TETRAHYDROFURAN-3-ONA, TRANS-4- (R, S) -AMINO-N- [ BENCILOXICARBONIL) -S-LEUCINA] -3-HIDROXITETRAHIDROFURANO, AMONG OTHERS. IT ALSO REFERS TO A PROCEDURE FOR PREPARATION. COMPOUND (I) INHIBITS THE CYSTEINE ENZYME PROTEASE IN PARTICULAR CATEPSIN K, SO IT MAY BE USEFUL TO INHIBIT LOSS OF OSEA, OSTEOPOROSIS, GINGIVAL OR PERIODONTAL DISEASE; TREAT A DISEASE CHARACTERIZED BY EXCESSIVE DEGRADATION OF CARTILAGO OR MATRIX LIKE OSTEOARTHRITIS OR RHEUMATOID ARTHRITIS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US4575897P | 1997-05-06 | 1997-05-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE71599A1 true PE71599A1 (en) | 1999-09-15 |
Family
ID=21939723
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE1998000336A PE71599A1 (en) | 1997-05-06 | 1998-05-05 | PROTEASE INHIBITORS |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP1003846A4 (en) |
JP (1) | JP2001525804A (en) |
KR (1) | KR20010012256A (en) |
CN (1) | CN1255161A (en) |
AR (1) | AR013079A1 (en) |
AU (1) | AU7562598A (en) |
BR (1) | BR9809306A (en) |
CA (1) | CA2288868A1 (en) |
CO (1) | CO4950618A1 (en) |
HU (1) | HUP0002247A3 (en) |
IL (1) | IL132088A0 (en) |
NO (1) | NO995434D0 (en) |
NZ (1) | NZ337889A (en) |
PE (1) | PE71599A1 (en) |
PL (1) | PL336856A1 (en) |
TR (1) | TR199902766T2 (en) |
UY (1) | UY25143A1 (en) |
WO (1) | WO1998050533A1 (en) |
ZA (1) | ZA983762B (en) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CO5150165A1 (en) * | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | PROTEASE INHIBITORS: KATEPSIN K TYPE |
DZ3083A1 (en) * | 1999-02-19 | 2004-06-02 | Smithkline Beecham Corp | New protease inhibitor compounds, process for their preparation and pharmaceutical compositions containing them |
GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
WO2001034599A1 (en) * | 1999-11-10 | 2001-05-17 | Smithkline Beecham Corporation | Protease inhibitors |
US20040024000A1 (en) * | 2000-10-19 | 2004-02-05 | Rajeshwar Singh | Dihydropyrimidine derivatives as cysteine protease inhibitors |
JP2004513942A (en) * | 2000-11-17 | 2004-05-13 | メディヴァー ユーケイ リミテッド | Cysteine protease inhibitor |
JP2004520439A (en) * | 2000-11-17 | 2004-07-08 | メディヴィル・アクチボラグ | Cysteine protease inhibitor |
JP2004522738A (en) * | 2001-01-17 | 2004-07-29 | アミュラ テラピューティクス リミテッド | Cyclic 2-carbonylaminoketones as inhibitors of cruzipaine and other cysteine proteases |
US7132449B2 (en) | 2001-01-17 | 2006-11-07 | Amura Therapeutics Limited | Inhibitors of cruzipain and other cysteine proteases |
AU2002219397B2 (en) * | 2001-01-17 | 2008-02-14 | Grünenthal GmbH | Inhibitors of cruzipain and other cysteine proteases |
NZ526912A (en) * | 2001-01-17 | 2005-02-25 | Amura Therapeutics Ltd | Inhibitors of cruzipain and other cysteine proteases |
WO2003037892A1 (en) * | 2001-10-29 | 2003-05-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cysteine proteases |
NZ537853A (en) * | 2002-07-16 | 2007-02-23 | Amura Therapeutics Ltd | Inhibitors of cathepsin K and related cysteine protesases of the CA clan |
KR100962972B1 (en) | 2002-07-26 | 2010-06-09 | 주식회사유한양행 | 1-phenylpiperidin-3-one derivatives and processes for the preparation thereof |
BRPI0413324A (en) | 2003-08-06 | 2006-10-10 | Senomyx Inc | t1r hetero-oligomeric taste receptors, cell lines expressing said receptors, and taste compounds |
AU2016206281B2 (en) * | 2003-08-06 | 2017-11-30 | Senomyx, Inc. | Novel flavors, flavor modifiers, tastants, taste enhancers, umami or sweet tastants, and/or enhancers and use thereof |
DE602005019971D1 (en) * | 2004-01-08 | 2010-04-29 | Medivir Ab | INHIBITORS OF CYSTONE PROTEASE |
CA2619706A1 (en) * | 2005-08-17 | 2007-02-22 | Schering Corporation | Novel high affinity quinoline-based kinase ligands |
GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
MX2009012847A (en) * | 2007-06-13 | 2009-12-08 | Bristol Myers Squibb Co | Dipeptide analogs as coagulation factor inhibitors. |
US7893067B2 (en) | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
EP2240491B1 (en) | 2008-01-09 | 2015-07-15 | Amura Therapeutics Limited | TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES |
GB0817424D0 (en) * | 2008-09-24 | 2008-10-29 | Medivir Ab | Protease inhibitors |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3190431B2 (en) * | 1991-07-01 | 2001-07-23 | 三菱化学株式会社 | Ketone derivatives |
JPH05140063A (en) * | 1991-11-19 | 1993-06-08 | Suntory Ltd | Dipeptide derivative and medicine for preventing and improving osteopathy, containing the same compound as active component |
CA2111930A1 (en) * | 1992-12-25 | 1994-06-26 | Ryoichi Ando | Aminoketone derivatives |
JP2848232B2 (en) * | 1993-02-19 | 1999-01-20 | 武田薬品工業株式会社 | Aldehyde derivatives |
JP3599287B2 (en) * | 1993-04-28 | 2004-12-08 | 三菱化学株式会社 | Sulfonamide derivative |
US5403952A (en) * | 1993-10-08 | 1995-04-04 | Merck & Co., Inc. | Substituted cyclic derivatives as novel antidegenerative agents |
SK88997A3 (en) * | 1995-10-30 | 1998-05-06 | Smithkline Beecham Corp | Method of inhibiting cathepsin k |
TW448172B (en) * | 1996-03-08 | 2001-08-01 | Pharmacia & Upjohn Co Llc | Novel hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation |
WO1998004539A1 (en) * | 1996-07-29 | 1998-02-05 | Mitsubishi Chemical Corporation | Oxygenic heterocyclic derivatives |
-
1998
- 1998-05-04 AR ARP980102069A patent/AR013079A1/en unknown
- 1998-05-05 PE PE1998000336A patent/PE71599A1/en not_active Application Discontinuation
- 1998-05-05 ZA ZA983762A patent/ZA983762B/en unknown
- 1998-05-06 CO CO98024945A patent/CO4950618A1/en unknown
- 1998-05-06 CN CN98804791A patent/CN1255161A/en active Pending
- 1998-05-06 EP EP98923299A patent/EP1003846A4/en not_active Withdrawn
- 1998-05-06 WO PCT/US1998/003200 patent/WO1998050533A1/en not_active Application Discontinuation
- 1998-05-06 KR KR1019997010207A patent/KR20010012256A/en not_active Application Discontinuation
- 1998-05-06 JP JP54804998A patent/JP2001525804A/en active Pending
- 1998-05-06 BR BR9809306-1A patent/BR9809306A/en not_active Application Discontinuation
- 1998-05-06 PL PL98336856A patent/PL336856A1/en unknown
- 1998-05-06 HU HU0002247A patent/HUP0002247A3/en unknown
- 1998-05-06 TR TR1999/02766T patent/TR199902766T2/en unknown
- 1998-05-06 IL IL13208898A patent/IL132088A0/en unknown
- 1998-05-06 NZ NZ337889A patent/NZ337889A/en unknown
- 1998-05-06 CA CA002288868A patent/CA2288868A1/en not_active Abandoned
- 1998-05-06 AU AU75625/98A patent/AU7562598A/en not_active Abandoned
- 1998-08-17 UY UY25143A patent/UY25143A1/en unknown
-
1999
- 1999-11-05 NO NO995434A patent/NO995434D0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NO995434L (en) | 1999-11-05 |
KR20010012256A (en) | 2001-02-15 |
TR199902766T2 (en) | 2000-02-21 |
CA2288868A1 (en) | 1998-11-12 |
EP1003846A1 (en) | 2000-05-31 |
WO1998050533A1 (en) | 1998-11-12 |
NO995434D0 (en) | 1999-11-05 |
PL336856A1 (en) | 2000-07-17 |
UY25143A1 (en) | 1998-11-27 |
CO4950618A1 (en) | 2000-09-01 |
JP2001525804A (en) | 2001-12-11 |
IL132088A0 (en) | 2001-03-19 |
AR013079A1 (en) | 2000-12-13 |
AU7562598A (en) | 1998-11-27 |
CN1255161A (en) | 2000-05-31 |
HUP0002247A3 (en) | 2003-01-28 |
HUP0002247A2 (en) | 2001-05-28 |
BR9809306A (en) | 2000-07-04 |
EP1003846A4 (en) | 2002-11-13 |
NZ337889A (en) | 2001-09-28 |
ZA983762B (en) | 1998-11-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD | Application declared void or lapsed |