CO5150165A1 - PROTEASE INHIBITORS: KATEPSIN K TYPE - Google Patents

PROTEASE INHIBITORS: KATEPSIN K TYPE

Info

Publication number
CO5150165A1
CO5150165A1 CO99070943A CO99070943A CO5150165A1 CO 5150165 A1 CO5150165 A1 CO 5150165A1 CO 99070943 A CO99070943 A CO 99070943A CO 99070943 A CO99070943 A CO 99070943A CO 5150165 A1 CO5150165 A1 CO 5150165A1
Authority
CO
Colombia
Prior art keywords
katepsin
type
protease inhibitors
compound according
mfi
Prior art date
Application number
CO99070943A
Other languages
Spanish (es)
Inventor
Andrew D Gribble
Jason Witherington
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of CO5150165A1 publication Critical patent/CO5150165A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

U n compuesto de acuerdo con la fórmula (I) :<EMI FILE="99070943_1" ID="1" IMF=JPEG >en la que:n es 1 ó 2;o una de sus sales farmacéuticamente aceptables.Un método para inhibir una cisteína-proteasa que comprende administrar a un paciente que necesita de ello una cantidad eficaz de un compuesto de acuerdo con la reivindicación 1.A compound according to formula (I): <EMI FILE = "99070943_1" ID = "1" MFI = JPEG> in which: n is 1 or 2; or one of its pharmaceutically acceptable salts. A method to inhibit a cysteine protease comprising administering to a patient in need thereof an effective amount of a compound according to claim 1.

CO99070943A 1998-11-13 1999-11-10 PROTEASE INHIBITORS: KATEPSIN K TYPE CO5150165A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10841098P 1998-11-13 1998-11-13

Publications (1)

Publication Number Publication Date
CO5150165A1 true CO5150165A1 (en) 2002-04-29

Family

ID=22322023

Family Applications (1)

Application Number Title Priority Date Filing Date
CO99070943A CO5150165A1 (en) 1998-11-13 1999-11-10 PROTEASE INHIBITORS: KATEPSIN K TYPE

Country Status (5)

Country Link
AR (1) AR021241A1 (en)
AU (1) AU1393900A (en)
CO (1) CO5150165A1 (en)
PE (1) PE20001237A1 (en)
WO (1) WO2000029408A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030144175A1 (en) 1998-12-23 2003-07-31 Smithkline Beecham Corporation Protease inhibitors
WO2001034599A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
EP1229914A4 (en) 1999-11-10 2004-06-23 Smithkline Beecham Corp Protease inhibitors
WO2001034600A1 (en) 1999-11-10 2001-05-17 Smithkline Beecham Corporation Protease inhibitors
NZ520588A (en) 2000-03-21 2004-06-25 Smithkline Beecham Corp Protease inhibitors
JP2004520439A (en) * 2000-11-17 2004-07-08 メディヴィル・アクチボラグ Cysteine protease inhibitor
JP2004522738A (en) * 2001-01-17 2004-07-29 アミュラ テラピューティクス リミテッド Cyclic 2-carbonylaminoketones as inhibitors of cruzipaine and other cysteine proteases
US7132449B2 (en) 2001-01-17 2006-11-07 Amura Therapeutics Limited Inhibitors of cruzipain and other cysteine proteases
NZ526912A (en) * 2001-01-17 2005-02-25 Amura Therapeutics Ltd Inhibitors of cruzipain and other cysteine proteases
AU2002219397B2 (en) 2001-01-17 2008-02-14 Grünenthal GmbH Inhibitors of cruzipain and other cysteine proteases
WO2003062192A1 (en) 2002-01-17 2003-07-31 Smithkline Beecham Corporation Cycloalkyl ketoamides derivatives useful as cathepsin k inhibitors
EP2240491B1 (en) 2008-01-09 2015-07-15 Amura Therapeutics Limited TETRAHYDROFURO(2,3-b)PYRROL-3-ONE DERIVATIVES AS INHIBITORS OF CYSTEINE PROTEINASES

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5374623A (en) * 1992-08-20 1994-12-20 Prototek, Inc. Cysteine protease inhibitors effective for in vivo use
CA2111930A1 (en) * 1992-12-25 1994-06-26 Ryoichi Ando Aminoketone derivatives
MA26487A1 (en) * 1997-04-29 2004-12-20 Smithkline Beecham Corp PROTEASE INHIBITOR HETEROCYCLECETOHYDRAZIDES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM.
AR013079A1 (en) * 1997-05-06 2000-12-13 Smithkline Beecham Corp SUBSTITUTED DERIVATIVES OF TETRAHIDROFURANO-3-ONAS, TETRAHIDROPIRANO-3- ONAS AND TETRAHIDROTIOFEN-3-ONAS, A PROCEDURE FOR THE PREPARATION OF A PHARMACEUTICAL COMPOSITION OF A MEDICINAL PRODUCT USEFUL AS INTERMEDIATE PROTEIN INHIBITORS
EP0983228A4 (en) * 1997-05-08 2002-08-07 Smithkline Beecham Corp Protease inhibitors
US6369077B1 (en) * 1997-05-08 2002-04-09 Smithkline Beecham Corporation Protease inhibitors
MA26618A1 (en) * 1998-04-09 2004-12-20 Smithkline Beecham Corp PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF MALARIA
MA26631A1 (en) * 1998-05-21 2004-12-20 Smithkline Beecham Corp NEW BIS-AMINOMETHYL-CARBONYL FUNCTIONAL COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

Also Published As

Publication number Publication date
WO2000029408A1 (en) 2000-05-25
PE20001237A1 (en) 2000-12-23
AU1393900A (en) 2000-06-05
AR021241A1 (en) 2002-07-03

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