AR005549A1 - DERIVATIVES OF 1-PIRAZOL-3-ILETIL-4-INDOL-3-ILPIPERIDINA, A PROCEDURE FOR PREPARING THEM, MEDICINES AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, A PROCEDURE FOR PREPARING THE PHARMACEUTICAL PREPARATIONS AND USE OF THE SAME MEDICINAL PREPARATIONS FOR THE PREPARATIONS - Google Patents
DERIVATIVES OF 1-PIRAZOL-3-ILETIL-4-INDOL-3-ILPIPERIDINA, A PROCEDURE FOR PREPARING THEM, MEDICINES AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, A PROCEDURE FOR PREPARING THE PHARMACEUTICAL PREPARATIONS AND USE OF THE SAME MEDICINAL PREPARATIONS FOR THE PREPARATIONSInfo
- Publication number
- AR005549A1 AR005549A1 ARP970100297A ARP970100297A AR005549A1 AR 005549 A1 AR005549 A1 AR 005549A1 AR P970100297 A ARP970100297 A AR P970100297A AR P970100297 A ARP970100297 A AR P970100297A AR 005549 A1 AR005549 A1 AR 005549A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparations
- preparing
- procedure
- pharmaceutical preparations
- indol
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Se refiere a derivados de la 1-pirazol-3-iletil-4-indol-3-ilpiperidina de fórmula (I), en donde, R1 es H o A; R2 es H, fenilo monosustituido atrisustituido con Hal, NO2, CON(R4)2, SO2N(R4)2, ciano, A o R4-O; R3 es H, Hal, A, A-O-, amino,ciano , carboxamida, NO2, SO2N(R4)2; R4 es H o A; R5 esH o A; A es alquilo de 1 a 6 átomos de C, o bien alquilo de 1 a 6 átomos de C mono a trisustituido con flúor; Hal es F, Cl, Br o I; y a sus sales.También se refiere a un procedimiento parapreparar estos compuestos y sus sales, a preparaciones farmacéuticas que los contienen y al empleo de losmismos para el tratamiento de enfermedades ocasionadas por un funcionamiento defectuoso y por alteraciones del sistema nervioso central.Estos co mpuestos ysus sales han demostrado poseer una actividad farmacéutica ventajosa, pues actúan selectivamente sobre el sistema nervioso central, pero al mismo tiempotienen pocos efectos colaterales y un potencial de dependencia nulo o muy baj o.Refers to 1-pyrazol-3-ylethyl-4-indol-3-ylpiperidine derivatives of formula (I), wherein, R1 is H or A; R2 is H, monosubstituted phenyl atrisubstituted with Hal, NO2, CON (R4) 2, SO2N (R4) 2, cyano, A or R4-O; R3 is H, Hal, A, A-O-, amino, cyano, carboxamide, NO2, SO2N (R4) 2; R4 is H or A; R5 is H or A; A is alkyl of 1 to 6 carbon atoms, or alkyl of 1 to 6 carbon atoms mono to tri-substituted with fluorine; Hal is F, Cl, Br, or I; and their salts. It also refers to a process to prepare these compounds and their salts, to pharmaceutical preparations that contain them and to the use of them for the treatment of diseases caused by a malfunction and by alterations of the central nervous system. These compounds and their Salts have been shown to have an advantageous pharmaceutical activity, since they act selectively on the central nervous system, but at the same time they have few side effects and a zero or very low dependence potential.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE19602505A DE19602505A1 (en) | 1996-01-25 | 1996-01-25 | 1- (pyrazol-4-indol-3-yl) piperidines |
Publications (1)
Publication Number | Publication Date |
---|---|
AR005549A1 true AR005549A1 (en) | 1999-06-23 |
Family
ID=7783568
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP970100297A AR005549A1 (en) | 1996-01-25 | 1997-01-24 | DERIVATIVES OF 1-PIRAZOL-3-ILETIL-4-INDOL-3-ILPIPERIDINA, A PROCEDURE FOR PREPARING THEM, MEDICINES AND PHARMACEUTICAL PREPARATIONS THAT CONTAIN THEM, A PROCEDURE FOR PREPARING THE PHARMACEUTICAL PREPARATIONS AND USE OF THE SAME MEDICINAL PREPARATIONS FOR THE PREPARATIONS |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP0879234A1 (en) |
JP (1) | JP2000503972A (en) |
KR (1) | KR19990081970A (en) |
CN (1) | CN1209807A (en) |
AR (1) | AR005549A1 (en) |
AU (1) | AU715785B2 (en) |
BR (1) | BR9707467A (en) |
CA (1) | CA2244136A1 (en) |
CZ (1) | CZ231898A3 (en) |
DE (1) | DE19602505A1 (en) |
HU (1) | HUP9900980A2 (en) |
NO (1) | NO983439L (en) |
PL (1) | PL328228A1 (en) |
SK (1) | SK99298A3 (en) |
WO (1) | WO1997027186A1 (en) |
ZA (1) | ZA97572B (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2219385T3 (en) * | 1999-09-09 | 2004-12-01 | H. Lundbeck A/S | INDOLES REPLACED WITH 5-AMINOALQUILO AND 5-AMINOCARBONILO. |
US7179823B1 (en) | 1999-11-10 | 2007-02-20 | Takeda Pharmaceutical Company Limited | 5-membered n-heterocyclic compounds with hypoglycemic and hypolipidemic activity |
US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
CN1329392C (en) | 2000-08-14 | 2007-08-01 | 奥索-麦克尼尔药品公司 | Substituted pyrazoles |
BR0214046A (en) * | 2001-11-14 | 2004-10-13 | Merck Patent Gmbh | Pyrazole derivatives as psychopharmaceuticals |
AU2006301377B2 (en) | 2005-10-11 | 2012-03-08 | F. Hoffmann-La Roche Ag | Imidazo benzodiazepine derivatives |
CN101541765A (en) * | 2005-10-24 | 2009-09-23 | 詹森药业有限公司 | 3-piperidin-4-yl-indole ORL-1 receptor modulators |
TWI548630B (en) * | 2011-04-06 | 2016-09-11 | Lg生命科學有限公司 | 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline form and the producing method thereof |
TW202336015A (en) * | 2020-11-04 | 2023-09-16 | 南韓商Lg化學股份有限公司 | Method for preparation of 1-(3-cyano-1-isopropyl-indol-5-yl)pyrazole-4-carboxylic acid crystalline and pharmaceutical composition comprising the same |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2060816C3 (en) * | 1970-12-10 | 1980-09-04 | Merck Patent Gmbh, 6100 Darmstadt | 4-Phenylpiperidine derivatives Process for their production and pharmaceutical preparations containing these compounds |
DE2258033A1 (en) * | 1972-11-27 | 1974-05-30 | Merck Patent Gmbh | 3-Heterocyclylalkyl-pyrazoles prodn. - by dehydrogenation or acid elimination from pyrazol(id)ines, useful as CNS depressants |
GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
US5045550A (en) * | 1990-09-20 | 1991-09-03 | Warner-Lambert Co. | Substituted tetrahydropyridines as central nervous system agents |
US5521196A (en) * | 1994-10-05 | 1996-05-28 | Eli Lilly And Company | 5-HT1F agonists for the treatment of migraine |
-
1996
- 1996-01-25 DE DE19602505A patent/DE19602505A1/en not_active Withdrawn
-
1997
- 1997-01-17 JP JP9526493A patent/JP2000503972A/en active Pending
- 1997-01-17 HU HU9900980A patent/HUP9900980A2/en unknown
- 1997-01-17 CA CA002244136A patent/CA2244136A1/en not_active Abandoned
- 1997-01-17 BR BR9707467A patent/BR9707467A/en unknown
- 1997-01-17 WO PCT/EP1997/000187 patent/WO1997027186A1/en not_active Application Discontinuation
- 1997-01-17 SK SK992-98A patent/SK99298A3/en unknown
- 1997-01-17 CZ CZ982318A patent/CZ231898A3/en unknown
- 1997-01-17 PL PL97328228A patent/PL328228A1/en unknown
- 1997-01-17 KR KR1019980705688A patent/KR19990081970A/en not_active Application Discontinuation
- 1997-01-17 AU AU14432/97A patent/AU715785B2/en not_active Ceased
- 1997-01-17 EP EP97901049A patent/EP0879234A1/en not_active Withdrawn
- 1997-01-17 CN CN97191852A patent/CN1209807A/en active Pending
- 1997-01-23 ZA ZA9700572A patent/ZA97572B/en unknown
- 1997-01-24 AR ARP970100297A patent/AR005549A1/en unknown
-
1998
- 1998-07-24 NO NO983439A patent/NO983439L/en unknown
Also Published As
Publication number | Publication date |
---|---|
CZ231898A3 (en) | 1998-10-14 |
JP2000503972A (en) | 2000-04-04 |
EP0879234A1 (en) | 1998-11-25 |
CN1209807A (en) | 1999-03-03 |
BR9707467A (en) | 1999-07-20 |
AU715785B2 (en) | 2000-02-10 |
SK99298A3 (en) | 1999-01-11 |
NO983439L (en) | 1998-09-25 |
NO983439D0 (en) | 1998-07-24 |
HUP9900980A2 (en) | 1999-07-28 |
AU1443297A (en) | 1997-08-20 |
ZA97572B (en) | 1997-08-04 |
WO1997027186A1 (en) | 1997-07-31 |
CA2244136A1 (en) | 1997-07-31 |
DE19602505A1 (en) | 1997-07-31 |
PL328228A1 (en) | 1999-01-18 |
KR19990081970A (en) | 1999-11-15 |
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