DE60234028D1 - Hydantion-derivate als hemmer von matrix-metalloproteinasen - Google Patents

Hydantion-derivate als hemmer von matrix-metalloproteinasen

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Publication number
DE60234028D1
DE60234028D1 DE60234028T DE60234028T DE60234028D1 DE 60234028 D1 DE60234028 D1 DE 60234028D1 DE 60234028 T DE60234028 T DE 60234028T DE 60234028 T DE60234028 T DE 60234028T DE 60234028 D1 DE60234028 D1 DE 60234028D1
Authority
DE
Germany
Prior art keywords
inhibitors
matrix metalloproteinases
derivatives
hydantion
aggrecanase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60234028T
Other languages
English (en)
Inventor
James E Sheppeck
Jingwu Duan
Chu-Biao Xue
Zelda Wasserman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=23129620&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60234028(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Application granted granted Critical
Publication of DE60234028D1 publication Critical patent/DE60234028D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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DE60234028T 2001-05-25 2002-05-23 Hydantion-derivate als hemmer von matrix-metalloproteinasen Expired - Lifetime DE60234028D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29357101P 2001-05-25 2001-05-25
PCT/US2002/016381 WO2002096426A1 (en) 2001-05-25 2002-05-23 Hydantion derivatives as inhibitors of matrix metalloproteinases

Publications (1)

Publication Number Publication Date
DE60234028D1 true DE60234028D1 (de) 2009-11-26

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DE60234028T Expired - Lifetime DE60234028D1 (de) 2001-05-25 2002-05-23 Hydantion-derivate als hemmer von matrix-metalloproteinasen

Country Status (8)

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US (3) US6890915B2 (de)
EP (1) EP1397137B1 (de)
JP (1) JP2004535411A (de)
AT (1) ATE445400T1 (de)
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DE (1) DE60234028D1 (de)
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US20040209874A1 (en) 2004-10-21
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