IL156774A0 - Inhibitors of cruzipain and other cysteine proteases - Google Patents
Inhibitors of cruzipain and other cysteine proteasesInfo
- Publication number
- IL156774A0 IL156774A0 IL15677402A IL15677402A IL156774A0 IL 156774 A0 IL156774 A0 IL 156774A0 IL 15677402 A IL15677402 A IL 15677402A IL 15677402 A IL15677402 A IL 15677402A IL 156774 A0 IL156774 A0 IL 156774A0
- Authority
- IL
- Israel
- Prior art keywords
- inhibitors
- cruzipain
- cysteine proteases
- general formula
- compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Tropical Medicine & Parasitology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0101179A GB0101179D0 (en) | 2001-01-17 | 2001-01-17 | Biologically active compounds |
| US27535901P | 2001-03-13 | 2001-03-13 | |
| PCT/GB2002/000184 WO2002057270A1 (en) | 2001-01-17 | 2002-01-17 | Inhibitors of cruzipain and other cysteine proteases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL156774A0 true IL156774A0 (en) | 2004-02-08 |
Family
ID=26245571
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL15677402A IL156774A0 (en) | 2001-01-17 | 2002-01-17 | Inhibitors of cruzipain and other cysteine proteases |
| IL156774A IL156774A (en) | 2001-01-17 | 2003-07-03 | Inhibitors of crucifine and other cysteine proteases |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL156774A IL156774A (en) | 2001-01-17 | 2003-07-03 | Inhibitors of crucifine and other cysteine proteases |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US7425562B2 (no) |
| EP (1) | EP1362052B1 (no) |
| JP (1) | JP4608183B2 (no) |
| KR (1) | KR100860067B1 (no) |
| CN (1) | CN1269822C (no) |
| AT (1) | ATE356130T1 (no) |
| AU (1) | AU2002219397B2 (no) |
| BR (1) | BR0206501A (no) |
| CA (1) | CA2436462C (no) |
| CY (1) | CY1106640T1 (no) |
| DE (1) | DE60218633T2 (no) |
| DK (1) | DK1362052T3 (no) |
| ES (1) | ES2281516T3 (no) |
| HK (1) | HK1060729A1 (no) |
| IL (2) | IL156774A0 (no) |
| MX (1) | MXPA03006224A (no) |
| NO (1) | NO328208B1 (no) |
| NZ (1) | NZ526913A (no) |
| PT (1) | PT1362052E (no) |
| RU (1) | RU2329266C2 (no) |
| WO (1) | WO2002057270A1 (no) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
| MXPA04002282A (es) | 2001-09-14 | 2005-03-07 | Axis Pharmaceutical Inc | Nuevos compuestos y preparaciones como inhibidores de la catepsina. |
| RU2004117877A (ru) | 2001-11-14 | 2006-01-10 | Авентис Фармасьютикалз Инк. (Us) | Олигопептиды и композиции, содержащие их, в качестве ингибиторов катепсина s |
| BR0312662A (pt) * | 2002-07-16 | 2005-05-03 | Amura Therapeutics Ltd | Compostos biologicamente ativos |
| US7399765B2 (en) * | 2003-09-19 | 2008-07-15 | Abbott Laboratories | Substituted diazabicycloalkane derivatives |
| WO2005066180A1 (en) | 2004-01-08 | 2005-07-21 | Medivir Ab | Cysteine protease inhibitors |
| JP2005350417A (ja) * | 2004-06-11 | 2005-12-22 | Dai Ichi Seiyaku Co Ltd | 還元的エーテル化法を用いたピロリジン誘導体の製造法 |
| EA017874B1 (ru) * | 2005-03-21 | 2013-03-29 | Вайробей, Инк. | Производные альфа-кетоамидов в качестве ингибиторов цистеинпротеаз |
| GB0513840D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0513839D0 (en) * | 2005-07-07 | 2005-08-10 | Medivir Ab | Cysteine protease inhibitors |
| GB0614053D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614052D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614044D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614042D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614037D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614046D0 (en) | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| GB0614073D0 (en) * | 2006-07-14 | 2006-08-23 | Amura Therapeutics Ltd | Compounds |
| WO2008114054A1 (en) * | 2007-03-19 | 2008-09-25 | Medivir Ab | Protease inhibitors |
| US7893067B2 (en) * | 2007-06-27 | 2011-02-22 | Medivir Ab | Cysteine protease inhibitors |
| WO2009087379A2 (en) * | 2008-01-09 | 2009-07-16 | Amura Therapeutics Limited | Tetrahydrofuro (3, 2 -b) pyrrol- 3 -one derivatives as inhibitors of cysteine proteinases |
| GB0804701D0 (en) * | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| GB0804702D0 (en) * | 2008-03-13 | 2008-04-16 | Amura Therapeutics Ltd | Compounds |
| WO2012099785A2 (en) * | 2011-01-20 | 2012-07-26 | The Regents Of The University Of Colorado, A Body Corporate | Modulators of tlr3/dsrna complex and uses thereof |
| JP6218734B2 (ja) | 2012-08-30 | 2017-10-25 | 国立大学法人 東京大学 | 内部寄生虫防除剤 |
| CN106279188A (zh) * | 2016-07-21 | 2017-01-04 | 青岛科技大学 | 一种多取代呋喃并[2,3‑b]吡咯衍生物的制备方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3652574A (en) * | 1970-04-01 | 1972-03-28 | Abbott Lab | Certain 1 2 3 4 - tetrahydro-5h-pyrido (4 3-b)indoles and the corresponding 1 2 3 4-tetrahydro-9h-pyrido(3 4-b)indoles and derivatives thereof |
| DZ2285A1 (fr) | 1996-08-08 | 2002-12-25 | Smithkline Beecham Corp | Inhibiteurs de protéase de la cystéine. |
| WO1998008802A1 (en) | 1996-08-28 | 1998-03-05 | Smithkline Beecham Corporation | Inhibitors of cysteine protease |
| EA002100B1 (ru) | 1996-12-23 | 2001-12-24 | Элан Фармасьютикалз, Инк. | ЦИКЛОАЛКИЛЬНЫЕ СОЕДИНЕНИЯ, ЛАКТАМЫ, ЛАКТОНЫ И РОДСТВЕННЫЕ СОЕДИНЕНИЯ, СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЫСВОБОЖДЕНИЯ И/ИЛИ СИНТЕЗА β-АМИЛОИДНОГО ПЕПТИДА С ПОМОЩЬЮ УКАЗАННЫХ СОЕДИНЕНИЙ |
| AR013079A1 (es) | 1997-05-06 | 2000-12-13 | Smithkline Beecham Corp | Derivados sustituidos de tetrahidrofurano-3-onas, de tetrahidropirano-3- onas y tetrahidrotiofen-3-onas, un procedimiento para su preparacion unacomposicion farmaceutica de un medicamento util como inhibidores de proteasas e intermediarios |
| MA26618A1 (fr) | 1998-04-09 | 2004-12-20 | Smithkline Beecham Corp | Composes et compositions pharmaceutiques pour le traitement du paludisme |
| CO5150165A1 (es) | 1998-11-13 | 2002-04-29 | Smithkline Beecham Plc | Inhibidores de proteasa: tipo catepsina k |
| GB9911417D0 (en) * | 1999-05-18 | 1999-07-14 | Peptide Therapeutics Ltd | Furanone derivatives as inhibitors of cathepsin s |
| IL155961A0 (en) | 2000-11-17 | 2003-12-23 | Medivir Uk Ltd | Cysteine protease inhibitors |
| JP2004523506A (ja) | 2000-12-22 | 2004-08-05 | アクシス・ファーマシューティカルズ・インコーポレイテッド | カテプシン阻害剤としての新規な化合物と組成物 |
-
2002
- 2002-01-17 WO PCT/GB2002/000184 patent/WO2002057270A1/en active IP Right Grant
- 2002-01-17 RU RU2003125270/04A patent/RU2329266C2/ru not_active IP Right Cessation
- 2002-01-17 DK DK02732145T patent/DK1362052T3/da active
- 2002-01-17 US US10/466,384 patent/US7425562B2/en not_active Expired - Fee Related
- 2002-01-17 AT AT02732145T patent/ATE356130T1/de active
- 2002-01-17 DE DE60218633T patent/DE60218633T2/de not_active Expired - Lifetime
- 2002-01-17 NZ NZ526913A patent/NZ526913A/xx not_active IP Right Cessation
- 2002-01-17 PT PT02732145T patent/PT1362052E/pt unknown
- 2002-01-17 KR KR1020037009524A patent/KR100860067B1/ko not_active IP Right Cessation
- 2002-01-17 JP JP2002557947A patent/JP4608183B2/ja not_active Expired - Fee Related
- 2002-01-17 ES ES02732145T patent/ES2281516T3/es not_active Expired - Lifetime
- 2002-01-17 CA CA2436462A patent/CA2436462C/en not_active Expired - Fee Related
- 2002-01-17 IL IL15677402A patent/IL156774A0/xx active IP Right Grant
- 2002-01-17 BR BR0206501-0A patent/BR0206501A/pt not_active IP Right Cessation
- 2002-01-17 MX MXPA03006224A patent/MXPA03006224A/es active IP Right Grant
- 2002-01-17 EP EP02732145A patent/EP1362052B1/en not_active Expired - Lifetime
- 2002-01-17 CN CNB028038142A patent/CN1269822C/zh not_active Expired - Fee Related
- 2002-01-17 AU AU2002219397A patent/AU2002219397B2/en not_active Ceased
-
2003
- 2003-07-03 IL IL156774A patent/IL156774A/en not_active IP Right Cessation
- 2003-07-16 NO NO20033220A patent/NO328208B1/no not_active IP Right Cessation
-
2004
- 2004-05-14 HK HK04103421A patent/HK1060729A1/xx not_active IP Right Cessation
-
2007
- 2007-06-04 CY CY20071100742T patent/CY1106640T1/el unknown
-
2008
- 2008-09-15 US US12/211,069 patent/US20090247471A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1269822C (zh) | 2006-08-16 |
| AU2002219397B2 (en) | 2008-02-14 |
| RU2003125270A (ru) | 2005-02-20 |
| CY1106640T1 (el) | 2012-01-25 |
| EP1362052B1 (en) | 2007-03-07 |
| WO2002057270A1 (en) | 2002-07-25 |
| DE60218633T2 (de) | 2008-02-21 |
| DK1362052T3 (da) | 2007-07-09 |
| US7425562B2 (en) | 2008-09-16 |
| KR100860067B1 (ko) | 2008-09-24 |
| DE60218633D1 (de) | 2007-04-19 |
| CA2436462A1 (en) | 2002-07-25 |
| ATE356130T1 (de) | 2007-03-15 |
| NO20033220L (no) | 2003-09-17 |
| CA2436462C (en) | 2011-07-05 |
| NO328208B1 (no) | 2010-01-11 |
| HK1060729A1 (en) | 2004-08-20 |
| RU2329266C2 (ru) | 2008-07-20 |
| PT1362052E (pt) | 2007-04-30 |
| NZ526913A (en) | 2004-12-24 |
| JP2004518674A (ja) | 2004-06-24 |
| JP4608183B2 (ja) | 2011-01-05 |
| NO20033220D0 (no) | 2003-07-16 |
| US20090247471A1 (en) | 2009-10-01 |
| MXPA03006224A (es) | 2004-10-15 |
| ES2281516T3 (es) | 2007-10-01 |
| CN1486320A (zh) | 2004-03-31 |
| EP1362052A1 (en) | 2003-11-19 |
| KR20030075161A (ko) | 2003-09-22 |
| US20040138250A1 (en) | 2004-07-15 |
| IL156774A (en) | 2008-08-07 |
| BR0206501A (pt) | 2004-01-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| HK1060729A1 (en) | Inhibitors of cruzipain and other cysteine proteases | |
| TR199901191T2 (xx) | Benzamidoaldehitlerin sistein proteaz� inhibit�r� olarak kullan�m�. | |
| UA74372C2 (uk) | Інгібітори серинових протеаз, фармацевтична композиція на їх основі | |
| SE0201976D0 (sv) | Novel compounds | |
| CY1114554T1 (el) | Ινδαζολια, βενζοτριαζολια και ν-αναλογα αυτων ως αναστολεις p38 κινασης | |
| DE60112974D1 (en) | Carbolinderivate | |
| DE60216233D1 (en) | Carbolinderivate | |
| ATE303384T1 (de) | 1-biaryl-1,8-naphthyridin-4-one als phosphodieseterase-inhibitoren | |
| ATE275544T1 (de) | Serinprotease-inhibitoren | |
| AU2220702A (en) | Serine protease inhibitors | |
| GB0030306D0 (en) | Compounds | |
| MXPA04006041A (es) | Antivirales de piridoquinoxalina. | |
| SE0101038D0 (sv) | Novel compounds | |
| SE0003476D0 (sv) | Compounds | |
| UA83266C2 (en) | Oxazole derivatives of tetracyclines | |
| DE60202669D1 (de) | 6-phenylbenzonaphthyidine | |
| DE60033809D1 (de) | Inhibitoren von metalloproteinasen | |
| DK1204659T3 (da) | Serotonerge benzofuraner | |
| WO2002057246A3 (en) | Inhibitors of cruzipain and other cysteine proteases | |
| DE60121048D1 (de) | PYRAZINOi1'2':1,6öPYRIDOi3,4-BöINDOLDERIVATE | |
| WO2002057248A3 (en) | Inhibitors of cruzipain and other cysteine proteases | |
| ATE269313T1 (de) | Tryptase-inhibitoren | |
| UA85994C2 (en) | N, n'-substituted-1,3-diamino-2-hydroxypropane derivatives | |
| DE60216920D1 (en) | Tryptase-inhibitoren | |
| CY1110139T1 (el) | Γλυκοπεπτιδικα αντιβιοτικα |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |