ATE349448T1 - Pyrazol-3,4-d-pyrimidinderivate und ihre verwendung bei der behandlung von h.pylori- infektionen - Google Patents

Pyrazol-3,4-d-pyrimidinderivate und ihre verwendung bei der behandlung von h.pylori- infektionen

Info

Publication number
ATE349448T1
ATE349448T1 AT03781250T AT03781250T ATE349448T1 AT E349448 T1 ATE349448 T1 AT E349448T1 AT 03781250 T AT03781250 T AT 03781250T AT 03781250 T AT03781250 T AT 03781250T AT E349448 T1 ATE349448 T1 AT E349448T1
Authority
AT
Austria
Prior art keywords
treatment
pyrazole
pyrimidine derivatives
pylori infections
novel compounds
Prior art date
Application number
AT03781250T
Other languages
English (en)
Inventor
Gregory Basarab
Joseph Eyermann
Madhusudhan Govravaram
Oluyinka Green
Lawrence Macpherson
Marshall Morningstar
Thanh Nguyen
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Application granted granted Critical
Publication of ATE349448T1 publication Critical patent/ATE349448T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
AT03781250T 2002-12-20 2003-12-19 Pyrazol-3,4-d-pyrimidinderivate und ihre verwendung bei der behandlung von h.pylori- infektionen ATE349448T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE0203825A SE0203825D0 (sv) 2002-12-20 2002-12-20 Novel fused heterocycles and uses thereof

Publications (1)

Publication Number Publication Date
ATE349448T1 true ATE349448T1 (de) 2007-01-15

Family

ID=20289974

Family Applications (1)

Application Number Title Priority Date Filing Date
AT03781250T ATE349448T1 (de) 2002-12-20 2003-12-19 Pyrazol-3,4-d-pyrimidinderivate und ihre verwendung bei der behandlung von h.pylori- infektionen

Country Status (9)

Country Link
US (1) US20070004761A1 (de)
EP (1) EP1585748B1 (de)
JP (1) JP2006512366A (de)
AT (1) ATE349448T1 (de)
AU (1) AU2003288869A1 (de)
DE (1) DE60310767T2 (de)
ES (1) ES2278211T3 (de)
SE (1) SE0203825D0 (de)
WO (1) WO2004056831A1 (de)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005511500A (ja) 2001-08-31 2005-04-28 ザ ロックフェラー ユニバーシティー 脳におけるホスホジエステラーゼ活性およびホスホジエステラーゼ１ｂ媒介シグナル伝達の調節
EP2023729B1 (de) 2006-06-06 2016-05-04 Intra-Cellular Therapies, Inc. Organische verbindungen
EP2081431B1 (de) 2006-11-13 2013-01-16 Intra-Cellular Therapies, Inc. Organische verbindungen
ES2588238T3 (es) 2007-12-06 2016-10-31 Intra-Cellular Therapies, Inc. Derivados de pirazolopirimidin-4,6-diona y su uso como producto farmacéutico
JP5216912B2 (ja) 2008-04-29 2013-06-19 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体拮抗薬としてのインダゾール化合物
WO2009137338A1 (en) 2008-05-06 2009-11-12 Boehringer Ingelheim International Gmbh Pyrazole compounds as ccr1 antagonists
KR20110060904A (ko) 2008-09-26 2011-06-08 베링거 인겔하임 인터내셔날 게엠베하 Ｃｃｒ1 수용체 길항제로서의 아자인다졸 화합물
WO2010065153A1 (en) * 2008-12-06 2010-06-10 Intra-Cellular Therapies, Inc. Organic compounds
EA201170768A1 (ru) 2008-12-06 2012-05-30 Интра-Селлулар Терапиз, Инк. Органические соединения
MX2011005934A (es) 2008-12-06 2011-12-16 Intra Cellular Therapies Inc Compuestos organicos.
JP6166534B2 (ja) 2009-08-05 2017-07-19 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 新規調節タンパク質および阻害剤
AU2010308277A1 (en) 2009-10-21 2012-04-26 Boehringer Ingelheim International Gmbh Indazole and pyrazolopyridine compounds as CCR1 receptor antagonists
JP5542214B2 (ja) 2009-10-27 2014-07-09 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしての複素環化合物
KR20120101667A (ko) * 2009-12-08 2012-09-14 베링거 인겔하임 인터내셔날 게엠베하 치환된 인다졸 및 아자인다졸 화합물을 제조하는데 유용한 중간체의 합성 방법
WO2011137109A1 (en) 2010-04-30 2011-11-03 Boehringer Ingelheim International Gmbh Azaindazole amide compounds as ccr1 receptor antagonists
US9434730B2 (en) 2010-05-31 2016-09-06 Intra-Cellular Therapies, Inc. PDE1 inhibitor compounds
JP5894148B2 (ja) 2010-05-31 2016-03-23 イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． 有機化合物
JP5684406B2 (ja) 2010-12-23 2015-03-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃｃｒ１受容体アンタゴニストとしてのピラゾロピペリジン化合物
US9546175B2 (en) 2014-08-07 2017-01-17 Intra-Cellular Therapies, Inc. Organic compounds
JP7478673B2 (ja) 2018-06-04 2024-05-07 エクスシエンティア・エルティーディー アデノシン受容体アンタゴニストとしてのピラゾロピリミジン化合物

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3839839A1 (de) * 1988-11-25 1990-05-31 Henning Berlin Gmbh Mittel zur behandlung von chronisch entzuendlichen darmerkrankungen
SE0102315D0 (sv) * 2001-06-28 2001-06-28 Astrazeneca Ab Compounds

Also Published As

Publication number Publication date
US20070004761A1 (en) 2007-01-04
ES2278211T3 (es) 2007-08-01
JP2006512366A (ja) 2006-04-13
EP1585748B1 (de) 2006-12-27
DE60310767T2 (de) 2007-10-11
AU2003288869A1 (en) 2004-07-14
WO2004056831A1 (en) 2004-07-08
SE0203825D0 (sv) 2002-12-20
EP1585748A1 (de) 2005-10-19
DE60310767D1 (de) 2007-02-08

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