DE69229108T2 - Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese - Google Patents
Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoeseInfo
- Publication number
- DE69229108T2 DE69229108T2 DE69229108T DE69229108T DE69229108T2 DE 69229108 T2 DE69229108 T2 DE 69229108T2 DE 69229108 T DE69229108 T DE 69229108T DE 69229108 T DE69229108 T DE 69229108T DE 69229108 T2 DE69229108 T2 DE 69229108T2
- Authority
- DE
- Germany
- Prior art keywords
- nucleosides
- acyl derivatives
- oxypurin
- hematopoesis
- improve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1816—Erythropoietin [EPO]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/193—Colony stimulating factors [CSF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/08—Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Virology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65388291A | 1991-02-08 | 1991-02-08 | |
PCT/US1992/000887 WO1992013561A1 (en) | 1991-02-08 | 1992-02-05 | Oxypurine nucleosides and their congeners, and acyl derivatives thereof, for improvement of hematopoiesis |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69229108D1 DE69229108D1 (de) | 1999-06-10 |
DE69229108T2 true DE69229108T2 (de) | 1999-09-23 |
Family
ID=24622651
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69229108T Expired - Fee Related DE69229108T2 (de) | 1991-02-08 | 1992-02-05 | Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP0570519B1 (de) |
JP (6) | JP3393645B2 (de) |
KR (2) | KR100263943B1 (de) |
AT (1) | ATE179615T1 (de) |
AU (1) | AU663309C (de) |
CA (2) | CA2444071C (de) |
DE (1) | DE69229108T2 (de) |
HK (1) | HK1003425A1 (de) |
IL (1) | IL100874A (de) |
RU (1) | RU2158269C2 (de) |
WO (1) | WO1992013561A1 (de) |
ZA (1) | ZA92914B (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE9800452D0 (sv) * | 1998-02-13 | 1998-02-13 | Medivir Ab | Antivirals |
US6458772B1 (en) | 1909-10-07 | 2002-10-01 | Medivir Ab | Prodrugs |
US6060459A (en) * | 1987-10-28 | 2000-05-09 | Pro-Neuron, Inc. | Enhancing blood cell count with oxypurine nucleosides |
CA2504078C (en) * | 1991-07-05 | 2007-08-28 | Wellstat Therapeutics Corporation | Treatment of chemotherapeutic agent and antiviral agent toxicity with acylated pyrimidine nucleosides |
US5641758A (en) * | 1993-11-10 | 1997-06-24 | Kluge; Michael | Cytarabine derivatives, the preparation and use thereof |
US5762922A (en) * | 1994-01-31 | 1998-06-09 | Ludwig Institute For Cancer Research | Antioxidants and intracellular gluthathione raising agents for therapeutic treatments |
KR100290129B1 (ko) * | 1994-08-12 | 2001-05-15 | 마이클 바마트 | 옥시퓨린 누클레오시드로 패혈증 또는 염증성 질병을 치료하는 방법 |
PT988304E (pt) * | 1997-08-15 | 2001-10-31 | Medivir Ab | Analogos de nucleosidos tais como os antivirais que contem inibidores de transcritase reversa retroviral e de adn-polimerase do virus da hepatite b (hbv) |
WO1999051613A1 (en) * | 1998-04-03 | 1999-10-14 | Medivir Ab | Prodrugs of phosphorous-containing pharmaceuticals |
NZ539873A (en) * | 2002-11-22 | 2008-09-26 | Smithkline Beecham Corp | Novel chemical compounds, thiazolidin-4-one, thiazol-4-one |
JP3929949B2 (ja) * | 2003-08-08 | 2007-06-13 | 独立行政法人科学技術振興機構 | 酸化により機能性ユニットを放出するヌクレオシドおよびそれを含むオリゴヌクレオチドの製造法 |
AU2016222458B2 (en) * | 2007-08-16 | 2018-11-08 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Compositions containing Nucleosides and Manganese and their Uses |
US9186406B2 (en) | 2007-08-16 | 2015-11-17 | The Henry M. Jackson Foundation for Advancement of Military Medicine, Inc. | Compositions containing nucleosides and manganese and their uses |
US9234168B2 (en) | 2010-04-29 | 2016-01-12 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Compositions containing amino acids, phosphate and manganese and their uses |
CN110339203A (zh) * | 2013-04-08 | 2019-10-18 | 得克萨斯系统大学评议会 | 用于改变端粒酶介导的端粒的巯基嘌呤核糖核苷类似物 |
US20210007999A1 (en) * | 2018-03-02 | 2021-01-14 | January Therapeutics, Inc. | Nanoparticle compositions |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4002963A (en) * | 1975-05-29 | 1977-01-11 | North Electric Company | Converter circuit and method having fast responding current balance and limiting |
IT1202370B (it) * | 1976-07-12 | 1989-02-09 | Hoffmann La Roche | Soluzioni inietabili in cui l'atti vita' emolitica degli agenti di formazione di micelle naturali e' evitata mediante l'aggiunta di lipoidi e relativi prodotti |
US4849411A (en) * | 1982-11-09 | 1989-07-18 | Scripps Clinic And Research Foundation | Modulation of animal cellular responses with compositions containing 8-substituted guanine derivatives |
GB2177914B (en) * | 1985-06-04 | 1989-10-25 | Chugai Pharmaceutical Co Ltd | A pharmaceutical composition containing human erythropoietin and a surface active agent for nasal administration for the treatment of anemia |
KR890701609A (ko) * | 1987-10-28 | 1989-12-21 | 원본미기재 | 아실 데옥시리보뉴클레오시드 유도체 및 그의 사용 |
CA1321994C (en) * | 1987-10-28 | 1993-09-07 | Reid Von Borstel | Acylated uridine and cytidine and uses thereof |
ZA892928B (en) * | 1988-04-25 | 1991-01-30 | Pro Neuron Inc | Pharmaceutical compositions containing deoxyribonucleosides for wound healing |
DE68918091T2 (de) * | 1988-04-29 | 1995-04-06 | Genetics Inst | Lagerungsstabile zusammensetzungen von homogenem dimerem m-csf. |
-
1992
- 1992-02-05 RU RU93053905/14A patent/RU2158269C2/ru not_active IP Right Cessation
- 1992-02-05 JP JP50663292A patent/JP3393645B2/ja not_active Expired - Fee Related
- 1992-02-05 WO PCT/US1992/000887 patent/WO1992013561A1/en active IP Right Grant
- 1992-02-05 AU AU14177/92A patent/AU663309C/en not_active Ceased
- 1992-02-05 AT AT92906893T patent/ATE179615T1/de not_active IP Right Cessation
- 1992-02-05 IL IL10087492A patent/IL100874A/en not_active IP Right Cessation
- 1992-02-05 KR KR1019930702355A patent/KR100263943B1/ko not_active IP Right Cessation
- 1992-02-05 EP EP92906893A patent/EP0570519B1/de not_active Expired - Lifetime
- 1992-02-05 DE DE69229108T patent/DE69229108T2/de not_active Expired - Fee Related
- 1992-02-05 CA CA002444071A patent/CA2444071C/en not_active Expired - Fee Related
- 1992-02-05 CA CA002100655A patent/CA2100655C/en not_active Expired - Fee Related
- 1992-02-07 ZA ZA92914A patent/ZA92914B/xx unknown
-
1998
- 1998-03-27 HK HK98102606A patent/HK1003425A1/xx not_active IP Right Cessation
-
1999
- 1999-06-29 KR KR1019990025477A patent/KR100418483B1/ko not_active IP Right Cessation
-
2001
- 2001-02-08 JP JP2001032992A patent/JP3996352B2/ja not_active Expired - Fee Related
-
2002
- 2002-07-24 JP JP2002215904A patent/JP3885006B2/ja not_active Expired - Fee Related
- 2002-09-24 JP JP2002278122A patent/JP3760149B2/ja not_active Expired - Fee Related
- 2002-09-24 JP JP2002278123A patent/JP4067926B2/ja not_active Expired - Fee Related
-
2005
- 2005-12-28 JP JP2005380181A patent/JP2006096772A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
JP2003119152A (ja) | 2003-04-23 |
JP3760149B2 (ja) | 2006-03-29 |
WO1992013561A1 (en) | 1992-08-20 |
EP0570519A1 (de) | 1993-11-24 |
JP2006096772A (ja) | 2006-04-13 |
EP0570519A4 (en) | 1996-02-21 |
EP0570519B1 (de) | 1999-05-06 |
AU663309C (en) | 2002-08-08 |
ATE179615T1 (de) | 1999-05-15 |
JP2003064092A (ja) | 2003-03-05 |
JP2003160585A (ja) | 2003-06-03 |
JP4067926B2 (ja) | 2008-03-26 |
JP3996352B2 (ja) | 2007-10-24 |
IL100874A (en) | 1996-01-19 |
AU1417792A (en) | 1992-09-07 |
DE69229108D1 (de) | 1999-06-10 |
JP3393645B2 (ja) | 2003-04-07 |
CA2100655A1 (en) | 1992-08-09 |
KR100418483B1 (ko) | 2004-02-11 |
CA2100655C (en) | 2004-02-03 |
CA2444071A1 (en) | 1992-08-20 |
CA2444071C (en) | 2008-10-07 |
KR100263943B1 (ko) | 2000-08-16 |
HK1003425A1 (en) | 1998-10-30 |
RU2158269C2 (ru) | 2000-10-27 |
JP3885006B2 (ja) | 2007-02-21 |
ZA92914B (en) | 1993-08-09 |
IL100874A0 (en) | 1992-11-15 |
JP2001270896A (ja) | 2001-10-02 |
JPH06511473A (ja) | 1994-12-22 |
AU663309B2 (en) | 1995-10-05 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: WELLSTAT THERAPEUTICS CORP.(N.D.GES.D. STAATES CAL |
|
8339 | Ceased/non-payment of the annual fee |