ATE99315T1 - Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel. - Google Patents

Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel.

Info

Publication number
ATE99315T1
ATE99315T1 AT89105369T AT89105369T ATE99315T1 AT E99315 T1 ATE99315 T1 AT E99315T1 AT 89105369 T AT89105369 T AT 89105369T AT 89105369 T AT89105369 T AT 89105369T AT E99315 T1 ATE99315 T1 AT E99315T1
Authority
AT
Austria
Prior art keywords
antitumors
complexes
platinum
production
application
Prior art date
Application number
AT89105369T
Other languages
English (en)
Inventor
Silvano Spinelli
Ernesto Menta
Alessandro Pasini
Franco Zunino
Sergio Tognella
Original Assignee
Boehringer Mannheim Italia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Mannheim Italia filed Critical Boehringer Mannheim Italia
Application granted granted Critical
Publication of ATE99315T1 publication Critical patent/ATE99315T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
    • C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
    • C07F15/0086—Platinum compounds
    • C07F15/0093—Platinum compounds without a metal-carbon linkage
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AT89105369T 1988-04-01 1989-03-25 Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel. ATE99315T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8820074A IT1216687B (it) 1988-04-01 1988-04-01 Complessi di platino (ii), loro preparazione e impiego come antitumorali.
EP89105369A EP0341409B1 (de) 1988-04-01 1989-03-25 Platin(II)-Komplexe, Verfahren zu ihrer Herstellung und Anwendung als Antitumormittel

Publications (1)

Publication Number Publication Date
ATE99315T1 true ATE99315T1 (de) 1994-01-15

Family

ID=11163596

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89105369T ATE99315T1 (de) 1988-04-01 1989-03-25 Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel.

Country Status (12)

Country Link
US (1) US5104895A (de)
EP (2) EP0415939A1 (de)
JP (1) JPH03503529A (de)
AT (1) ATE99315T1 (de)
AU (1) AU633817B2 (de)
DE (1) DE68911745T2 (de)
DK (1) DK235690D0 (de)
ES (1) ES2061756T3 (de)
HU (1) HU206220B (de)
IT (1) IT1216687B (de)
WO (1) WO1989009218A1 (de)
ZA (1) ZA892398B (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1238693B (it) * 1990-02-16 1993-09-01 Montedipe Srl Mescole a base di polimeri vinilaromatici ad elevate caratteristiche meccaniche
EP0550385A1 (de) * 1991-12-19 1993-07-07 Ciba-Geigy Ag Peroral zu verabreichende pharmazeutische Zusammensetzungen, die Methandiphosphonsäure-Derivate und 18-Krone-6 Ether enthalten
US6900012B1 (en) 1997-06-03 2005-05-31 The University Of Chicago Plant artificial chromosome compositions and methods
US7166733B2 (en) * 2000-01-04 2007-01-23 Access Pharmaceuticals, Inc. O,O'-Amidomalonate and N,O-Amidomalonate platinum complexes
US7138520B2 (en) * 2003-01-13 2006-11-21 Massachusetts Institute Of Technology Coordination complexes having tethered therapeutic agents and/or targeting moieties, and methods of making and using the same
WO2005027895A2 (en) 2003-09-15 2005-03-31 Ordway Research Institute Thyroid hormone analogs and methods of use in angiogenesis
US9198887B2 (en) 2003-09-15 2015-12-01 Nanopharmaceuticals Llc Thyroid hormone analogs and methods of use
US8071134B2 (en) * 2003-09-15 2011-12-06 Ordway Research Institute, Inc. Thyroid hormone analogs and methods of use
US8668926B1 (en) 2003-09-15 2014-03-11 Shaker A. Mousa Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof
EA018427B1 (ru) * 2003-12-16 2013-07-30 Нектар Терапьютикс Химически модифицированный налоксон
US20100047338A1 (en) 2008-03-14 2010-02-25 Angela Brodie Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens, In Vitro Biological Activities, Pharmacokinetics and Antitumor Activity
CN101203278A (zh) * 2005-04-19 2008-06-18 默克专利股份有限公司 紫外线保护
US10130686B2 (en) 2005-09-15 2018-11-20 Nanopharmaceuticals Llc Method and composition of thyroid hormone analogues and nanoformulations thereof for treating inflammatory disorders
US9220788B2 (en) * 2009-06-17 2015-12-29 Nanopharmaceuticals Llc Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof
US20090022806A1 (en) * 2006-12-22 2009-01-22 Mousa Shaker A Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists and formulations and uses thereof
US9498536B2 (en) 2005-09-15 2016-11-22 Nanopharmaceuticals Llc Method and composition of thyroid hormone analogues and nanoformulations thereof for treating anti-inflammatory disorders
WO2007035612A2 (en) 2005-09-16 2007-03-29 Ordway Research Institute, Inc. Polyphenol conjugates as rgd-binding compounds and methods of use
WO2008140507A2 (en) * 2006-12-22 2008-11-20 Clf Medical Technology Acceleration Program, Inc. Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations and uses thereof
GB2470873A (en) * 2008-03-12 2010-12-08 Univ Maryland Androgen receptor inactivation contributes to antitumor efficacy of CYP17 inhibitors in prostrate cancer
WO2010075332A1 (en) * 2008-12-23 2010-07-01 Charitable Leadership Foundation Small molecule ligands of the integrin rgd recognition site and methods of use
AU2010210422A1 (en) 2009-02-05 2011-08-18 Tokai Pharmaceuticals, Inc. Novel prodrugs of steroidal CYP17 inhibitors/antiandrogens
WO2010120506A1 (en) * 2009-03-31 2010-10-21 Ordway Research Institute, Inc. Combination treatment of cancer with cetuximab and tetrac
US8802240B2 (en) 2011-01-06 2014-08-12 Nanopharmaceuticals Llc Uses of formulations of thyroid hormone analogs and nanoparticulate forms thereof to increase chemosensitivity and radiosensitivity in tumor or cancer cells
KR20150127720A (ko) 2013-03-14 2015-11-17 유니버시티 오브 매릴랜드, 발티모어 안드로겐 수용체 하향 조절제 및 그의 용도
WO2015023710A1 (en) 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
WO2015074050A1 (en) 2013-11-18 2015-05-21 Nanopharmaceuticals Llc Methods for screening patients for resistance to angioinhibition, treatment and prophylaxis thereof
AU2017279536A1 (en) 2016-06-07 2018-12-20 Nanopharmaceuticals, Llc Non-cleavable polymer conjugated with αvβ3 integrin thyroid antagonists
US11351137B2 (en) 2018-04-11 2022-06-07 Nanopharmaceuticals Llc Composition and method for dual targeting in treatment of neuroendocrine tumors
US10328043B1 (en) 2018-04-11 2019-06-25 Nanopharmaceuticals, Llc. Composition and method for dual targeting in treatment of neuroendocrine tumors
US10961204B1 (en) 2020-04-29 2021-03-30 Nanopharmaceuticals Llc Composition of scalable thyrointegrin antagonists with improved blood brain barrier penetration and retention into brain tumors
US11723888B2 (en) 2021-12-09 2023-08-15 Nanopharmaceuticals Llc Polymer conjugated thyrointegrin antagonists

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL67789A (en) * 1983-01-31 1986-09-30 Yissum Res Dev Co Amino-substituted malonato platinum(ii)complexes and method for their preparation
US4565884A (en) * 1983-05-10 1986-01-21 Andrulis Research Corporation Bis-platinum complexes as antitumor agents
GB2163163B (en) * 1984-01-23 1987-10-07 Inst Obschei I Neoorganichesko Blended carboxylate complexes of platinum
GB8416048D0 (en) * 1984-06-22 1984-07-25 Johnson Matthey Plc Anti-tumour compounds of platinum
DE3582961D1 (de) * 1984-06-27 1991-07-04 Johnson Matthey Plc Platinkoordinationsverbindungen.
EP0169645A1 (de) * 1984-06-27 1986-01-29 Johnson Matthey Public Limited Company Platin-Koordinationsverbindungen
DE3432320A1 (de) * 1984-09-03 1986-03-13 Behringwerke Ag, 3550 Marburg Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel
US4665210A (en) * 1984-12-17 1987-05-12 American Cyanamid Company Platinum complexes of aliphatic tricarboxylic acids
US4737589A (en) * 1985-08-27 1988-04-12 Nippon Kayaku Kabushiki Kaisha Platinum Complexes
JPS62207283A (ja) * 1986-03-07 1987-09-11 Yoshinori Kitani 新規な白金錯体
DE3630497A1 (de) * 1986-09-08 1988-03-10 Behringwerke Ag Cis-platin-komplexe, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische mittel
JPS63203692A (ja) * 1987-02-19 1988-08-23 Nippon Kayaku Co Ltd 新規白金錯体
US4882447A (en) * 1987-02-20 1989-11-21 Tanabe Seiyaku Co., Ltd. Novel organic platinum complex and process for the preparation thereof
IL85595A0 (en) * 1987-03-06 1988-08-31 Tanabe Seiyaku Co Organic platinum complex and its preparation
US4904809A (en) * 1987-09-25 1990-02-27 Ss Pharmaceutical Co., Ltd. Platinum complex
EP0376076A1 (de) * 1988-12-27 1990-07-04 Ss Pharmaceutical Co., Ltd. Platinkomplexe
JP2740919B2 (ja) * 1989-03-30 1998-04-15 塩野義製薬株式会社 白金錯体およびこれらを有効成分として含有する抗腫瘍剤
US4994591A (en) * 1989-06-02 1991-02-19 The Research Foundation Of State University Of Ny Platinum complexes derived from b-silyamines

Also Published As

Publication number Publication date
HU892555D0 (en) 1991-03-28
ZA892398B (en) 1989-11-29
ES2061756T3 (es) 1994-12-16
DE68911745T2 (de) 1994-05-19
EP0341409B1 (de) 1993-12-29
WO1989009218A1 (en) 1989-10-05
IT1216687B (it) 1990-03-08
AU633817B2 (en) 1993-02-11
HUT55401A (en) 1991-05-28
AU3292789A (en) 1989-10-16
IT8820074A0 (it) 1988-04-01
DK235690A (da) 1990-09-28
JPH03503529A (ja) 1991-08-08
EP0341409A1 (de) 1989-11-15
HU206220B (en) 1992-09-28
DK235690D0 (da) 1990-09-28
US5104895A (en) 1992-04-14
DE68911745D1 (de) 1994-02-10
EP0415939A1 (de) 1991-03-13

Similar Documents

Publication Publication Date Title
ATE99315T1 (de) Platin(ii)-komplexe, verfahren zu ihrer herstellung und anwendung als antitumormittel.
MD420C2 (ro) Derivaţi ai acidului acrilic
ATE65500T1 (de) Arylthioalkylphenylcarbonsaeuren, diese enthaltende zusammensetzungen und deren verwendung.
ATE59646T1 (de) 4-brommethyl-5-methyl-1,3-dioxolen-2 -on und verfahren zu seiner herstellung.
ATE55116T1 (de) Neue sulfobetaine von ammoniocarbonsaeureamiden und verfahren zu ihrer herstellung.
ATE193531T1 (de) Phenyl-carboxamide-isoxazole-derivate und salze, verfahren zu ihrer herstellung ihre anwendung als arzneimittel und pharmazeutische zusammensetzungen die sie enthalten
DE3869028D1 (de) 1,2,5,6-tetrahydropyridinoxim-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel und diese enthaltende zusammensetzungen.
ATE67199T1 (de) Benzoxazin-derivate und verfahren zu ihrer herstellung.
DE3870096D1 (de) 2,4,6-triaminopyrimidin n-3-oxid-harnstoff-derivate, deren herstellung und deren kosmetische und dermopharmazeutische verwendung.
GR3030234T3 (en) 4-Phenylcarbamoyl-3-isoxazolecarboxylic acid derivatives with antiinflammatory activity
ATE62233T1 (de) Imidazolderivate, verfahren zu deren herstellung und deren anwendung als fungizide.
DE3787878D1 (de) 2-Methylthiomethyl-dihydropyridine, Verfahren zur Herstellung und pharmazeutische Zusammenstellungen, die sie enthalten.
AR248276A1 (es) Derivados de imidazolidina, procedimiento para producirlos y pesticidas que los contienen
TW328083B (en) New derivatives of β-methoxy acrylic acid, their preparation process and their use as pesticides
ATE82747T1 (de) Verfahren zur herstellung von hydroxyalkylierungsmitteln, die erhaltenen mittel und deren verwendung.
ATE47592T1 (de) Piperidinderivate und diese enthaltende fungizide sowie verfahren zur bekaempfung von pilzen.
NO934058L (de)
DE3673129D1 (de) Alkylcarbonsaeureamide von pyridinalkylaminen, ihre herstellung und ihre verwendung als arzneimittel.
DE69332707D1 (de) Verfahren zur Herstellung von 3-Vinylcephalosporinen
ATE92074T1 (de) Beta-d-phenylthioxyloside, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel.
ATE35681T1 (de) 4,4-dimethyl-tetrahydro-2h-pyran-2-on-derivate, verfahren zu deren herstellung und deren verwendung fuer die synthese von cyclopropanischen derivaten.
ATE150780T1 (de) Verwendung von phosphanen und/oder diphosphanen bei der herstellung von kunststoffen auf isocyanatbasis
DE3669508D1 (de) Verbrueckungsreagenz, verfahren zu seiner herstellung und seine anwendung.
ATE35545T1 (de) Stickstoff enthaltende benzotricyclische dione und verfahren zu ihrer herstellung.
ATE66463T1 (de) 1,4-cyclohexandiamine, verfahren zu ihrer herstellung und ihre verwendung als fungizide.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties