ATE35545T1 - Stickstoff enthaltende benzotricyclische dione und verfahren zu ihrer herstellung. - Google Patents
Stickstoff enthaltende benzotricyclische dione und verfahren zu ihrer herstellung.Info
- Publication number
- ATE35545T1 ATE35545T1 AT85300226T AT85300226T ATE35545T1 AT E35545 T1 ATE35545 T1 AT E35545T1 AT 85300226 T AT85300226 T AT 85300226T AT 85300226 T AT85300226 T AT 85300226T AT E35545 T1 ATE35545 T1 AT E35545T1
- Authority
- AT
- Austria
- Prior art keywords
- benzotricyclic
- diones
- preparation
- radical
- nitrogen containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/22—Oxygen atoms attached in position 2 or 4
- C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- C07D209/38—Oxygen atoms in positions 2 and 3, e.g. isatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
- C07D455/04—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/576,242 US4530929A (en) | 1984-02-02 | 1984-02-02 | Benzotricyclic nitrogen-containing diones and their use in reversing electroconvulsive shock-induced amnesia |
EP85300226A EP0153006B1 (de) | 1984-02-02 | 1985-01-14 | Stickstoff enthaltende benzotricyclische Dione und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE35545T1 true ATE35545T1 (de) | 1988-07-15 |
Family
ID=24303549
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT85300226T ATE35545T1 (de) | 1984-02-02 | 1985-01-14 | Stickstoff enthaltende benzotricyclische dione und verfahren zu ihrer herstellung. |
Country Status (9)
Country | Link |
---|---|
US (1) | US4530929A (de) |
EP (1) | EP0153006B1 (de) |
JP (1) | JPS60248687A (de) |
AT (1) | ATE35545T1 (de) |
AU (1) | AU564210B2 (de) |
DE (1) | DE3563625D1 (de) |
DK (1) | DK43585A (de) |
ES (1) | ES8702407A1 (de) |
GR (1) | GR850267B (de) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4677112A (en) * | 1984-02-02 | 1987-06-30 | Warner-Lambert Company | 1,2,3,4-tetrahydro-2-oxo-8-quinolineacetic and -propanoic acids and derivatives as cognition activators |
US5426191A (en) * | 1993-12-03 | 1995-06-20 | Warner-Lambert Company | Process for the synthesis of 3-chlorobenzo[b]thiophene-2-carbonyl chlorides |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1242175A (en) * | 1969-03-11 | 1971-08-11 | Biorex Laboratories Ltd | A new isoquinoline derivative |
US4015005A (en) * | 1974-05-28 | 1977-03-29 | Sandoz, Inc. | 1,2,5,6-Tetrahydro-4H-pyrrolo(3,2,1-j)quinolin-2-ones |
US4115555A (en) * | 1976-09-29 | 1978-09-19 | E. R. Squibb & Sons, Inc. | 2-Substituted-1H-benz[de]-isoquinoline-1,3(2H)-diones |
US4372966A (en) * | 1980-09-15 | 1983-02-08 | Warner-Lambert Company | Use of dihydro-1H-pyrrolizine-3,5(2H,6H)-dione as a cognition activator |
US4400386A (en) * | 1981-11-06 | 1983-08-23 | Riker Laboratories, Inc. | Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine |
US4547519A (en) * | 1982-05-24 | 1985-10-15 | Warner-Lambert Company | Tetrahydro-3,5-dioxo-1H-pyrrolizine-7a(5H)-carboxylic acid and benzyl esters and amides thereof and their use in reversing amnesia |
-
1984
- 1984-02-02 US US06/576,242 patent/US4530929A/en not_active Expired - Fee Related
-
1985
- 1985-01-14 AT AT85300226T patent/ATE35545T1/de not_active IP Right Cessation
- 1985-01-14 DE DE8585300226T patent/DE3563625D1/de not_active Expired
- 1985-01-14 EP EP85300226A patent/EP0153006B1/de not_active Expired
- 1985-01-30 ES ES539966A patent/ES8702407A1/es not_active Expired
- 1985-01-30 GR GR850267A patent/GR850267B/el unknown
- 1985-01-31 DK DK43585A patent/DK43585A/da not_active Application Discontinuation
- 1985-01-31 AU AU38224/85A patent/AU564210B2/en not_active Ceased
- 1985-02-01 JP JP60016688A patent/JPS60248687A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
JPS60248687A (ja) | 1985-12-09 |
US4530929A (en) | 1985-07-23 |
ES8702407A1 (es) | 1986-12-16 |
DK43585A (da) | 1985-08-03 |
AU3822485A (en) | 1985-08-08 |
DK43585D0 (da) | 1985-01-31 |
GR850267B (de) | 1985-05-28 |
AU564210B2 (en) | 1987-08-06 |
ES539966A0 (es) | 1986-12-16 |
EP0153006B1 (de) | 1988-07-06 |
DE3563625D1 (en) | 1988-08-11 |
EP0153006A1 (de) | 1985-08-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
UEP | Publication of translation of european patent specification | ||
REN | Ceased due to non-payment of the annual fee |