ITUA20164793A1 - Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene - Google Patents

Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Info

Publication number
ITUA20164793A1
ITUA20164793A1 ITUA2016A004793A ITUA20164793A ITUA20164793A1 IT UA20164793 A1 ITUA20164793 A1 IT UA20164793A1 IT UA2016A004793 A ITUA2016A004793 A IT UA2016A004793A IT UA20164793 A ITUA20164793 A IT UA20164793A IT UA20164793 A1 ITUA20164793 A1 IT UA20164793A1
Authority
IT
Italy
Prior art keywords
androsta
benzimidazol
diene
hydroxy
preparation
Prior art date
Application number
ITUA2016A004793A
Other languages
English (en)
Inventor
Francesco Barbieri
Roberto Lenna
Original Assignee
Ind Chimica Srl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ind Chimica Srl filed Critical Ind Chimica Srl
Priority to ITUA2016A004793A priority Critical patent/ITUA20164793A1/it
Priority to ES201890072A priority patent/ES2697706R1/es
Priority to PCT/IB2017/053147 priority patent/WO2017208132A1/en
Priority to CH01484/18A priority patent/CH714035B1/it
Publication of ITUA20164793A1 publication Critical patent/ITUA20164793A1/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
    • C07J1/0003—Androstane derivatives
    • C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
    • C07J13/005—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17 with double bond in position 16 (17)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
ITUA2016A004793A 2016-06-01 2016-06-30 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene ITUA20164793A1 (it)

Priority Applications (4)

Application Number Priority Date Filing Date Title
ITUA2016A004793A ITUA20164793A1 (it) 2016-06-30 2016-06-30 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene
ES201890072A ES2697706R1 (es) 2016-06-01 2017-05-29 Proceso Para La Preparación De Galeterona.
PCT/IB2017/053147 WO2017208132A1 (en) 2016-06-01 2017-05-29 Process for the preparation of galeterone
CH01484/18A CH714035B1 (it) 2016-06-01 2017-05-29 Processo per la preparazione di 3Beta-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITUA2016A004793A ITUA20164793A1 (it) 2016-06-30 2016-06-30 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Publications (1)

Publication Number Publication Date
ITUA20164793A1 true ITUA20164793A1 (it) 2017-12-30

Family

ID=57750478

Family Applications (1)

Application Number Title Priority Date Filing Date
ITUA2016A004793A ITUA20164793A1 (it) 2016-06-01 2016-06-30 Processo per la preparazione di 3β-idrossi-17-(1H-benzimidazol-1-il)androsta-5,16-diene

Country Status (1)

Country Link
IT (1) ITUA20164793A1 (it)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009120565A2 (en) * 2008-03-25 2009-10-01 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
CN103059090A (zh) * 2011-10-20 2013-04-24 连云港润众制药有限公司 醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法
WO2015023710A1 (en) * 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009120565A2 (en) * 2008-03-25 2009-10-01 University Of Maryland, Baltimore Novel prodrugs of c-17-heteroaryl steroidal cyp17 inhibitors/antiandrogens: synthesis, in vitro biological activities, pharmacokinetics and antitumor activity
CN103059090A (zh) * 2011-10-20 2013-04-24 连云港润众制药有限公司 醋酸阿比特龙草酸盐以及醋酸阿比特龙的纯化方法
WO2015023710A1 (en) * 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 201364, Derwent World Patents Index; AN 2013-P77147, XP002767503 *
HANDRATTA VENKATESH D ET AL: "Novel C-17-Heteroaryl Steroidal CYP17 Inhibitors/Antiandrogens: Synthesis, in Vitro Biological Activity, Pharmacokinetics, and Antitumor Activity in the LAPC4 Human Prostate Cancer Xenograft Model", JOURNAL OF MEDICINAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY, US, vol. 48, no. 8, 25 March 2005 (2005-03-25), pages 2972 - 2984, XP002535274, ISSN: 0022-2623, DOI: 10.1021/JM040202W *

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