ATE522509T1 - Pyrimidylcyclopentane als inhibitoren der akt- proteinkinase - Google Patents
Pyrimidylcyclopentane als inhibitoren der akt- proteinkinaseInfo
- Publication number
- ATE522509T1 ATE522509T1 AT08781340T AT08781340T ATE522509T1 AT E522509 T1 ATE522509 T1 AT E522509T1 AT 08781340 T AT08781340 T AT 08781340T AT 08781340 T AT08781340 T AT 08781340T AT E522509 T1 ATE522509 T1 AT E522509T1
- Authority
- AT
- Austria
- Prior art keywords
- protein kinase
- kinase inhibitors
- pyrimidylcyclopentanes
- act protein
- act
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Hospice & Palliative Care (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Epidemiology (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US94814707P | 2007-07-05 | 2007-07-05 | |
PCT/US2008/069147 WO2009006569A1 (en) | 2007-07-05 | 2008-07-03 | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE522509T1 true ATE522509T1 (de) | 2011-09-15 |
Family
ID=39830222
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT08781340T ATE522509T1 (de) | 2007-07-05 | 2008-07-03 | Pyrimidylcyclopentane als inhibitoren der akt- proteinkinase |
Country Status (16)
Country | Link |
---|---|
US (1) | US8377937B2 (de) |
EP (2) | EP2404907B1 (de) |
JP (2) | JP5542282B2 (de) |
KR (2) | KR20150091196A (de) |
CN (1) | CN101918373B (de) |
AT (1) | ATE522509T1 (de) |
AU (1) | AU2008272832B2 (de) |
BR (1) | BRPI0813993A2 (de) |
CA (1) | CA2692506C (de) |
ES (1) | ES2533557T3 (de) |
HK (2) | HK1136832A1 (de) |
IL (1) | IL202617A0 (de) |
MX (1) | MX2009014013A (de) |
SI (1) | SI2173723T1 (de) |
WO (1) | WO2009006569A1 (de) |
ZA (1) | ZA200908901B (de) |
Families Citing this family (16)
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US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
RU2486181C2 (ru) * | 2007-07-05 | 2013-06-27 | Эррэй Биофарма Инк. | Пиримидилциклопентаны как ингибиторы акт-протеинкиназ |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
CN101959887B (zh) | 2008-01-08 | 2013-07-31 | 阵列生物制药公司 | 作为激酶抑制剂的吡咯并吡啶 |
ES2392014T3 (es) | 2008-01-09 | 2012-12-03 | Array Biopharma, Inc. | Pirazolopiridinas como inhibidores de la cinasa |
ES2401685T3 (es) | 2008-01-09 | 2013-04-23 | Array Biopharma, Inc. | Pirimidil ciclopentano hidroxilado como inhibidor de la proteína quinasa AKT |
US8329709B2 (en) | 2008-01-09 | 2012-12-11 | Genentech, Inc. | 5H-cyclopenta[D]pyrimidines as AKT protein kinase inhibitors |
GB201110546D0 (en) * | 2011-06-22 | 2011-08-03 | Imp Innovations Ltd | Compositions |
AU2013262568B2 (en) * | 2012-05-17 | 2017-08-31 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
WO2017156350A1 (en) | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
KR20190084063A (ko) | 2016-10-28 | 2019-07-15 | 이칸 스쿨 오브 메디슨 엣 마운트 시나이 | Ezh2-매개성 암 치료용 조성물 및 방법 |
CN110267659A (zh) | 2016-12-08 | 2019-09-20 | 西奈山伊坎医学院 | 用于治疗cdk4/6介导的癌症的组合物和方法 |
US11472799B2 (en) | 2018-03-06 | 2022-10-18 | Icahn School Of Medicine At Mount Sinai | Serine threonine kinase (AKT) degradation / disruption compounds and methods of use |
BR112022017856A2 (pt) * | 2020-03-17 | 2022-11-01 | Jiangsu Hengrui Pharmaceuticals Co Ltd | Derivado bicíclico fundido, método de preparação do mesmo e uso farmacêutico do mesmo |
CN113444110B (zh) * | 2020-03-25 | 2023-05-12 | 江苏恒瑞医药股份有限公司 | 四氢吡咯并吡唑类衍生物、其制备方法及其在医药上的应用 |
CA3231865A1 (en) | 2021-09-17 | 2023-03-23 | Tingting SHANG | Fused bicyclic derivative, pharmaceutically acceptable salt, crystal form thereof and preparation method therefor |
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WO2008003697A1 (en) | 2006-07-06 | 2008-01-10 | Glaxo Group Limited | Substituted n-phenylmethyl -5-oxo-proline-2-amides as p2x7-receptor antagonists and their methods of use |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
TW200808325A (en) | 2006-07-06 | 2008-02-16 | Astrazeneca Ab | Novel compounds |
WO2008012635A2 (en) | 2006-07-26 | 2008-01-31 | Pfizer Products Inc. | Amine derivatives useful as anticancer agents |
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2008
- 2008-07-03 SI SI200830441T patent/SI2173723T1/sl unknown
- 2008-07-03 JP JP2010515270A patent/JP5542282B2/ja active Active
- 2008-07-03 US US12/667,850 patent/US8377937B2/en active Active
- 2008-07-03 EP EP11169324.8A patent/EP2404907B1/de active Active
- 2008-07-03 AU AU2008272832A patent/AU2008272832B2/en not_active Ceased
- 2008-07-03 WO PCT/US2008/069147 patent/WO2009006569A1/en active Application Filing
- 2008-07-03 KR KR1020157020348A patent/KR20150091196A/ko not_active Application Discontinuation
- 2008-07-03 AT AT08781340T patent/ATE522509T1/de not_active IP Right Cessation
- 2008-07-03 MX MX2009014013A patent/MX2009014013A/es not_active Application Discontinuation
- 2008-07-03 KR KR1020107002547A patent/KR101624361B1/ko active IP Right Grant
- 2008-07-03 EP EP08781340.8A patent/EP2173723B3/de active Active
- 2008-07-03 ES ES11169324.8T patent/ES2533557T3/es active Active
- 2008-07-03 CA CA2692506A patent/CA2692506C/en not_active Expired - Fee Related
- 2008-07-03 CN CN2008801058708A patent/CN101918373B/zh active Active
- 2008-07-03 BR BRPI0813993-8A patent/BRPI0813993A2/pt not_active Application Discontinuation
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2009
- 2009-12-09 IL IL202617A patent/IL202617A0/en unknown
- 2009-12-14 ZA ZA2009/08901A patent/ZA200908901B/en unknown
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2010
- 2010-05-06 HK HK10104442.4A patent/HK1136832A1/xx unknown
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2012
- 2012-07-11 HK HK12106808.5A patent/HK1166078A1/xx unknown
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Also Published As
Publication number | Publication date |
---|---|
EP2173723B1 (de) | 2011-08-31 |
EP2173723A1 (de) | 2010-04-14 |
JP2010532387A (ja) | 2010-10-07 |
IL202617A0 (en) | 2010-06-30 |
BRPI0813993A2 (pt) | 2015-06-16 |
CN101918373A (zh) | 2010-12-15 |
CA2692506C (en) | 2015-11-24 |
KR20150091196A (ko) | 2015-08-07 |
AU2008272832A1 (en) | 2009-01-08 |
AU2008272832B2 (en) | 2014-02-20 |
JP5542282B2 (ja) | 2014-07-09 |
HK1136832A1 (en) | 2010-07-09 |
HK1166078A1 (en) | 2012-10-19 |
RU2010103811A (ru) | 2011-08-10 |
JP2014040489A (ja) | 2014-03-06 |
CN101918373B (zh) | 2013-06-05 |
ZA200908901B (en) | 2011-10-26 |
KR101624361B1 (ko) | 2016-05-25 |
KR20100029846A (ko) | 2010-03-17 |
WO2009006569A1 (en) | 2009-01-08 |
EP2404907B1 (de) | 2015-01-14 |
MX2009014013A (es) | 2010-01-28 |
US20110160221A1 (en) | 2011-06-30 |
CA2692506A1 (en) | 2009-01-08 |
SI2173723T1 (sl) | 2011-12-30 |
EP2404907A1 (de) | 2012-01-11 |
EP2173723B3 (de) | 2014-11-19 |
US8377937B2 (en) | 2013-02-19 |
ES2533557T3 (es) | 2015-04-13 |
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