BRPI0506765A - composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composição - Google Patents
composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composiçãoInfo
- Publication number
- BRPI0506765A BRPI0506765A BRPI0506765-0A BRPI0506765A BRPI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A BR PI0506765 A BRPI0506765 A BR PI0506765A
- Authority
- BR
- Brazil
- Prior art keywords
- substituted
- compound
- phenyl
- lower alkyl
- composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPOSTO OU UM SEU SAL, HIDRATO E/OU PRó-DROGAFARMACêUTICAMENTE ACEITáVEIS, COMPOSIçãO FARMACêUTICA, MéTODOS PARA INIBIR A PRODUçãO DE BETA-AMILóIDE EM UM PACIENTE E PARA TRATAR DE UMA DOENçA, KIT FARMACêUTICO, USO DE UM COMPOSTO OU DE UMA COMPOSIçãO Composto úteis para reduzir os níveis da beta - amilióde são providos. Os compostos têm a estrutura de fórmula Ia: em que R~ 1~ é alquila inferior, alquila inferior substituída fenila,fenila substituída, benzila, benzila substituída, benzilóxi, benzilóxi substituído, ou SO~ 2~ R~ 5~; R~ 5~ é fenila, fenila substituída, heterociclo, heterociclo susbstituído, alquila ou alquila substituída; R~ 2~é alquila inferior, alquila inferior substituída, CF~ 3~ alquenila, alquenila substituída, alquinila, alquinila substitúida, fenila, fenila substituída ou cicloalquila;R~ 3~ é hidrogênio, alquila inferior ou alquila inferior substituída; R~4~ é fenila, fenila substituída, heteroclico, heteroclicosubstituído, tiofeno ou tiofeno substituído; R~ 6~ é hidrogênio, alquila inferior, alquila inferior substituída, CF~ 3~, alquenila, alquenila substituída,alquinila,alquinila substituída, fenila, fenila substituída, cicloalquila ou cicloalquila substituída W,X,Y são independentes CR~ 7~ ou N; e R~ 7~ é hidrogênio, halogênio, alquila inferior ou alquila inferior substituída
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US53708604P | 2004-01-16 | 2004-01-16 | |
PCT/US2005/001082 WO2005073198A1 (en) | 2004-01-16 | 2005-01-13 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0506765A true BRPI0506765A (pt) | 2007-05-22 |
Family
ID=34825912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0506765-0A BRPI0506765A (pt) | 2004-01-16 | 2005-01-13 | composto ou um seu sal, hidrato e/ou pró-droga farmaceuticamente aceitáveis, composição farmacêutica, métodos para inibir a produção de beta-amilóide em um paciente e para tratar de uma doença, kit farmacêutico, uso de um composto ou de uma composição |
Country Status (11)
Country | Link |
---|---|
US (3) | US7399778B2 (pt) |
EP (1) | EP1709003B1 (pt) |
JP (1) | JP2007517905A (pt) |
CN (1) | CN1910158A (pt) |
AT (1) | ATE443701T1 (pt) |
AU (1) | AU2005207835A1 (pt) |
BR (1) | BRPI0506765A (pt) |
CA (1) | CA2552558A1 (pt) |
DE (1) | DE602005016775D1 (pt) |
ES (1) | ES2330451T3 (pt) |
WO (1) | WO2005073198A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0311767A (pt) * | 2002-06-11 | 2005-03-08 | Wyeth Corp | Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos |
JP2006522126A (ja) | 2003-03-31 | 2006-09-28 | ワイス | βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 |
WO2005073198A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
CA2571002A1 (en) * | 2004-06-18 | 2006-01-05 | Chiron Corporation | N-(1-(1-benzyl-4-phenyl-1h-imidazol-2-yl)-2,2-dimethylpropyl)benzamide derivatives and related compounds as kinesin spindle protein (ksp) inhibitors for the treatment of cancer |
AU2007217965A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
CN101384579A (zh) * | 2006-02-17 | 2009-03-11 | 惠氏公司 | 2-氨基三氟烷基取代的醇的选择性n-磺酰化 |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
BRPI0710470A2 (pt) | 2006-04-21 | 2011-08-16 | Wyeth Corp | métodos para preparar seletivamente um aminoálcool quiral e uma sulfonamida quiral |
US20090111860A1 (en) * | 2006-04-21 | 2009-04-30 | Astrazeneca Ab | Sulfonamide compounds useful as adg receptor modulators |
EP2073827A4 (en) * | 2006-11-03 | 2012-04-25 | Univ Northwestern | THERAPY OF PLATE SCLEROSIS |
TW200911778A (en) * | 2007-07-16 | 2009-03-16 | Wyeth Corp | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides |
PA8789801A1 (es) * | 2007-07-16 | 2009-02-09 | Wyeth Corp | Procesos e intermadiarios para la preparacion de compuestos de silfonamida heterocíclica |
PA8789701A1 (es) * | 2007-07-16 | 2009-04-23 | Wyeth Corp | Inhibidores de producción de beta amiloide |
WO2009089237A1 (en) * | 2008-01-11 | 2009-07-16 | Wyeth | Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors |
US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
ES2634421T3 (es) * | 2008-03-27 | 2017-09-27 | Chase Pharmaceuticals Corporation | Uso y composición para tratar la demencia |
EP2478099B1 (en) | 2009-09-18 | 2019-06-05 | Chase Pharmaceuticals Corporation | Combination for treating alzheimer-type dementia |
JP2011043839A (ja) * | 2010-09-29 | 2011-03-03 | Panasonic Corp | レジスト材料及びそれを用いたパターン形成方法 |
CN102786447A (zh) * | 2011-08-01 | 2012-11-21 | 四川大学 | N,n-二取代芳基磺酰胺类化合物及其制备方法和用途 |
AU2013312749B2 (en) | 2012-09-05 | 2018-01-18 | Chase Pharmaceuticals Corporation | Anticholinergic neuroprotective composition and methods |
US10519112B2 (en) | 2014-06-10 | 2019-12-31 | Ube Industries, Ltd. | Method for producing heteroaromatic sulfonamide compound |
US10774072B2 (en) | 2014-06-10 | 2020-09-15 | Ube Industries, Ltd. | Crystal of N-substituted sulfonamide compound |
US10428046B2 (en) | 2014-06-10 | 2019-10-01 | Ube Industries, Ltd. | N-substituted sulfonamide compound and method for producing same |
WO2016179558A1 (en) | 2015-05-06 | 2016-11-10 | The Regents Of The University Of California | K-ras modulators |
JP2020517600A (ja) | 2017-04-20 | 2020-06-18 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | K−Rasモジュレーター |
TW202012396A (zh) * | 2018-04-18 | 2020-04-01 | 美商德洛斯股份有限公司 | 具乙烯磺醯胺部分之k-ras調節劑 |
Family Cites Families (21)
Publication number | Priority date | Publication date | Assignee | Title |
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GB9200209D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
ZA945719B (en) | 1993-08-09 | 1996-02-01 | Lilly Co Eli | Identification and use of protease inhibitors |
JP2002515860A (ja) | 1995-11-28 | 2002-05-28 | セフアロン・インコーポレーテツド | システイン及びセリンプロテアーゼのd―アミノ酸由来のインヒビター |
US5703129A (en) | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
IL129477A0 (en) | 1996-11-22 | 2000-02-29 | Elan Pharm Inc | N-(aryl/heteroaryl)amino acid derivatives pharmaceutical compositions comprising same and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds |
AU8998598A (en) * | 1997-09-11 | 1999-03-29 | Nissan Chemical Industries Ltd. | Pyrazole compounds and plant disease control agent |
EP1159263A1 (en) | 1999-02-26 | 2001-12-05 | Merck & Co., Inc. | Novel sulfonamide compounds and uses thereof |
ATE305782T1 (de) | 1999-08-12 | 2005-10-15 | Pharmacia Italia Spa | 3(5)-amino-pyrazolderivate, deren herstellungsverfahren und verwendung als krebshemmende mittel |
EP1088815A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
EP1088821A1 (en) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonamide derivatives |
EP1222176A1 (en) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
AU4086101A (en) | 2000-03-20 | 2001-10-03 | Merck Sharp & Dohme | Sulphonamido-substituted bridged bicycloalkyl derivatives |
US6951948B2 (en) | 2000-06-05 | 2005-10-04 | Ortho-Mcneil Pharmaceutical, Inc. | Method for synthesis of substituted azole libraries |
CA2436526C (en) * | 2000-12-13 | 2010-10-19 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
EP1461332A4 (en) | 2001-12-11 | 2009-10-21 | Wyeth Corp | PRODUCTION OF ALPHA-AMINO ACIDS AND CHIRALLY PURE ALPHA-AMINO N-SULFONYL ACIDS |
DE10163582A1 (de) * | 2001-12-21 | 2003-07-03 | Thomson Brandt Gmbh | Automatische Verstärkungsregelung für einen Tuner |
JP2006522126A (ja) * | 2003-03-31 | 2006-09-28 | ワイス | βアミロイド生産のフルオロ含有およびトリフルオロアルキル含有複素環スルホンアミド阻害物質およびその誘導体 |
WO2005073198A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
-
2005
- 2005-01-13 WO PCT/US2005/001082 patent/WO2005073198A1/en not_active Application Discontinuation
- 2005-01-13 JP JP2006549589A patent/JP2007517905A/ja active Pending
- 2005-01-13 AT AT05705638T patent/ATE443701T1/de not_active IP Right Cessation
- 2005-01-13 CA CA002552558A patent/CA2552558A1/en not_active Abandoned
- 2005-01-13 AU AU2005207835A patent/AU2005207835A1/en not_active Abandoned
- 2005-01-13 ES ES05705638T patent/ES2330451T3/es active Active
- 2005-01-13 CN CNA2005800025879A patent/CN1910158A/zh active Pending
- 2005-01-13 DE DE602005016775T patent/DE602005016775D1/de active Active
- 2005-01-13 EP EP05705638A patent/EP1709003B1/en active Active
- 2005-01-13 US US11/035,005 patent/US7399778B2/en not_active Expired - Fee Related
- 2005-01-13 BR BRPI0506765-0A patent/BRPI0506765A/pt not_active IP Right Cessation
-
2008
- 2008-06-19 US US12/142,306 patent/US7674813B2/en not_active Expired - Fee Related
-
2010
- 2010-02-19 US US12/708,557 patent/US20100144812A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20050171180A1 (en) | 2005-08-04 |
US7399778B2 (en) | 2008-07-15 |
US20080249150A1 (en) | 2008-10-09 |
CA2552558A1 (en) | 2005-08-11 |
DE602005016775D1 (de) | 2009-11-05 |
EP1709003A1 (en) | 2006-10-11 |
US20100144812A1 (en) | 2010-06-10 |
JP2007517905A (ja) | 2007-07-05 |
ES2330451T3 (es) | 2009-12-10 |
CN1910158A (zh) | 2007-02-07 |
WO2005073198A1 (en) | 2005-08-11 |
EP1709003B1 (en) | 2009-09-23 |
ATE443701T1 (de) | 2009-10-15 |
US7674813B2 (en) | 2010-03-09 |
AU2005207835A1 (en) | 2005-08-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A ANUIDADE. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2158 DE 15/05/2012. |