ATE443701T1 - Heterocyclische, ein azol enthaltende sulfonamidinhibitoren der beta-amyloid-produktion - Google Patents
Heterocyclische, ein azol enthaltende sulfonamidinhibitoren der beta-amyloid-produktionInfo
- Publication number
- ATE443701T1 ATE443701T1 AT05705638T AT05705638T ATE443701T1 AT E443701 T1 ATE443701 T1 AT E443701T1 AT 05705638 T AT05705638 T AT 05705638T AT 05705638 T AT05705638 T AT 05705638T AT E443701 T1 ATE443701 T1 AT E443701T1
- Authority
- AT
- Austria
- Prior art keywords
- substituted
- phenyl
- lower alkyl
- sulfonamidine
- inhibitors
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 2
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 11
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 10
- 125000000623 heterocyclic group Chemical group 0.000 abstract 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000000304 alkynyl group Chemical group 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000005017 substituted alkenyl group Chemical group 0.000 abstract 2
- 125000004426 substituted alkynyl group Chemical group 0.000 abstract 2
- 229930192474 thiophene Natural products 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- -1 benzyloxy, substituted benzyloxy Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 125000005346 substituted cycloalkyl group Chemical group 0.000 abstract 1
- 150000003577 thiophenes Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US53708604P | 2004-01-16 | 2004-01-16 | |
| PCT/US2005/001082 WO2005073198A1 (en) | 2004-01-16 | 2005-01-13 | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE443701T1 true ATE443701T1 (de) | 2009-10-15 |
Family
ID=34825912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT05705638T ATE443701T1 (de) | 2004-01-16 | 2005-01-13 | Heterocyclische, ein azol enthaltende sulfonamidinhibitoren der beta-amyloid-produktion |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US7399778B2 (de) |
| EP (1) | EP1709003B1 (de) |
| JP (1) | JP2007517905A (de) |
| CN (1) | CN1910158A (de) |
| AT (1) | ATE443701T1 (de) |
| AU (1) | AU2005207835A1 (de) |
| BR (1) | BRPI0506765A (de) |
| CA (1) | CA2552558A1 (de) |
| DE (1) | DE602005016775D1 (de) |
| ES (1) | ES2330451T3 (de) |
| WO (1) | WO2005073198A1 (de) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050010882A (ko) * | 2002-06-11 | 2005-01-28 | 와이어쓰 | 베타 아밀로이드 생산의 치환 페닐술폰아미드 저해제 |
| AU2004230844B2 (en) | 2003-03-31 | 2010-12-09 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
| CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
| JP4836280B2 (ja) | 2004-06-18 | 2011-12-14 | ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド | 癌を治療するためのキネシンスピンドルタンパク質（ｋｓｐ）阻害剤としてのｎ−（１−（１−ベンジル−４−フェニル−１ｈ−イミダゾール−２−イル）−２，２−ジメチルプロピル）ベンズアミド誘導体および関連化合物 |
| AR059517A1 (es) * | 2006-02-17 | 2008-04-09 | Wyeth Corp | N- sulfonilacion selectiva de alcoholes sustituidos con 2- aminotrifluoralquilo |
| AR059518A1 (es) * | 2006-02-17 | 2008-04-09 | Wyeth Corp | Metodos para preparar alcoholes sustituidos con sulfonamidas y sus compuestos intermedios |
| US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
| US20090111860A1 (en) * | 2006-04-21 | 2009-04-30 | Astrazeneca Ab | Sulfonamide compounds useful as adg receptor modulators |
| CA2649396A1 (en) * | 2006-04-21 | 2007-11-08 | Wyeth | Production of chirally pure amino alcohol intermediates, derivatives thereof, and uses thereof |
| US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
| JP2010509235A (ja) * | 2006-11-03 | 2010-03-25 | ノースウェスタン ユニバーシティ | 多発性硬化症の治療 |
| TW200914409A (en) * | 2007-07-16 | 2009-04-01 | Wyeth Corp | Processes and intermediates for the preparation of heterocyclic sulfonamide compounds |
| WO2009012201A2 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Process for the preparation of trifluoroalkyl-phenyl and heterocyclic sulfonamides |
| CA2693959A1 (en) * | 2007-07-16 | 2009-01-22 | Wyeth | Inhibitors of beta amyloid production |
| WO2009089237A1 (en) * | 2008-01-11 | 2009-07-16 | Wyeth | Compositions containing o-sulfate and o-phosphate containing aryl sulfonamide derivatives useful as beta-amyloid inhibitors |
| US20110201597A1 (en) | 2008-03-27 | 2011-08-18 | Chase Thomas N | Method and composition for treating alzheimer-type dementia |
| DK2271218T3 (en) | 2008-03-27 | 2017-09-11 | Chase Pharmaceuticals Corp | USE AND COMPOSITION TO TREAT DEMENS |
| US8877768B2 (en) | 2009-09-18 | 2014-11-04 | Chase Pharmaceuticals Corporation | Method and composition for treating alzheimer-type dementia |
| JP2011043839A (ja) * | 2010-09-29 | 2011-03-03 | Panasonic Corp | レジスト材料及びそれを用いたパターン形成方法 |
| CN102786447A (zh) * | 2011-08-01 | 2012-11-21 | 四川大学 | N,n-二取代芳基磺酰胺类化合物及其制备方法和用途 |
| EP2892514A4 (de) | 2012-09-05 | 2016-04-13 | Chase Pharmaceuticals Corp | Neuroprotektive anticholinergische zusammensetzung und verfahren |
| US10774072B2 (en) | 2014-06-10 | 2020-09-15 | Ube Industries, Ltd. | Crystal of N-substituted sulfonamide compound |
| WO2015190507A1 (ja) * | 2014-06-10 | 2015-12-17 | 宇部興産株式会社 | Ｎ－置換スルホンアミド化合物およびその製造方法 |
| ES2712454T3 (es) | 2014-06-10 | 2019-05-13 | Ube Industries | Método para producir compuesto de sulfonamida heteroaromático |
| KR20180017013A (ko) | 2015-05-06 | 2018-02-20 | 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 | K-Ras 조절제 |
| CN110785414A (zh) | 2017-04-20 | 2020-02-11 | 加利福尼亚大学董事会 | K-Ras调节剂 |
| TW202012396A (zh) * | 2018-04-18 | 2020-04-01 | 美商德洛斯股份有限公司 | 具乙烯磺醯胺部分之k-ras調節劑 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9200209D0 (en) | 1992-01-07 | 1992-02-26 | British Bio Technology | Compounds |
| US5766846A (en) | 1992-07-10 | 1998-06-16 | Athena Neurosciences | Methods of screening for compounds which inhibit soluble β-amyloid peptide production |
| US5968942A (en) | 1992-08-25 | 1999-10-19 | G. D. Searle & Co. | α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors |
| CZ184194A3 (en) | 1993-08-09 | 1995-03-15 | Lilly Co Eli | Aspartylprotease inhibitor and method of identifying thereof |
| WO1997021690A1 (en) | 1995-11-28 | 1997-06-19 | Cephalon, Inc. | D-amino acid derived inhibitors of cysteine and serine proteases |
| US5703129A (en) | 1996-09-30 | 1997-12-30 | Bristol-Myers Squibb Company | 5-amino-6-cyclohexyl-4-hydroxy-hexanamide derivatives as inhibitors of β-amyloid protein production |
| JP2001519769A (ja) | 1996-11-22 | 2001-10-23 | エラン・ファーマシューティカルズ・インコーポレイテッド | Ｎ―（アリール／ヘテロアリール）アミノ酸誘導体、その医薬組成物および該化合物を用いたβ―アミロイドペプチドの放出および／またはその合成を阻害する方法 |
| AU8998598A (en) * | 1997-09-11 | 1999-03-29 | Nissan Chemical Industries Ltd. | Pyrazole compounds and plant disease control agent |
| EP1159263A1 (de) | 1999-02-26 | 2001-12-05 | Merck & Co., Inc. | Sulfonamid-verbindungen und anwendungen davon |
| GEP20053476B (en) * | 1999-08-12 | 2005-03-25 | Upjohn Co | 3(5)-Amino-Pyrazole Derivatives, Process for Their Preparation and Their Use as Antitumor Agents |
| EP1088815A1 (de) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutisch Aktive Sulfonyl-Aminosäurederivate |
| EP1088821A1 (de) | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmazeutisch wirksamer Sulfonamid Derivate |
| EP1222176A1 (de) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | Amino-laktam-sulfonamide als inhibitoren der bildung von a-beta-protein |
| US7365196B2 (en) | 2000-03-20 | 2008-04-29 | Merck Sharp & Dohme Ltd. | Sulphonamido-substituted bridged bicycloalkyl derivatives |
| WO2001094318A2 (en) | 2000-06-05 | 2001-12-13 | Ortho-Mcneil Pharmaceutical, Inc. | Method for synthesis of substituted azole libraries |
| US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
| NZ538100A (en) | 2000-12-13 | 2006-07-28 | Arqule Inc | Heterocyclic sulfonamide inhibitors of beta amyloid production |
| MXPA04005366A (es) | 2001-12-11 | 2004-09-27 | Wyeth Corp | Produccion de alfa-aminoacidos de n-sulfonilo y alfa-aminoacidos quiralmente puros. |
| DE10163582A1 (de) * | 2001-12-21 | 2003-07-03 | Thomson Brandt Gmbh | Automatische Verstärkungsregelung für einen Tuner |
| AU2004230844B2 (en) * | 2003-03-31 | 2010-12-09 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
| CA2552558A1 (en) * | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
-
2005
- 2005-01-13 CA CA002552558A patent/CA2552558A1/en not_active Abandoned
- 2005-01-13 US US11/035,005 patent/US7399778B2/en not_active Expired - Fee Related
- 2005-01-13 AU AU2005207835A patent/AU2005207835A1/en not_active Abandoned
- 2005-01-13 CN CNA2005800025879A patent/CN1910158A/zh active Pending
- 2005-01-13 JP JP2006549589A patent/JP2007517905A/ja active Pending
- 2005-01-13 AT AT05705638T patent/ATE443701T1/de not_active IP Right Cessation
- 2005-01-13 ES ES05705638T patent/ES2330451T3/es not_active Expired - Lifetime
- 2005-01-13 BR BRPI0506765-0A patent/BRPI0506765A/pt not_active IP Right Cessation
- 2005-01-13 EP EP05705638A patent/EP1709003B1/de not_active Expired - Lifetime
- 2005-01-13 DE DE602005016775T patent/DE602005016775D1/de not_active Expired - Lifetime
- 2005-01-13 WO PCT/US2005/001082 patent/WO2005073198A1/en not_active Ceased
-
2008
- 2008-06-19 US US12/142,306 patent/US7674813B2/en not_active Expired - Fee Related
-
2010
- 2010-02-19 US US12/708,557 patent/US20100144812A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| CN1910158A (zh) | 2007-02-07 |
| EP1709003A1 (de) | 2006-10-11 |
| US7674813B2 (en) | 2010-03-09 |
| AU2005207835A1 (en) | 2005-08-11 |
| US20100144812A1 (en) | 2010-06-10 |
| EP1709003B1 (de) | 2009-09-23 |
| JP2007517905A (ja) | 2007-07-05 |
| CA2552558A1 (en) | 2005-08-11 |
| US20050171180A1 (en) | 2005-08-04 |
| US20080249150A1 (en) | 2008-10-09 |
| DE602005016775D1 (de) | 2009-11-05 |
| ES2330451T3 (es) | 2009-12-10 |
| WO2005073198A1 (en) | 2005-08-11 |
| US7399778B2 (en) | 2008-07-15 |
| BRPI0506765A (pt) | 2007-05-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |