HUP0001383A3 - N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use - Google Patents

N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use

Info

Publication number
HUP0001383A3
HUP0001383A3 HU0001383A HUP0001383A HUP0001383A3 HU P0001383 A3 HUP0001383 A3 HU P0001383A3 HU 0001383 A HU0001383 A HU 0001383A HU P0001383 A HUP0001383 A HU P0001383A HU P0001383 A3 HUP0001383 A3 HU P0001383A3
Authority
HU
Hungary
Prior art keywords
heteroaryl
aryl
amino acid
same
pharmaceutical compositions
Prior art date
Application number
HU0001383A
Other languages
Hungarian (hu)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HUP0001383A1 publication Critical patent/HUP0001383A1/en
Publication of HUP0001383A3 publication Critical patent/HUP0001383A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HU0001383A 1996-11-22 1997-11-20 N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use HUP0001383A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US75533496A 1996-11-22 1996-11-22
PCT/US1997/018704 WO1998022493A2 (en) 1996-11-22 1997-11-20 N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS

Publications (2)

Publication Number Publication Date
HUP0001383A1 HUP0001383A1 (en) 2001-05-28
HUP0001383A3 true HUP0001383A3 (en) 2001-11-28

Family

ID=25038718

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0001383A HUP0001383A3 (en) 1996-11-22 1997-11-20 N-(aryl/heteroaryl) amino acid derivatives, pharmaceutical compositions comprising same and their use

Country Status (13)

Country Link
EP (1) EP0942923A2 (en)
JP (1) JP2001519769A (en)
CN (1) CN1237978A (en)
AU (1) AU5354398A (en)
BR (1) BR9714358A (en)
CA (1) CA2270876A1 (en)
HU (1) HUP0001383A3 (en)
ID (1) ID22275A (en)
IL (1) IL129477A0 (en)
NO (1) NO992426L (en)
NZ (1) NZ335157A (en)
TR (1) TR199901132T2 (en)
WO (1) WO1998022493A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
EP1131634A2 (en) 1998-09-30 2001-09-12 Elan Pharmaceuticals, Inc. Determining the mechanism of beta-amyloid peptide generation
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
CN1636011A (en) 1998-12-24 2005-07-06 杜邦药品公司 Succinoylamino lactams as inhibitors and as a beta protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
AU7997700A (en) 1999-10-08 2001-04-23 Du Pont Pharmaceuticals Company Amino lactam sulfonamides as inhibitors of abeta protein production
CA2395862A1 (en) 2000-02-17 2001-08-23 Hong Liu Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
IL151576A0 (en) 2000-04-03 2003-04-10 Bristol Myers Squibb Pharma Co Cyclic lactams as inhibitors of a-beta protein production
CN1434803A (en) 2000-04-03 2003-08-06 布里斯托尔-迈尔斯斯奎布药品公司 Cyclic lactams as inhibitors os A-alpha protein production
AU2001257006A1 (en) 2000-04-11 2001-10-23 Du Pont Pharmaceuticals Company Substituted lactams as inhibitors of abeta protein production
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
CA2379445C (en) 2000-06-01 2007-08-21 Bristol-Myers Squibb Pharma Company Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
EP1334091B1 (en) 2000-08-24 2012-09-19 University of Pittsburgh - Of the Commonwealth System of Higher Education Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
MXPA03005255A (en) 2000-12-13 2004-10-14 Wyeth Corp Heterocyclic sulfonamide inhibitors of beta amyloid production.
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
CH698246B1 (en) * 2001-12-20 2009-06-30 Hoffmann La Roche Test to identify inhibitors of beta secretases.
DE10306202A1 (en) 2003-02-13 2004-08-26 Grünenthal GmbH 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist
AU2004221897B2 (en) * 2003-03-14 2010-11-18 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Benzothiazole derivative compounds, compositions and uses
NZ542468A (en) 2003-03-31 2009-01-31 Wyeth Corp Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
CA2528496C (en) 2003-06-05 2011-04-12 Elan Pharmaceuticals, Inc. Acylated amino acid amidyl pyrazoles and related compounds
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
WO2005073198A1 (en) 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
EP1725522B1 (en) 2004-03-03 2014-09-10 GlaxoSmithKline LLC Aniline derivatives as selective androgen receptor modulators
EP1871379A4 (en) * 2005-04-15 2010-06-02 Glaxosmithkline Llc Cyanoarylamines
CN100999546B (en) * 2007-01-11 2010-08-11 清华大学 Polypeptide compound with aza-containing heterocyclic modification and its application
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
CN111777571B (en) * 2020-06-28 2023-07-11 武汉药明康德新药开发有限公司 Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0721449T3 (en) * 1993-10-01 2002-04-22 Merrell Pharma Inc Inhibitors of beta-amyloid protein production
US6017887A (en) * 1995-01-06 2000-01-25 Sibia Neurosciences, Inc. Peptide, peptide analog and amino acid analog protease inhibitors

Also Published As

Publication number Publication date
HUP0001383A1 (en) 2001-05-28
ID22275A (en) 1999-09-23
IL129477A0 (en) 2000-02-29
NZ335157A (en) 2001-01-26
CN1237978A (en) 1999-12-08
BR9714358A (en) 2000-03-21
WO1998022493A2 (en) 1998-05-28
TR199901132T2 (en) 1999-08-23
EP0942923A2 (en) 1999-09-22
CA2270876A1 (en) 1998-05-28
AU5354398A (en) 1998-06-10
NO992426L (en) 1999-06-30
WO1998022493A3 (en) 1998-07-23
JP2001519769A (en) 2001-10-23
NO992426D0 (en) 1999-05-20

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