BR9714358A - Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds - Google Patents
Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compoundsInfo
- Publication number
- BR9714358A BR9714358A BR9714358A BR9714358A BR9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A BR 9714358 A BR9714358 A BR 9714358A
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- release
- methods
- pharmaceutical compositions
- beta
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Patente de Invenção: <B>"DERIVADOS DE N-(ARILA/HETMPREENDENDO OS MESMOS, E MéTODOS PARA A INIBIçãO DE LIBERAçãO DE PEPTìDEO BETA-AMILóIDE E/OU SUA SìNTESE POR USO DE TAIS COMPOSTOS"<D>. Revelados são os compostos que inibem liberação de peptídeo beta-amilóide e/ou sua síntese, e, correspondentemente, têm utilidade no tratamento de doença de Alzheimer. Também revelados são composições farmacêuticas compreendendo um composto que inibe liberação de étodos para o tratamento de doença de Alzheimer tanto pofilaticamente quando terapeuticamente com tais composições farmacêuticas.Invention Patent: <B> "N- (ARILA / HETMPREENDING DERIVATIVES, AND METHODS FOR THE INHIBITION OF BETA-AMYLOID PEPTIDE RELEASE AND / OR ITS SYNTHESIS BY THE USE OF SUCH COMPOUNDS" <D>. which inhibit beta-amyloid peptide release and / or its synthesis, and, correspondingly, are useful in the treatment of Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound that inhibits the release of methods for the treatment of Alzheimer's disease both pophilatically when therapeutically with such pharmaceutical compositions.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75533496A | 1996-11-22 | 1996-11-22 | |
PCT/US1997/018704 WO1998022493A2 (en) | 1996-11-22 | 1997-11-20 | N-(ARYL/HETEROARYL) AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9714358A true BR9714358A (en) | 2000-03-21 |
Family
ID=25038718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9714358A BR9714358A (en) | 1996-11-22 | 1997-11-20 | Derivatives of n- (aryl / heteroaryl) amino acid, pharmaceutical compositions comprising them, and methods for inhibiting the release of beta-amyloid peptide and / or its synthesis by using such compounds |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0942923A2 (en) |
JP (1) | JP2001519769A (en) |
CN (1) | CN1237978A (en) |
AU (1) | AU5354398A (en) |
BR (1) | BR9714358A (en) |
CA (1) | CA2270876A1 (en) |
HU (1) | HUP0001383A3 (en) |
ID (1) | ID22275A (en) |
IL (1) | IL129477A0 (en) |
NO (1) | NO992426L (en) |
NZ (1) | NZ335157A (en) |
TR (1) | TR199901132T2 (en) |
WO (1) | WO1998022493A2 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
EP1131634A2 (en) | 1998-09-30 | 2001-09-12 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
CN1636011A (en) | 1998-12-24 | 2005-07-06 | 杜邦药品公司 | Succinoylamino lactams as inhibitors and as a beta protein production |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
AU7997700A (en) | 1999-10-08 | 2001-04-23 | Du Pont Pharmaceuticals Company | Amino lactam sulfonamides as inhibitors of abeta protein production |
CA2395862A1 (en) | 2000-02-17 | 2001-08-23 | Hong Liu | Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production |
IL151576A0 (en) | 2000-04-03 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic lactams as inhibitors of a-beta protein production |
CN1434803A (en) | 2000-04-03 | 2003-08-06 | 布里斯托尔-迈尔斯斯奎布药品公司 | Cyclic lactams as inhibitors os A-alpha protein production |
AU2001257006A1 (en) | 2000-04-11 | 2001-10-23 | Du Pont Pharmaceuticals Company | Substituted lactams as inhibitors of abeta protein production |
AU2001261728A1 (en) | 2000-05-17 | 2001-11-26 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands for diagnostic imaging |
CA2379445C (en) | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
EP1334091B1 (en) | 2000-08-24 | 2012-09-19 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
MXPA03005255A (en) | 2000-12-13 | 2004-10-14 | Wyeth Corp | Heterocyclic sulfonamide inhibitors of beta amyloid production. |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
CH698246B1 (en) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test to identify inhibitors of beta secretases. |
DE10306202A1 (en) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
AU2004221897B2 (en) * | 2003-03-14 | 2010-11-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Benzothiazole derivative compounds, compositions and uses |
NZ542468A (en) | 2003-03-31 | 2009-01-31 | Wyeth Corp | Fluoro- and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
CA2528496C (en) | 2003-06-05 | 2011-04-12 | Elan Pharmaceuticals, Inc. | Acylated amino acid amidyl pyrazoles and related compounds |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
WO2005073198A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
EP1725522B1 (en) | 2004-03-03 | 2014-09-10 | GlaxoSmithKline LLC | Aniline derivatives as selective androgen receptor modulators |
EP1871379A4 (en) * | 2005-04-15 | 2010-06-02 | Glaxosmithkline Llc | Cyanoarylamines |
CN100999546B (en) * | 2007-01-11 | 2010-08-11 | 清华大学 | Polypeptide compound with aza-containing heterocyclic modification and its application |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
CN111777571B (en) * | 2020-06-28 | 2023-07-11 | 武汉药明康德新药开发有限公司 | Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK0721449T3 (en) * | 1993-10-01 | 2002-04-22 | Merrell Pharma Inc | Inhibitors of beta-amyloid protein production |
US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
-
1997
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/en unknown
- 1997-11-20 JP JP52364998A patent/JP2001519769A/en active Pending
- 1997-11-20 EP EP97950576A patent/EP0942923A2/en not_active Withdrawn
- 1997-11-20 BR BR9714358A patent/BR9714358A/en not_active IP Right Cessation
- 1997-11-20 NZ NZ335157A patent/NZ335157A/en unknown
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/en not_active Application Discontinuation
- 1997-11-20 IL IL12947797A patent/IL129477A0/en unknown
- 1997-11-20 CN CN97199776A patent/CN1237978A/en active Pending
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/en unknown
- 1997-11-20 CA CA002270876A patent/CA2270876A1/en not_active Abandoned
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 ID IDW990395A patent/ID22275A/en unknown
-
1999
- 1999-05-20 NO NO992426A patent/NO992426L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
HUP0001383A3 (en) | 2001-11-28 |
HUP0001383A1 (en) | 2001-05-28 |
ID22275A (en) | 1999-09-23 |
IL129477A0 (en) | 2000-02-29 |
NZ335157A (en) | 2001-01-26 |
CN1237978A (en) | 1999-12-08 |
WO1998022493A2 (en) | 1998-05-28 |
TR199901132T2 (en) | 1999-08-23 |
EP0942923A2 (en) | 1999-09-22 |
CA2270876A1 (en) | 1998-05-28 |
AU5354398A (en) | 1998-06-10 |
NO992426L (en) | 1999-06-30 |
WO1998022493A3 (en) | 1998-07-23 |
JP2001519769A (en) | 2001-10-23 |
NO992426D0 (en) | 1999-05-20 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 6A,7A E 8A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1833 DE 21/02/2006. |