ID22275A - PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS. - Google Patents
PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS.Info
- Publication number
- ID22275A ID22275A IDW990395A ID990395A ID22275A ID 22275 A ID22275 A ID 22275A ID W990395 A IDW990395 A ID W990395A ID 990395 A ID990395 A ID 990395A ID 22275 A ID22275 A ID 22275A
- Authority
- ID
- Indonesia
- Prior art keywords
- amiloid
- heteroaril
- aril
- derivates
- respond
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Public Health (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75533496A | 1996-11-22 | 1996-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
ID22275A true ID22275A (en) | 1999-09-23 |
Family
ID=25038718
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IDW990395A ID22275A (en) | 1996-11-22 | 1997-11-20 | PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS. |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP0942923A2 (en) |
JP (1) | JP2001519769A (en) |
CN (1) | CN1237978A (en) |
AU (1) | AU5354398A (en) |
BR (1) | BR9714358A (en) |
CA (1) | CA2270876A1 (en) |
HU (1) | HUP0001383A3 (en) |
ID (1) | ID22275A (en) |
IL (1) | IL129477A0 (en) |
NO (1) | NO992426L (en) |
NZ (1) | NZ335157A (en) |
TR (1) | TR199901132T2 (en) |
WO (1) | WO1998022493A2 (en) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ525513A (en) | 1998-08-07 | 2004-09-24 | Pont Pharmaceuticals Du | Succinoylamino lactams as inhibitors of Abeta protein production |
HRP990246A2 (en) | 1998-08-07 | 2000-06-30 | Du Pont Pharm Co | Succinoylamino benzodiazepines as inhibitors of a beta protein production |
WO2000019210A2 (en) | 1998-09-30 | 2000-04-06 | Elan Pharmaceuticals, Inc. | Determining the mechanism of beta-amyloid peptide generation |
US6737038B1 (en) | 1998-11-12 | 2004-05-18 | Bristol-Myers Squibb Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
BR9917082A (en) | 1998-12-24 | 2001-11-06 | Du Pont Pharm Co | Compounds that inhibit the production of "beta" proteins, a method of treating neurological disorders associated with the production of "beta" -amyloid, pharmaceutical composition and, method of inhibiting y-secretase activity |
US6503902B2 (en) | 1999-09-13 | 2003-01-07 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production |
US6960576B2 (en) | 1999-09-13 | 2005-11-01 | Bristol-Myers Squibb Pharma Company | Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production |
EP1222176A1 (en) | 1999-10-08 | 2002-07-17 | Bristol-Myers Squibb Pharma Company | AMINO LACTAM SULFONAMIDES AS INHIBITORS OF A$g(b) PROTEIN PRODUCTION |
US6525044B2 (en) | 2000-02-17 | 2003-02-25 | Bristol-Myers Squibb Company | Succinoylamino carbocycles and heterocycles as inhibitors of a-β protein production |
IL151576A0 (en) | 2000-04-03 | 2003-04-10 | Bristol Myers Squibb Pharma Co | Cyclic lactams as inhibitors of a-beta protein production |
AU2001253108A1 (en) | 2000-04-03 | 2001-10-15 | Bristol-Myers Squibb Pharma Company | Cyclic lactams as inhibitors of a-beta protein production |
US6632812B2 (en) | 2000-04-11 | 2003-10-14 | Dupont Pharmaceuticals Company | Substituted lactams as inhibitors of Aβ protein production |
US6878363B2 (en) | 2000-05-17 | 2005-04-12 | Bristol-Myers Squibb Pharma Company | Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging |
CA2379445C (en) | 2000-06-01 | 2007-08-21 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of a.beta. protein production |
US6432944B1 (en) | 2000-07-06 | 2002-08-13 | Bristol-Myers Squibb Company | Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives |
HU230375B1 (en) | 2000-08-24 | 2016-03-29 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Thioflavin derivatives and their use in diagnosis and treatment of alzheimer's disease |
US7270800B2 (en) | 2000-08-24 | 2007-09-18 | University Of Pittsburgh | Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition |
NZ526213A (en) | 2000-12-13 | 2005-05-27 | Wyeth Corp | Heterocyclic sulfonamide inhibitors of beta amyloid production |
US6657070B2 (en) | 2000-12-13 | 2003-12-02 | Wyeth | Production of chirally pure α-amino acids and N-sulfonyl α-amino acids |
CH698246B1 (en) * | 2001-12-20 | 2009-06-30 | Hoffmann La Roche | Test to identify inhibitors of beta secretases. |
DE10306202A1 (en) | 2003-02-13 | 2004-08-26 | Grünenthal GmbH | 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist |
AU2004221897B2 (en) * | 2003-03-14 | 2010-11-18 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Benzothiazole derivative compounds, compositions and uses |
WO2004092155A1 (en) | 2003-03-31 | 2004-10-28 | Wyeth | Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof |
JP4220548B2 (en) | 2003-06-05 | 2009-02-04 | エラン ファーマシューティカルズ,インコーポレイテッド | Acylated amino acids, amidylpyrazole, and related compounds |
US8236282B2 (en) | 2003-08-22 | 2012-08-07 | University of Pittsburgh—of the Commonwealth System of Higher Education | Benzothiazole derivative compounds, compositions and uses |
CA2552558A1 (en) | 2004-01-16 | 2005-08-11 | Wyeth | Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole |
US7514470B2 (en) | 2004-03-03 | 2009-04-07 | Smithkline Beecham Corporation | Aniline derivatives as selective androgen receptor modulators |
JP2008536868A (en) * | 2005-04-15 | 2008-09-11 | スミスクライン・ビーチャム・コーポレイション | Cyanoarylamine |
CN100999546B (en) * | 2007-01-11 | 2010-08-11 | 清华大学 | Polypeptide compound with aza-containing heterocyclic modification and its application |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
CN111777571B (en) * | 2020-06-28 | 2023-07-11 | 武汉药明康德新药开发有限公司 | Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2170104T3 (en) * | 1993-10-01 | 2002-08-01 | Merrell Pharma Inc | INHIBITORS OF THE PRODUCTION OF BETA-AMILOID PROTEINS. |
US6017887A (en) * | 1995-01-06 | 2000-01-25 | Sibia Neurosciences, Inc. | Peptide, peptide analog and amino acid analog protease inhibitors |
-
1997
- 1997-11-20 HU HU0001383A patent/HUP0001383A3/en unknown
- 1997-11-20 TR TR1999/01132T patent/TR199901132T2/en unknown
- 1997-11-20 IL IL12947797A patent/IL129477A0/en unknown
- 1997-11-20 CN CN97199776A patent/CN1237978A/en active Pending
- 1997-11-20 BR BR9714358A patent/BR9714358A/en not_active IP Right Cessation
- 1997-11-20 ID IDW990395A patent/ID22275A/en unknown
- 1997-11-20 CA CA002270876A patent/CA2270876A1/en not_active Abandoned
- 1997-11-20 WO PCT/US1997/018704 patent/WO1998022493A2/en not_active Application Discontinuation
- 1997-11-20 AU AU53543/98A patent/AU5354398A/en not_active Abandoned
- 1997-11-20 EP EP97950576A patent/EP0942923A2/en not_active Withdrawn
- 1997-11-20 NZ NZ335157A patent/NZ335157A/en unknown
- 1997-11-20 JP JP52364998A patent/JP2001519769A/en active Pending
-
1999
- 1999-05-20 NO NO992426A patent/NO992426L/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
NZ335157A (en) | 2001-01-26 |
HUP0001383A1 (en) | 2001-05-28 |
WO1998022493A3 (en) | 1998-07-23 |
AU5354398A (en) | 1998-06-10 |
BR9714358A (en) | 2000-03-21 |
WO1998022493A2 (en) | 1998-05-28 |
NO992426L (en) | 1999-06-30 |
HUP0001383A3 (en) | 2001-11-28 |
TR199901132T2 (en) | 1999-08-23 |
CA2270876A1 (en) | 1998-05-28 |
CN1237978A (en) | 1999-12-08 |
NO992426D0 (en) | 1999-05-20 |
EP0942923A2 (en) | 1999-09-22 |
JP2001519769A (en) | 2001-10-23 |
IL129477A0 (en) | 2000-02-29 |
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