ID22275A - PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS. - Google Patents

PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS.

Info

Publication number
ID22275A
ID22275A IDW990395A ID990395A ID22275A ID 22275 A ID22275 A ID 22275A ID W990395 A IDW990395 A ID W990395A ID 990395 A ID990395 A ID 990395A ID 22275 A ID22275 A ID 22275A
Authority
ID
Indonesia
Prior art keywords
amiloid
heteroaril
aril
derivates
respond
Prior art date
Application number
IDW990395A
Other languages
Indonesian (id)
Inventor
James E Audia
Beverly K Polmer
Varghese John
Lee H Latimer
Jeffrey S Nissen
Warren J Porter
Eugene D Thorsett
Jing Wu
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of ID22275A publication Critical patent/ID22275A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
IDW990395A 1996-11-22 1997-11-20 PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS. ID22275A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75533496A 1996-11-22 1996-11-22

Publications (1)

Publication Number Publication Date
ID22275A true ID22275A (en) 1999-09-23

Family

ID=25038718

Family Applications (1)

Application Number Title Priority Date Filing Date
IDW990395A ID22275A (en) 1996-11-22 1997-11-20 PHARMACEUTICAL COMPOSITION CONSIST OF AMINO N-ACID (ARIL OR HETEROARIL) DERIVATES AND METHODS TO RESPOND TO B-AMILOID RELEASE PEPTIDES AND OR SYNTHESIS USING SUCH COMPOUNDS.

Country Status (13)

Country Link
EP (1) EP0942923A2 (en)
JP (1) JP2001519769A (en)
CN (1) CN1237978A (en)
AU (1) AU5354398A (en)
BR (1) BR9714358A (en)
CA (1) CA2270876A1 (en)
HU (1) HUP0001383A3 (en)
ID (1) ID22275A (en)
IL (1) IL129477A0 (en)
NO (1) NO992426L (en)
NZ (1) NZ335157A (en)
TR (1) TR199901132T2 (en)
WO (1) WO1998022493A2 (en)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HRP990246A2 (en) 1998-08-07 2000-06-30 Du Pont Pharm Co Succinoylamino benzodiazepines as inhibitors of a beta protein production
NZ525513A (en) 1998-08-07 2004-09-24 Pont Pharmaceuticals Du Succinoylamino lactams as inhibitors of Abeta protein production
WO2000019210A2 (en) 1998-09-30 2000-04-06 Elan Pharmaceuticals, Inc. Determining the mechanism of beta-amyloid peptide generation
US6737038B1 (en) 1998-11-12 2004-05-18 Bristol-Myers Squibb Company Use of small molecule radioligands to discover inhibitors of amyloid-beta peptide production and for diagnostic imaging
EP1313426A2 (en) 1998-12-24 2003-05-28 Bristol-Myers Squibb Pharma Company Succinoylamino benzodiazepines as inhibitors of a-beta protein production
US6503902B2 (en) 1999-09-13 2003-01-07 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of a β protein production
US6960576B2 (en) 1999-09-13 2005-11-01 Bristol-Myers Squibb Pharma Company Hydroxyalkanoylaminolactams and related structures as inhibitors of Aβ protein production
CA2387493A1 (en) 1999-10-08 2001-04-19 Lorin Andrew Thompson Amino lactam sulfonamides as inhibitors of a.beta. protein production
CA2395862A1 (en) 2000-02-17 2001-08-23 Hong Liu Succinoylamino carbocycles and heterocycles as inhibitors of a.beta. protein production
MXPA02009755A (en) 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co CYCLIC LACTAMS AS INHIBITORS OF Abeta PROTEIN PRODUCTION.
MXPA02009729A (en) 2000-04-03 2003-03-27 Bristol Myers Squibb Pharma Co CYCLIC LACTAMS AS INHIBITORS OF A beta PROTEIN PRODUCTION.
AU2001257006A1 (en) 2000-04-11 2001-10-23 Du Pont Pharmaceuticals Company Substituted lactams as inhibitors of abeta protein production
AU2001261728A1 (en) 2000-05-17 2001-11-26 Bristol-Myers Squibb Pharma Company Use of small molecule radioligands for diagnostic imaging
BR0106717A (en) 2000-06-01 2002-04-16 Bristol Myers Squibb Pharma Co Compounds, pharmaceutical composition and uses of innovative lactam compounds
US6432944B1 (en) 2000-07-06 2002-08-13 Bristol-Myers Squibb Company Benzodiazepinone β-amyloid inhibitors: arylacetamidoalanyl derivatives
EP1334091B1 (en) 2000-08-24 2012-09-19 University of Pittsburgh - Of the Commonwealth System of Higher Education Thioflavin derivatives and their use in diagnosis and therapy of alzheimer's disease
US7270800B2 (en) 2000-08-24 2007-09-18 University Of Pittsburgh Thioflavin derivatives for use in antemortem diagnosis of Alzheimer's disease and in vivo imaging and prevention of amyloid deposition
US6657070B2 (en) 2000-12-13 2003-12-02 Wyeth Production of chirally pure α-amino acids and N-sulfonyl α-amino acids
EP1341779B1 (en) 2000-12-13 2006-06-21 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production
CH698246B1 (en) * 2001-12-20 2009-06-30 Hoffmann La Roche Test to identify inhibitors of beta secretases.
DE10306202A1 (en) 2003-02-13 2004-08-26 Grünenthal GmbH 2-(hetero)aryl-2-(N-((hetero)aryl)-amino)-acetic acid derivatives useful e.g. for treating anxiety, inflammation, allergy, depression, diarrhea or especially pain is NMDA antagonist
SI1611115T1 (en) * 2003-03-14 2012-12-31 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Benzothiazole derivative compounds, compositions and uses
CA2517155A1 (en) 2003-03-31 2004-10-28 Wyeth Fluoro-and trifluoroalkyl-containing heterocyclic sulfonamide inhibitors of beta amyloid production and derivatives thereof
WO2005009344A2 (en) 2003-06-05 2005-02-03 Elan Pharmaceuticals, Inc. Acylated amino acid amidyl pyrazoles and related compounds
US8236282B2 (en) 2003-08-22 2012-08-07 University of Pittsburgh—of the Commonwealth System of Higher Education Benzothiazole derivative compounds, compositions and uses
AU2005207835A1 (en) 2004-01-16 2005-08-11 Wyeth Heterocyclic sulfonamide inhibitors of beta amyloid production containing an azole
WO2005085185A1 (en) * 2004-03-03 2005-09-15 Smithkline Beecham Corporation Aniline derivatives as selective androgen receptor modulators
JP2008536868A (en) * 2005-04-15 2008-09-11 スミスクライン・ビーチャム・コーポレイション Cyanoarylamine
CN100999546B (en) * 2007-01-11 2010-08-11 清华大学 Polypeptide compound with aza-containing heterocyclic modification and its application
WO2012172449A1 (en) 2011-06-13 2012-12-20 Pfizer Inc. Lactams as beta secretase inhibitors
CN111777571B (en) * 2020-06-28 2023-07-11 武汉药明康德新药开发有限公司 Synthesis method of chiral 2-amino-3- (1, 3-benzothiazole-2-yl) propionic acid hydrochloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1078886C (en) * 1993-10-01 2002-02-06 默里尔药物公司 Inhibitors of beta-amyloid production
US5863902A (en) * 1995-01-06 1999-01-26 Sibia Neurosciences, Inc. Methods of treating neurodegenerative disorders using protease inhibitors

Also Published As

Publication number Publication date
CA2270876A1 (en) 1998-05-28
EP0942923A2 (en) 1999-09-22
NZ335157A (en) 2001-01-26
NO992426L (en) 1999-06-30
AU5354398A (en) 1998-06-10
JP2001519769A (en) 2001-10-23
HUP0001383A1 (en) 2001-05-28
IL129477A0 (en) 2000-02-29
HUP0001383A3 (en) 2001-11-28
WO1998022493A3 (en) 1998-07-23
NO992426D0 (en) 1999-05-20
TR199901132T2 (en) 1999-08-23
CN1237978A (en) 1999-12-08
BR9714358A (en) 2000-03-21
WO1998022493A2 (en) 1998-05-28

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