NO992998L - New analogues of camptotecin, use as drugs and pharmaceutical compositions containing them - Google Patents

New analogues of camptotecin, use as drugs and pharmaceutical compositions containing them

Info

Publication number
NO992998L
NO992998L NO992998A NO992998A NO992998L NO 992998 L NO992998 L NO 992998L NO 992998 A NO992998 A NO 992998A NO 992998 A NO992998 A NO 992998A NO 992998 L NO992998 L NO 992998L
Authority
NO
Norway
Prior art keywords
camptotecin
drugs
pharmaceutical compositions
compositions containing
new analogues
Prior art date
Application number
NO992998A
Other languages
Norwegian (no)
Other versions
NO326464B1 (en
NO992998D0 (en
Inventor
Dennis Bigg
Olivier Lavergne
Francesc Pla Rodas
Jacques Pommier
Gerard Ulibarri
Original Assignee
Sod Conseils Rech Applic
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sod Conseils Rech Applic filed Critical Sod Conseils Rech Applic
Publication of NO992998D0 publication Critical patent/NO992998D0/en
Publication of NO992998L publication Critical patent/NO992998L/en
Publication of NO326464B1 publication Critical patent/NO326464B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/61—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/64—One oxygen atom attached in position 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
NO19992998A 1996-12-20 1999-06-18 Analogues of camptotecin, its use, and drug NO326464B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9615774A FR2757514B1 (en) 1996-12-20 1996-12-20 NOVEL CAMPTOTHECIN ANALOGS, PREPARATION METHODS, USE THEREOF AS MEDICAMENTS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
PCT/FR1997/002218 WO1998028305A1 (en) 1996-12-20 1997-12-05 Novel counterparts of camptothecin, their application as medicine and pharmaceutical compositions containing them

Publications (3)

Publication Number Publication Date
NO992998D0 NO992998D0 (en) 1999-06-18
NO992998L true NO992998L (en) 1999-08-18
NO326464B1 NO326464B1 (en) 2008-12-08

Family

ID=9498938

Family Applications (1)

Application Number Title Priority Date Filing Date
NO19992998A NO326464B1 (en) 1996-12-20 1999-06-18 Analogues of camptotecin, its use, and drug

Country Status (26)

Country Link
EP (1) EP0946567B1 (en)
JP (2) JP3576175B2 (en)
KR (1) KR100516874B1 (en)
CN (1) CN1097056C (en)
AR (1) AR008543A1 (en)
AT (1) ATE248177T1 (en)
AU (1) AU734485B2 (en)
BR (1) BR9714170A (en)
CA (1) CA2275351C (en)
CZ (1) CZ299795B6 (en)
DE (1) DE69724453T2 (en)
DK (1) DK0946567T3 (en)
ES (1) ES2206761T3 (en)
FR (1) FR2757514B1 (en)
HK (1) HK1024695A1 (en)
HU (1) HUP9904210A3 (en)
MX (1) MXPA99005776A (en)
MY (1) MY119473A (en)
NO (1) NO326464B1 (en)
NZ (1) NZ335939A (en)
PL (1) PL188181B1 (en)
PT (1) PT946567E (en)
RU (1) RU2194051C2 (en)
UA (1) UA57758C2 (en)
WO (1) WO1998028305A1 (en)
ZA (1) ZA9711129B (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2790261B1 (en) * 1999-02-26 2004-09-10 Sod Conseils Rech Applic NOVEL OPTICALLY PURE CAMPTOTHECIN ANALOGS AND PROCESSES FOR THEIR PREPARATION
US6291676B1 (en) * 1999-03-03 2001-09-18 University Of Kentucky Research Foundation Water-soluble derivatives of camptothecin/homocamptothecin
US6207832B1 (en) 1999-04-09 2001-03-27 University Of Pittsburgh Camptothecin analogs and methods of preparation thereof
WO2000073273A1 (en) * 1999-05-28 2000-12-07 Nippon Chemiphar Co., Ltd. Process for the preparation of 2-halo-3-(3-quinolyl)propionic acid derivatives
US6372906B1 (en) 2001-04-12 2002-04-16 University Of Pittsburgh Synthesis of silyl camptothecins and silyl homocamptothecins
US6723853B2 (en) 2001-08-27 2004-04-20 University Of Pittsburgh Intermediates and methods of preparation of intermediates in the enantiomeric synthesis of (20R)homocamptothecins and the enantiomeric synthesis of (20R)homocamptothecins
AU2003225642A1 (en) * 2002-03-01 2003-09-16 Fluorous Techonologies Inc Mappicine analogs, intermediates in the synthesis of mappicine analogs and methods of synthesis of mappicine analogs
ITRM20040288A1 (en) * 2004-06-11 2004-09-11 Sigma Tau Ind Farmaceuti USE OF 7-T-BUTOXYIMINOMETHYL CAMPTOTECIN FOR THE PREPARATION OF A MEDICATION FOR THE TREATMENT OF UTERUS NEOPLASIES.
WO2006033011A1 (en) * 2004-09-21 2006-03-30 Societe De Conseils De Recherches Et D'applications Scientifique (S.C.R.A.S.) Novel processes for the production of useful intermediates
CN102746314B (en) * 2011-04-18 2016-07-06 华东师范大学 Containing stablizing the camptothecine compounds of 7 yuan of lactonic rings, preparation method and purposes
CN117164601A (en) * 2022-06-02 2023-12-05 华东师范大学 High-camptothecin small molecule and application thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5391745A (en) * 1992-07-23 1995-02-21 Sloan-Kettering Institute For Cancer Research Methods of preparation of camptothecin analogs
DK0835258T3 (en) * 1995-06-21 2003-02-03 Sod Conseils Rech Applic New Camptothecin Analogs, Methods of Preparation thereof, Their Use as Medicines and Pharmaceutical Preparations Containing These

Also Published As

Publication number Publication date
JP2001505922A (en) 2001-05-08
JP2004115535A (en) 2004-04-15
ES2206761T3 (en) 2004-05-16
HUP9904210A3 (en) 2000-09-28
AR008543A1 (en) 2000-01-19
PL334125A1 (en) 2000-02-14
ATE248177T1 (en) 2003-09-15
UA57758C2 (en) 2003-07-15
EP0946567A1 (en) 1999-10-06
KR100516874B1 (en) 2005-09-26
CZ299795B6 (en) 2008-11-26
NO326464B1 (en) 2008-12-08
PL188181B1 (en) 2004-12-31
DE69724453T2 (en) 2004-06-09
EP0946567B1 (en) 2003-08-27
ZA9711129B (en) 1999-05-03
MY119473A (en) 2005-05-31
MXPA99005776A (en) 2004-08-31
AU734485B2 (en) 2001-06-14
CA2275351A1 (en) 1998-07-02
HUP9904210A2 (en) 2000-05-28
RU2194051C2 (en) 2002-12-10
NZ335939A (en) 2000-04-28
CZ220599A3 (en) 1999-09-15
DE69724453D1 (en) 2003-10-02
PT946567E (en) 2004-01-30
WO1998028305A1 (en) 1998-07-02
KR20000069608A (en) 2000-11-25
AU5326598A (en) 1998-07-17
HK1024695A1 (en) 2000-10-20
FR2757514A1 (en) 1998-06-26
JP3576175B2 (en) 2004-10-13
NO992998D0 (en) 1999-06-18
FR2757514B1 (en) 1999-02-12
CN1241191A (en) 2000-01-12
CA2275351C (en) 2008-10-14
DK0946567T3 (en) 2003-12-22
BR9714170A (en) 2000-02-29
CN1097056C (en) 2002-12-25

Similar Documents

Publication Publication Date Title
NO20004353L (en) New pyridazine derivatives and drugs containing these as active ingredients
FI973279A (en) Novel farnesyltransferase inhibitors, their preparation and pharmaceutical compositions containing them
IS5409A (en) Replacement of carboxamidothiazole, their preparation and pharmaceutical preparations containing them
NO996433L (en) New formulations of drugs, methods of preparation thereof and methods of use thereof
FI973039A0 (en) New farnecyltransferase inhibitors, their preparation, and these containing pharmaceutical compositions
NO307783B1 (en) Quinoline derivatives such as tachykinin NK3 receptor antagonists, pharmaceutical preparations containing them and use of such derivatives
EE03879B1 (en) LH-RH peptide analogs, their use and pharmaceutical compositions containing them
NO973922L (en) New taxoids, their preparation and pharmaceutical compositions containing the compounds
NO955034L (en) New substituted 1H-imidazoles and pharmaceutical compositions containing them
HUP9900413A3 (en) Use of coralyne derivatives, new coralyne derivatives and use thereof, pharmaceutical compositions containing these new coralyne derivatives
NO308294B1 (en) Dimethyl-3 (aryl-but-3-enyl) -amine compound as pharmaceutical compounds and their use
NO984878D0 (en) Preparation and Use as Medicines of 3-Alkoxypyridine-2-Carboxylic Acid Amesters
NO994620D0 (en) New 2- (iminomethyl) amino-phenyl derivatives, preparation, use as medicines and pharmaceutical compositions containing them
DK1006110T3 (en) Derivatives of acylpiperazinylpyrimidines, their preparation and use as pharmaceuticals
NO976128L (en) Compounds and pharmaceutical compositions containing them
NO305903B1 (en) Benzonitriles and benzofluorides, drugs comprising the compounds, pharmaceutical compositions containing the compounds, and use of the compounds for the preparation of pharmaceutical preparations
ID22523A (en) AEROSOL FORMULATION OF DRUGS CONTAINING BUDESONIDES
NO20010031D0 (en) Derivatives of 2-aminopyridines, their use as drugs and pharmaceutical preparations containing them
NO992997L (en) Promotional forms and new analogues of camptotecin, as well as their use as drugs
NO992998L (en) New analogues of camptotecin, use as drugs and pharmaceutical compositions containing them
NO302368B1 (en) Quinoxaline compounds, pharmaceutical compositions containing them, and use of the compounds for the preparation of the preparations
NO308842B1 (en) New retinoids, their use, and pharmaceutical compositions containing them
NO994908D0 (en) New 4-halogenated steroids, method of preparation and intermediates, use as medicine, and pharmaceutical compositions containing these
NO992298D0 (en) Conformationally limited LH-RH analogs, their use and pharmaceutical compositions containing these
NO991481D0 (en) New heteroaryloxyethylamines, process for preparation, use as medicine and pharmaceutical compositions containing these

Legal Events

Date Code Title Description
MM1K Lapsed by not paying the annual fees