PA8789601A1 - Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas - Google Patents
Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicasInfo
- Publication number
- PA8789601A1 PA8789601A1 PA20088789601A PA8789601A PA8789601A1 PA 8789601 A1 PA8789601 A1 PA 8789601A1 PA 20088789601 A PA20088789601 A PA 20088789601A PA 8789601 A PA8789601 A PA 8789601A PA 8789601 A1 PA8789601 A1 PA 8789601A1
- Authority
- PA
- Panama
- Prior art keywords
- sulfonamids
- phenyl
- preparation
- heterocyclic
- trifluoralquil
- Prior art date
Links
- -1 SULFONAMIDE COMPOUNDS Chemical class 0.000 abstract 4
- 229940124530 sulfonamide Drugs 0.000 abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
- C07D263/26—Oxygen atoms attached in position 2 with hetero atoms or acyl radicals directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
Abstract
SE DESCRIBE UN NUEVO AGENTE DE TRIFLUORACETILACIÓN, ES DECIR, N-TRIFLUORACETILMORFOLINA. ESTE REACTIVO ES ÚTIL EN LA PREPARACIÓN DE COMPUESTOS DE FENIL SULFONAMIDA Y DE SULFONAMIDA HETEROCÍCLICA. POR CONSIGUIENTE SE DESCRIBEN MÉTODOS PARA PREPARAR COMPUESTOS DE SULFONAMIDA DE LA SIGUIENTE ESTRUCTURA, EN DONDE R1 Y R2 SE DEFINEN EN LA PRESENTE, UTILIZANDO N-TRIFLUORACETILMORFOLINA. LOS COMPUESTOS DE SULFONAMIDA QUE SE PUEDEN PREPARAR SEGÚN SE DESCRIBE EN LA PRESENTE INCLUYEN [(1S,2R)-2-(3,5-DIFLUOR-FENIL)-3,3,3-TRIFLUOR-1-HIDROXIMETIL-PROPIL]-AMIDA DE ÁCIDO 5-CLORO-TIOFEN-2-SULFÓNICO UTILIZANDO N-TRIFLUORACETILMORFOLINA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95965907P | 2007-07-16 | 2007-07-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
PA8789601A1 true PA8789601A1 (es) | 2009-02-09 |
Family
ID=40260327
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PA20088789601A PA8789601A1 (es) | 2007-07-16 | 2008-07-14 | Proceso para la preparación de trifluoralquil-fenil sulfonamidas y de sulfonamidas heterocíclicas |
Country Status (7)
Country | Link |
---|---|
US (1) | US20090023903A1 (es) |
AR (1) | AR067534A1 (es) |
CL (1) | CL2008002058A1 (es) |
PA (1) | PA8789601A1 (es) |
PE (1) | PE20090824A1 (es) |
TW (1) | TW200911778A (es) |
WO (1) | WO2009012201A2 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR20060002908A (ko) * | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
US9223217B2 (en) | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing topcoat and photoresist additive compositions and methods of use |
US9223209B2 (en) * | 2010-02-19 | 2015-12-29 | International Business Machines Corporation | Sulfonamide-containing photoresist compositions and methods of use |
CN102964233A (zh) * | 2012-11-18 | 2013-03-13 | 大连九信生物化工科技有限公司 | 一种3,5-二氟三氟甲基苯酮的合成方法 |
CN103214413B (zh) * | 2013-03-22 | 2015-05-13 | 郑州泰基鸿诺药物科技有限公司 | 一种含杂环的三氟甲基酮化合物及其制备方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2703802A (en) * | 1953-08-20 | 1955-03-08 | Dow Chemical Co | 4-(trifluoroacetyl) morpholine |
US5461162A (en) * | 1994-07-27 | 1995-10-24 | Merck & Co., Inc. | Process of synthesizing n-acyl auxiliaries |
US5594134A (en) * | 1995-03-31 | 1997-01-14 | Merck & Co., Inc. | Process of synthesizing N-acyl auxiliaries |
CN1263750C (zh) * | 2000-12-13 | 2006-07-12 | 惠氏 | β淀粉样蛋白产生的杂环磺酰胺类抑制剂 |
BR0311767A (pt) * | 2002-06-11 | 2005-03-08 | Wyeth Corp | Compostos inibidores de sulfonamida substituìda da produção de beta amilóide, suas composições e usos |
KR20060002908A (ko) * | 2003-03-31 | 2006-01-09 | 와이어쓰 | 베타 아밀로이드 생산 억제제인 플루오로- 및트리플루오로알킬-함유 헤테로사이클릭 설폰아미드 및 이의유도체 |
CN1910158A (zh) * | 2004-01-16 | 2007-02-07 | 惠氏公司 | 含有氮杂环的β淀粉样蛋白生成的杂环磺酰胺抑制剂 |
CA2641013A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Methods for preparing sulfonamide substituted alcohols and intermediates thereof |
AU2007217966A1 (en) * | 2006-02-17 | 2007-08-30 | Wyeth | Selective N-sulfonylation of 2-amino trifluoroalkyl substituted alcohols |
US7550629B2 (en) * | 2006-04-21 | 2009-06-23 | Wyeth | Trifluoromethyl-containing phenylsulfonamide beta amyloid inhibitors |
US7476762B2 (en) * | 2006-04-21 | 2009-01-13 | Wyeth | Methods for preparing sulfonamide compounds |
-
2008
- 2008-07-14 US US12/172,486 patent/US20090023903A1/en not_active Abandoned
- 2008-07-14 PE PE2008001177A patent/PE20090824A1/es not_active Application Discontinuation
- 2008-07-14 CL CL2008002058A patent/CL2008002058A1/es unknown
- 2008-07-14 PA PA20088789601A patent/PA8789601A1/es unknown
- 2008-07-14 TW TW097126639A patent/TW200911778A/zh unknown
- 2008-07-14 AR ARP080103020A patent/AR067534A1/es unknown
- 2008-07-14 WO PCT/US2008/069934 patent/WO2009012201A2/en active Application Filing
Also Published As
Publication number | Publication date |
---|---|
AR067534A1 (es) | 2009-10-14 |
WO2009012201A2 (en) | 2009-01-22 |
CL2008002058A1 (es) | 2008-11-14 |
PE20090824A1 (es) | 2009-07-24 |
TW200911778A (en) | 2009-03-16 |
US20090023903A1 (en) | 2009-01-22 |
WO2009012201A3 (en) | 2009-07-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0911681B8 (pt) | composto, composição farmacêutica, e, método para ativar a via de proteína quinase ativada por 5'-amp em uma célula in vitro | |
HN2010001059A (es) | Nuevo titulo modificado: compuestos derivados de pirimidina, un proceso para la preparacion de los mismos, una composicion farmaceutica que los comprenden y combinaciones de dichos compuestos con otros agentes. | |
CL2012002319A1 (es) | Compuestos derivados de amino-tienopirimidinas que contienen un grupo alquilo sustituido, inhibidores de mnk| o mnk2; composición farmacéutica; y su uso para la profilaxis o la terapia de enfermedades metabólicas, trastornos hematopoyéticos, enfermedades neurodegenerativas, cáncer, entre otras. | |
ECSP109917A (es) | Nuevos derivados de ácido azabifenilaminobenzoico | |
BR112015022456A2 (pt) | síntese de líquidos iônicos de compostos derivados de lignina | |
GT200600112A (es) | Composiciiones de tigeciclina y metodos de preparacion | |
UY31806A (es) | Compuestos de tiazole y oxazole de sulfonamida de benceno | |
SV2010003673A (es) | Compuestos heterociclicos novedosos y usos de los mismos | |
CL2010001348A1 (es) | Compuestos derivados de 1-oxo-2,3-dihidro-1h-isoindolin-5-il)-isoxazol-3-carboxamida, potenciadores de los mglur2; composicion farmaceutica; y su uso para aliviar los sintomas o disminuir la aparicion de los sintomas de ezquizofrenia o ansiedad. | |
CL2008003910A1 (es) | Formulacion liquida, estable, conteniendo anticuerpo que comprende arginina y metionina; procedimiento para inhibir la deamidacion de moleculas de un anticuerpo que comprende agregar arginina a la formulacion liquida. | |
CL2008002076A1 (es) | Compuestos derivados de ariloxazoles sustituidos; procedimiento de preparacion de dichos compuestos; composicion farmaceutica que los comprende; y su uso para tratar diabetes, sindrome metabolico, dislipidemias, entre otras enfermedades. | |
BR112013023876A2 (pt) | derivados de pirroltriazinona como inibidores de pi3k | |
BRPI0820171B8 (pt) | compostos de carboxamida, sulfonamida e amina para distúrbios metabólicos, composição farmacêutica, e, uso dos mesmos | |
MX352627B (es) | Agentes estabilizantes de emulsion para fluidos de perforacion y terminacion. | |
CL2007001759A1 (es) | Compuesto metformina r-(+) lipoato; mezcla que comprende metformina y acido r-(+) lipoico; composicion farmaceutica que comprende el compuesto; metodo para preparar el compuesto; kit; y uso para tratar la diabetes. | |
UY32239A (es) | Nuevos derivados de (3-oxo)piridazin-4-ilurea | |
AR068369A1 (es) | Sal de xinafoato de n4-[(2,2-difluor-4h-benzo[1,4]oxazin-3-on)-6-il]-5-fluor-n2-[3-(metilaminocarbonilmetilenoxi)-fenil]2,4-pirimidindiamina" | |
UY30472A1 (es) | Nuevos derivados de pirimidina, procesos para su preparacion composiciones farmacéuticas conteniédolos, procesos para su preparacion y aplicaciones. | |
BR112012022775A2 (pt) | composições para a lavagem, do cólon e métodos para a produção e utilização das mesmas | |
CL2008001951A1 (es) | Compuestos derivados de imidazo[1,2-a]pirimidin-2-ilmetil sustituidos; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el trastorno del sueno, depresion, ansiedad, trastorno relacionado con el abuso de sustancias, entre otras. | |
BR112013025777A2 (pt) | imidazopiridazinas como inibidores da quinase akt | |
ECSP099296A (es) | Inmuno-reguladores, preparaciones y composiciones que incluyen los inmuno-reguladores, pruebas para evaluar la actividad de los inmuno-reguladores y preparaciones y composiciones que incluyen los mismos y métodos | |
CL2007002971A1 (es) | Compuestos derivados de aminometil-4-imidazol; procedimiento de preparacion; composicion farmaceutica que los contiene; y su uso para tratar depresion, ansiedad, trastorno bipolar, entre otras. | |
CL2007001784A1 (es) | Compuestos derivados de benzoxazol de formula la, su composicion farmaceutica, metodo para medir in vivo depositos de amoloide empleando dicha composicion, y uso del compuesto la para preparar un medicamento, y compuesto de formula ib, y su uso como precursor en la preparacion de un compuesto marcado. | |
UY31502A1 (es) | Proceso mejorado para sintetizar 5-cyclopentyl-5-11-dihydro-10-oxa-1-aza-dibenzo[a,d]cyclohepten-5-ol usando tmeda |