ATE496029T1 - Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren - Google Patents
Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitorenInfo
- Publication number
- ATE496029T1 ATE496029T1 AT07785908T AT07785908T ATE496029T1 AT E496029 T1 ATE496029 T1 AT E496029T1 AT 07785908 T AT07785908 T AT 07785908T AT 07785908 T AT07785908 T AT 07785908T AT E496029 T1 ATE496029 T1 AT E496029T1
- Authority
- AT
- Austria
- Prior art keywords
- pyridinylalkylene
- alcohols
- phenyl
- derivatives
- phosphodiesterase inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/61—Halogen atoms or nitro radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06014672 | 2006-07-14 | ||
PCT/EP2007/005982 WO2008006509A1 (en) | 2006-07-14 | 2007-07-06 | Derivatives of 1-phenyl-2-pyridynyl alkylene alcohols as phosphodiesterase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE496029T1 true ATE496029T1 (de) | 2011-02-15 |
Family
ID=38691860
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT07785908T ATE496029T1 (de) | 2006-07-14 | 2007-07-06 | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
Country Status (10)
Country | Link |
---|---|
US (1) | US7671066B2 (de) |
EP (1) | EP2044023B1 (de) |
CN (1) | CN101490004B (de) |
AR (1) | AR062074A1 (de) |
AT (1) | ATE496029T1 (de) |
DE (1) | DE602007012105D1 (de) |
HK (1) | HK1135383A1 (de) |
PE (1) | PE20080552A1 (de) |
TW (1) | TW200813010A (de) |
WO (1) | WO2008006509A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2022783A1 (de) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | 1-Phenyl-2-Pyridinylalkyl-Alkoholderivate als Phosphodiesterasehemmer |
EP2070913A1 (de) * | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester-Derivate als Phosphodiesterase-Hemmer |
EP2110375A1 (de) | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4-Hemmer der Tertiäraminklasse |
EP2216327A1 (de) * | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | (1-Phenyl-2-Pyridin-4-yl)ethyl-benzoate als Phosphodiesterasehemmer |
BR112012018358A2 (pt) | 2009-12-21 | 2016-08-09 | Bayer Cropscience Ag | tienilpiri(mi)dinilazol e seu uso para controlar fungos fitopatogênicos |
WO2011131663A1 (en) | 2010-04-21 | 2011-10-27 | Chiesi Farmaceutici S.P.A. | "process for providing particles with reduced electrostatic charges" |
EP2600829B1 (de) | 2010-08-03 | 2017-06-14 | Chiesi Farmaceutici S.p.A. | Pharmazeutische formulierung mit einem phosphodiesterasehemmer |
CN102060762B (zh) * | 2011-01-28 | 2013-05-29 | 海南美大制药有限公司 | 孟鲁司特化合物及其新制法 |
CN102617457A (zh) * | 2011-01-28 | 2012-08-01 | 天津药物研究院 | 一种制备罗氟司特的新方法 |
US20130005716A1 (en) * | 2011-06-06 | 2013-01-03 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
JP5759305B2 (ja) * | 2011-08-19 | 2015-08-05 | キヤノン株式会社 | アクセス管理システム、アクセス管理方法、アクセス管理サーバ、連携サーバ、およびプログラム |
CN103827088B (zh) * | 2011-09-26 | 2017-10-13 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物 |
KR20140078719A (ko) * | 2011-10-21 | 2014-06-25 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
CN102603623A (zh) * | 2011-12-26 | 2012-07-25 | 北京赛林泰医药技术有限公司 | 制备高纯度罗氟司特的方法 |
CN102417449A (zh) * | 2012-01-09 | 2012-04-18 | 四川蜀中制药有限公司 | 一种3-环丙基甲氧基-4-二氟甲氧基苯甲酸的制备方法 |
WO2013131255A1 (en) | 2012-03-07 | 2013-09-12 | Scinopharm (Changshu) Pharmaceutical, Ltd. | Preparation method of roflumilast |
EP2855450B1 (de) | 2012-06-04 | 2016-07-06 | Chiesi Farmaceutici S.p.A. | 1-phenyl-2-pyridinylalkyl-alkoholderivate als phosphodiesterasehemmer |
EP2928883B1 (de) * | 2012-12-05 | 2018-02-14 | Chiesi Farmaceutici S.p.A. | Phenylethylpyridin derivate als pde4-inhibitoren und muscarin rezeptor antagonisten |
CN104822659A (zh) * | 2012-12-05 | 2015-08-05 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1-苯基-2-吡啶基烷基醇衍生物 |
US10366264B2 (en) * | 2013-08-09 | 2019-07-30 | Korea Advanced Institute Of Science And Technology | System and method for transferring content among devices |
US9427376B2 (en) | 2013-10-10 | 2016-08-30 | Chiesi Farmaceutici S.P.A. | Process for preparing pharmaceutical formulations for inhalation comprising a high-dosage strength active ingredient |
EP3587400B1 (de) * | 2013-10-22 | 2024-03-20 | Chiesi Farmaceutici S.p.A. | Verfahren zur herstellung eines pde4-inhibitors |
CN103992220B (zh) * | 2014-06-05 | 2015-11-18 | 山东省医学科学院药物研究所 | 一种罗氟司特中间体的制备方法 |
TW201613934A (en) * | 2014-06-23 | 2016-04-16 | Leo Pharma As | Methods for the preparation of 1,3-benzodioxole heterocyclic compounds |
CN104447244B (zh) * | 2014-10-29 | 2017-06-06 | 成都森科制药有限公司 | 罗氟司特中间体及罗氟司特的制备方法 |
CN104447245B (zh) * | 2014-10-29 | 2017-06-06 | 成都森科制药有限公司 | 罗氟司特中间体、中间体制备方法及罗氟司特的制备方法 |
CN105254559B (zh) * | 2015-11-30 | 2017-07-11 | 山东罗欣药业集团股份有限公司 | 一种高纯度罗氟司特的制备方法 |
JP6934872B2 (ja) | 2015-12-18 | 2021-09-15 | レオ ファーマ アクティーゼルスカブ | 1,3−ベンゾジオキソール複素環化合物の製造方法 |
EP3732164A1 (de) | 2017-12-28 | 2020-11-04 | Chiesi Farmaceutici S.p.A. | Verwendung von 1-phenyl-2-pyridinyl-alkylalkohol-derivaten zur behandlung von zystischer fibrose |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HUT72656A (en) * | 1992-07-28 | 1996-05-28 | Rhone Poulenc Rorer Ltd | Inhibitors of c-amp phosphodiesterase and tnf, their preparation pharmaceuticals contg. them and their use |
US5786354A (en) * | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
-
2007
- 2007-07-06 EP EP07785908A patent/EP2044023B1/de active Active
- 2007-07-06 AT AT07785908T patent/ATE496029T1/de not_active IP Right Cessation
- 2007-07-06 WO PCT/EP2007/005982 patent/WO2008006509A1/en active Application Filing
- 2007-07-06 DE DE602007012105T patent/DE602007012105D1/de active Active
- 2007-07-06 CN CN2007800262568A patent/CN101490004B/zh active Active
- 2007-07-12 TW TW096125354A patent/TW200813010A/zh unknown
- 2007-07-12 US US11/827,673 patent/US7671066B2/en active Active
- 2007-07-12 PE PE2007000895A patent/PE20080552A1/es not_active Application Discontinuation
- 2007-07-13 AR ARP070103145A patent/AR062074A1/es unknown
-
2009
- 2009-12-24 HK HK09112145.0A patent/HK1135383A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN101490004A (zh) | 2009-07-22 |
AR062074A1 (es) | 2008-10-15 |
CN101490004B (zh) | 2012-01-11 |
DE602007012105D1 (de) | 2011-03-03 |
TW200813010A (en) | 2008-03-16 |
EP2044023A1 (de) | 2009-04-08 |
WO2008006509A1 (en) | 2008-01-17 |
PE20080552A1 (es) | 2008-06-24 |
US20080015226A1 (en) | 2008-01-17 |
HK1135383A1 (en) | 2010-06-04 |
US7671066B2 (en) | 2010-03-02 |
EP2044023B1 (de) | 2011-01-19 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |