CL2007001482A1 - Compuestos derivados de pirrolidin-2-amida sustituidas, inhibidores de proteasa activadora de canal; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como disquinesia ciliar primaria, carcinoma pulmonar, bronquitis cronica, e - Google Patents

Compuestos derivados de pirrolidin-2-amida sustituidas, inhibidores de proteasa activadora de canal; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como disquinesia ciliar primaria, carcinoma pulmonar, bronquitis cronica, e

Info

Publication number
CL2007001482A1
CL2007001482A1 CL200701482A CL2007001482A CL2007001482A1 CL 2007001482 A1 CL2007001482 A1 CL 2007001482A1 CL 200701482 A CL200701482 A CL 200701482A CL 2007001482 A CL2007001482 A CL 2007001482A CL 2007001482 A1 CL2007001482 A1 CL 2007001482A1
Authority
CL
Chile
Prior art keywords
activadora
ciliar
proteasa
pirrolidin
amida
Prior art date
Application number
CL200701482A
Other languages
English (en)
Inventor
David C Chatterjee Arnab Tully
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Publication of CL2007001482A1 publication Critical patent/CL2007001482A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
CL200701482A 2006-05-23 2007-05-23 Compuestos derivados de pirrolidin-2-amida sustituidas, inhibidores de proteasa activadora de canal; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como disquinesia ciliar primaria, carcinoma pulmonar, bronquitis cronica, e CL2007001482A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80801406P 2006-05-23 2006-05-23
US86062206P 2006-11-22 2006-11-22

Publications (1)

Publication Number Publication Date
CL2007001482A1 true CL2007001482A1 (es) 2008-05-09

Family

ID=38521007

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200701482A CL2007001482A1 (es) 2006-05-23 2007-05-23 Compuestos derivados de pirrolidin-2-amida sustituidas, inhibidores de proteasa activadora de canal; composicion farmaceutica; y uso para el tratamiento de enfermedades tales como disquinesia ciliar primaria, carcinoma pulmonar, bronquitis cronica, e

Country Status (18)

Country Link
US (2) US7939547B2 (es)
EP (1) EP2019837B1 (es)
JP (1) JP5270538B2 (es)
KR (1) KR101069089B1 (es)
CN (1) CN101443348A (es)
AR (1) AR061110A1 (es)
AT (1) ATE502951T1 (es)
AU (1) AU2007267733B9 (es)
CA (1) CA2651043A1 (es)
CL (1) CL2007001482A1 (es)
DE (1) DE602007013387D1 (es)
MX (1) MX2008014838A (es)
PE (1) PE20080101A1 (es)
PL (1) PL2019837T3 (es)
PT (1) PT2019837E (es)
RU (1) RU2419625C2 (es)
TW (1) TW200808748A (es)
WO (1) WO2007140117A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
WO2007137080A2 (en) * 2006-05-23 2007-11-29 Irm Llc Compounds and compositions as channel activating protease inhibitors
JP2010518099A (ja) * 2007-02-09 2010-05-27 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤としての化合物および組成物
BRPI0806970A2 (pt) * 2007-02-09 2014-04-08 Irm Llc Compostos e composições como inibidores de protease de ativação de canal
WO2009143493A2 (en) * 2008-05-22 2009-11-26 Attagene Inc. MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
MX339433B (es) * 2011-07-26 2016-05-26 Sanofi Sa Derivados de acido 3 - tiazoloamino - propionico sustituidos y su uso como sustancias farmaceuticas.
MX2014006211A (es) * 2011-11-25 2014-08-08 Hoffmann La Roche Nuevos derivados de pirrolidina como inhibidores de catepsina.
WO2013109991A1 (en) * 2012-01-20 2013-07-25 Acucela Inc. Substituted heterocyclic compounds for disease treatment
WO2014031784A1 (en) * 2012-08-23 2014-02-27 Alios Biopharma, Inc. Compounds for the treatment of paramoxyvirus viral infections
KR101890134B1 (ko) 2013-07-08 2018-08-23 우리윈시스템 주식회사 Cctv 감시장치 비트맵에 의한 이미지 데이터 처리 움직임 분석 제어 방법
DK3422845T3 (da) * 2016-02-29 2021-08-30 Regeneron Pharma Gnavere med et humaniseret tmprss-gen
KR20220079527A (ko) 2019-09-17 2022-06-13 메레오 바이오파마 4 리미티드 이식편 거부반응, 폐쇄성 세기관지염 증후군 및 이식편 대 숙주병의 치료에 사용하기 위한 알베레스타트
IL297211A (en) 2020-04-16 2022-12-01 Mereo Biopharma 4 Ltd Methods involving the neutrophil elastase inhibitor albalstat for the treatment of respiratory disease mediated by alpha-1 antitrypsin deficiency
AU2022373971A1 (en) 2021-10-20 2024-04-04 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis
WO2024094827A1 (en) * 2022-11-02 2024-05-10 Philochem Ag Carbonic anhydrase ix ligands for targeted delivery applications

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US6211154B1 (en) * 1995-06-07 2001-04-03 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
TW523513B (en) * 1996-03-01 2003-03-11 Akzo Nobel Nv Serine protease inhibitors
IL121474A0 (en) 1996-08-23 1998-02-08 Akzo Nobel Nv Thrombin inhibitors
US6323219B1 (en) * 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
CA2361479A1 (en) * 1999-01-27 2000-08-03 Ortho-Mcneil Pharmaceutical, Inc. Peptidyl heterocyclic ketones useful as tryptase inhibitors
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6797504B1 (en) * 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
PL206255B1 (pl) * 2000-07-21 2010-07-30 Dendreon Corporationdendreon Corporation Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii
JP2002138048A (ja) * 2000-08-25 2002-05-14 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
JP2005060379A (ja) * 2003-07-31 2005-03-10 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
US7205384B2 (en) 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
US20050222383A1 (en) 2004-02-05 2005-10-06 Irm Llc Prostasin substrates and inhibitors
WO2007137080A2 (en) * 2006-05-23 2007-11-29 Irm Llc Compounds and compositions as channel activating protease inhibitors

Also Published As

Publication number Publication date
ATE502951T1 (de) 2011-04-15
WO2007140117A1 (en) 2007-12-06
TW200808748A (en) 2008-02-16
DE602007013387D1 (de) 2011-05-05
CN101443348A (zh) 2009-05-27
AU2007267733A1 (en) 2007-12-06
PT2019837E (pt) 2011-07-05
PL2019837T3 (pl) 2011-09-30
US20110177055A1 (en) 2011-07-21
KR20090016725A (ko) 2009-02-17
AU2007267733B2 (en) 2011-03-17
KR101069089B1 (ko) 2011-09-30
AR061110A1 (es) 2008-08-06
PE20080101A1 (es) 2008-04-01
US7939547B2 (en) 2011-05-10
MX2008014838A (es) 2008-12-05
RU2008150613A (ru) 2010-06-27
EP2019837B1 (en) 2011-03-23
AU2007267733B9 (en) 2011-04-21
RU2419625C2 (ru) 2011-05-27
JP2009538326A (ja) 2009-11-05
CA2651043A1 (en) 2007-12-06
EP2019837A1 (en) 2009-02-04
JP5270538B2 (ja) 2013-08-21
US20070276002A1 (en) 2007-11-29

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