ATE502951T1 - Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer - Google Patents

Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer

Info

Publication number
ATE502951T1
ATE502951T1 AT07762204T AT07762204T ATE502951T1 AT E502951 T1 ATE502951 T1 AT E502951T1 AT 07762204 T AT07762204 T AT 07762204T AT 07762204 T AT07762204 T AT 07762204T AT E502951 T1 ATE502951 T1 AT E502951T1
Authority
AT
Austria
Prior art keywords
compositions
compounds
channel
protease inhibitors
activate protease
Prior art date
Application number
AT07762204T
Other languages
English (en)
Inventor
David Tully
Arnab Chatterjee
Hank Petrassi
Badry Bursulaya
Glen Spraggon
Original Assignee
Irm Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Irm Llc filed Critical Irm Llc
Application granted granted Critical
Publication of ATE502951T1 publication Critical patent/ATE502951T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT07762204T 2006-05-23 2007-05-15 Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer ATE502951T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US80801406P 2006-05-23 2006-05-23
US86062206P 2006-11-22 2006-11-22
PCT/US2007/068987 WO2007140117A1 (en) 2006-05-23 2007-05-15 Compounds and compositions as channel activating protease inhibitors

Publications (1)

Publication Number Publication Date
ATE502951T1 true ATE502951T1 (de) 2011-04-15

Family

ID=38521007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07762204T ATE502951T1 (de) 2006-05-23 2007-05-15 Verbindungen und zusammensetzungen als kanalaktivierende protease-hemmer

Country Status (18)

Country Link
US (2) US7939547B2 (de)
EP (1) EP2019837B1 (de)
JP (1) JP5270538B2 (de)
KR (1) KR101069089B1 (de)
CN (1) CN101443348A (de)
AR (1) AR061110A1 (de)
AT (1) ATE502951T1 (de)
AU (1) AU2007267733B9 (de)
CA (1) CA2651043A1 (de)
CL (1) CL2007001482A1 (de)
DE (1) DE602007013387D1 (de)
MX (1) MX2008014838A (de)
PE (1) PE20080101A1 (de)
PL (1) PL2019837T3 (de)
PT (1) PT2019837E (de)
RU (1) RU2419625C2 (de)
TW (1) TW200808748A (de)
WO (1) WO2007140117A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0507577D0 (en) * 2005-04-14 2005-05-18 Novartis Ag Organic compounds
JP2009538327A (ja) 2006-05-23 2009-11-05 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤である化合物および組成物
BRPI0807483A2 (pt) * 2007-02-09 2014-05-13 Irm Llc Compostos e composições como inibidores de protease de ativação de canal
US20100239551A1 (en) * 2007-02-09 2010-09-23 Irm Llc Compounds and compositions as channel activating protease inhibitors
WO2009143493A2 (en) * 2008-05-22 2009-11-26 Attagene Inc. MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF
JP5585822B2 (ja) * 2010-05-11 2014-09-10 東レ・ファインケミカル株式会社 光学活性ニペコチン酸誘導体の製造方法
CN102153579B (zh) * 2011-02-23 2013-05-29 兰州米诺生物科技有限公司 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法
KR20140049020A (ko) * 2011-07-26 2014-04-24 사노피 치환된 ３-（티아졸-４-카보닐）- 또는 ３-（티아졸-２-카보닐）아미노프로피온산 유도체 및 이의 약제로서의 용도
KR20140102253A (ko) * 2011-11-25 2014-08-21 에프. 호프만-라 로슈 아게 카텝신의 억제제로서의 피롤리딘 유도체
US9447078B2 (en) 2012-01-20 2016-09-20 Acucela Inc. Substituted heterocyclic compounds for disease treatment
HK1211589A1 (zh) 2012-08-23 2016-05-27 Alios Biopharma, Inc. 用於治疗副粘病毒病毒性感染的化合物
KR101890134B1 (ko) 2013-07-08 2018-08-23 우리윈시스템 주식회사 Cctv 감시장치 비트맵에 의한 이미지 데이터 처리 움직임 분석 제어 방법
JP6980674B2 (ja) 2016-02-29 2021-12-15 リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. ヒト化ｔｍｐｒｓｓ遺伝子を有する齧歯類
BR112022004861A2 (pt) 2019-09-17 2022-06-07 Univ Duke Alvelestat para uso no tratamento de rejeição de transplante, síndrome de bronquiolite obliterante e doença de transplante versus hospedeiro
SI4106757T1 (sl) 2020-04-16 2023-11-30 Mereo Biopharma 4 Limited Postopki, ki vključujejo zaviralec nevtrofilne elastaze alvelestat, za zdravljenje bolezni dihal, ki jo sproži pomanjkanje antitripsina alfa-1
IL312002A (en) 2021-10-20 2024-06-01 Mereo Biopharma 4 Ltd Neutrophil elastase inhibitors for use in the treatment of fibrosis
WO2024094827A1 (en) * 2022-11-02 2024-05-10 Philochem Ag Carbonic anhydrase ix ligands for targeted delivery applications

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GB8809316D0 (en) * 1987-05-11 1988-05-25 Ici America Inc Heterocyclic ketones
US5296591A (en) * 1990-12-31 1994-03-22 Fujisawa Pharmaceutical Co., Ltd. Trifluoromethylketone derivatives, processes for preparation thereof and use thereof
US6211154B1 (en) * 1995-06-07 2001-04-03 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US6022861A (en) * 1995-06-07 2000-02-08 Cor Therapeutics, Inc. Ketoheterocyclic inhibitors of factor Xa
US5523308A (en) * 1995-06-07 1996-06-04 Costanzo; Michael J. Peptidyl heterocycles useful in the treatment of thrombin related disorders
IL120311A (en) * 1996-03-01 2001-10-31 Akzo Nobel Nv Serine protease inhibitors and pharmaceuticals containing them
IL121474A0 (en) * 1996-08-23 1998-02-08 Akzo Nobel Nv Thrombin inhibitors
US6323219B1 (en) * 1998-04-02 2001-11-27 Ortho-Mcneil Pharmaceutical, Inc. Methods for treating immunomediated inflammatory disorders
AU3208500A (en) * 1999-01-27 2000-08-18 Ortho-Mcneil Pharmaceutical, Inc. Peptidyl heterocyclic ketones useful as tryptase inhibitors
JP2000256396A (ja) * 1999-03-03 2000-09-19 Dainippon Pharmaceut Co Ltd 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤
US6797504B1 (en) * 2000-09-08 2004-09-28 Dendreon San Diego Llc Inhibitors of serine protease activity of matriptase or MTSP1
CZ303213B6 (cs) * 2000-07-21 2012-05-23 Schering Corporation Peptidové inhibitory serinové proteázy NS3 a farmaceutický prostredek
JP2002138048A (ja) * 2000-08-25 2002-05-14 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
JP2005060379A (ja) * 2003-07-31 2005-03-10 Dainippon Pharmaceut Co Ltd 複素環式化合物からなる医薬
US7205384B2 (en) 2003-08-05 2007-04-17 Ortho-Mcneil Pharmaceutical Inc. Process for preparing peptidyl heterocyclic ketone derivatives
WO2005076886A2 (en) 2004-02-05 2005-08-25 Irm Llc Prostasin substrates and inhibitors
JP2009538327A (ja) * 2006-05-23 2009-11-05 アイアールエム・リミテッド・ライアビリティ・カンパニー チャネル活性化プロテアーゼ阻害剤である化合物および組成物

Also Published As

Publication number Publication date
KR20090016725A (ko) 2009-02-17
US20070276002A1 (en) 2007-11-29
EP2019837A1 (de) 2009-02-04
CA2651043A1 (en) 2007-12-06
JP5270538B2 (ja) 2013-08-21
PL2019837T3 (pl) 2011-09-30
JP2009538326A (ja) 2009-11-05
DE602007013387D1 (de) 2011-05-05
AU2007267733A1 (en) 2007-12-06
WO2007140117A1 (en) 2007-12-06
US20110177055A1 (en) 2011-07-21
RU2419625C2 (ru) 2011-05-27
CN101443348A (zh) 2009-05-27
RU2008150613A (ru) 2010-06-27
AU2007267733B9 (en) 2011-04-21
EP2019837B1 (de) 2011-03-23
CL2007001482A1 (es) 2008-05-09
AR061110A1 (es) 2008-08-06
US7939547B2 (en) 2011-05-10
PE20080101A1 (es) 2008-04-01
TW200808748A (en) 2008-02-16
KR101069089B1 (ko) 2011-09-30
PT2019837E (pt) 2011-07-05
AU2007267733B2 (en) 2011-03-17
MX2008014838A (es) 2008-12-05

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