ATE434618T1 - Spirozyklische verbindungen als hdac-hemmer - Google Patents
Spirozyklische verbindungen als hdac-hemmerInfo
- Publication number
- ATE434618T1 ATE434618T1 AT06837965T AT06837965T ATE434618T1 AT E434618 T1 ATE434618 T1 AT E434618T1 AT 06837965 T AT06837965 T AT 06837965T AT 06837965 T AT06837965 T AT 06837965T AT E434618 T1 ATE434618 T1 AT E434618T1
- Authority
- AT
- Austria
- Prior art keywords
- hdac inhibitors
- spirocyclic compounds
- spirocyclic
- compounds
- hdac
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73932405P | 2005-11-23 | 2005-11-23 | |
PCT/US2006/044754 WO2007061880A1 (en) | 2005-11-23 | 2006-11-17 | Spirocyclic compounds as hdac inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE434618T1 true ATE434618T1 (de) | 2009-07-15 |
Family
ID=37811669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06837965T ATE434618T1 (de) | 2005-11-23 | 2006-11-17 | Spirozyklische verbindungen als hdac-hemmer |
Country Status (17)
Country | Link |
---|---|
US (4) | US7544695B2 (de) |
EP (1) | EP1954698B1 (de) |
JP (1) | JP4921485B2 (de) |
KR (1) | KR20080069630A (de) |
CN (1) | CN101312976A (de) |
AR (1) | AR057579A1 (de) |
AT (1) | ATE434618T1 (de) |
AU (1) | AU2006318773B2 (de) |
BR (1) | BRPI0618904A2 (de) |
CA (1) | CA2629777C (de) |
DE (1) | DE602006007482D1 (de) |
DO (1) | DOP2006000260A (de) |
NO (1) | NO20082823L (de) |
PE (1) | PE20071084A1 (de) |
RU (1) | RU2008125068A (de) |
TW (1) | TW200804381A (de) |
WO (2) | WO2007061978A1 (de) |
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EP1896395B1 (de) | 2005-06-24 | 2015-07-15 | Merck Sharp & Dohme Corp. | Modifizierte malonatderivate |
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US20070213311A1 (en) * | 2006-03-02 | 2007-09-13 | Yun-Long Li | Modulators of 11-beta hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
EP2007720B1 (de) * | 2006-04-07 | 2013-12-25 | MethylGene Inc. | Benzamidderivate als histondeacetylase-hemmer |
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
US8119652B2 (en) * | 2006-05-18 | 2012-02-21 | Merck Sharp & Dohme Corp. | Aryl-fused spirocyclic compounds |
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CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
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CA2736563C (en) * | 2007-09-10 | 2016-01-26 | Boston Biomedical, Inc. | A novel group of stat3 pathway inhibitors and cancer stem cell pathway inhibitors |
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2006
- 2006-11-14 AR ARP060104989A patent/AR057579A1/es not_active Application Discontinuation
- 2006-11-15 TW TW095142295A patent/TW200804381A/zh unknown
- 2006-11-16 US US11/600,426 patent/US7544695B2/en active Active
- 2006-11-17 CA CA2629777A patent/CA2629777C/en active Active
- 2006-11-17 DE DE602006007482T patent/DE602006007482D1/de active Active
- 2006-11-17 CN CNA2006800439455A patent/CN101312976A/zh active Pending
- 2006-11-17 BR BRPI0618904A patent/BRPI0618904A2/pt not_active IP Right Cessation
- 2006-11-17 WO PCT/US2006/044948 patent/WO2007061978A1/en active Application Filing
- 2006-11-17 RU RU2008125068/04A patent/RU2008125068A/ru unknown
- 2006-11-17 JP JP2008542379A patent/JP4921485B2/ja active Active
- 2006-11-17 AT AT06837965T patent/ATE434618T1/de not_active IP Right Cessation
- 2006-11-17 KR KR1020087012410A patent/KR20080069630A/ko not_active Application Discontinuation
- 2006-11-17 AU AU2006318773A patent/AU2006318773B2/en active Active
- 2006-11-17 US US12/085,396 patent/US7834026B2/en active Active
- 2006-11-17 EP EP06837965A patent/EP1954698B1/de active Active
- 2006-11-17 WO PCT/US2006/044754 patent/WO2007061880A1/en active Application Filing
- 2006-11-21 PE PE2006001482A patent/PE20071084A1/es not_active Application Discontinuation
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Also Published As
Publication number | Publication date |
---|---|
AU2006318773A1 (en) | 2007-05-31 |
TW200804381A (en) | 2008-01-16 |
US7544695B2 (en) | 2009-06-09 |
US8349825B2 (en) | 2013-01-08 |
EP1954698A1 (de) | 2008-08-13 |
DOP2006000260A (es) | 2007-06-30 |
JP4921485B2 (ja) | 2012-04-25 |
WO2007061880A1 (en) | 2007-05-31 |
AR057579A1 (es) | 2007-12-05 |
US7834026B2 (en) | 2010-11-16 |
PE20071084A1 (es) | 2008-01-10 |
DE602006007482D1 (de) | 2009-08-06 |
WO2007061978A1 (en) | 2007-05-31 |
AU2006318773B2 (en) | 2012-03-22 |
CA2629777C (en) | 2011-08-16 |
US20130131041A1 (en) | 2013-05-23 |
RU2008125068A (ru) | 2009-12-27 |
EP1954698B1 (de) | 2009-06-24 |
BRPI0618904A2 (pt) | 2016-09-13 |
US20070117824A1 (en) | 2007-05-24 |
CA2629777A1 (en) | 2007-05-31 |
NO20082823L (no) | 2008-08-19 |
US20110098268A1 (en) | 2011-04-28 |
CN101312976A (zh) | 2008-11-26 |
US20090209566A1 (en) | 2009-08-20 |
KR20080069630A (ko) | 2008-07-28 |
US8686020B2 (en) | 2014-04-01 |
JP2009516743A (ja) | 2009-04-23 |
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