PE20071084A1 - Compuestos espirociclicos como inhibidores de hdac - Google Patents
Compuestos espirociclicos como inhibidores de hdacInfo
- Publication number
- PE20071084A1 PE20071084A1 PE2006001482A PE2006001482A PE20071084A1 PE 20071084 A1 PE20071084 A1 PE 20071084A1 PE 2006001482 A PE2006001482 A PE 2006001482A PE 2006001482 A PE2006001482 A PE 2006001482A PE 20071084 A1 PE20071084 A1 PE 20071084A1
- Authority
- PE
- Peru
- Prior art keywords
- heteroaryl
- aryl
- link
- compounds
- aminophenil
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Virology (AREA)
- AIDS & HIV (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Transplantation (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
SE REFIERE A COMPUESTOS ESPIROCICLICOS DE FORMULA (II), EN DONDE A, B Y D SON INDEPENDIENTEMENTE CR12, NR1a, C(O) Y O; E SE SELECCIONA ENTRE UN ENLACE, CR12, NR1a, C(O) Y O; EN DONDE AL MENOS UNO DE A, B, C, D O E ES CR12; Y CON LA CONDICION DE QUE CUANDO A ES O; E NO SEA O; LAS LINEAS PUNTEADAS REPRESENTAN UN DOBLE ENLACE OPCIONAL; W ES ARILO O HETEROARILO, OPCIONALMENTE SUSTITUIDO CON R7; Z ES UN ARILO O HETEROARILO; R1 ES H, ALQUILO(C1-C6), (CR62)nR10, ENTRE OTROS; L1 ES UN ENLACE, -CR112, -C(O)NR5-, -NR5C(O)-, -C(O)-; R3 ES H, ALQUILO(C1-C6), ARILO, HETEROARILO, ENTRE OTROS, OPCIONALMENTE SUSTITUIDO; m ES 0, 1 O 2; p ES 0, 1 O 2. SON SELECCIONADOS: N-(2-AMINOFENIL)-6-(4-OXO-1-FENIL-1,3,8-TRIAZAESPIRO[4.5]DEC-8-IL)NICOTINAMIDA, N-(2-AMINOFENIL)-6-(7-BENCIL-2,7-DIAZAESPIRO[4.4]NON-2-IL)NICOTINAMIDA, 7-(5-{[(2-AMINOFENIL)AMINO]CARBONIL}PIRIDIN-2-IL)-N-FENIL-1-OXA-2,7-DIAZAESPIRO[4.4]NON-2-EN-3-CARBOXAMIDA, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. ESTOS COMPUESTOS SON INHIBIDORES DE LA HISTONA DEACETILASA (HDAC) Y SON UTILES PARA TRATAMIENTO DEL CANCER, Y ENFERMEDADES MEDIADAS POR TIORREDOXINA (TRX) TALES COMO ENFERMEDADES AUTOINMUNES, ALERGICAS E INFLAMATORIAS
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73932405P | 2005-11-23 | 2005-11-23 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20071084A1 true PE20071084A1 (es) | 2008-01-10 |
Family
ID=37811669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2006001482A PE20071084A1 (es) | 2005-11-23 | 2006-11-21 | Compuestos espirociclicos como inhibidores de hdac |
Country Status (17)
Country | Link |
---|---|
US (4) | US7544695B2 (es) |
EP (1) | EP1954698B1 (es) |
JP (1) | JP4921485B2 (es) |
KR (1) | KR20080069630A (es) |
CN (1) | CN101312976A (es) |
AR (1) | AR057579A1 (es) |
AT (1) | ATE434618T1 (es) |
AU (1) | AU2006318773B2 (es) |
BR (1) | BRPI0618904A2 (es) |
CA (1) | CA2629777C (es) |
DE (1) | DE602006007482D1 (es) |
DO (1) | DOP2006000260A (es) |
NO (1) | NO20082823L (es) |
PE (1) | PE20071084A1 (es) |
RU (1) | RU2008125068A (es) |
TW (1) | TW200804381A (es) |
WO (2) | WO2007061978A1 (es) |
Families Citing this family (81)
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CA2603986A1 (en) | 2005-04-20 | 2006-11-02 | Merck & Co., Inc. | Benzothiophene hydroxamic acid derivatives |
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AR057579A1 (es) * | 2005-11-23 | 2007-12-05 | Merck & Co Inc | Compuestos espirociclicos como inhibidores de histona de acetilasa (hdac) |
TW200808807A (en) * | 2006-03-02 | 2008-02-16 | Incyte Corp | Modulators of 11-β hydroxyl steroid dehydrogenase type 1, pharmaceutical compositions thereof, and methods of using the same |
WO2007103719A2 (en) * | 2006-03-03 | 2007-09-13 | Incyte Corporation | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME |
JP5554988B2 (ja) * | 2006-04-07 | 2014-07-23 | メチルジーン インコーポレイテッド | ヒストンデアセチラーゼの阻害剤 |
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CL2008001839A1 (es) | 2007-06-21 | 2009-01-16 | Incyte Holdings Corp | Compuestos derivados de 2,7-diazaespirociclos, inhibidores de 11-beta hidroxil esteroide deshidrogenasa tipo 1; composicion farmaceutica que comprende a dichos compuestos; utiles para tratar la obesidad, diabetes, intolerancia a la glucosa, diabetes tipo ii, entre otras enfermedades. |
FR2920774B1 (fr) | 2007-09-06 | 2009-10-30 | Galderma Res & Dev | Nouveaux derives de n-phenul acatamide, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contentant |
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DE602006007482D1 (de) | 2009-08-06 |
US20070117824A1 (en) | 2007-05-24 |
AU2006318773A1 (en) | 2007-05-31 |
CA2629777C (en) | 2011-08-16 |
JP2009516743A (ja) | 2009-04-23 |
US7834026B2 (en) | 2010-11-16 |
JP4921485B2 (ja) | 2012-04-25 |
AR057579A1 (es) | 2007-12-05 |
US8686020B2 (en) | 2014-04-01 |
RU2008125068A (ru) | 2009-12-27 |
CN101312976A (zh) | 2008-11-26 |
US20130131041A1 (en) | 2013-05-23 |
TW200804381A (en) | 2008-01-16 |
US8349825B2 (en) | 2013-01-08 |
NO20082823L (no) | 2008-08-19 |
DOP2006000260A (es) | 2007-06-30 |
US20090209566A1 (en) | 2009-08-20 |
CA2629777A1 (en) | 2007-05-31 |
AU2006318773B2 (en) | 2012-03-22 |
WO2007061978A1 (en) | 2007-05-31 |
US20110098268A1 (en) | 2011-04-28 |
BRPI0618904A2 (pt) | 2016-09-13 |
EP1954698B1 (en) | 2009-06-24 |
EP1954698A1 (en) | 2008-08-13 |
ATE434618T1 (de) | 2009-07-15 |
US7544695B2 (en) | 2009-06-09 |
KR20080069630A (ko) | 2008-07-28 |
WO2007061880A1 (en) | 2007-05-31 |
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