MX2017007623A - Derivados de piperidina como inhibidores de hdac1/2. - Google Patents

Derivados de piperidina como inhibidores de hdac1/2.

Info

Publication number
MX2017007623A
MX2017007623A MX2017007623A MX2017007623A MX2017007623A MX 2017007623 A MX2017007623 A MX 2017007623A MX 2017007623 A MX2017007623 A MX 2017007623A MX 2017007623 A MX2017007623 A MX 2017007623A MX 2017007623 A MX2017007623 A MX 2017007623A
Authority
MX
Mexico
Prior art keywords
hdac1
inhibitors
piperidine derivatives
compounds
hdacl
Prior art date
Application number
MX2017007623A
Other languages
English (en)
Inventor
H Van Duzer John
Mazitschek Ralph
Original Assignee
Regenacy Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Regenacy Pharmaceuticals Llc filed Critical Regenacy Pharmaceuticals Llc
Publication of MX2017007623A publication Critical patent/MX2017007623A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Se proporcionan en la presente compuestos, composiciones farmacéuticas que comprenden tales compuestos y métodos para usar tales compuestos para tratar enfermedades o trastornos asociados con actividad de HDAC1 y/o la HDAC2.
MX2017007623A 2014-12-12 2015-12-11 Derivados de piperidina como inhibidores de hdac1/2. MX2017007623A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462091221P 2014-12-12 2014-12-12
US201562238931P 2015-10-08 2015-10-08
PCT/US2015/065289 WO2016094824A1 (en) 2014-12-12 2015-12-11 Piperidine derivatives as hdac1/2 inhibitors

Publications (1)

Publication Number Publication Date
MX2017007623A true MX2017007623A (es) 2018-09-26

Family

ID=56108272

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017007623A MX2017007623A (es) 2014-12-12 2015-12-11 Derivados de piperidina como inhibidores de hdac1/2.
MX2020002487A MX2020002487A (es) 2014-12-12 2017-06-09 Derivados de piperidina como inhibidores de hdac1/2.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2020002487A MX2020002487A (es) 2014-12-12 2017-06-09 Derivados de piperidina como inhibidores de hdac1/2.

Country Status (17)

Country Link
US (6) US9790180B2 (es)
EP (2) EP3292113B1 (es)
JP (1) JP6693957B2 (es)
KR (1) KR20170095964A (es)
CN (1) CN107835810A (es)
AU (2) AU2015360270B9 (es)
BR (1) BR112017012504A2 (es)
CA (1) CA2970500C (es)
CL (1) CL2017001511A1 (es)
EA (1) EA035120B1 (es)
ES (1) ES2816641T3 (es)
HK (1) HK1251566A1 (es)
IL (1) IL252828A0 (es)
MX (2) MX2017007623A (es)
PH (1) PH12017501095A1 (es)
SG (1) SG11201704759QA (es)
WO (1) WO2016094824A1 (es)

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CR20160308A (es) 2013-12-03 2016-11-08 Acetylon Pharmaceuticals Inc Combinaciones de inhibidores de histona deacetilasa y farmacos inmunomoduladores
PL3231793T3 (pl) 2014-12-12 2020-07-27 Japan Tobacco Inc. Związki dihydropirymidyn-2-onu i ich zastosowania medyczne
SG11201704759QA (en) 2014-12-12 2017-07-28 Regenacy Pharmaceuticals Llc Piperidine derivatives as hdac1/2 inhibitors
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Also Published As

Publication number Publication date
EP3292113A4 (en) 2018-07-04
AU2015360270B9 (en) 2019-12-05
US11702389B2 (en) 2023-07-18
AU2015360270B2 (en) 2019-11-28
SG11201704759QA (en) 2017-07-28
US20230348389A1 (en) 2023-11-02
US20190359569A1 (en) 2019-11-28
US20210179559A1 (en) 2021-06-17
PH12017501095A1 (en) 2017-10-18
CA2970500C (en) 2023-08-29
EP3292113A1 (en) 2018-03-14
JP2018502841A (ja) 2018-02-01
CA2970500A1 (en) 2016-06-16
HK1251566A1 (zh) 2019-02-01
JP6693957B2 (ja) 2020-05-13
CL2017001511A1 (es) 2018-02-16
WO2016094824A1 (en) 2016-06-16
BR112017012504A2 (pt) 2018-01-09
AU2015360270A1 (en) 2017-07-13
US20160168093A1 (en) 2016-06-16
EA201791259A1 (ru) 2017-11-30
EP3292113B1 (en) 2020-07-08
US10239837B2 (en) 2019-03-26
US20180022702A1 (en) 2018-01-25
US9790180B2 (en) 2017-10-17
ES2816641T3 (es) 2021-04-05
IL252828A0 (en) 2017-08-31
US10358421B2 (en) 2019-07-23
US20170369441A1 (en) 2017-12-28
EP3725787A1 (en) 2020-10-21
US10968180B2 (en) 2021-04-06
AU2020200846A1 (en) 2020-02-27
EP3725787B1 (en) 2023-11-29
MX2020002487A (es) 2020-07-13
EA035120B1 (ru) 2020-04-29
CN107835810A (zh) 2018-03-23
KR20170095964A (ko) 2017-08-23

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