PT2019837E - Compostos e composições como inibidores das proteases activadoras de canal - Google Patents
Compostos e composições como inibidores das proteases activadoras de canal Download PDFInfo
- Publication number
- PT2019837E PT2019837E PT07762204T PT07762204T PT2019837E PT 2019837 E PT2019837 E PT 2019837E PT 07762204 T PT07762204 T PT 07762204T PT 07762204 T PT07762204 T PT 07762204T PT 2019837 E PT2019837 E PT 2019837E
- Authority
- PT
- Portugal
- Prior art keywords
- compositions
- compounds
- protease inhibitors
- activating protease
- channel activating
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/55—Protease inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06165—Dipeptides with the first amino acid being heterocyclic and Pro-amino acid; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Pulmonology (AREA)
- Biochemistry (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80801406P | 2006-05-23 | 2006-05-23 | |
US86062206P | 2006-11-22 | 2006-11-22 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2019837E true PT2019837E (pt) | 2011-07-05 |
Family
ID=38521007
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT07762204T PT2019837E (pt) | 2006-05-23 | 2007-05-15 | Compostos e composições como inibidores das proteases activadoras de canal |
Country Status (18)
Country | Link |
---|---|
US (2) | US7939547B2 (pt) |
EP (1) | EP2019837B1 (pt) |
JP (1) | JP5270538B2 (pt) |
KR (1) | KR101069089B1 (pt) |
CN (1) | CN101443348A (pt) |
AR (1) | AR061110A1 (pt) |
AT (1) | ATE502951T1 (pt) |
AU (1) | AU2007267733B9 (pt) |
CA (1) | CA2651043A1 (pt) |
CL (1) | CL2007001482A1 (pt) |
DE (1) | DE602007013387D1 (pt) |
MX (1) | MX2008014838A (pt) |
PE (1) | PE20080101A1 (pt) |
PL (1) | PL2019837T3 (pt) |
PT (1) | PT2019837E (pt) |
RU (1) | RU2419625C2 (pt) |
TW (1) | TW200808748A (pt) |
WO (1) | WO2007140117A1 (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0507577D0 (en) * | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
AU2007253819B2 (en) * | 2006-05-23 | 2011-02-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
EA200901082A1 (ru) * | 2007-02-09 | 2010-02-26 | Айрм Ллк | Соединения и композиции в качестве ингибиторов протеазы, активирующей каналы |
EP2117537A1 (en) * | 2007-02-09 | 2009-11-18 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
WO2009143493A2 (en) * | 2008-05-22 | 2009-11-26 | Attagene Inc. | MODULATORS OF TNFα-DEPENDENT SIGNALING PATHWAYS AND USES THEREOF |
JP5585822B2 (ja) * | 2010-05-11 | 2014-09-10 | 東レ・ファインケミカル株式会社 | 光学活性ニペコチン酸誘導体の製造方法 |
CN102153579B (zh) * | 2011-02-23 | 2013-05-29 | 兰州米诺生物科技有限公司 | 氮-叔丁氧羰基-1,2,5,6-四氢吡啶-4-硼酸频哪醇酯的合成方法 |
AU2012288843B2 (en) * | 2011-07-26 | 2016-08-04 | Sanofi | Substituted 3 - (thiazole - 4 - carbonyl) - or 3 - (thiazole - 2 - carbonyl) aminopropionic acid derivatives and their use as pharmaceuticals |
WO2013076063A1 (en) * | 2011-11-25 | 2013-05-30 | F. Hoffmann-La Roche Ag | Novel pyrrolidine derivatives as inhibitors of cathepsin |
WO2013109991A1 (en) * | 2012-01-20 | 2013-07-25 | Acucela Inc. | Substituted heterocyclic compounds for disease treatment |
KR20150046259A (ko) | 2012-08-23 | 2015-04-29 | 앨리오스 바이오파마 인크. | 파라믹소바이러스 바이러스성 감염의 치료용 화합물 |
KR101890134B1 (ko) | 2013-07-08 | 2018-08-23 | 우리윈시스템 주식회사 | Cctv 감시장치 비트맵에 의한 이미지 데이터 처리 움직임 분석 제어 방법 |
ES2886958T3 (es) * | 2016-02-29 | 2021-12-21 | Regeneron Pharma | Roedores que tienen un gen TMPRSS humanizado |
AU2020349353A1 (en) | 2019-09-17 | 2022-04-14 | Duke University | Alvelestat for use in the treatment of graft rejection, bronchiolitis obliterans syndrome and graft versus host disease |
US20230218596A1 (en) | 2020-04-16 | 2023-07-13 | Mereo Biopharma 4 Limited | Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection |
WO2023067103A1 (en) | 2021-10-20 | 2023-04-27 | Mereo Biopharma 4 Limited | Neutrophil elastase inhibitors for use in the treatment of fibrosis |
WO2024094827A1 (en) * | 2022-11-02 | 2024-05-10 | Philochem Ag | Carbonic anhydrase ix ligands for targeted delivery applications |
Family Cites Families (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5296591A (en) * | 1990-12-31 | 1994-03-22 | Fujisawa Pharmaceutical Co., Ltd. | Trifluoromethylketone derivatives, processes for preparation thereof and use thereof |
US5523308A (en) * | 1995-06-07 | 1996-06-04 | Costanzo; Michael J. | Peptidyl heterocycles useful in the treatment of thrombin related disorders |
US6211154B1 (en) * | 1995-06-07 | 2001-04-03 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
US6022861A (en) * | 1995-06-07 | 2000-02-08 | Cor Therapeutics, Inc. | Ketoheterocyclic inhibitors of factor Xa |
IL120311A (en) * | 1996-03-01 | 2001-10-31 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
IL121474A0 (en) * | 1996-08-23 | 1998-02-08 | Akzo Nobel Nv | Thrombin inhibitors |
US6323219B1 (en) * | 1998-04-02 | 2001-11-27 | Ortho-Mcneil Pharmaceutical, Inc. | Methods for treating immunomediated inflammatory disorders |
CN1353701A (zh) * | 1999-01-27 | 2002-06-12 | 奥索-麦克尼尔药品公司 | 用作类胰蛋白酶抑制剂的肽基杂环酮类化合物 |
JP2000256396A (ja) * | 1999-03-03 | 2000-09-19 | Dainippon Pharmaceut Co Ltd | 複素環式化合物およびその中間体ならびにエラスターゼ阻害剤 |
US6797504B1 (en) * | 2000-09-08 | 2004-09-28 | Dendreon San Diego Llc | Inhibitors of serine protease activity of matriptase or MTSP1 |
PL206255B1 (pl) * | 2000-07-21 | 2010-07-30 | Dendreon Corporationdendreon Corporation | Inhibitor proteazy wirusa zapalenia wątroby C, zawierająca go kompozycja farmaceutyczna i zastosowanie inhibitora do wytwarzania leku do leczenia chorób związanych z HCV oraz zastosowanie do wytwarzania kompozycji do stosowania w kombinowanej terapii |
JP2002138048A (ja) * | 2000-08-25 | 2002-05-14 | Dainippon Pharmaceut Co Ltd | 複素環式化合物からなる医薬 |
JP2005060379A (ja) * | 2003-07-31 | 2005-03-10 | Dainippon Pharmaceut Co Ltd | 複素環式化合物からなる医薬 |
US7205384B2 (en) | 2003-08-05 | 2007-04-17 | Ortho-Mcneil Pharmaceutical Inc. | Process for preparing peptidyl heterocyclic ketone derivatives |
US20050222383A1 (en) | 2004-02-05 | 2005-10-06 | Irm Llc | Prostasin substrates and inhibitors |
AU2007253819B2 (en) * | 2006-05-23 | 2011-02-17 | Irm Llc | Compounds and compositions as channel activating protease inhibitors |
-
2007
- 2007-05-15 CN CNA2007800172307A patent/CN101443348A/zh active Pending
- 2007-05-15 AU AU2007267733A patent/AU2007267733B9/en not_active Ceased
- 2007-05-15 WO PCT/US2007/068987 patent/WO2007140117A1/en active Application Filing
- 2007-05-15 MX MX2008014838A patent/MX2008014838A/es active IP Right Grant
- 2007-05-15 DE DE602007013387T patent/DE602007013387D1/de active Active
- 2007-05-15 US US11/749,001 patent/US7939547B2/en not_active Expired - Fee Related
- 2007-05-15 KR KR1020087031131A patent/KR101069089B1/ko not_active IP Right Cessation
- 2007-05-15 RU RU2008150613/04A patent/RU2419625C2/ru not_active IP Right Cessation
- 2007-05-15 EP EP07762204A patent/EP2019837B1/en not_active Not-in-force
- 2007-05-15 AT AT07762204T patent/ATE502951T1/de active
- 2007-05-15 PL PL07762204T patent/PL2019837T3/pl unknown
- 2007-05-15 CA CA002651043A patent/CA2651043A1/en not_active Abandoned
- 2007-05-15 PT PT07762204T patent/PT2019837E/pt unknown
- 2007-05-15 JP JP2009512221A patent/JP5270538B2/ja not_active Expired - Fee Related
- 2007-05-23 AR ARP070102232A patent/AR061110A1/es not_active Application Discontinuation
- 2007-05-23 PE PE2007000639A patent/PE20080101A1/es not_active Application Discontinuation
- 2007-05-23 TW TW096118428A patent/TW200808748A/zh unknown
- 2007-05-23 CL CL200701482A patent/CL2007001482A1/es unknown
-
2011
- 2011-03-29 US US13/074,910 patent/US20110177055A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
JP5270538B2 (ja) | 2013-08-21 |
EP2019837A1 (en) | 2009-02-04 |
AU2007267733B2 (en) | 2011-03-17 |
CL2007001482A1 (es) | 2008-05-09 |
US7939547B2 (en) | 2011-05-10 |
PL2019837T3 (pl) | 2011-09-30 |
KR101069089B1 (ko) | 2011-09-30 |
RU2008150613A (ru) | 2010-06-27 |
AU2007267733A1 (en) | 2007-12-06 |
CA2651043A1 (en) | 2007-12-06 |
AR061110A1 (es) | 2008-08-06 |
US20110177055A1 (en) | 2011-07-21 |
JP2009538326A (ja) | 2009-11-05 |
DE602007013387D1 (de) | 2011-05-05 |
ATE502951T1 (de) | 2011-04-15 |
US20070276002A1 (en) | 2007-11-29 |
CN101443348A (zh) | 2009-05-27 |
AU2007267733B9 (en) | 2011-04-21 |
PE20080101A1 (es) | 2008-04-01 |
TW200808748A (en) | 2008-02-16 |
RU2419625C2 (ru) | 2011-05-27 |
MX2008014838A (es) | 2008-12-05 |
EP2019837B1 (en) | 2011-03-23 |
WO2007140117A1 (en) | 2007-12-06 |
KR20090016725A (ko) | 2009-02-17 |
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