MX2009006215A - 4-imidazolinas como ligandos de aminas trazas. - Google Patents

4-imidazolinas como ligandos de aminas trazas.

Info

Publication number
MX2009006215A
MX2009006215A MX2009006215A MX2009006215A MX2009006215A MX 2009006215 A MX2009006215 A MX 2009006215A MX 2009006215 A MX2009006215 A MX 2009006215A MX 2009006215 A MX2009006215 A MX 2009006215A MX 2009006215 A MX2009006215 A MX 2009006215A
Authority
MX
Mexico
Prior art keywords
disorders
sup
lower alkyl
phenyl
lower alkoxy
Prior art date
Application number
MX2009006215A
Other languages
English (en)
Inventor
Guido Galley
Katrin Groebke Zbinden
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009006215A publication Critical patent/MX2009006215A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invención se refiere a compuestos de la fórmula (ver fórmula (I)) en la que R es hidrógeno, alquilo inferior o amino; X-R1 es -CH2-, -CH(alcoxi inferior)- o -CH(OH)- y Y-R2 es -CH2-, -CH(alquilo inferior)-, -CH(alcoxi inferior)- -O-, -S-, -S(O)-, S(O)2-, -CH(fenil)- o -C(alquilo inferior)2-; o X-R1 es -NH- y Y-R2 es -CH2, -CH(alquilo inferior)-, -CH(alcoxi inferior)-, -CH(fenil)- o -C(alquilo inferior)2-; es fenilo, naftilo o benzofuranilo, los anillos están sin sustituir o sustituidos por uno o más sustituyentes elegidos entre el grupo formado por alquilo inferior, alquilo inferior sustituido por halógeno, halógeno, alcoxi inferior, alcoxi inferior sustituido por halógeno, hidroxi, amino, di-alquilamino, morfolinilo, fenilo, bencilo y por O-bencilo; o las sales de adición de ácido farmacéuticamente aceptables. Se ha encontrado que los compuestos de la fórmula I tienen buena afinidad con los receptores asociados con las aminas trazas (TAAR), en especial con el TAAR1. Los compuestos pueden utilizarse para el tratamiento de la depresión, los trastornos de ansiedad, el trastorno bipolar, el trastorno de hiperactividad con déficit de atención (ADHD), los trastornos relacionados con el estrés, los trastornos psicóticos como la esquizofrenia, las enfermedades neurológicas como es la enfermedad de Parkinson, los trastornos neurodegenerativos como es la enfermedad de Alzheimer, la epilepsia, la migraña, la hipertensión, el abuso de sustancias y lo trastornos metabólicos como son los trastornos de ingestión de comida, la diabetes, las complicaciones diabéticas, la obesidad, la dislipidemia, los trastornos de consumo y asimilación de energía, los trastornos y la difusión de la temperatura corporal, la homeostasis, los trastornos del sueño y del ritmo circadiano y los trastornos cardiovasculares.
MX2009006215A 2006-12-18 2007-12-10 4-imidazolinas como ligandos de aminas trazas. MX2009006215A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06126307 2006-12-18
PCT/EP2007/063585 WO2008074679A2 (en) 2006-12-18 2007-12-10 4-imidazolines as taar's ligands

Publications (1)

Publication Number Publication Date
MX2009006215A true MX2009006215A (es) 2009-06-22

Family

ID=39153757

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009006215A MX2009006215A (es) 2006-12-18 2007-12-10 4-imidazolinas como ligandos de aminas trazas.

Country Status (18)

Country Link
US (3) US20080146523A1 (es)
EP (1) EP2094668A2 (es)
JP (1) JP5175297B2 (es)
KR (1) KR101188992B1 (es)
CN (1) CN101578271B (es)
AR (1) AR064376A1 (es)
AU (1) AU2007336351A1 (es)
BR (1) BRPI0721291A2 (es)
CA (1) CA2671838A1 (es)
CL (1) CL2007003653A1 (es)
IL (1) IL198878A0 (es)
MX (1) MX2009006215A (es)
NO (1) NO20091936L (es)
PE (1) PE20081386A1 (es)
RU (1) RU2465269C2 (es)
TW (1) TWI345467B (es)
WO (1) WO2008074679A2 (es)
ZA (1) ZA200903841B (es)

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RU2460725C2 (ru) 2007-02-15 2012-09-10 Ф. Хоффманн-Ля Рош Аг Новые 2-аминооксазолины в качестве лигандов taar1
WO2009097995A1 (de) * 2008-02-07 2009-08-13 Sanofi-Aventis Neue phenyl-substituierte imidazolidine, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2648723A4 (en) 2010-12-08 2014-04-02 Univ Vanderbilt USE OF BICYCLIC PYRAZOLE COMPOUNDS AS ALLUSTERIC MODULATORS OF MGLUR5 RECEPTORS
JP2014508172A (ja) * 2011-03-15 2014-04-03 ヴァンダービルト ユニバーシティー Ｍｇｌｕｒ５受容体のアロステリック調節剤としての置換イミダゾピリミジン−５（６ｈ）−オン
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103910658B (zh) * 2013-12-23 2016-08-17 宁夏大学 一种硫醚氧化成砜的方法
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Also Published As

Publication number Publication date
BRPI0721291A2 (pt) 2014-03-25
NO20091936L (no) 2009-07-14
US8399463B2 (en) 2013-03-19
WO2008074679A2 (en) 2008-06-26
CN101578271B (zh) 2013-06-19
ZA200903841B (en) 2010-03-31
IL198878A0 (en) 2010-02-17
PE20081386A1 (es) 2008-09-18
JP2010513373A (ja) 2010-04-30
CA2671838A1 (en) 2008-06-26
KR20090081431A (ko) 2009-07-28
US20120004230A1 (en) 2012-01-05
KR101188992B1 (ko) 2012-10-08
RU2009122665A (ru) 2011-01-27
JP5175297B2 (ja) 2013-04-03
AR064376A1 (es) 2009-04-01
EP2094668A2 (en) 2009-09-02
WO2008074679A3 (en) 2008-10-09
US20100204233A1 (en) 2010-08-12
CL2007003653A1 (es) 2008-07-11
RU2465269C2 (ru) 2012-10-27
TW200833327A (en) 2008-08-16
AU2007336351A1 (en) 2008-06-26
CN101578271A (zh) 2009-11-11
TWI345467B (en) 2011-07-21
US20080146523A1 (en) 2008-06-19

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