GB2229719B - Novel aromatase inhibiting 4(5)-imidazoles - Google Patents

Novel aromatase inhibiting 4(5)-imidazoles

Info

Publication number
GB2229719B
GB2229719B GB8907218A GB8907218A GB2229719B GB 2229719 B GB2229719 B GB 2229719B GB 8907218 A GB8907218 A GB 8907218A GB 8907218 A GB8907218 A GB 8907218A GB 2229719 B GB2229719 B GB 2229719B
Authority
GB
United Kingdom
Prior art keywords
imidazoles
aromatase inhibiting
novel
novel aromatase
inhibiting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
GB8907218A
Other versions
GB8907218D0 (en
GB2229719A (en
Inventor
Matti Antero Lahde
Risto Arvo Sakari Lammintausta
Arto Johannes Karjalainen
Reino Pelkonen Olavi
Marja-Liisa Sodervall
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Farmos Yhtyma Oy
Original Assignee
Farmos Yhtyma Oy
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmos Yhtyma Oy filed Critical Farmos Yhtyma Oy
Priority to GB8907218A priority Critical patent/GB2229719B/en
Publication of GB8907218D0 publication Critical patent/GB8907218D0/en
Priority to FI901316A priority patent/FI901316A0/en
Priority to AU52325/90A priority patent/AU627559B2/en
Priority to JP2080548A priority patent/JPH032168A/en
Priority to DD90339203A priority patent/DD296916A5/en
Priority to NZ233127A priority patent/NZ233127A/en
Priority to NO901451A priority patent/NO172797C/en
Priority to DE69012184T priority patent/DE69012184T2/en
Priority to AT90303362T priority patent/ATE111084T1/en
Priority to SU904743449A priority patent/RU2021263C1/en
Priority to EP90303362A priority patent/EP0390558B1/en
Priority to CS901555A priority patent/CZ281611B6/en
Priority to CA002013395A priority patent/CA2013395A1/en
Priority to HU914010A priority patent/HU206685B/en
Priority to DK90303362.9T priority patent/DK0390558T3/en
Priority to PT93606A priority patent/PT93606B/en
Priority to ES90303362T priority patent/ES2063260T3/en
Priority to IL9394090A priority patent/IL93940A/en
Priority to HU901894A priority patent/HU205345B/en
Priority to IE115290A priority patent/IE64655B1/en
Priority to IL10726090A priority patent/IL107260A/en
Priority to UA4895673A priority patent/UA13471A/en
Priority to PL28455290A priority patent/PL162513B1/en
Priority to ZA902479A priority patent/ZA902479B/en
Priority to CN90102676A priority patent/CN1046527A/en
Priority to PL28896290A priority patent/PL162554B1/en
Publication of GB2229719A publication Critical patent/GB2229719A/en
Priority to NO911040A priority patent/NO172119C/en
Priority to SU914895673A priority patent/RU1836354C/en
Priority to UA4895687A priority patent/UA19310A1/en
Priority to SU914895687A priority patent/RU1836355C/en
Application granted granted Critical
Publication of GB2229719B publication Critical patent/GB2229719B/en
Priority to US08/063,471 priority patent/US5439928A/en
Priority to CN93108897A priority patent/CN1086812A/en
Priority to LTIP847A priority patent/LT3657B/en
Priority to IL107260A priority patent/IL107260A0/en
Priority to LVP-95-273A priority patent/LV11027B/en
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
GB8907218A 1989-03-30 1989-03-30 Novel aromatase inhibiting 4(5)-imidazoles Revoked GB2229719B (en)

Priority Applications (35)

Application Number Priority Date Filing Date Title
GB8907218A GB2229719B (en) 1989-03-30 1989-03-30 Novel aromatase inhibiting 4(5)-imidazoles
FI901316A FI901316A0 (en) 1989-03-30 1990-03-16 FREQUENCY REFRIGERATION FOR AV 4 (5) -IMIDAZOLER.
AU52325/90A AU627559B2 (en) 1989-03-30 1990-03-28 Novel aromatase inhibiting 4(5)-imidazoles
JP2080548A JPH032168A (en) 1989-03-30 1990-03-28 Novel 4 (5)-imidazole having aromatase inhibitive activity
HU901894A HU205345B (en) 1989-03-30 1990-03-29 Process for producing new 4(5)-imidazole derivatives
UA4895673A UA13471A (en) 1989-03-30 1990-03-29 METHOD OF OBTAINING SUBSTITUTED IMIDAZOLE OR ITS NON-TOXIC PHARMACEUTICALLY ACCEPTABLE ACID-ADDITIVE SALT
NO901451A NO172797C (en) 1989-03-30 1990-03-29 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE SUBSTITUTED IMIDAZOLE COMPOUNDS
DE69012184T DE69012184T2 (en) 1989-03-30 1990-03-29 Aromatase inhibiting 4 (5) imidazoles.
AT90303362T ATE111084T1 (en) 1989-03-30 1990-03-29 AROMATASE INHIBITING 4(5)-IMIDAZOLE.
SU904743449A RU2021263C1 (en) 1989-03-30 1990-03-29 Method of synthesis of substituted imidazole or its nontoxic pharmaceutically acceptable acid-additive salt
EP90303362A EP0390558B1 (en) 1989-03-30 1990-03-29 Aromatase inhibiting 4(5)-imidazoles
CS901555A CZ281611B6 (en) 1989-03-30 1990-03-29 4(5)-diarylalkylimidazole derivatives, process of their preparation, pharmaceutical preparatin in which said derivatives are comprised and their use
CA002013395A CA2013395A1 (en) 1989-03-30 1990-03-29 Aromatase inhibiting 4(5)-imidazoles
HU914010A HU206685B (en) 1989-03-30 1990-03-29 Process for producing new 4/5/-imidazol derivatives
DK90303362.9T DK0390558T3 (en) 1989-03-30 1990-03-29 Aromatase inhibitor 4 (5) -imidazoles
PT93606A PT93606B (en) 1989-03-30 1990-03-29 METHOD FOR PREPARING NEW 4 (5) -IMIDAZOES THAT INHIBIT THE AROMATASE
ES90303362T ES2063260T3 (en) 1989-03-30 1990-03-29 NEW 4 (5) -IMIDAZOLES INHIBITORS OF AROMATASE.
IL9394090A IL93940A (en) 1989-03-30 1990-03-29 Aromatase inhibiting diphenylalkyl 4(5)-imidazoles and pharmaceutical compositions containing them
DD90339203A DD296916A5 (en) 1989-03-30 1990-03-29 NEW AROMATASE INHIBITED 4 (5) SUBSTITUTED IMIDAZOLE DERIVATIVES
IE115290A IE64655B1 (en) 1989-03-30 1990-03-29 Novel aromatase inhibiting 4(5)-imidazoles
IL10726090A IL107260A (en) 1989-03-30 1990-03-29 Aromatase inhibiting diphenylalkyl 4(5)-imidazoles and pharmaceutical compositions containing them
NZ233127A NZ233127A (en) 1989-03-30 1990-03-29 Imidazole derivatives and pharmaceutical compositions
PL28896290A PL162554B1 (en) 1989-03-30 1990-03-30 Method of obtaining novel derivatives of imidazole
PL28455290A PL162513B1 (en) 1989-03-30 1990-03-30 Method for manufacturing new derivatives of imidazol
ZA902479A ZA902479B (en) 1989-03-30 1990-03-30 Aromatase inhibiting 4(5)-imidazoles
CN90102676A CN1046527A (en) 1989-03-30 1990-03-30 Novel aromatization enzyme inhibitor 4 (5)-imidazoles
NO911040A NO172119C (en) 1989-03-30 1991-03-15 ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE SUBSTITUTED IMIDAZOLE COMPOUNDS
SU914895673A RU1836354C (en) 1989-03-30 1991-06-25 Method for obtaining substituted imidazole or its nontoxic pharmaceutically acceptable acid-additive salt
UA4895687A UA19310A1 (en) 1989-03-30 1991-06-25 Process for preparation of substituted imidazole or nontoxic pharmaceutically acceptable acid-additive salt thereof
SU914895687A RU1836355C (en) 1989-03-30 1991-06-25 Method for obtaining substituted imidazole or its nontoxic pharmaceutically acceptable acid-additive salt
US08/063,471 US5439928A (en) 1989-03-30 1993-05-19 Aromatase inhibiting 4(5)-imidazoles
CN93108897A CN1086812A (en) 1989-03-30 1993-07-14 The preparation method of novel aromatization enzyme inhibitor 4 (5)-imidazoles
LTIP847A LT3657B (en) 1989-03-30 1993-08-10 Process for preparing imidazole derivatives
IL107260A IL107260A0 (en) 1989-03-30 1993-10-12 Aromatase inhibiting diphenylalkyl 4(5)-imidazoles and pharmaceutical compositions containing them
LVP-95-273A LV11027B (en) 1989-03-30 1995-09-07 Aromatase inhibiting 4(5)-imidazoles aromatase inhibiting 4(5)-imidazoles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8907218A GB2229719B (en) 1989-03-30 1989-03-30 Novel aromatase inhibiting 4(5)-imidazoles

Publications (3)

Publication Number Publication Date
GB8907218D0 GB8907218D0 (en) 1989-05-10
GB2229719A GB2229719A (en) 1990-10-03
GB2229719B true GB2229719B (en) 1992-04-29

Family

ID=10654204

Family Applications (1)

Application Number Title Priority Date Filing Date
GB8907218A Revoked GB2229719B (en) 1989-03-30 1989-03-30 Novel aromatase inhibiting 4(5)-imidazoles

Country Status (9)

Country Link
CA (1) CA2013395A1 (en)
DD (1) DD296916A5 (en)
FI (1) FI901316A0 (en)
GB (1) GB2229719B (en)
LT (1) LT3657B (en)
PL (1) PL162554B1 (en)
RU (2) RU2021263C1 (en)
UA (1) UA19310A1 (en)
ZA (1) ZA902479B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2248058B (en) * 1990-09-21 1994-09-14 Orion Yhtymae Oy Aromatase inhibiting 4(5)-imidazoles
DE102006019906A1 (en) * 2006-04-28 2007-10-31 Müller-Enoch, Dieter, Prof. Dr. Use of compounds comprising a hydrophilic tail linked via a hydrocarbon group to a group comprising a carbon or heteroatom free electron pair and/or pi electrons to prepare pharmaceutical compositions
US20080146523A1 (en) * 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072615A1 (en) * 1981-07-10 1983-02-23 Farmos Group Ltd. Substituted imidazole derivatives and their preparation and use
EP0168965A1 (en) * 1984-06-18 1986-01-22 Eli Lilly And Company 4(5)-substituted imidazoles
EP0194984A1 (en) * 1985-01-28 1986-09-17 Continental Pharma, Inc. Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
GB2210875A (en) * 1987-10-09 1989-06-21 Farmos Oy Aromatase inhibiting 4(5)-imidazoles

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3759944A (en) 1970-10-14 1973-09-18 Smith Kline French Lab Isothioureas and their derivatives
AU627559B2 (en) 1989-03-30 1992-08-27 Farmos-Yhtyma Oy Novel aromatase inhibiting 4(5)-imidazoles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0072615A1 (en) * 1981-07-10 1983-02-23 Farmos Group Ltd. Substituted imidazole derivatives and their preparation and use
EP0168965A1 (en) * 1984-06-18 1986-01-22 Eli Lilly And Company 4(5)-substituted imidazoles
EP0194984A1 (en) * 1985-01-28 1986-09-17 Continental Pharma, Inc. Derivatives of imidazole, their preparation and utilisation, and pharmaceutical compositions containing these derivatives
GB2210875A (en) * 1987-10-09 1989-06-21 Farmos Oy Aromatase inhibiting 4(5)-imidazoles

Also Published As

Publication number Publication date
LTIP847A (en) 1995-02-27
PL162554B1 (en) 1993-12-31
DD296916A5 (en) 1991-12-19
CA2013395A1 (en) 1991-09-29
GB8907218D0 (en) 1989-05-10
ZA902479B (en) 1990-12-28
RU1836355C (en) 1993-08-23
GB2229719A (en) 1990-10-03
RU2021263C1 (en) 1994-10-15
PL288962A1 (en) 1991-10-21
LT3657B (en) 1996-01-25
FI901316A0 (en) 1990-03-16
UA19310A1 (en) 1997-12-25

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Legal Events

Date Code Title Description
773H Revocation action is not pursued (sect. 73(2)/1977)
773K Patent revoked under sect. 73(2)/1977