PE20081386A1 - 4-imidazolinas como ligandos de taar - Google Patents

4-imidazolinas como ligandos de taar

Info

Publication number
PE20081386A1
PE20081386A1 PE2007001804A PE2007001804A PE20081386A1 PE 20081386 A1 PE20081386 A1 PE 20081386A1 PE 2007001804 A PE2007001804 A PE 2007001804A PE 2007001804 A PE2007001804 A PE 2007001804A PE 20081386 A1 PE20081386 A1 PE 20081386A1
Authority
PE
Peru
Prior art keywords
phenyl
lower alkyl
taar
imidazolines
compounds
Prior art date
Application number
PE2007001804A
Other languages
English (en)
Inventor
Guido Galley
Katrin Groebke Zbinden
Henri Stalder
Roger Norcross
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PE20081386A1 publication Critical patent/PE20081386A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/06Antihyperlipidemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Addiction (AREA)
  • Child & Adolescent Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE 4-IMIDAZOLINAS DE FORMULA (I) DONDE R ES H, ALQUILO INFERIOR O AMINO; X-R1 ES -CH2-, -CH(ALCOXI INFERIOR)-, -CH(OH)- O -NH-; Y-R2 ES -CH2, -CH(ALQUILO INFERIOR)-, -S(O)2-, -CH(FENIL)-, ENTRE OTROS; Ar ES FENILO, NAFTILO O BENZOFURANILO OPCIONALMENTE SUSTITUIDO CON ALQUILO INFERIOR, HALOGENO, HIDROXI, AMINO, FENILO, ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: 4-[2-(2-CLORO-FENIL)-ETIL]-1H-IMIDAZOL, 4-(2,3-DICLORO-FENOXIMETIL)-1H-IMIDAZOL, 5-(2,3-DICLORO-FENILSULFANILMETIL)-1H-IMIDAZOL, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS TIENEN BUENA AFINIDAD CON LOS RECEPTORES DE LAS AMINAS TRAZAS (TAAR) SIENDO UTILES EN EL TRATAMIENTO DE DEPRESION, TRASTORNOS DE ANSIEDAD, ESQUIZOFRENIA, ENFERMEDAD DE PARKINSON
PE2007001804A 2006-12-18 2007-12-14 4-imidazolinas como ligandos de taar PE20081386A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06126307 2006-12-18

Publications (1)

Publication Number Publication Date
PE20081386A1 true PE20081386A1 (es) 2008-09-18

Family

ID=39153757

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001804A PE20081386A1 (es) 2006-12-18 2007-12-14 4-imidazolinas como ligandos de taar

Country Status (18)

Country Link
US (3) US20080146523A1 (es)
EP (1) EP2094668A2 (es)
JP (1) JP5175297B2 (es)
KR (1) KR101188992B1 (es)
CN (1) CN101578271B (es)
AR (1) AR064376A1 (es)
AU (1) AU2007336351A1 (es)
BR (1) BRPI0721291A2 (es)
CA (1) CA2671838A1 (es)
CL (1) CL2007003653A1 (es)
IL (1) IL198878A0 (es)
MX (1) MX2009006215A (es)
NO (1) NO20091936L (es)
PE (1) PE20081386A1 (es)
RU (1) RU2465269C2 (es)
TW (1) TWI345467B (es)
WO (1) WO2008074679A2 (es)
ZA (1) ZA200903841B (es)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
CA2676944C (en) 2007-02-15 2016-01-19 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
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WO2012078817A1 (en) 2010-12-08 2012-06-14 Vanderbilt University Bicyclic pyrazole compounds as allosteric modulators of mglur5 receptors
US8865725B2 (en) 2011-03-15 2014-10-21 Vanderbilt University Substituted imidazopyrimidin-5(6H)-ones as allosteric modulators of MGLUR5 receptors
JP2014508172A (ja) * 2011-03-15 2014-04-03 ヴァンダービルト ユニバーシティー Mglur5受容体のアロステリック調節剤としての置換イミダゾピリミジン−5(6h)−オン
EP2567959B1 (en) 2011-09-12 2014-04-16 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CN103910658B (zh) * 2013-12-23 2016-08-17 宁夏大学 一种硫醚氧化成砜的方法
WO2015165085A1 (en) 2014-04-30 2015-11-05 F.Hoffmann-La Roche Ag Morpholin-pyridine derivatives

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Also Published As

Publication number Publication date
AU2007336351A1 (en) 2008-06-26
CN101578271A (zh) 2009-11-11
US20120004230A1 (en) 2012-01-05
EP2094668A2 (en) 2009-09-02
NO20091936L (no) 2009-07-14
JP5175297B2 (ja) 2013-04-03
TW200833327A (en) 2008-08-16
KR20090081431A (ko) 2009-07-28
US8399463B2 (en) 2013-03-19
CA2671838A1 (en) 2008-06-26
US20100204233A1 (en) 2010-08-12
US20080146523A1 (en) 2008-06-19
BRPI0721291A2 (pt) 2014-03-25
RU2465269C2 (ru) 2012-10-27
MX2009006215A (es) 2009-06-22
WO2008074679A2 (en) 2008-06-26
TWI345467B (en) 2011-07-21
CL2007003653A1 (es) 2008-07-11
JP2010513373A (ja) 2010-04-30
KR101188992B1 (ko) 2012-10-08
ZA200903841B (en) 2010-03-31
AR064376A1 (es) 2009-04-01
WO2008074679A3 (en) 2008-10-09
IL198878A0 (en) 2010-02-17
CN101578271B (zh) 2013-06-19
RU2009122665A (ru) 2011-01-27

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