AT373887B - Verfahren zur herstellung von neuen n-heterocyclyl-4-piperidinaminen und deren saeureadditionssalzen - Google Patents

Verfahren zur herstellung von neuen n-heterocyclyl-4-piperidinaminen und deren saeureadditionssalzen

Info

Publication number
AT373887B
AT373887B AT0242579A AT242579A AT373887B AT 373887 B AT373887 B AT 373887B AT 0242579 A AT0242579 A AT 0242579A AT 242579 A AT242579 A AT 242579A AT 373887 B AT373887 B AT 373887B
Authority
AT
Austria
Prior art keywords
piperidinamines
heterocyclyl
acid addition
addition salts
producing new
Prior art date
Application number
AT0242579A
Other languages
English (en)
Other versions
ATA242579A (de
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26670178&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AT373887(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US06/002,276 external-priority patent/US4219559A/en
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Priority to AT0453882A priority Critical patent/AT373888B/de
Publication of ATA242579A publication Critical patent/ATA242579A/de
Application granted granted Critical
Publication of AT373887B publication Critical patent/AT373887B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/54—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/26—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/34—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings
    • C07D265/36—1,4-Oxazines; Hydrogenated 1,4-oxazines condensed with carbocyclic rings condensed with one six-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
AT0242579A 1978-04-03 1979-04-02 Verfahren zur herstellung von neuen n-heterocyclyl-4-piperidinaminen und deren saeureadditionssalzen AT373887B (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AT0453882A AT373888B (de) 1979-01-10 1982-12-14 Verfahren zur herstellung von neuen 4-piperidinaminen und deren saeureadditionssalzen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US89253478A 1978-04-03 1978-04-03
US06/002,276 US4219559A (en) 1979-01-10 1979-01-10 N-Heterocyclyl-4-piperidinamines

Publications (2)

Publication Number Publication Date
ATA242579A ATA242579A (de) 1983-07-15
AT373887B true AT373887B (de) 1984-02-27

Family

ID=26670178

Family Applications (1)

Application Number Title Priority Date Filing Date
AT0242579A AT373887B (de) 1978-04-03 1979-04-02 Verfahren zur herstellung von neuen n-heterocyclyl-4-piperidinaminen und deren saeureadditionssalzen

Country Status (29)

Country Link
EP (1) EP0005318B1 (de)
JP (2) JPS54151982A (de)
AT (1) AT373887B (de)
AU (1) AU523352B2 (de)
BG (1) BG38164A3 (de)
CA (1) CA1140119A (de)
CS (1) CS256358B2 (de)
CY (1) CY1250A (de)
DE (1) DE2961740D1 (de)
DK (1) DK169325B1 (de)
EG (1) EG13913A (de)
ES (1) ES479206A1 (de)
FI (1) FI64801C (de)
GR (1) GR64907B (de)
HK (1) HK3184A (de)
HU (1) HU182965B (de)
IE (1) IE47818B1 (de)
IL (1) IL56992A (de)
MY (1) MY8500046A (de)
NO (2) NO154058C (de)
NZ (1) NZ189978A (de)
PH (1) PH15877A (de)
PL (1) PL123380B1 (de)
PT (1) PT69429A (de)
RO (1) RO79320A (de)
SG (1) SG29883G (de)
SU (1) SU1056902A3 (de)
YU (2) YU42484B (de)
ZA (1) ZA791557B (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
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MA19091A1 (fr) * 1980-03-10 1981-10-01 Janssen Pharmaceutica Nv Nouveaux derives de i-(4-aryl-cyclohexyl)piperidine .
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
IN156065B (de) * 1982-07-12 1985-05-04 Janssen Pharmaceutica Nv
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
EP0144101B1 (de) * 1983-11-30 1991-02-06 Janssen Pharmaceutica N.V. Bizyklisches Heterozyklyl aufveisende N-(bizyklisches Heterozyklyl-4-piperidinamine
JPS60174778A (ja) * 1984-01-09 1985-09-09 ジヤンセン・フア−マシユ−チカ・ナ−ムロ−ゼ・フエンノ−トシヤツプ Ｎ−ヘテロシクリル−４−ピペリジンアミン
KR930005004B1 (ko) * 1985-04-15 1993-06-11 쟈안센 파아마슈우티카 엔. 부이. 치환된 n-[(4-피페리디닐)알킬]이환 축합 옥사졸아민 및 티아졸아민의 제조방법
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
CA1327579C (en) * 1986-02-03 1994-03-08 Frans Eduard Janssens Anti-histaminic compositions containing n-heterocyclyl-4-piperidinamines
NZ223654A (en) * 1987-03-09 1990-03-27 Janssen Pharmaceutica Nv 1-alkyl-substituted-benzimidazole-4-piperidinamines and pharmaceutical compositions
FR2618435B1 (fr) * 1987-07-23 1989-10-27 Synthelabo Derives de benzimidazole, leur preparation et leur application en therapeutique
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use
US5624948A (en) * 1993-05-20 1997-04-29 Kissei Pharmaceutical Co., Ltd. 1-(2-benzimidazolyl)-1,5-diazacyclooctane compounds
US5547966A (en) * 1993-10-07 1996-08-20 Bristol-Myers Squibb Company Aryl urea and related compounds
SK13082000A3 (sk) * 1998-03-06 2001-03-12 Janssen Pharmaceutica N. V. Inhibítory prenosu glycínu, spôsob ich prípravy, farmaceutický prostriedok s ich obsahom a ich použitie
ES2215670T3 (es) * 1999-06-28 2004-10-16 Janssen Pharmaceutica N.V. Inhibidores de la replicacion del virus sincitial respiratorio.
EA005027B1 (ru) 1999-06-28 2004-10-28 Янссен Фармацевтика Н.В. Ингибиторы репликации респираторно-синцитиального вируса
JP2003503401A (ja) 1999-06-28 2003-01-28 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 呼吸合胞体ウイルス複製阻害剤
KR100879647B1 (ko) 2000-03-06 2009-01-20 아카디아 파마슈티칼스 인코포레이티드 세로토닌 관련 질병의 치료에 사용되는 아자시클릭 화합물
DE02706135T1 (de) 2001-02-02 2004-05-19 Teva Pharmaceutical Industries Ltd. Verfahren zur herstellung von substituierten 2-(2-pyridylmethyl)sulfinyl-1h-benzimidazolen
MXPA04006280A (es) 2001-12-28 2004-09-27 Acadia Pharm Inc Compuestos espiroazaciclicos como moduladores de receptor de monoamina.
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
AU2003247615B2 (en) 2002-06-24 2007-08-09 Acadia Pharmaceuticals Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7538222B2 (en) 2002-06-24 2009-05-26 Acadia Pharmaceuticals, Inc. N-substituted piperidine derivatives as serotonin receptor agents
US7253186B2 (en) 2002-06-24 2007-08-07 Carl-Magnus Andersson N-substituted piperidine derivatives as serotonin receptor agents
ES2314362T3 (es) 2003-01-16 2009-03-16 Acadia Pharmaceuticals Inc. Agonistas inversos selectivos de los receptores 2a o 2c de serotonina utilizados como agentes terapeuticos contra enfermedades neurodegenerativas.
AR046770A1 (es) 2003-12-18 2005-12-21 Tibotec Pharm Ltd Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio
CA2548657A1 (en) 2003-12-18 2005-06-30 Tibotec Pharmaceuticals Ltd. Aminobenzimidazoles and benzimidazoles as inhibitors of respiratory syncytial virus replication
RU2381224C2 (ru) * 2003-12-18 2010-02-10 Тиботек Фармасьютикалз Лтд. Пиперидинаминобензимидазольные производные как ингибиторы репликации респираторного синцитиального вируса
US20050261278A1 (en) 2004-05-21 2005-11-24 Weiner David M Selective serotonin receptor inverse agonists as therapeutics for disease
US7820695B2 (en) 2004-05-21 2010-10-26 Acadia Pharmaceuticals, Inc. Selective serotonin receptor inverse agonists as therapeutics for disease
US7790899B2 (en) 2004-09-27 2010-09-07 Acadia Pharmaceuticals, Inc. Synthesis of N-(4-fluorobenzyl)-N-(1-methylpiperidin-4-yl)-N′-(4-(2-methylpropyloxy)phenylmethyl)carbamide and its tartrate salt and crystalline forms
CN101031548B (zh) 2004-09-27 2011-04-06 阿卡蒂亚药品公司 N-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n'-(4-(2-甲基丙氧基)-苯基甲基)脲的盐及其制备
JP2010522198A (ja) 2007-03-19 2010-07-01 アカドイア プハルマセウチカルス インコーポレーテッド ５−ｈｔ２ａインバースアゴニスト及びアンタゴニストの抗精神病薬との併用
CN107848972B (zh) 2015-07-20 2021-06-18 阿卡蒂亚药品公司 用于制备n-(4-氟苄基)-n-(1-甲基哌啶-4-基)-n’-(4-(2-甲基丙氧基)苯基甲基)脲及其酒石酸盐和多晶型c的方法
US10953000B2 (en) 2016-03-25 2021-03-23 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome P450 modulators
WO2017165635A1 (en) 2016-03-25 2017-09-28 Acadia Pharmaceuticals Inc. Combination of pimavanserin and cytochrome p450 modulators
EP3558311A1 (de) 2016-12-20 2019-10-30 Acadia Pharmaceuticals Inc. Pimavanserin allein oder in kombination zur verwendung in der behandlung von morbus-alzheimer-psychose
WO2018200977A1 (en) 2017-04-28 2018-11-01 Acadia Pharmaceuticals Inc. Pimavanserin for treating impulse control disorder
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US2857391A (en) * 1955-04-15 1958-10-21 Merck & Co Inc Aminomethylbenzimidazoles
US2971005A (en) * 1958-10-17 1961-02-07 Merck & Co Inc Nu-substituted derivatives of 2-benzylaminobenzimidazoles
BE788065A (fr) * 1971-08-26 1973-02-26 Degussa Nouvelles aza-benzimidazoles et procede pour leur preparation

Also Published As

Publication number Publication date
DK169325B1 (da) 1994-10-10
JPS641477B2 (de) 1989-01-11
CS222779A2 (en) 1987-03-12
FI64801B (fi) 1983-09-30
NO154090C (no) 1986-07-16
FI64801C (fi) 1984-01-10
SG29883G (en) 1984-04-19
NO791097L (no) 1979-10-04
YU50283A (en) 1983-12-31
PH15877A (en) 1983-04-13
JPH0240666B2 (de) 1990-09-12
AU4529679A (en) 1979-10-18
IL56992A0 (en) 1979-07-25
IE790676L (en) 1979-10-03
FI791084A (fi) 1979-10-04
YU42484B (en) 1988-10-31
HK3184A (en) 1984-01-20
NO154090B (no) 1986-04-07
JPH01117880A (ja) 1989-05-10
YU43158B (en) 1989-04-30
JPS54151982A (en) 1979-11-29
PL214648A1 (de) 1980-03-24
EG13913A (en) 1982-09-30
PT69429A (pt) 1979-05-01
IE47818B1 (en) 1984-06-27
NO154058B (no) 1986-04-01
ES479206A1 (es) 1979-12-16
NO842563L (no) 1979-10-04
AU523352B2 (en) 1982-07-22
DK129879A (da) 1979-10-04
GR64907B (en) 1980-06-07
HU182965B (en) 1984-03-28
ZA791557B (en) 1980-11-26
CY1250A (en) 1984-08-31
PL123380B1 (en) 1982-10-30
EP0005318B1 (de) 1982-01-06
BG38164A3 (en) 1985-10-15
CA1140119A (en) 1983-01-25
ATA242579A (de) 1983-07-15
SU1056902A3 (ru) 1983-11-23
RO79320A (ro) 1982-08-17
MY8500046A (en) 1985-12-31
IL56992A (en) 1983-03-31
NZ189978A (en) 1984-05-31
CS256358B2 (en) 1988-04-15
NO154058C (no) 1986-07-09
DE2961740D1 (en) 1982-02-25
EP0005318A1 (de) 1979-11-14
YU78479A (en) 1983-10-31

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