AR046770A1 - Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio - Google Patents

Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio

Info

Publication number
AR046770A1
AR046770A1 ARP040104808A ARP040104808A AR046770A1 AR 046770 A1 AR046770 A1 AR 046770A1 AR P040104808 A ARP040104808 A AR P040104808A AR P040104808 A ARP040104808 A AR P040104808A AR 046770 A1 AR046770 A1 AR 046770A1
Authority
AR
Argentina
Prior art keywords
het
alkyl
hydrogen
replication
substituted
Prior art date
Application number
ARP040104808A
Other languages
English (en)
Original Assignee
Tibotec Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tibotec Pharm Ltd filed Critical Tibotec Pharm Ltd
Publication of AR046770A1 publication Critical patent/AR046770A1/es

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente se refiere a derivados de bencimidazol 5- o 6-sustituidos que tienen actividad inhibidora sobre la replicación sobre el virus sincitial respiratorio y que tienen la formula (1), profármacos, N-oxido, sal de adición, amina cuaternaria, complejo metálico o forma estereoquímicamente isomérica del mismo donde Q es Ar2, R6a, pirrolidinilo substituido con R6, piperidinilo substituido con R6 u homopiperidinilo con R6; G es un enlace directo o un alcanodiilo C1-10 opcionalmente sustituido; R1 es Ar1 o un heterociclo monocíclico o bicíclico; uno de R2a y R2b es cianoalquilo C1-6, cianoalquenilo C2-6, Ar3-alquilo C1-6, Het-alquilo C1-6, N(R8aR8b)alquilo C1-6, Ar3-alquenilo C2-6, Het-alquenilo C2-6, Ar3-aminoalquilo C1-6, Het- aminoalquilo C1-6, Ar3-tioalquilo C1-6, Het-tioalquilo C1-6, Ar3-sulfonilalquilo C1-6, Het-sulfonilalquilo C1-6, Ar3-aminocarbonilo, Het-aminocarbonilo, Ar3(CH2)naminocarbonilo, Het-(CH2)naminocarbonilo, Ar3-carbonilamino, Het-carbonilamino, Ar3(CH2)ncarbonilamino, Y otro de R2a y R2b es hidrógeno; en el caso de que R2a sea hidrógeno, entonces R3 es hidrógeno; en el caso de que R2b sea hidrógeno, entonces R3 es hidrógeno o alquilo C1-6. Se refiere además a su preparación y a las composiciones que los comprenden así como también a su uso como medicamento.
ARP040104808A 2003-12-18 2004-12-20 Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio AR046770A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03104806 2003-12-18
US56686704P 2004-04-30 2004-04-30

Publications (1)

Publication Number Publication Date
AR046770A1 true AR046770A1 (es) 2005-12-21

Family

ID=43646156

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104808A AR046770A1 (es) 2003-12-18 2004-12-20 Derivados bencimidazol 5- o 6-substituidos como inhibidores de la replicacion del virus sincitial respiratorio

Country Status (19)

Country Link
US (2) US20070093502A1 (es)
EP (1) EP1697347B1 (es)
JP (1) JP2007514719A (es)
KR (1) KR101123055B1 (es)
CN (1) CN1914196B (es)
AR (1) AR046770A1 (es)
AT (1) ATE499361T1 (es)
AU (1) AU2004298459B2 (es)
BR (1) BRPI0417273A (es)
CA (1) CA2548793A1 (es)
DE (1) DE602004031555D1 (es)
DK (1) DK1697347T3 (es)
HR (1) HRP20110313T1 (es)
MX (1) MXPA06007111A (es)
MY (1) MY142783A (es)
RU (1) RU2369606C2 (es)
SI (1) SI1697347T1 (es)
TW (1) TWI382981B (es)
WO (1) WO2005058874A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2612264C (en) * 2005-06-20 2014-09-23 Tibotec Pharmaceuticals Ltd. Heterocyclylaminoalkyl substituted benzimidazoles
WO2013056070A2 (en) 2011-10-14 2013-04-18 Ambit Biosciences Corporation Heterocyclic compounds and methods of use thereof
TW201825465A (zh) 2016-09-23 2018-07-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
NZ763766A (en) 2017-03-20 2023-07-28 Novo Nordisk Healthcare Ag Pyrrolopyrrole compositions as pyruvate kinase (pkr) activators
US10793551B2 (en) 2017-10-19 2020-10-06 Effector Therapeutics Inc. Benzimidazole-indole inhibitors of Mnk1 and Mnk2
EP3852791B1 (en) 2018-09-19 2024-07-03 Novo Nordisk Health Care AG Activating pyruvate kinase r
BR112021005188A2 (pt) 2018-09-19 2021-06-08 Forma Therapeutics, Inc. tratamento de anemia falciforme com um composto de ativação de piruvato cinase r

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4025621A (en) * 1975-01-09 1977-05-24 Purdy Clarence L Method of curing and providing immunity from viral infections
CA1140119A (en) 1978-04-03 1983-01-25 Joseph Torremans N-heterocyclyl-4-piperidinamines
US4556660A (en) 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
KR100190299B1 (ko) 1990-07-19 1999-06-01 디르크 반테 신규한 옥사졸릴 유도체
NZ515418A (en) * 1999-06-28 2003-11-28 Janssen Pharmaceutica Nv Respiratory syncytial virus replication inhibitors
EA004746B1 (ru) * 1999-06-28 2004-08-26 Янссен Фармацевтика Н.В. Производные бензимидазола и имидазопиридина в качестве ингибиторов репликации респираторно-синцитиального вируса
EP1196409B1 (en) * 1999-06-28 2004-02-04 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
US20040157866A1 (en) * 2001-04-30 2004-08-12 Hisashi Takasugi Amide compounds
US7030150B2 (en) * 2001-05-11 2006-04-18 Trimeris, Inc. Benzimidazole compounds and antiviral uses thereof
FR2833948B1 (fr) * 2001-12-21 2004-02-06 Sod Conseils Rech Applic Nouveaux derives de benzimidazole et leur utilisation en tant que medicament

Also Published As

Publication number Publication date
CA2548793A1 (en) 2005-06-30
AU2004298459B2 (en) 2011-03-17
EP1697347A1 (en) 2006-09-06
ATE499361T1 (de) 2011-03-15
RU2369606C2 (ru) 2009-10-10
CN1914196B (zh) 2012-01-25
EP1697347B1 (en) 2011-02-23
US8278455B2 (en) 2012-10-02
KR101123055B1 (ko) 2012-04-12
WO2005058874A1 (en) 2005-06-30
HRP20110313T1 (hr) 2011-05-31
AU2004298459A1 (en) 2005-06-30
CN1914196A (zh) 2007-02-14
DE602004031555D1 (de) 2011-04-07
TWI382981B (zh) 2013-01-21
SI1697347T1 (sl) 2011-06-30
RU2006125727A (ru) 2008-01-27
MY142783A (en) 2010-12-31
JP2007514719A (ja) 2007-06-07
US20090062278A1 (en) 2009-03-05
US20070093502A1 (en) 2007-04-26
TW200531970A (en) 2005-10-01
DK1697347T3 (da) 2011-06-06
MXPA06007111A (es) 2006-08-23
KR20060127047A (ko) 2006-12-11
BRPI0417273A (pt) 2007-03-27

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