AR046771A1 - Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio - Google Patents
Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorioInfo
- Publication number
- AR046771A1 AR046771A1 ARP040104809A ARP040104809A AR046771A1 AR 046771 A1 AR046771 A1 AR 046771A1 AR P040104809 A ARP040104809 A AR P040104809A AR P040104809 A ARP040104809 A AR P040104809A AR 046771 A1 AR046771 A1 AR 046771A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- hydrogen
- phenyl
- mono
- optionally substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a piperidina-amino-bencimidazoles que tienen actividad inhibidora sobre la replicación sobre el virus sincitial respiratorio y que tienen la formula (1) sus profármacos, N-óxidos, sales de adición, aminas cuaternarias, complejos metálicos y formas estereoquímicamente isoméricas donde Q es alquilo C1-6 opcionalmente sustituido con uno o mas sustituyentes cada uno independientemente seleccionados del grupo que consiste en trifluormetilo, cicloalquilo C3-7, Ar2, hidroxi, alcoxi C1-4, alquiltio C1-4, Ar2-oxi-, Ar2-tio-, Ar2(CH2)noxi, Ar2(CH2)ntio, hidroxicarbonilo, aminocarbonilo, alquilcarbonilo C1-4, Ar2carbonilo, alcoxicarbonilo C1-4, Ar2(CH2)ncarbonilo, aminocarboniloxi, alquilcarboniloxi C1-4, Ar2carboniloxi, Ar2(CH2)ncarboniloxi, alcoxicarbonilo C1-4(CH2)noxi, mono- o di(alquilo C1-4)aminocarbonilo, mono- o di(alquilo C1-4)aminocarboniloxi, aminosulfonio, mono- o di(alquilo C1-4)aminosulfonilo o un heterociclo seleccionado del grupo que consiste en pirrolidinilo, pirrolilo, dihidropirrolilo, imidazolilo, triazolilo, piperidinilo, homopiperidinilo, piperazinilo, morfolinilo, tiomorfolinilo, 1-oxo-tiomorfolinilo, 1,1-dioxotiomorfolinilo, piridilo, y tetrahidropiridilo, donde cada uno de dichos heterociclos puede estar opcionalmente sustituido con oxo o alquilo C1-6; G es un enlace directo o un alcanodiilo C1-10 opcionalmente sustituido; R1 es Ar1 o un heterociclo monocíclico o bicíclico; uno de R2a y R3a es alquilo C1-6 y el otro de R2a y R3a es hidrógeno; en el caso en el que R2a es diferente de hidrógeno, entonces R2b es hidrógeno o alquilo C1-6, y R3b es hidrógeno; en el caso en el que R3a es diferente de hidrógeno, entonces R3b es hidrógeno o alquilo C1-6, y R2b es hidrógeno; t es 1, 2 ó 3; Ar1 es fenilo o fenilo sustituido; y Ar2 es fenilo o fenilo sustituido. Además se refiere a la preparación y a las composiciones que los comprenden así como también a su uso como medicamento.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP03104802 | 2003-12-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR046771A1 true AR046771A1 (es) | 2005-12-21 |
Family
ID=34924150
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP040104809A AR046771A1 (es) | 2003-12-18 | 2004-12-20 | Derivados piperidina-amino-bencimidazol como inhibidores de la replicacion del virus sincitial respiratorio |
Country Status (17)
Country | Link |
---|---|
US (2) | US7355051B2 (es) |
EP (1) | EP1723136B1 (es) |
JP (1) | JP2007514715A (es) |
KR (1) | KR101074334B1 (es) |
CN (2) | CN1894239A (es) |
AR (1) | AR046771A1 (es) |
AT (1) | ATE501135T1 (es) |
AU (1) | AU2004298456B2 (es) |
BR (1) | BRPI0417668A (es) |
CA (1) | CA2548654C (es) |
DE (1) | DE602004031776D1 (es) |
DK (1) | DK1723136T3 (es) |
HR (1) | HRP20110428T1 (es) |
MX (1) | MXPA06007109A (es) |
RU (1) | RU2381224C2 (es) |
TW (1) | TWI349007B (es) |
WO (1) | WO2005058873A1 (es) |
Families Citing this family (49)
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HU230382B1 (hu) * | 2001-02-24 | 2016-03-29 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xantinszármazékok, előállításuk és alkalmazásuk gyógyszerként |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7495005B2 (en) * | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10254304A1 (de) * | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
US7566707B2 (en) * | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10355304A1 (de) | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
US7501426B2 (en) * | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
DE102004009039A1 (de) * | 2004-02-23 | 2005-09-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und Verwendung als Arzneimittel |
US7393847B2 (en) * | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
US7179809B2 (en) * | 2004-04-10 | 2007-02-20 | Boehringer Ingelheim International Gmbh | 2-Amino-imidazo[4,5-d]pyridazin-4-ones, their preparation and their use as pharmaceutical compositions |
US7439370B2 (en) | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
DE102004030502A1 (de) * | 2004-06-24 | 2006-01-12 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Imidazole und Triazole, deren Herstellung und Verwendung als Arzneimittel |
DE102004043944A1 (de) * | 2004-09-11 | 2006-03-30 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(3-Amino-piperidin-1-yl)-7-(but-2-inyl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004044221A1 (de) * | 2004-09-14 | 2006-03-16 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 3-Methyl-7-butinyl-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE102004054054A1 (de) * | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
TWI370820B (en) | 2005-04-27 | 2012-08-21 | Takeda Pharmaceutical | Fused heterocyclic compounds |
DE102005035891A1 (de) * | 2005-07-30 | 2007-02-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
NZ619413A (en) | 2006-05-04 | 2015-08-28 | Boehringer Ingelheim Int | Polymorphs of a dpp-iv enzyme inhibitor |
PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
WO2008017670A1 (en) | 2006-08-08 | 2008-02-14 | Boehringer Ingelheim International Gmbh | Pyrrolo [3, 2 -d] pyrimidines as dpp-iv inhibitors for the treatment of diabetes mellitus |
AR071175A1 (es) | 2008-04-03 | 2010-06-02 | Boehringer Ingelheim Int | Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante |
UY32030A (es) | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
KR20190016601A (ko) | 2008-08-06 | 2019-02-18 | 베링거 인겔하임 인터내셔날 게엠베하 | 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료 |
RU2011113823A (ru) | 2008-09-10 | 2012-10-20 | БЕРИНГЕР ИНГЕЛЬХАЙМ ИНТЕРНАЦИОНАЛЬ ГмбХ (DE) | Комбинированная терапия, предназначенная для лечения диабета и связанных с ним состояний |
US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
JP2012512848A (ja) | 2008-12-23 | 2012-06-07 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 有機化合物の塩の形態 |
AR074990A1 (es) | 2009-01-07 | 2011-03-02 | Boehringer Ingelheim Int | Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina |
WO2011016576A1 (en) | 2009-08-04 | 2011-02-10 | Takeda Pharmaceutical Company Limited | Alanine derivatives as inhibitors of apoptosis proteins |
JP2013512229A (ja) | 2009-11-27 | 2013-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 遺伝子型が同定された糖尿病患者のリナグリプチン等のddp−iv阻害薬による治療 |
BR112012028136A2 (pt) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | terapia de combinaçao |
EP3725325B1 (en) | 2010-06-24 | 2023-05-31 | Boehringer Ingelheim International GmbH | Diabetes therapy |
US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
WO2012174312A2 (en) * | 2011-06-15 | 2012-12-20 | Glaxosmithkline Llc | Benzimidazole derivatives as antiviral agents |
CN103781788B (zh) | 2011-07-15 | 2016-08-17 | 勃林格殷格翰国际有限公司 | 经取代的喹唑啉、其制备及其在药物组合物中的用途 |
US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
EP3685839A1 (en) | 2012-05-14 | 2020-07-29 | Boehringer Ingelheim International GmbH | Linagliptin for use in the treatment of albuminuria and kidney related diseases |
WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
EP3110449B1 (en) | 2014-02-28 | 2023-06-28 | Boehringer Ingelheim International GmbH | Medical use of a dpp-4 inhibitor |
MA41614A (fr) * | 2015-02-25 | 2018-01-02 | Alios Biopharma Inc | Composés antiviraux |
MX2018015089A (es) | 2016-06-10 | 2019-05-13 | Boehringer Ingelheim Int | Combinacion de linagliptina y metformina. |
TW201825465A (zh) | 2016-09-23 | 2018-07-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201815787A (zh) | 2016-09-23 | 2018-05-01 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
TW201813963A (zh) | 2016-09-23 | 2018-04-16 | 美商基利科學股份有限公司 | 磷脂醯肌醇3-激酶抑制劑 |
KR102296703B1 (ko) | 2017-03-20 | 2021-09-01 | 포르마 세라퓨틱스 인크. | 피루베이트 키나제 (pkr) 활성화제로서의 피롤로피롤 조성물 |
BR112021005188A2 (pt) | 2018-09-19 | 2021-06-08 | Forma Therapeutics, Inc. | tratamento de anemia falciforme com um composto de ativação de piruvato cinase r |
US20230055923A1 (en) | 2018-09-19 | 2023-02-23 | Forma Therapeutics, Inc. | Activating pyruvate kinase r |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4219559A (en) * | 1979-01-10 | 1980-08-26 | Janssen Pharmaceutica N.V. | N-Heterocyclyl-4-piperidinamines |
CA1140119A (en) * | 1978-04-03 | 1983-01-25 | Joseph Torremans | N-heterocyclyl-4-piperidinamines |
US4556660A (en) | 1982-07-12 | 1985-12-03 | Janssen Pharmaceutica N.V. | N-(Bicyclic heterocyclyl)-4-piperidinamines |
US4634704A (en) | 1983-10-06 | 1987-01-06 | Janssen Pharmaceutica, N.V. | Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines |
KR100190299B1 (ko) | 1990-07-19 | 1999-06-01 | 디르크 반테 | 신규한 옥사졸릴 유도체 |
CA2376785A1 (en) * | 1999-06-28 | 2001-01-04 | Janssen Pharmaceutica N.V. | Benzimidazoles and imidazopyridines as respiratory syncytial virus replication inhibitors |
SK18942001A3 (sk) | 1999-06-28 | 2002-10-08 | Janssen Pharmaceutica N. V. | Inhibítory replikácie respiračného syncytiálneho vírusu |
UA74787C2 (en) * | 1999-06-28 | 2006-02-15 | Janssen Pharmaceutica Nv | Respiratory syncytial virus replication inhibitors |
-
2004
- 2004-12-20 DK DK04804942.3T patent/DK1723136T3/da active
- 2004-12-20 MX MXPA06007109A patent/MXPA06007109A/es active IP Right Grant
- 2004-12-20 CN CNA2004800372846A patent/CN1894239A/zh active Pending
- 2004-12-20 TW TW093139922A patent/TWI349007B/zh not_active IP Right Cessation
- 2004-12-20 BR BRPI0417668-5A patent/BRPI0417668A/pt not_active IP Right Cessation
- 2004-12-20 AT AT04804942T patent/ATE501135T1/de not_active IP Right Cessation
- 2004-12-20 US US10/596,519 patent/US7355051B2/en active Active
- 2004-12-20 DE DE602004031776T patent/DE602004031776D1/de active Active
- 2004-12-20 AR ARP040104809A patent/AR046771A1/es not_active Application Discontinuation
- 2004-12-20 WO PCT/EP2004/053606 patent/WO2005058873A1/en active Application Filing
- 2004-12-20 CN CN201310195044XA patent/CN103450159A/zh active Pending
- 2004-12-20 JP JP2006544461A patent/JP2007514715A/ja not_active Withdrawn
- 2004-12-20 AU AU2004298456A patent/AU2004298456B2/en not_active Ceased
- 2004-12-20 CA CA2548654A patent/CA2548654C/en not_active Expired - Fee Related
- 2004-12-20 EP EP04804942A patent/EP1723136B1/en active Active
- 2004-12-20 RU RU2006125720/04A patent/RU2381224C2/ru not_active IP Right Cessation
-
2006
- 2006-06-30 KR KR1020067013313A patent/KR101074334B1/ko not_active IP Right Cessation
-
2008
- 2008-02-13 US US12/030,483 patent/US20080146613A1/en not_active Abandoned
-
2011
- 2011-06-08 HR HR20110428T patent/HRP20110428T1/hr unknown
Also Published As
Publication number | Publication date |
---|---|
US7355051B2 (en) | 2008-04-08 |
AU2004298456A1 (en) | 2005-06-30 |
MXPA06007109A (es) | 2006-08-23 |
HRP20110428T1 (hr) | 2011-08-31 |
DK1723136T3 (da) | 2011-06-27 |
JP2007514715A (ja) | 2007-06-07 |
BRPI0417668A (pt) | 2007-04-03 |
TW200533669A (en) | 2005-10-16 |
EP1723136A1 (en) | 2006-11-22 |
EP1723136B1 (en) | 2011-03-09 |
TWI349007B (en) | 2011-09-21 |
CN103450159A (zh) | 2013-12-18 |
RU2381224C2 (ru) | 2010-02-10 |
WO2005058873A1 (en) | 2005-06-30 |
KR101074334B1 (ko) | 2011-10-17 |
DE602004031776D1 (de) | 2011-04-21 |
RU2006125720A (ru) | 2008-01-27 |
CN1894239A (zh) | 2007-01-10 |
US20080146613A1 (en) | 2008-06-19 |
ATE501135T1 (de) | 2011-03-15 |
AU2004298456B2 (en) | 2011-04-07 |
CA2548654A1 (en) | 2005-06-30 |
CA2548654C (en) | 2012-08-07 |
US20070093659A1 (en) | 2007-04-26 |
KR20060117985A (ko) | 2006-11-17 |
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