IT7927284A0 - 5- (2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione. - Google Patents

5- (2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione.

Info

Publication number
IT7927284A0
IT7927284A0 IT7927284A IT2728479A IT7927284A0 IT 7927284 A0 IT7927284 A0 IT 7927284A0 IT 7927284 A IT7927284 A IT 7927284A IT 2728479 A IT2728479 A IT 2728479A IT 7927284 A0 IT7927284 A0 IT 7927284A0
Authority
IT
Italy
Prior art keywords
imidazolin
preparation
substituted aminopyrimidines
aminopyrimidines
substituted
Prior art date
Application number
IT7927284A
Other languages
English (en)
Other versions
IT1127225B (it
Inventor
Stenzel Wolfgang
Cohnen Erich
Fleck Wolfgang
Armah Ben
Original Assignee
Beiersdorf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2849537A external-priority patent/DE2849537C2/de
Priority claimed from DE19792937023 external-priority patent/DE2937023A1/de
Application filed by Beiersdorf Ag filed Critical Beiersdorf Ag
Publication of IT7927284A0 publication Critical patent/IT7927284A0/it
Application granted granted Critical
Publication of IT1127225B publication Critical patent/IT1127225B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
IT27284/79A 1978-11-15 1979-11-14 5-(2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione IT1127225B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2849537A DE2849537C2 (de) 1978-11-15 1978-11-15 Substituierte 5-(2-Imidazolin-2-yl)-aminopyrimidine, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel
DE19792937023 DE2937023A1 (de) 1979-09-13 1979-09-13 Neue substituierte 5-(2-imidazolin-2-yl)-aminopyrimidine und verfahren zu deren herstellung

Publications (2)

Publication Number Publication Date
IT7927284A0 true IT7927284A0 (it) 1979-11-14
IT1127225B IT1127225B (it) 1986-05-21

Family

ID=25776489

Family Applications (1)

Application Number Title Priority Date Filing Date
IT27284/79A IT1127225B (it) 1978-11-15 1979-11-14 5-(2-imidazolin-2-il)-aminopirimidine sostituite e processo per la loro preparazione

Country Status (12)

Country Link
US (1) US4323570A (it)
AT (1) AT374197B (it)
AU (1) AU541305B1 (it)
CA (1) CA1138454A (it)
CH (1) CH642965A5 (it)
DK (1) DK150142C (it)
ES (1) ES486349A1 (it)
FR (1) FR2441625A1 (it)
GB (1) GB2039275B (it)
IT (1) IT1127225B (it)
NL (2) NL190553C (it)
SE (1) SE440079B (it)

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EP0139477A3 (en) * 1983-09-23 1985-11-21 Eli Lilly And Company Process for preparing 5-substituted pyrimidines
DE3729299A1 (de) * 1987-09-02 1989-03-23 Beiersdorf Ag Transdermales therapeutisches system
DE3739779A1 (de) * 1987-11-24 1989-06-08 Beiersdorf Ag Pharmazeutische praeparate
DE3904795C2 (de) * 1989-02-17 2000-10-12 Lilly Pharma Produktion Gmbh & Pharmazeutisches Präparat und dessen Verwendung
US5972948A (en) * 1994-07-01 1999-10-26 Solvay Pharmaceuticals Gmbh Method of inhibiting hyperglycemia and pharmaceutical composition for use therein
DE4423177A1 (de) * 1994-07-01 1996-01-04 Kali Chemie Pharma Gmbh Antihyperglykämisch wirksame Arzneimittel
CA2212294A1 (en) * 1995-02-28 1996-09-06 Beiersdorf-Lilly Gmbh Use of moxonidine for the treatment of atherosclerosis
DE19514579A1 (de) * 1995-04-20 1996-10-24 Boehringer Ingelheim Kg Verwendung von alpha¶1¶¶L¶-Agonisten zur Behandlung der Harninkontinenz
US5658903A (en) * 1995-06-07 1997-08-19 Smithkline Beecham Corporation Imidazole compounds, compositions and use
CA2182851A1 (en) * 1995-08-15 1997-02-16 August Masaru Watanabe Method for treating substance abuse withdrawal
WO1997046241A1 (en) * 1996-06-06 1997-12-11 Eli Lilly And Company Formulation and method for treating congestive heart failure
NO980546L (no) * 1997-02-11 1998-08-12 Lilly Co Eli Farmas°ytiske midler
DE19722322A1 (de) * 1997-05-28 1998-12-03 Solvay Pharm Gmbh Nephroprotektives Arzneimittel
CA2269971A1 (en) * 1997-09-03 1999-03-11 Trent Lee Abraham Pyrimidine derivatives
DE19911371A1 (de) 1999-03-15 2000-09-21 Solvay Pharm Gmbh Arzneimittel zur Behandlung von funktionellen Störungen und Erkrankungen der unteren Darmwege, insbesondere von damit einhergehenden abdominalen visceralen Schmerzen
PL372695A1 (en) * 2002-06-19 2005-07-25 Solvay Pharmaceuticals Gmbh Medicament for the treatment of diseases requiring inhibition or a reduction in the activity of ph value-regulating bicarbonate transporter proteins
JP2009524619A (ja) * 2006-01-27 2009-07-02 エフ．ホフマン−ラ ロシュ アーゲー Ｃｎｓ障害の処置のための２−イミダゾールの使用
DK1873152T3 (da) * 2006-06-26 2009-02-09 Chemagis Ltd Hidtil ukendt fremgangsmåde til oprensning af Moxonidin
EP1894926A1 (en) * 2006-06-26 2008-03-05 Chemagis Ltd. Polymorphs of moxonidine and processes for preparation therefor
EP1982983B1 (en) 2006-06-26 2011-08-17 Chemagis Ltd. Improved process for producing moxonidine
EP2054391A4 (en) * 2006-08-17 2009-08-26 Chemagis Ltd A SINGLE TAUTOMER-CONTAINING CRYSTALLINE MOXONIDINE AND METHOD FOR THE PRODUCTION THEREOF
EP1894927B1 (en) * 2006-08-31 2010-11-10 Chemagis Ltd. The use of moxonidine salts for purification of moxonidine
MX2009003887A (es) * 2006-10-19 2009-04-22 Hoffmann La Roche Aminometil-2-imidazoles con afinidad con los receptores asociados a trazas de amina.
CN101528710B (zh) * 2006-10-19 2012-11-07 弗·哈夫曼-拉罗切有限公司 氨基甲基-4-咪唑类
WO2008052907A1 (en) * 2006-11-02 2008-05-08 F. Hoffmann-La Roche Ag Substituted 2-imidazoles as modulators of the trace amine associated receptors
JP2010510184A (ja) * 2006-11-16 2010-04-02 エフ．ホフマン−ラ ロシュ アーゲー 置換４−イミダゾール類
WO2008073125A1 (en) * 2006-12-12 2008-06-19 Chemagis Ltd. Moxonidine analogs, preparation processes and uses therefor
CN101557810B (zh) * 2006-12-13 2012-11-21 弗·哈夫曼-拉罗切有限公司 作为痕量胺相关受体（taar）的配体的新的2-咪唑类
US20080146523A1 (en) 2006-12-18 2008-06-19 Guido Galley Imidazole derivatives
KR101174191B1 (ko) * 2007-02-02 2012-08-14 에프. 호프만-라 로슈 아게 중추 신경계 장애의 치료용 ｔａａｒ1 리간드로서 2-아미노옥사졸린
WO2008098857A1 (en) * 2007-02-15 2008-08-21 F. Hoffmann-La Roche Ag 2-aminooxazolines as taar1 ligands
EP2173720A2 (en) 2007-07-02 2010-04-14 F. Hoffmann-Roche AG 2-imidazolines having a good affinity to the trace amine associated receptors (taars)
CA2691704A1 (en) * 2007-07-03 2009-01-08 F. Hoffmann-La Roche Ag 4-imidazolines and their use as antidepressants
KR101133862B1 (ko) * 2007-07-27 2012-04-06 에프. 호프만-라 로슈 아게 Ｔａａｒ 리간드로서의 2-아제티딘메테인아민 및 2-피롤리딘메테인아민
CN101765425A (zh) * 2007-08-02 2010-06-30 弗·哈夫曼-拉罗切有限公司 苯甲酰胺衍生物用于治疗cns障碍的用途
WO2009019149A1 (en) * 2007-08-03 2009-02-12 F. Hoffmann-La Roche Ag Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US8242153B2 (en) * 2008-07-24 2012-08-14 Hoffmann-La Roche Inc. 4,5-dihydro-oxazol-2YL derivatives
CA2728480A1 (en) * 2008-07-24 2010-01-28 F. Hoffmann-La Roche Ag 4,5-dihydro-oxazol-2-yl derivatives
US20100311798A1 (en) * 2009-06-05 2010-12-09 Decoret Guillaume 2-aminooxazolines as taar1 ligands
US8354441B2 (en) * 2009-11-11 2013-01-15 Hoffmann-La Roche Inc. Oxazoline derivatives
US9452980B2 (en) 2009-12-22 2016-09-27 Hoffmann-La Roche Inc. Substituted benzamides
EP2586779A1 (en) 2011-10-24 2013-05-01 Hetero Research Foundation Process for the preparation of moxonidine
DE102012215896A1 (de) * 2012-09-07 2014-03-13 Wörwag Pharma GmbH & Co.KG Moxonidinsynthese mit Hilfe organischer Basen
ES2608004T3 (es) 2012-12-03 2017-04-05 WÖRWAG PHARMA GmbH & Co. KG Método mediante catálisis por transferencia de fase
EP2765131B1 (en) 2013-02-08 2016-11-23 Arevipharma GmbH Process for the production of Moxonidine
EP2970214A1 (en) * 2013-03-14 2016-01-20 Farmak, A.S. Improved process for the manufacture of moxonidine
EP2829540A1 (en) 2013-07-26 2015-01-28 Abbott Healthcare Products B.V. Synthesis of substituted aminopyridines
MX2016001714A (es) 2013-08-09 2016-10-03 Ardelyx Inc Compuestos y metodos para inhibir el transporte de fosfato.
WO2017157873A1 (en) 2016-03-17 2017-09-21 F. Hoffmann-La Roche Ag 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of taar
US20240002369A1 (en) 2020-11-12 2024-01-04 3Z Ehf Novel treatments of attention deficit/hyperactivity disorder

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754832A (fr) 1969-08-14 1971-02-15 Beecham Group Ltd Iminazolines
GB1319840A (en) * 1970-08-27 1973-06-13 Beecham Group Ltd Substituted 5-amino imidazoles
BE795636A (fr) * 1972-02-19 1973-08-20 Schering Ag Nitroimidazolylpyrimidines, et leur procede de preparation
US4029792A (en) * 1972-02-29 1977-06-14 Pfizer Inc. (2-Imidazolin-2-ylamino) substituted -quinoxalines and -quinazolines as antihypertensive agents
DE2220906A1 (de) * 1972-04-28 1973-11-15 Boehringer Sohn Ingelheim Neue substituierte 2-phenylaminoimidazoline-(2), deren saeureadditionssalze sowie verfahren zu deren herstellung
BE503170A (it) * 1975-09-02

Also Published As

Publication number Publication date
AT374197B (de) 1984-03-26
SE440079B (sv) 1985-07-15
US4323570A (en) 1982-04-06
NL940011I1 (nl) 1994-08-01
FR2441625B1 (it) 1981-12-31
FR2441625A1 (fr) 1980-06-13
ATA727079A (de) 1983-08-15
CH642965A5 (de) 1984-05-15
NL190553C (nl) 1994-04-18
SE7909392L (sv) 1980-05-16
DK150142B (da) 1986-12-15
DK150142C (da) 1987-06-01
NL7908192A (nl) 1980-05-19
AU541305B1 (en) 1985-01-03
GB2039275B (en) 1982-11-17
IT1127225B (it) 1986-05-21
NL190553B (nl) 1993-11-16
ES486349A1 (es) 1980-06-16
GB2039275A (en) 1980-08-06
NL940011I2 (nl) 1998-05-06
DK481879A (da) 1980-05-16
CA1138454A (en) 1982-12-28

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Legal Events

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971126