ES2115303T3 - Uso de compuestos de 5-tia-1,4-diazabiciclo(4.2.0)octan-3,8-dioxo en terapia antitumoral. - Google Patents

Uso de compuestos de 5-tia-1,4-diazabiciclo(4.2.0)octan-3,8-dioxo en terapia antitumoral.

Info

Publication number
ES2115303T3
ES2115303T3 ES95114673T ES95114673T ES2115303T3 ES 2115303 T3 ES2115303 T3 ES 2115303T3 ES 95114673 T ES95114673 T ES 95114673T ES 95114673 T ES95114673 T ES 95114673T ES 2115303 T3 ES2115303 T3 ES 2115303T3
Authority
ES
Spain
Prior art keywords
hydrogen
diazabiciclo
octan
tia
dioxo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95114673T
Other languages
English (en)
Inventor
Mice D Sc Kovacevic
Mira D Sc Grdisa
Kresimir D Sc Pavelic
Marjeta M Sc Horvatic
Zora M Sc Mandic
Mirjana M Sc Tomic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pliva Farmaceutika dd
Original Assignee
Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd filed Critical Pliva Farmaceutska Kemijska Prehrambena I Kozmeticka Industrija dd
Application granted granted Critical
Publication of ES2115303T3 publication Critical patent/ES2115303T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/549—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame having two or more nitrogen atoms in the same ring, e.g. hydrochlorothiazide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A USO DE 5-TIA-1,4-DIAZABICICLO [4.2.0]OCTANO-3,8-DIOXO DE LA FORMULA GENERAL (I) DONDE LOS RADICALES POSEEN LOS SIGUIENTES SIGNIFICADOS: R1 ES HIDROGENO, HALOGENO R2- ES HIDROGENO, HALOGENO, AMINO, PHCH2-CONH, PHOCH2-CONH, EFTALIMIDO, O-MENH-COC6-H4-CONH, 3-OCLOROFENIL-5-METIL-ISOXAZOLIL-4-CARBONIL AMINO, R3 ES HIDROGENO, ALQUILO, BENCIL, ANILLO HETEROCICLICO POR EJEMPLO ISOXAZOL, PIRAZOL, N ES 1 O 2. EN LA APLICACION , SE MUESTRAN EJEMPLOS DE LA SUPRESION ED CELULAS DE CALCINOMA DEL CERVIX DEL UTERO (HELA) MEDIANTE EL USO DE VARIOS DERIVADOS DE 5-TIA-1,4-DIAZABICICLO [4.2.0]OCATNO-3,8DIOXO.
ES95114673T 1994-09-21 1995-09-18 Uso de compuestos de 5-tia-1,4-diazabiciclo(4.2.0)octan-3,8-dioxo en terapia antitumoral. Expired - Lifetime ES2115303T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HR940577A HRP940577B1 (en) 1994-09-21 1994-09-21 Use of 5-thia-1,4-diazabicyclo (4.2.0) octane-3,8-dioxo compounds in antitumor therapy

Publications (1)

Publication Number Publication Date
ES2115303T3 true ES2115303T3 (es) 1998-06-16

Family

ID=10946157

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95114673T Expired - Lifetime ES2115303T3 (es) 1994-09-21 1995-09-18 Uso de compuestos de 5-tia-1,4-diazabiciclo(4.2.0)octan-3,8-dioxo en terapia antitumoral.

Country Status (14)

Country Link
EP (1) EP0705606B1 (es)
JP (1) JPH08310954A (es)
CN (1) CN1127115A (es)
AT (1) ATE164069T1 (es)
BG (1) BG62237B1 (es)
CA (1) CA2158678C (es)
CZ (1) CZ285621B6 (es)
DE (1) DE69501810T2 (es)
ES (1) ES2115303T3 (es)
HR (1) HRP940577B1 (es)
HU (1) HU218287B (es)
RU (1) RU2136284C1 (es)
SI (1) SI9500297A (es)
SK (1) SK280815B6 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101671336B (zh) * 2009-09-23 2013-11-13 辽宁利锋科技开发有限公司 芳杂环并嘧啶衍生物和类似物及其制备方法和用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5598188A (en) * 1979-01-23 1980-07-25 Mitsui Toatsu Chem Inc Novel cephalosporin and its preparation
JPS57171994A (en) * 1981-04-15 1982-10-22 Asahi Chem Ind Co Ltd Novel compound
HRP921292A2 (en) 1992-11-17 1994-08-31 Pliva Pharm & Chem Works 5-thia-1,4-diazabicyclo (4.2.0.)octane -3,8-dioxo analogs of beta-lactams, the process for the preparation and use thereof

Also Published As

Publication number Publication date
HU9502770D0 (en) 1995-11-28
EP0705606B1 (en) 1998-03-18
JPH08310954A (ja) 1996-11-26
DE69501810T2 (de) 1998-09-24
RU2136284C1 (ru) 1999-09-10
CN1127115A (zh) 1996-07-24
HRP940577B1 (en) 1998-12-31
HUT74422A (en) 1996-12-30
CZ285621B6 (cs) 1999-10-13
BG100020A (bg) 1996-04-30
HU218287B (en) 2000-07-28
SK117095A3 (en) 1996-09-04
CA2158678A1 (en) 1996-03-22
DE69501810D1 (de) 1998-04-23
BG62237B1 (bg) 1999-06-30
CZ244795A3 (en) 1996-04-17
CA2158678C (en) 2000-04-18
EP0705606A1 (en) 1996-04-10
HRP940577A2 (en) 1997-04-30
SK280815B6 (sk) 2000-08-14
ATE164069T1 (de) 1998-04-15
SI9500297A (en) 1996-04-30

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