ATA20485A - Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten - Google Patents

Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten

Info

Publication number
ATA20485A
ATA20485A AT204/85A AT20485A ATA20485A AT A20485 A ATA20485 A AT A20485A AT 204/85 A AT204/85 A AT 204/85A AT 20485 A AT20485 A AT 20485A AT A20485 A ATA20485 A AT A20485A
Authority
AT
Austria
Prior art keywords
tetrahydrocarbazol
derivatives
producing new
producing
new
Prior art date
Application number
AT204/85A
Other languages
English (en)
Other versions
AT392276B (de
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ATA20485A publication Critical patent/ATA20485A/de
Application granted granted Critical
Publication of AT392276B publication Critical patent/AT392276B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT204/85A 1984-01-25 1985-01-25 Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten AT392276B (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
ATA20485A true ATA20485A (de) 1990-08-15
AT392276B AT392276B (de) 1991-02-25

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
AT204/85A AT392276B (de) 1984-01-25 1985-01-25 Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten

Country Status (29)

Country Link
KR (1) KR920003064B1 (de)
AT (1) AT392276B (de)
AU (1) AU579132B2 (de)
BE (1) BE901576A (de)
CA (1) CA1252793A (de)
CH (1) CH664152A5 (de)
CY (1) CY1479A (de)
CZ (1) CZ404391A3 (de)
DE (2) DE19375046I2 (de)
DK (1) DK169521B1 (de)
ES (3) ES8609309A1 (de)
FI (1) FI84349C (de)
FR (1) FR2561244B1 (de)
GB (1) GB2153821B (de)
GR (1) GR850219B (de)
HK (1) HK33189A (de)
HU (1) HU193592B (de)
IE (1) IE57809B1 (de)
IL (1) IL74165A (de)
IT (1) IT1182150B (de)
LU (2) LU88268I2 (de)
NL (2) NL190373C (de)
NO (2) NO164025C (de)
NZ (1) NZ210940A (de)
PH (1) PH22672A (de)
PT (1) PT79890B (de)
SE (1) SE460359B (de)
SG (1) SG7089G (de)
SK (1) SK404391A3 (de)

Families Citing this family (80)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.
EP0201165B1 (de) * 1985-03-14 1994-07-20 Beecham Group Plc Arzneimittel zur Behandlung von Emesis
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
NL8701682A (nl) * 1986-07-30 1988-02-16 Sandoz Ag Werkwijze voor het therapeutisch toepassen van serotonine antagonisten, aktieve verbindingen en farmaceutische preparaten die deze verbindingen bevatten.
AT396870B (de) * 1986-08-07 1993-12-27 Sandoz Ag Verfahren zur herstellung einer galenischen formulierung zur nasalen verabreichung von serotoninantagonisten
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
EP0279114B2 (de) * 1986-11-21 1995-08-23 Glaxo Group Limited Arzneimittel zur Behandlung oder Vorbeugung des Entzugssyndromes
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
DE3788057T2 (de) * 1986-12-17 1994-03-03 Glaxo Group Ltd Verwendung von heterocyclischen Verbindungen zur Behandlung von Depressionen.
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
IE60991B1 (en) * 1986-12-17 1994-09-07 Glaxo Group Ltd Use of ketone derivatives in the treatment of cognitive disorders
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
DE3876006T2 (de) * 1987-04-14 1993-03-25 Glaxo Group Ltd Keton-derivate.
DE3874229T2 (de) * 1987-06-16 1993-03-25 British Tech Group Verwendung von dioxopiperidin-derivaten zur herstellung eines topischen praeparates als analgetika.
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
JPH01258673A (ja) * 1987-10-22 1989-10-16 Glaxo Group Ltd ケトン誘導体
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (ja) * 1988-04-07 1990-02-20 Glaxo Group Ltd イミダゾール誘導体
DK185489A (da) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaaindoloner, deres fremstilling og anvendelse
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
FR2639944B1 (fr) * 1988-12-06 1991-01-18 Adir Nouveaux derives de l'indole, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0377238A1 (de) * 1988-12-22 1990-07-11 Duphar International Research B.V Annelierte Indolo(3,2-c)-lactame
EP0392663A1 (de) * 1989-03-13 1990-10-17 Ono Pharmaceutical Co., Ltd. Ein Carbolin-Derivat als 5-HT3-Rezeptor-Antagonist
DK0422154T3 (da) * 1989-04-21 1994-03-07 Sandoz Ag Terapeutisk anvendelse af 5-HT3-receptorantagonister
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
CA2112487C (en) * 1991-06-26 2003-04-15 James W. Young Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (ja) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp シンノリン−３−カルボン酸誘導体
ES2043535B1 (es) * 1992-03-13 1994-08-01 Vita Invest Sa Procedimiento para la obtencion de la 1,2,3,9-tetrahidro-9-metil-3-(2-metil-1h-imidazol-1-il)metil*-4h-carbazol-4-ona.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2157671A1 (en) * 1993-03-08 1994-09-15 Kiyotaka Katsuta Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325409B (en) * 1994-06-28 1999-02-10 Kenneth Francis Prendergast Pharmaceutical use of ondansetron/cyclodextrin complexes
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (de) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Verfahren zur Herstellung von 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
RU2207340C2 (ru) * 2001-08-10 2003-06-27 Ципла Лтд. Способ получения 1,2,3,9-тетрагидро-9-метил-3-[(2-метил-1н-имидазол-1-ил)метил]-4н-карбазол -4-она или его фармацевтически приемлемых солей
CN1665823A (zh) 2002-04-29 2005-09-07 特瓦药厂有限公司 制备1,2,3,9－四氢－9－甲基－3－[(2－甲基－1h－咪唑－1－基)甲基]－4h－咔唑－4－酮的方法
FI6164U1 (fi) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronmuotoja
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (es) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. Nuevas formas polimorficas de ondansetron, procedimientos para su preparacion, composiciones farmaceuticas que los contienen y su uso como aantiemeticos.
CA2565854A1 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
US20090170872A1 (en) * 2005-07-05 2009-07-02 Orchid Research Laboratories Limited Compounds and Their Pharmaceutical Use
EP2253316B1 (de) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin-5-HT3-Rezeptorantagonisten zur Verwendung bei der Behandlung oder Prävention einer Innenohr-Pathologie mit Vestibularisdefiziten
WO2010133663A1 (en) 2009-05-20 2010-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
CN115611864A (zh) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 一种昂丹司琼类化合物及其制备方法与应用
GB202301322D0 (en) 2023-01-30 2023-03-15 Therakind Ltd Antiemetic pharmaceutical compositions for nasal delivery

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Also Published As

Publication number Publication date
CZ404391A3 (en) 1993-04-14
NL190373C (nl) 1994-02-01
BE901576A (fr) 1985-07-25
FI84349B (fi) 1991-08-15
DK35785A (da) 1985-07-26
ES8609309A1 (es) 1986-07-16
SK277923B6 (en) 1995-08-09
NO164025C (no) 1990-08-22
NL190373B (nl) 1993-09-01
ES8801247A1 (es) 1987-12-16
IT8547600A0 (it) 1985-01-25
SK404391A3 (en) 1995-08-09
FR2561244A1 (fr) 1985-09-20
IE57809B1 (en) 1993-04-21
NL940009I2 (nl) 1999-05-03
DE3502508C2 (de) 1990-05-03
ES548430A0 (es) 1987-10-01
NL940009I1 (nl) 1994-07-18
FR2561244B1 (fr) 1988-03-04
HU193592B (en) 1987-11-30
KR920003064B1 (ko) 1992-04-13
NO164025B (no) 1990-05-14
ES539852A0 (es) 1986-07-16
DK35785D0 (da) 1985-01-25
HUT37784A (en) 1986-02-28
PT79890B (en) 1987-02-03
IE850187L (en) 1985-07-25
CH664152A5 (fr) 1988-02-15
LU88268I2 (de) 1994-02-03
AU3809785A (en) 1985-08-01
SG7089G (en) 1989-06-09
AU579132B2 (en) 1988-11-17
IT1182150B (it) 1987-09-30
AT392276B (de) 1991-02-25
PH22672A (en) 1988-11-14
FI850323L (fi) 1985-07-26
PT79890A (en) 1985-02-01
GB2153821B (en) 1988-01-20
NZ210940A (en) 1989-08-29
KR850005439A (ko) 1985-08-26
GB8501889D0 (en) 1985-02-27
GB2153821A (en) 1985-08-29
DE3502508A1 (de) 1985-08-14
DE19375046I2 (de) 2002-10-10
LU85743A1 (fr) 1986-08-04
FI84349C (fi) 1991-11-25
NL8500202A (nl) 1985-08-16
SE8500368L (sv) 1985-07-26
NO850300L (no) 1985-07-26
IL74165A (en) 1988-11-15
DK169521B1 (da) 1994-11-21
ES556101A0 (es) 1987-12-16
GR850219B (de) 1985-05-23
ES8708224A1 (es) 1987-10-01
NO1994022I1 (no) 1994-11-09
HK33189A (en) 1989-04-28
SE8500368D0 (sv) 1985-01-25
SE460359B (sv) 1989-10-02
CY1479A (en) 1989-07-21
CA1252793A (en) 1989-04-18
FI850323A0 (fi) 1985-01-25

Similar Documents

Publication Publication Date Title
ATA20485A (de) Verfahren zur herstellung von neuen tetrahydrocarbazol-derivaten
ATA28687A (de) Verfahren zur herstellung von neuen dichloranilinderivaten
ATA251585A (de) Verfahren zur herstellung von neuen ethylendiaminmonoamid-derivaten
AT381091B (de) Verfahren zur herstellung von neuen ergolinderivaten
AT386197B (de) Verfahren zur herstellung von neuen indolderivaten
ATA5985A (de) Verfahren zur herstellung von neuen 8alpha-acylaminoergolinen
ATA404284A (de) Verfahren zur herstellung von neuen gonadoliberin-derivaten
AT385035B (de) Verfahren zur herstellung von neuen ergolinderivaten
ATA273486A (de) Verfahren zur herstellung von neuen dichloranilinderivaten
ATA258985A (de) Verfahren zur herstellung von neuen substituierten 7-oxomitosanen
AT384218B (de) Verfahren zur herstellung von neuen chinazolin-derivaten
AT380477B (de) Verfahren zur herstellung von neuen spirothiazolidindion-derivaten
ATA313686A (de) Verfahren zur herstellung von neuen carbapenemderivaten
ATA106084A (de) Verfahren zur herstellung von neuen gonadoliberin-derivaten
ATA298586A (de) Verfahren zur herstellung von neuen anthracyclinglykosiden
ATA284985A (de) Verfahren zur herstellung von neuen carbapenemderivaten
ATA52285A (de) Verfahren zur herstellung von neuen diazepinoindolen
AT386407B (de) Verfahren zur herstellung von neuen n-sulfamyl -3-halogenpropionamidinen
AT381318B (de) Verfahren zur herstellung von neuen nitrosoharnstoffderivaten
AT377264B (de) Verfahren zur herstellung von neuen nitrosoharnstoffderivaten
AT386410B (de) Verfahren zur herstellung von neuen ergolinderivaten
ATA294685A (de) Verfahren zur herstellung von neuen nucleosidderivaten
ATA341587A (de) Verfahren zur herstellung von neuen carbapenemderivaten
AT389508B (de) Verfahren zur herstellung von neuen 2-acetylthiomethyl-3-benzoylpropionsaeurederivat n
ATA224888A (de) Verfahren zur herstellung von neuen 8alpha-acylaminoergolinen

Legal Events

Date Code Title Description
SZA Application filed for a certificate of protection

Free format text: SZ36/94, 941109

EZF Grant of a certificate of protection

Free format text: SZ 36/1994, 19941109, EXPIRES:20050223

ELA Expired due to lapse of time