GB2153821B - 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives - Google Patents

3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives

Info

Publication number
GB2153821B
GB2153821B GB08501889A GB8501889A GB2153821B GB 2153821 B GB2153821 B GB 2153821B GB 08501889 A GB08501889 A GB 08501889A GB 8501889 A GB8501889 A GB 8501889A GB 2153821 B GB2153821 B GB 2153821B
Authority
GB
United Kingdom
Prior art keywords
imidazolylmethyl
carbazol
tetrahydro
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB08501889A
Other versions
GB2153821A (en
GB8501889D0 (en
Inventor
Ian Harold Coates
James Angus Bell
David Cedric Humber
George Blanch Ewan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of GB8501889D0 publication Critical patent/GB8501889D0/en
Publication of GB2153821A publication Critical patent/GB2153821A/en
Application granted granted Critical
Publication of GB2153821B publication Critical patent/GB2153821B/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
GB08501889A 1984-01-25 1985-01-25 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives Expired GB2153821B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
GB8501889D0 GB8501889D0 (en) 1985-02-27
GB2153821A GB2153821A (en) 1985-08-29
GB2153821B true GB2153821B (en) 1988-01-20

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
GB08501889A Expired GB2153821B (en) 1984-01-25 1985-01-25 3-imidazolylmethyl-1,2,3,9-tetrahydro-4h-carbazol-4-one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE19375046I2 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

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LT3074B (en) 1992-10-14 1994-11-25 Richter Gedeon Vegyeszet Carbazolone derivatives and process for preparing the same
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size

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US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
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GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
NL8701682A (en) * 1986-07-30 1988-02-16 Sandoz Ag METHOD FOR THE THERAPEUTIC USE OF SEROTONIN ANTAGONISTS, ACTIVE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
EP0279114B2 (en) * 1986-11-21 1995-08-23 Glaxo Group Limited Medicaments for the treatment or prevention of the withdrawal syndrome
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
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US4939144A (en) * 1987-10-22 1990-07-03 Glaxo Group Limited Tricyclic ketone derivatives as 5-HT antagonists
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
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US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
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CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
KR900013959A (en) * 1989-03-13 1990-10-22 원본미기재 γ-carbline or their pharmaceutically acceptable acid addition salts and / or hydrates, and pharmaceutical compositions composed thereof
DE69004924T2 (en) * 1989-04-21 1994-05-19 Sandoz Ag THERAPEUTIC USE OF 5-HT3 RECEPTOR ANTAGONISTS.
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
EP0591434A4 (en) * 1991-06-26 1994-09-14 Sepracor Inc Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
KR960700711A (en) * 1993-03-08 1996-02-24 후지야마 아키라 Medicine for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325409B (en) * 1994-06-28 1999-02-10 Kenneth Francis Prendergast Pharmaceutical use of ondansetron/cyclodextrin complexes
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
EP1181015A2 (en) 1999-03-01 2002-02-27 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
PL373191A1 (en) 2002-04-29 2005-08-22 Teva Gyogyszergyar Reszvenytarsasag Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
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RU2608458C2 (en) 2009-05-20 2017-01-18 Инсерм (Энститю Насьональ Де Ля Сантэ Э Де Ля Решерш Медикаль) Serotonin 5-ht3 receptor antagonists for application in treatment of lesional vestibular disorders
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LT3074B (en) 1992-10-14 1994-11-25 Richter Gedeon Vegyeszet Carbazolone derivatives and process for preparing the same
US7288660B2 (en) 2004-05-07 2007-10-30 Taro Pharmaceutical Industries Limited Process for preparing ondansetron hydrochloride dihydrate having a defined particle size

Also Published As

Publication number Publication date
IE57809B1 (en) 1993-04-21
PT79890A (en) 1985-02-01
CZ404391A3 (en) 1993-04-14
LU85743A1 (en) 1986-08-04
NL8500202A (en) 1985-08-16
FI850323L (en) 1985-07-26
DK35785A (en) 1985-07-26
DE3502508A1 (en) 1985-08-14
HUT37784A (en) 1986-02-28
KR920003064B1 (en) 1992-04-13
KR850005439A (en) 1985-08-26
IT8547600A0 (en) 1985-01-25
ES539852A0 (en) 1986-07-16
BE901576A (en) 1985-07-25
SK277923B6 (en) 1995-08-09
NL190373B (en) 1993-09-01
SG7089G (en) 1989-06-09
AU3809785A (en) 1985-08-01
NZ210940A (en) 1989-08-29
ES556101A0 (en) 1987-12-16
CY1479A (en) 1989-07-21
GB2153821A (en) 1985-08-29
CA1252793A (en) 1989-04-18
IE850187L (en) 1985-07-25
SK404391A3 (en) 1995-08-09
DK35785D0 (en) 1985-01-25
FR2561244B1 (en) 1988-03-04
DE19375046I2 (en) 2002-10-10
FI84349B (en) 1991-08-15
HU193592B (en) 1987-11-30
SE8500368L (en) 1985-07-26
CH664152A5 (en) 1988-02-15
ES8609309A1 (en) 1986-07-16
FR2561244A1 (en) 1985-09-20
NL190373C (en) 1994-02-01
ES548430A0 (en) 1987-10-01
HK33189A (en) 1989-04-28
NO164025B (en) 1990-05-14
DK169521B1 (en) 1994-11-21
PT79890B (en) 1987-02-03
AT392276B (en) 1991-02-25
SE8500368D0 (en) 1985-01-25
ES8708224A1 (en) 1987-10-01
GB8501889D0 (en) 1985-02-27
NL940009I2 (en) 1999-05-03
NO164025C (en) 1990-08-22
PH22672A (en) 1988-11-14
NO850300L (en) 1985-07-26
DE3502508C2 (en) 1990-05-03
NL940009I1 (en) 1994-07-18
IT1182150B (en) 1987-09-30
GR850219B (en) 1985-05-23
FI850323A0 (en) 1985-01-25
AU579132B2 (en) 1988-11-17
LU88268I2 (en) 1994-02-03
SE460359B (en) 1989-10-02
NO1994022I1 (en) 1994-11-09
IL74165A (en) 1988-11-15
ATA20485A (en) 1990-08-15
FI84349C (en) 1991-11-25
ES8801247A1 (en) 1987-12-16

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