DK35785A - Tetrahydrocarbazolonderivater - Google Patents

Tetrahydrocarbazolonderivater Download PDF

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Publication number
DK35785A
DK35785A DK35785A DK35785A DK35785A DK 35785 A DK35785 A DK 35785A DK 35785 A DK35785 A DK 35785A DK 35785 A DK35785 A DK 35785A DK 35785 A DK35785 A DK 35785A
Authority
DK
Denmark
Prior art keywords
tetrahydrocarbazolonderivater
Prior art date
Application number
DK35785A
Other languages
Danish (da)
Other versions
DK35785D0 (en
DK169521B1 (en
Inventor
Ian Harold Coates
James Angus Bell
David Cedric Humber
Georges Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to GB8401888 priority Critical
Priority to GB848401888A priority patent/GB8401888D0/en
Priority to GB8425959 priority
Priority to GB848425959A priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK35785D0 publication Critical patent/DK35785D0/en
Publication of DK35785A publication Critical patent/DK35785A/en
Application granted granted Critical
Publication of DK169521B1 publication Critical patent/DK169521B1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56Ring systems containing three or more rings
    • C07D209/80[b, c]- or [b, d]-condensed
    • C07D209/82Carbazoles; Hydrogenated carbazoles
    • C07D209/88Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK035785A 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazolones, process for their preparation and pharmaceutical compositions containing the compounds DK169521B1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB8401888 1984-01-25
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB8425959 1984-10-15
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
DK35785D0 DK35785D0 (en) 1985-01-25
DK35785A true DK35785A (en) 1985-07-26
DK169521B1 DK169521B1 (en) 1994-11-21

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035785A DK169521B1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazolones, process for their preparation and pharmaceutical compositions containing the compounds

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE3502508C2 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

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US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
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GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
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HU895334D0 (en) * 1986-07-30 1990-01-28 Sandoz Ag Process for the preparation of nasal pharmaceutical compositions
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
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US4948803A (en) * 1986-11-21 1990-08-14 Glaxo Group Limited Medicaments for treatment on prevention of withdrawal syndrome
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US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
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US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
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JPH01258673A (en) * 1987-10-22 1989-10-16 Glaxo Group Ltd Ketone derivative
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res Imidazolylmethyl-cycloalkanoebaa indolones, their preparation and use
JPH0256485A (en) * 1988-04-27 1990-02-26 Glaxo Group Ltd Lactam derivative
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir New indole derivatives, their preparation process and the pharmaceutical compositions containing them
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
KR900013959A (en) * 1989-03-13 1990-10-22 원본미기재 γ-carbline or their pharmaceutically acceptable acid addition salts and / or hydrates, and pharmaceutical compositions composed thereof
WO1990012569A1 (en) * 1989-04-21 1990-11-01 Sandoz Ag Therapeutic use of 5-ht3 receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
CA2112487C (en) * 1991-06-26 2003-04-15 James W. Young Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa Procedure for obtaining 1,2,3,9-tetrahydro-9-methyl-3- (2-methyl-1h-imidazol-1-il) methyl * -4h-carbazol-4-ona.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
AU683447B2 (en) * 1993-03-08 1997-11-13 Fujisawa Pharmaceutical Co., Ltd. Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2325409B (en) * 1994-06-28 1999-02-10 Kenneth Francis Prendergast Pharmaceutical use of ondansetron/cyclodextrin complexes
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
AU779696B2 (en) 1999-03-01 2005-02-10 Sepracor, Inc. Methods for treating apnea and apnea disorders using optically pure R(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
EP1499623B1 (en) 2002-04-29 2007-06-13 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-¬(2-methyl-1h-imidazol-1-yl)methyl|-4h-carbazol-4-one
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (en) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. New polymorphic forms of ondansetron, procedures for their preparation, pharmaceutical compositions containing them and their use as anantimetics.
WO2005108392A2 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
WO2007004041A2 (en) * 2005-07-05 2007-01-11 Orchid Research Laboratories Limited New compounds and their pharmaceutical use
EP2253316B1 (en) 2009-05-20 2013-08-14 INSERM (Institut National de la Santé et de la Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of an inner ear pathology with vestibular deficits
US8580730B2 (en) 2009-05-20 2013-11-12 (Inserm) Institut National De La Sante Et De La Recherche Medicale Methods of treating lesional vestibular disorders by administering serotonin 5-HT3 receptor antagonists

Family Cites Families (3)

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US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds

Also Published As

Publication number Publication date
ES8609309A1 (en) 1986-07-16
FI850323L (en) 1985-07-26
FR2561244A1 (en) 1985-09-20
AU579132B2 (en) 1988-11-17
LU88268I2 (en) 1994-02-03
CA1252793A (en) 1989-04-18
GB2153821A (en) 1985-08-29
HU193592B (en) 1987-11-30
IT8547600D0 (en) 1985-01-25
ES548430D0 (en)
AT392276B (en) 1991-02-25
KR920003064B1 (en) 1992-04-13
PT79890B (en) 1987-02-03
BE901576A (en) 1985-07-25
ES548430A0 (en) 1987-10-01
NL190373C (en) 1994-02-01
NO164025C (en) 1990-08-22
NZ210940A (en) 1989-08-29
NL190373B (en) 1993-09-01
CZ404391A3 (en) 1993-04-14
FI84349B (en) 1991-08-15
DE3502508C2 (en) 1990-05-03
CA1252793A1 (en)
SK277923B6 (en) 1995-08-09
FI84349C (en) 1991-11-25
SK404391A3 (en) 1995-08-09
ES8801247A1 (en) 1987-12-16
NO164025B (en) 1990-05-14
AU3809785A (en) 1985-08-01
GB2153821B (en) 1988-01-20
ES539852D0 (en)
ES539852A0 (en) 1986-07-16
FI850323D0 (en)
SE460359B (en) 1989-10-02
KR850005439A (en) 1985-08-26
DK35785D0 (en) 1985-01-25
DE19375046I2 (en) 2002-10-10
ES556101D0 (en)
GR850219B (en) 1985-05-23
PT79890A (en) 1985-02-01
SG7089G (en) 1989-06-09
NL940009I1 (en) 1994-07-18
NL940009I2 (en) 1999-05-03
LU85743A1 (en) 1986-08-04
IT1182150B (en) 1987-09-30
CY1479A (en) 1989-07-21
NO850300L (en) 1985-07-26
LU88268A9 (en)
HK33189A (en) 1989-04-28
CH664152A5 (en) 1988-02-15
ATA20485A (en) 1990-08-15
PH22672A (en) 1988-11-14
IL74165A (en) 1988-11-15
DK169521B1 (en) 1994-11-21
IE850187L (en) 1985-07-25
FR2561244B1 (en) 1988-03-04
FI850323A0 (en) 1985-01-25
DE3502508A1 (en) 1985-08-14
NL8500202A (en) 1985-08-16
GB8501889D0 (en) 1985-02-27
ES556101A0 (en) 1987-12-16
ES8708224A1 (en) 1987-10-01
SE8500368L (en) 1985-07-26
FI850323A (en)
HUT37784A (en) 1986-02-28
NO1994022I1 (en) 1994-11-09
BE901576A1 (en)
IE57809B1 (en) 1993-04-21
SE8500368D0 (en) 1985-01-25

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Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1995 00001, 950118

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1995 00001, 950118, EXPIRES: 20050223

PUP Patent expired