SE8500368D0 - Heterocyclic Associations - Google Patents

Heterocyclic Associations

Info

Publication number
SE8500368D0
SE8500368D0 SE8500368A SE8500368A SE8500368D0 SE 8500368 D0 SE8500368 D0 SE 8500368D0 SE 8500368 A SE8500368 A SE 8500368A SE 8500368 A SE8500368 A SE 8500368A SE 8500368 D0 SE8500368 D0 SE 8500368D0
Authority
SE
Sweden
Prior art keywords
phenyl
hydrogen
3alkyl
cycloalkyl
alkenyl
Prior art date
Application number
SE8500368A
Other languages
Swedish (sv)
Other versions
SE460359B (en
SE8500368L (en
Inventor
I H Coates
J A Bell
D C Humber
G B Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of SE8500368D0 publication Critical patent/SE8500368D0/en
Publication of SE8500368L publication Critical patent/SE8500368L/en
Publication of SE460359B publication Critical patent/SE460359B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Abstract

Compounds of formula (I). <IMAGE> [wherein R<1> is hydrogen C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl, and one of the groups represented by R<2>, R<3> and R<4> is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl and each of the other two groups, which may be the same or different, is hydrogen or C1-6alkyl; and physiologically acceptable salts and solvates, e.g. hydrates, thereof] are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia.
SE8500368A 1984-01-25 1985-01-25 3-IMIDAZOLYLMETHYLTRAHYDROCARBAZOLONES, PROCEDURES FOR PREPARING THESE AND A PHARMACEUTICAL COMPOSITION SE460359B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (3)

Publication Number Publication Date
SE8500368D0 true SE8500368D0 (en) 1985-01-25
SE8500368L SE8500368L (en) 1985-07-26
SE460359B SE460359B (en) 1989-10-02

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
SE8500368A SE460359B (en) 1984-01-25 1985-01-25 3-IMIDAZOLYLMETHYLTRAHYDROCARBAZOLONES, PROCEDURES FOR PREPARING THESE AND A PHARMACEUTICAL COMPOSITION

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE3502508A1 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK277923B6 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.
DE3688296T2 (en) * 1985-03-14 1993-11-04 Beecham Group Plc MEDICINES FOR TREATING EMERGENCY.
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
HU202108B (en) * 1986-07-30 1991-02-28 Sandoz Ag Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
DE3777805D1 (en) * 1986-11-21 1992-04-30 Glaxo Group Ltd MEDICINES FOR TREATING OR PREVENTING THE WITHDRAWAL SYNDROME.
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
DK662687A (en) * 1986-12-17 1988-06-18 Glaxo Group Ltd USE OF TRICYCLIC CARBAZOLONES
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
JPS63277622A (en) * 1986-12-17 1988-11-15 グラクソ、グループ、リミテッド Medicine
DE3876006T2 (en) * 1987-04-14 1993-03-25 Glaxo Group Ltd KETONE DERIVATIVES.
GB2205745B (en) * 1987-06-16 1990-09-19 Nat Res Dev Use of dioxopiperidine derivatives as analgesics
DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
EP0317088A1 (en) * 1987-10-22 1989-05-24 Glaxo Group Limited Ketone derivatives
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
AU631632B2 (en) * 1989-04-21 1992-12-03 Novartis Ag Therapeutic use of 5-ht3 receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
CA2112487C (en) * 1991-06-26 2003-04-15 James W. Young Method and compositions for treating emesis, nausea and other disorders using optically pure r(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
CN1118990A (en) * 1993-03-08 1996-03-20 藤泽药品工业株式会社 Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2327348A (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Pharmaceutical use of ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
WO2000051582A2 (en) 1999-03-01 2000-09-08 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
US7098345B2 (en) 2002-04-29 2006-08-29 TEVA Gyógyszergyár Zárkörüen Müködö Részvénytársaság Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-YL)methyl]-4H-carbazol-4-one
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (en) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS.
CA2565854A1 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
WO2007004041A2 (en) * 2005-07-05 2007-01-11 Orchid Research Laboratories Limited New compounds and their pharmaceutical use
ES2432618T3 (en) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit
SI2432467T1 (en) 2009-05-20 2018-06-29 Inserm (Institut National De La Sante Et De La Recherche Medicale) Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 Ondansetron compound and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
DE3680123D1 (en) * 1985-01-23 1991-08-14 Glaxo Group Ltd Tetrahydrocarbazolonderivate.

Also Published As

Publication number Publication date
NO850300L (en) 1985-07-26
GB2153821B (en) 1988-01-20
LU85743A1 (en) 1986-08-04
HK33189A (en) 1989-04-28
NL190373C (en) 1994-02-01
AU579132B2 (en) 1988-11-17
GB2153821A (en) 1985-08-29
KR920003064B1 (en) 1992-04-13
FR2561244B1 (en) 1988-03-04
AU3809785A (en) 1985-08-01
NO1994022I1 (en) 1994-11-09
SK404391A3 (en) 1995-08-09
DK35785D0 (en) 1985-01-25
DE3502508A1 (en) 1985-08-14
IT1182150B (en) 1987-09-30
ES8801247A1 (en) 1987-12-16
DK169521B1 (en) 1994-11-21
CZ404391A3 (en) 1993-04-14
SE460359B (en) 1989-10-02
FI84349C (en) 1991-11-25
GR850219B (en) 1985-05-23
FR2561244A1 (en) 1985-09-20
NL940009I2 (en) 1999-05-03
FI84349B (en) 1991-08-15
SE8500368L (en) 1985-07-26
IE57809B1 (en) 1993-04-21
GB8501889D0 (en) 1985-02-27
IL74165A (en) 1988-11-15
NL190373B (en) 1993-09-01
LU88268I2 (en) 1994-02-03
NL8500202A (en) 1985-08-16
HUT37784A (en) 1986-02-28
PH22672A (en) 1988-11-14
FI850323A0 (en) 1985-01-25
DE19375046I2 (en) 2002-10-10
KR850005439A (en) 1985-08-26
AT392276B (en) 1991-02-25
NL940009I1 (en) 1994-07-18
CA1252793A (en) 1989-04-18
DK35785A (en) 1985-07-26
SK277923B6 (en) 1995-08-09
IE850187L (en) 1985-07-25
NZ210940A (en) 1989-08-29
PT79890A (en) 1985-02-01
DE3502508C2 (en) 1990-05-03
PT79890B (en) 1987-02-03
ATA20485A (en) 1990-08-15
HU193592B (en) 1987-11-30
FI850323L (en) 1985-07-26
ES8708224A1 (en) 1987-10-01
ES539852A0 (en) 1986-07-16
ES556101A0 (en) 1987-12-16
CH664152A5 (en) 1988-02-15
NO164025C (en) 1990-08-22
ES8609309A1 (en) 1986-07-16
BE901576A (en) 1985-07-25
ES548430A0 (en) 1987-10-01
CY1479A (en) 1989-07-21
IT8547600A0 (en) 1985-01-25
SG7089G (en) 1989-06-09
NO164025B (en) 1990-05-14

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