PE20040557A1 - 2-HETEROARYLCARBOXYL ACIDS AMIDES - Google Patents

2-HETEROARYLCARBOXYL ACIDS AMIDES

Info

Publication number
PE20040557A1
PE20040557A1 PE2003000576A PE2003000576A PE20040557A1 PE 20040557 A1 PE20040557 A1 PE 20040557A1 PE 2003000576 A PE2003000576 A PE 2003000576A PE 2003000576 A PE2003000576 A PE 2003000576A PE 20040557 A1 PE20040557 A1 PE 20040557A1
Authority
PE
Peru
Prior art keywords
oct
benzofuran
carboxamide
halogen
phenyl
Prior art date
Application number
PE2003000576A
Other languages
Spanish (es)
Inventor
Frank-Gerhard Bob
Der Staay Franz-Josef Van
Joachim Luithle
Christina Erb
Frank-Thorsten Hafner
Katrin Schnizler
Timo Flebner
Kampen Marja Van Van
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE10257078A external-priority patent/DE10257078A1/en
Priority claimed from DE2002157537 external-priority patent/DE10257537A1/en
Priority claimed from DE10305922A external-priority patent/DE10305922A1/en
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of PE20040557A1 publication Critical patent/PE20040557A1/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I DONDE R1 ES 1-AZA-BICICLO[2.2.2]OCT-3-ILO SUSTITUIDO A TRAVES DEL NITROGENO POR ALQUILO C1-C4, BENCILO Y OXI; R2 ES H, ALQUILO C1-C6; R3 ES H, HALOGENO, ALQUILO C1-C6; R4 ES H, HALOGENO, CIANO, AMINO, ENTRE OTROS; A ES O, S; B ES ANILLO BENZO O PIRIDO SUSTITUIDOS POR HALOGENO, CIANO, FORMILO, ENTRE OTROS; E ES ETINILO, ARILO, HETEROARILO, ENTRE OTROS. SON COMPUESTOS PREFERIDOS: N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-6-[2-(HIDROXIMETIL)FENIL]-1-BENZOFURAN-2-CARBOXAMIDA; N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-6-[3-(HIDROXIMETIL)FENIL]-1-BENZOFURAN-2-CARBOXAMIDA Y N-[(3R)-1-AZABICICLO[2.2.2]OCT-3-IL]-6-[4-(4-MORFOLINIL)FENIL]-1-BENZOFURAN-2-CARBOXAMIDA. SE REFIERE TAMBIEN A UN PROCEDIMIENTODE PREPARACION DE DICHOS COMPUESTOS, LOS QUE SON UTILES EN EL TRATAMIENTO Y/O PROFILAXIS DE TRASTORNOS DE LA CAPACIDAD PERCEPTIVA, LA CAPACIDAD DE CONCENTRACION, APRENDIZAJE Y/O MEMORIAIT REFERS TO A COMPOUND OF FORMULA I WHERE R1 IS 1-AZA-BICYCLE [2.2.2] OCT-3-ILO SUBSTITUTED THROUGH NITROGEN BY C1-C4 ALKYL, BENZYL AND OXY; R2 IS H, C1-C6 ALKYL; R3 IS H, HALOGEN, C1-C6 ALKYL; R4 IS H, HALOGEN, CYANE, AMINO, AMONG OTHERS; A IS O, S; B IS BENZO OR PIRIDO RING REPLACED BY HALOGEN, CYANE, FORMIL, AMONG OTHERS; E IS ETHINYL, ARYL, HETEROARYL, AMONG OTHERS. PREFERRED COMPOUNDS ARE: N - [(3R) -1-AZABICYCLE [2.2.2] OCT-3-IL] -6- [2- (HYDROXIMETHYL) PHENYL] -1-BENZOFURAN-2-CARBOXAMIDE; N - [(3R) -1-AZABICYCLO [2.2.2] OCT-3-IL] -6- [3- (HYDROXIMETHYL) PHENYL] -1-BENZOFURAN-2-CARBOXAMIDE AND N - [(3R) -1- AZABICYCLO [2.2.2] OCT-3-IL] -6- [4- (4-MORPHOLINYL) PHENYL] -1-BENZOFURAN-2-CARBOXAMIDE. IT ALSO REFERS TO A PROCEDURE FOR THE PREPARATION OF SUCH COMPOUNDS, THOSE THAT ARE USEFUL IN THE TREATMENT AND / OR PROPHYLAXIS OF DISORDERS OF PERCEPTIVE ABILITY, THE ABILITY TO CONCENTRATION, LEARNING AND / OR MEMORY

PE2003000576A 2002-06-10 2003-06-10 2-HETEROARYLCARBOXYL ACIDS AMIDES PE20040557A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10225536 2002-06-10
DE10257078A DE10257078A1 (en) 2002-12-06 2002-12-06 New N-azabicyclooctyl bicyclic heteroaryl carboxamides, are alpha 7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance
DE2002157537 DE10257537A1 (en) 2002-12-10 2002-12-10 New N-azabicyclooctyl bicyclic heteroaryl carboxamides, are alpha 7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance
DE10305922A DE10305922A1 (en) 2002-06-10 2003-02-13 New N-azabicyclooctyl bicyclic heteroaryl carboxamides, are alpha 7-nicotinic acetylcholine receptor ligands useful for improving attention, concentration, learning and/or memory performance

Publications (1)

Publication Number Publication Date
PE20040557A1 true PE20040557A1 (en) 2004-10-01

Family

ID=41259016

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2003000576A PE20040557A1 (en) 2002-06-10 2003-06-10 2-HETEROARYLCARBOXYL ACIDS AMIDES

Country Status (6)

Country Link
AR (1) AR040261A1 (en)
DO (1) DOP2003000657A (en)
HN (1) HN2003000166A (en)
HR (1) HRP20050012A2 (en)
PE (1) PE20040557A1 (en)
TW (1) TW200410967A (en)

Also Published As

Publication number Publication date
AR040261A1 (en) 2005-03-23
HRP20050012A2 (en) 2006-04-30
HN2003000166A (en) 2004-07-27
TW200410967A (en) 2004-07-01
DOP2003000657A (en) 2004-01-31

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FD Application declared void or lapsed