AR040261A1 - AMIDES OF 2-HETEROARILCARBOXILIC ACIDS - Google Patents

Abstract

The present invention concerns amides of 2-heteroarylcarboxylic acids and their use for the preparation of medicaments for the treatment and / or prophylaxis of diseases and to improve the perceptual capacity, the concentration capacity, the learning capacity and / or the capacity of memory Also subject to this application are medications, procedures for preparing the compounds and use for preparing the medications. Claim 1: Compounds of the formula (1) wherein R 1 represents 1-aza-bicyclo [2.2.2] oct-3-yl, which is optionally substituted through the N atom by a moiety selected from the group C1-4 alkyl, benzyl and oxy; R2 is H or C1-6 alkyl; R3 is H, halogen or C1-6 alkyl; R4 is H, halogen, cyano, amino, trifluoromethyl, trifluoromethoxy, C1-6 alkyl, C1-6 alkylcarbonyl, C1-6 alkylamino, formyl, hydroxycarbonyl, C1-6 alkoxy, C1-6 alkoxycarbonyl, C1-6 alkylthio, C1 alkylcarbonylamino -6, C 1-6 alkylaminocarbonyl, C 1-6 alkylsulfonylamino, C 3-8 cycloalkylcarbonylamino, C 3-6 cycloalkylaminocarbonyl, pyrrolyl, C 1-6 alkylaminocarbonylamino, heterocyclylcarbonyl, heterocyclylcarbonylamino, heteroarylcarbonylamino, hydroxy, phenyl- or C 1-6 alkylalkyl optionally with hydroxy, cyano, amino, C 1-6 alkylaminocarbonylamino, C 1-6 alkylaminocarboxy, heterocyclyl or aryl, C 1-6 alkylaminocarbonyl, optionally, C 1-6 alkoxy or C 1-6 alkylamino, C 1-6 alkylcarbonylamino, optionally, with C 1- alkoxy 6 and heterocyclyl, optionally. With oxo, A represents O or S; Ring B is benzo or pyrido, which are optionally substituted with halogen, cyano, formyl, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-6 alkyl, and C1-6 alkoxy, respectively; and E, C ::: C, arylene and heteroarylene, arylene and heteroarylene may be substituted by halogen, cyano, trifluoromethyl, trifluoromethoxy, nitro, amino, C1-6 alkoxy and C1-6 alkyl series, as well as the solvates, salts or solvates of salts of these compounds.