DK35785D0 - TETRAHYDROCARBAZOLONE DERIVATIVES - Google Patents

TETRAHYDROCARBAZOLONE DERIVATIVES

Info

Publication number
DK35785D0
DK35785D0 DK35785A DK35785A DK35785D0 DK 35785 D0 DK35785 D0 DK 35785D0 DK 35785 A DK35785 A DK 35785A DK 35785 A DK35785 A DK 35785A DK 35785 D0 DK35785 D0 DK 35785D0
Authority
DK
Denmark
Prior art keywords
tetrahydrocarbazolone
derivatives
tetrahydrocarbazolone derivatives
Prior art date
Application number
DK35785A
Other languages
Danish (da)
Other versions
DK169521B1 (en
DK35785A (en
Inventor
Ian Harold Coates
James Angus Bell
David Cedric Humber
Georges Blanch Ewan
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of DK35785D0 publication Critical patent/DK35785D0/en
Publication of DK35785A publication Critical patent/DK35785A/en
Application granted granted Critical
Publication of DK169521B1 publication Critical patent/DK169521B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
DK035785A 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazolones, process for their preparation and pharmaceutical compositions containing the compounds DK169521B1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB8401888 1984-01-25
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds
GB8425959 1984-10-15

Publications (3)

Publication Number Publication Date
DK35785D0 true DK35785D0 (en) 1985-01-25
DK35785A DK35785A (en) 1985-07-26
DK169521B1 DK169521B1 (en) 1994-11-21

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
DK035785A DK169521B1 (en) 1984-01-25 1985-01-25 3-Imidazolylmethyltetrahydrocarbazolones, process for their preparation and pharmaceutical compositions containing the compounds

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE19375046I2 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds
DE3688296T2 (en) * 1985-03-14 1993-11-04 Beecham Group Plc MEDICINES FOR TREATING EMERGENCY.
US5578628A (en) * 1985-06-25 1996-11-26 Glaxo Group Limited Medicaments for the treatment of nausea and vomiting
GB8516083D0 (en) * 1985-06-25 1985-07-31 Glaxo Group Ltd Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518658D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Medicaments
GB8518745D0 (en) 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
US5204356A (en) * 1985-07-24 1993-04-20 Glaxo Group Limited Treatment of anxiety
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8617994D0 (en) * 1986-07-23 1986-08-28 Glaxo Group Ltd Heterocyclic compounds
NL8701682A (en) * 1986-07-30 1988-02-16 Sandoz Ag METHOD FOR THE THERAPEUTIC USE OF SEROTONIN ANTAGONISTS, ACTIVE COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE COMPOUNDS
AT396870B (en) * 1986-08-07 1993-12-27 Sandoz Ag Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists
GB8623819D0 (en) * 1986-10-03 1986-11-05 Glaxo Group Ltd Heterocyclic compounds
WO1988003801A1 (en) * 1986-11-21 1988-06-02 Glaxo Group Limited Medicaments for treatment or prevention of withdrawal syndrome
GB8627909D0 (en) * 1986-11-21 1986-12-31 Glaxo Group Ltd Medicaments
GB8628475D0 (en) * 1986-11-28 1987-01-07 Glaxo Group Ltd Medicaments
GR871809B (en) * 1986-11-28 1988-03-07 Glaxo Group Ltd Process for the preparation of tricyclic ketones
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
IL84845A0 (en) * 1986-12-17 1988-06-30 Glaxo Group Ltd Pharmaceutical compositions comprising a certain carbazolone derivative or a salt thereof
US5190954A (en) * 1986-12-17 1993-03-02 Glaxo Group Limited Methods for the treatment of cognitive disorders
DE3788057T2 (en) * 1986-12-17 1994-03-03 Glaxo Group Ltd Use of heterocyclic compounds for the treatment of depression.
GB8630079D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
US5200414A (en) * 1986-12-17 1993-04-06 Glaxo Group Limited Methods for the treatment of cognitive disorders
GB8630071D0 (en) * 1986-12-17 1987-01-28 Glaxo Group Ltd Medicaments
EP0291172B1 (en) * 1987-04-14 1992-11-19 Glaxo Group Limited Ketone derivatives
DE3874229T2 (en) * 1987-06-16 1993-03-25 British Tech Group USE OF DIOXOPIPERIDINE DERIVATIVES FOR PRODUCING A TOPICAL PREPARATION AS AN ANALGETIC.
DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
GB8723157D0 (en) * 1987-10-02 1987-11-04 Beecham Group Plc Compounds
CA1304082C (en) * 1987-10-22 1992-06-23 Tetsuya Tahara Benzoxazine compounds and pharmaceutical use thereof
US4939144A (en) * 1987-10-22 1990-07-03 Glaxo Group Limited Tricyclic ketone derivatives as 5-HT antagonists
US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
GB8805269D0 (en) * 1988-03-04 1988-04-07 Glaxo Group Ltd Medicaments
US5116984A (en) * 1988-04-07 1992-05-26 Glaxo Group Limited Imidazole derivatives
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
US4985422A (en) * 1988-04-27 1991-01-15 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
US5290785A (en) * 1988-09-27 1994-03-01 Fujisawa Pharmaceutical Co., Ltd. Therapeutic agent for ischemic diseases
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
FR2639944B1 (en) * 1988-12-06 1991-01-18 Adir NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
CA2004911A1 (en) * 1988-12-22 1990-06-22 Mitsuaki Ohta 4,5,6,7-tetrahydrobenzimidazole derivatives
EP0377238A1 (en) * 1988-12-22 1990-07-11 Duphar International Research B.V New annelated indolo (3,2-c)-lactams
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
CA2012092A1 (en) * 1989-03-13 1990-09-13 Tadao Okegawa 5-ht3 receptor antagonist
JPH0669963B2 (en) * 1989-04-21 1994-09-07 サンド・アクチエンゲゼルシャフト 5HT-Bottom 3 Therapeutic use of receptor antagonists
GB8914804D0 (en) * 1989-06-28 1989-08-16 Glaxo Group Ltd Process
US5276050A (en) * 1989-08-01 1994-01-04 Glaxo Group Limited Medicaments
GB8917557D0 (en) * 1989-08-01 1989-09-13 Glaxo Group Ltd Medicaments
US5126343A (en) * 1989-09-11 1992-06-30 G. D. Searle & Co. N-azabicyclo [3.3.0]octane amides of aromatic acids
GB2236751B (en) 1989-10-14 1993-04-28 Wyeth John & Brother Ltd Heterocyclic compounds
GB8928837D0 (en) * 1989-12-21 1990-02-28 Beecham Group Plc Pharmaceuticals
US5187166A (en) * 1990-07-31 1993-02-16 Nisshin Flour Milling Co., Ltd. Azabicyclo derivatives and their use as antiemetics
JPH06508836A (en) * 1991-06-26 1994-10-06 セプラコア，インコーポレーテッド Methods and compositions for the treatment of emesis, nausea and other disorders using optically pure R(+) ondansetron
JPH05310732A (en) * 1992-03-12 1993-11-22 Mitsubishi Kasei Corp Cinnoline-3-carboxylic acid derivative
ES2043535B1 (en) * 1992-03-13 1994-08-01 Vita Invest Sa PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA.
HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
CN1118990A (en) * 1993-03-08 1996-03-20 藤泽药品工业株式会社 Medicament for treating or preventing cerebrovascular diseases
GB9310756D0 (en) * 1993-05-25 1993-07-14 Glaxo Lab Sa Compositions
GB2327348A (en) * 1994-06-28 1999-01-27 Kenneth Francis Prendergast Pharmaceutical use of ondansetron
GB9423588D0 (en) * 1994-11-22 1995-01-11 Glaxo Wellcome Inc Compositions
AU702594B2 (en) * 1995-10-13 1999-02-25 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US6365743B1 (en) 1995-10-13 2002-04-02 Duphar International Research B.V. Process for the preparation of enantiomerically pure imidazolyl compounds
US5969137A (en) * 1996-09-19 1999-10-19 Virginia Commonwealth University Benzylamidine derivatives with serotonin receptor binding activity
US6548082B1 (en) 1999-03-01 2003-04-15 Sepracor Inc. Methods for treating apnea and apnea disorders using optically pure R(+) ondansetron
EP1207160A1 (en) * 2000-11-20 2002-05-22 Hanmi Pharm. Co., Ltd. Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one
ATE364611T1 (en) 2002-04-29 2007-07-15 Teva Gyogyszergyar Zartkoeruee METHOD FOR PRODUCING 1,2,3,9-TETRAHYDRO-9-METHYL-3-(2-METHYL-1H-IMIDAZOL-1-YL)METHYLÖ-H-CARBAZOL-4-ONE
FI6164U1 (en) * 2003-01-09 2004-03-15 Synthon Bv Ondansetronformer
GB2398071B (en) * 2003-01-24 2006-06-07 Synthon Bv Process for making ondansetron and intermediate thereof
ES2238001B1 (en) * 2004-01-21 2006-11-01 Vita Cientifica, S.L. NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS.
CA2565854A1 (en) 2004-05-07 2005-11-17 Taro Pharmaceutical Industries Ltd. Process for preparing ondansetron hydrochloride dihydrate having a defined particle size
WO2007004041A2 (en) * 2005-07-05 2007-01-11 Orchid Research Laboratories Limited New compounds and their pharmaceutical use
CN102458400B (en) 2009-05-20 2014-10-08 国立健康与医学研究所 Serotonin 5-ht3 receptor antagonists for use in the treatment of lesional vestibular disorders
ES2432618T3 (en) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit
CN115611864A (en) * 2022-11-01 2023-01-17 常州兰陵制药有限公司 Ondansetron compound and preparation method and application thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds

Also Published As

Publication number Publication date
SK277923B6 (en) 1995-08-09
ES8609309A1 (en) 1986-07-16
AU3809785A (en) 1985-08-01
FR2561244A1 (en) 1985-09-20
ATA20485A (en) 1990-08-15
HU193592B (en) 1987-11-30
ES548430A0 (en) 1987-10-01
ES539852A0 (en) 1986-07-16
GR850219B (en) 1985-05-23
SK404391A3 (en) 1995-08-09
ES8801247A1 (en) 1987-12-16
FI850323A0 (en) 1985-01-25
AU579132B2 (en) 1988-11-17
SE460359B (en) 1989-10-02
ES556101A0 (en) 1987-12-16
SE8500368L (en) 1985-07-26
NL190373B (en) 1993-09-01
SG7089G (en) 1989-06-09
GB2153821B (en) 1988-01-20
PT79890B (en) 1987-02-03
FI84349C (en) 1991-11-25
NZ210940A (en) 1989-08-29
ES8708224A1 (en) 1987-10-01
BE901576A (en) 1985-07-25
NO164025C (en) 1990-08-22
SE8500368D0 (en) 1985-01-25
IE57809B1 (en) 1993-04-21
HUT37784A (en) 1986-02-28
IL74165A (en) 1988-11-15
KR850005439A (en) 1985-08-26
DE3502508A1 (en) 1985-08-14
NO1994022I1 (en) 1994-11-09
FR2561244B1 (en) 1988-03-04
NO850300L (en) 1985-07-26
IT8547600A0 (en) 1985-01-25
CA1252793A (en) 1989-04-18
NL190373C (en) 1994-02-01
NL8500202A (en) 1985-08-16
IT1182150B (en) 1987-09-30
DE3502508C2 (en) 1990-05-03
DK169521B1 (en) 1994-11-21
LU88268I2 (en) 1994-02-03
PT79890A (en) 1985-02-01
NL940009I2 (en) 1999-05-03
KR920003064B1 (en) 1992-04-13
IE850187L (en) 1985-07-25
PH22672A (en) 1988-11-14
GB8501889D0 (en) 1985-02-27
LU85743A1 (en) 1986-08-04
FI850323L (en) 1985-07-26
CH664152A5 (en) 1988-02-15
NL940009I1 (en) 1994-07-18
FI84349B (en) 1991-08-15
CZ404391A3 (en) 1993-04-14
DK35785A (en) 1985-07-26
CY1479A (en) 1989-07-21
DE19375046I2 (en) 2002-10-10
HK33189A (en) 1989-04-28
AT392276B (en) 1991-02-25
NO164025B (en) 1990-05-14
GB2153821A (en) 1985-08-29

Similar Documents

Publication Publication Date Title
DK268285A (en) DIALCOXYPYRIDINE DERIVATIVES
DK35785D0 (en) TETRAHYDROCARBAZOLONE DERIVATIVES
DK243985D0 (en) AMINOALKYLPHENOXYDE DERIVATIVES
DE3463503D1 (en) SULFONAMIDO-BENZAMIDE DERIVATIVES
FI840024A0 (en) INSTAELLBART SAENGBOTTEN
DE3566887D1 (en) FLAVANON DERIVATIVES
DK524585D0 (en) CHOLECALCIFERAL DERIVATIVES
DK501085D0 (en) SUBSTITUTED BENZIMIDAZOLD DERIVATIVES
DK443685D0 (en) PIRIMIDINE DERIVATIVES
DK460785A (en) SUBSTITUTED FURANGE DERIVATIVES
DK320585D0 (en) FLUORALLYLAMINE DERIVATIVES
ES539508A0 (en) NEW ANDROSTENO DERIVATIVES
DK514585A (en) AMINOETHYLANILINE DERIVATIVES
DE3565100D1 (en) CYCLOALKANE-INDENE-CARBOXIMIDAMIDE DERIVATIVES
DK267190D0 (en) 13-substituted-5-ketomilbemycin derivatives
DK14485A (en) naphtahlene
DK54085D0 (en) PHENYLPROPARGYLAMINE DERIVATIVES
DE3564269D1 (en) EBURNANE DERIVATIVES
ES529437A0 (en) 3-PIRROLIDINOPROPIOPHENONE DERIVATIVES
SE8401359D0 (en) EXTENDED STUPRENNOR STUPROR
ES283027Y (en) CARRIED PARTS
ES281081Y (en) MUNECO MECANICO MECANICO
DK548284D0 (en) IS-DETECTOR
SE8401214D0 (en) COMBI-FLEX
IT8403405V0 (en) CARIGLIONE FUTURO

Legal Events

Date Code Title Description
B1 Patent granted (law 1993)
CTFF Application for supplementary protection certificate (spc) filed

Free format text: CA 1995 00001, 950118

CTFG Supplementary protection certificate (spc) issued

Free format text: CA 1995 00001, 950118, EXPIRES: 20050223

PUP Patent expired