NO164025C - ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3-IMIDAZOLYLMETHYL-TETRAHYDROCARBAZOLONE DERIVATIVES. - Google Patents
ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3-IMIDAZOLYLMETHYL-TETRAHYDROCARBAZOLONE DERIVATIVES.Info
- Publication number
- NO164025C NO164025C NO850300A NO850300A NO164025C NO 164025 C NO164025 C NO 164025C NO 850300 A NO850300 A NO 850300A NO 850300 A NO850300 A NO 850300A NO 164025 C NO164025 C NO 164025C
- Authority
- NO
- Norway
- Prior art keywords
- imidazolylmethyl
- preparation
- therapeutic active
- analogue procedure
- tetrahydrocarbazolone
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB848401888A GB8401888D0 (en) | 1984-01-25 | 1984-01-25 | Heterocyclic compounds |
GB848425959A GB8425959D0 (en) | 1984-10-15 | 1984-10-15 | Heterocyclic compounds |
Publications (3)
Publication Number | Publication Date |
---|---|
NO850300L NO850300L (en) | 1985-07-26 |
NO164025B NO164025B (en) | 1990-05-14 |
NO164025C true NO164025C (en) | 1990-08-22 |
Family
ID=26287221
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO850300A NO164025C (en) | 1984-01-25 | 1985-01-25 | ANALOGUE PROCEDURE FOR THE PREPARATION OF THERAPEUTIC ACTIVE 3-IMIDAZOLYLMETHYL-TETRAHYDROCARBAZOLONE DERIVATIVES. |
NO1994022C NO1994022I1 (en) | 1984-01-25 | 1994-11-09 | Ondansetron / 1,2,3,4-tetrahydro-9-methyl-3- (2-methylimidazol-1-ylmethyl) -carbazol-4-one |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO1994022C NO1994022I1 (en) | 1984-01-25 | 1994-11-09 | Ondansetron / 1,2,3,4-tetrahydro-9-methyl-3- (2-methylimidazol-1-ylmethyl) -carbazol-4-one |
Country Status (29)
Country | Link |
---|---|
KR (1) | KR920003064B1 (en) |
AT (1) | AT392276B (en) |
AU (1) | AU579132B2 (en) |
BE (1) | BE901576A (en) |
CA (1) | CA1252793A (en) |
CH (1) | CH664152A5 (en) |
CY (1) | CY1479A (en) |
CZ (1) | CZ404391A3 (en) |
DE (2) | DE3502508A1 (en) |
DK (1) | DK169521B1 (en) |
ES (3) | ES8609309A1 (en) |
FI (1) | FI84349C (en) |
FR (1) | FR2561244B1 (en) |
GB (1) | GB2153821B (en) |
GR (1) | GR850219B (en) |
HK (1) | HK33189A (en) |
HU (1) | HU193592B (en) |
IE (1) | IE57809B1 (en) |
IL (1) | IL74165A (en) |
IT (1) | IT1182150B (en) |
LU (2) | LU85743A1 (en) |
NL (2) | NL190373C (en) |
NO (2) | NO164025C (en) |
NZ (1) | NZ210940A (en) |
PH (1) | PH22672A (en) |
PT (1) | PT79890B (en) |
SE (1) | SE460359B (en) |
SG (1) | SG7089G (en) |
SK (1) | SK404391A3 (en) |
Families Citing this family (79)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4695578A (en) * | 1984-01-25 | 1987-09-22 | Glaxo Group Limited | 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances |
DE3680123D1 (en) * | 1985-01-23 | 1991-08-14 | Glaxo Group Ltd | Tetrahydrocarbazolonderivate. |
EP0201165B1 (en) * | 1985-03-14 | 1994-07-20 | Beecham Group Plc | Medicaments for the treatment of emesis |
US5578628A (en) * | 1985-06-25 | 1996-11-26 | Glaxo Group Limited | Medicaments for the treatment of nausea and vomiting |
GB8516083D0 (en) * | 1985-06-25 | 1985-07-31 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518742D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
GB8518658D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Medicaments |
GB8518743D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8518741D0 (en) * | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Process |
US5204356A (en) * | 1985-07-24 | 1993-04-20 | Glaxo Group Limited | Treatment of anxiety |
GB8518745D0 (en) | 1985-07-24 | 1985-08-29 | Glaxo Group Ltd | Heterocyclic compounds |
GB8617994D0 (en) * | 1986-07-23 | 1986-08-28 | Glaxo Group Ltd | Heterocyclic compounds |
HU202108B (en) * | 1986-07-30 | 1991-02-28 | Sandoz Ag | Process for producing pharmaceutical compositions containing serotonine antqgonistic derivatives of indol-carboxylic acid or imidazolyl-methyl-carbazol |
AT396870B (en) * | 1986-08-07 | 1993-12-27 | Sandoz Ag | Process for the production of a pharmaceutical formulation for the nasal administration of serotonin antagonists |
GB8623819D0 (en) * | 1986-10-03 | 1986-11-05 | Glaxo Group Ltd | Heterocyclic compounds |
JP2765845B2 (en) * | 1986-11-21 | 1998-06-18 | グラクソ、グループ、リミテッド | Remedies for prevention of discontinuation syndrome |
GB8627909D0 (en) * | 1986-11-21 | 1986-12-31 | Glaxo Group Ltd | Medicaments |
GR871809B (en) * | 1986-11-28 | 1988-03-07 | Glaxo Group Ltd | Process for the preparation of tricyclic ketones |
GB8812002D0 (en) * | 1988-05-20 | 1988-06-22 | Glaxo Group Ltd | Chemical compounds |
US5202343A (en) * | 1986-11-28 | 1993-04-13 | Glaxo Group Limited | Tricyclic ketones useful as HT3 -receptor antagonists |
GB8628475D0 (en) * | 1986-11-28 | 1987-01-07 | Glaxo Group Ltd | Medicaments |
US5190954A (en) * | 1986-12-17 | 1993-03-02 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
GB8630079D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
GB8630071D0 (en) * | 1986-12-17 | 1987-01-28 | Glaxo Group Ltd | Medicaments |
JPS63277622A (en) * | 1986-12-17 | 1988-11-15 | グラクソ、グループ、リミテッド | Medicine |
DK662687A (en) * | 1986-12-17 | 1988-06-18 | Glaxo Group Ltd | USE OF TRICYCLIC CARBAZOLONES |
US5200414A (en) * | 1986-12-17 | 1993-04-06 | Glaxo Group Limited | Methods for the treatment of cognitive disorders |
DE3876006T2 (en) * | 1987-04-14 | 1993-03-25 | Glaxo Group Ltd | KETONE DERIVATIVES. |
DE3874229T2 (en) * | 1987-06-16 | 1993-03-25 | British Tech Group | USE OF DIOXOPIPERIDINE DERIVATIVES FOR PRODUCING A TOPICAL PREPARATION AS AN ANALGETIC. |
DE3822792C2 (en) * | 1987-07-11 | 1997-11-27 | Sandoz Ag | New use of 5HT¶3¶ antagonists |
GB8723157D0 (en) * | 1987-10-02 | 1987-11-04 | Beecham Group Plc | Compounds |
CA1304082C (en) * | 1987-10-22 | 1992-06-23 | Tetsuya Tahara | Benzoxazine compounds and pharmaceutical use thereof |
US4939144A (en) * | 1987-10-22 | 1990-07-03 | Glaxo Group Limited | Tricyclic ketone derivatives as 5-HT antagonists |
US5225431A (en) * | 1987-10-23 | 1993-07-06 | Burroughs Wellcome Co. | Therapeutic substituted indole compounds and compositions thereof |
GB8805269D0 (en) * | 1988-03-04 | 1988-04-07 | Glaxo Group Ltd | Medicaments |
JPH0249772A (en) * | 1988-04-07 | 1990-02-20 | Glaxo Group Ltd | Imidazole derivative |
DK185489A (en) * | 1988-04-22 | 1989-10-23 | Duphar Int Res | IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE |
JPH0256485A (en) * | 1988-04-27 | 1990-02-26 | Glaxo Group Ltd | Lactam derivative |
GB8812636D0 (en) * | 1988-05-27 | 1988-06-29 | Glaxo Group Ltd | Chemical compounds |
AU627221B2 (en) * | 1988-09-27 | 1992-08-20 | Fujisawa Pharmaceutical Co., Ltd. | Pyridoindole derivatives and processes for preparation thereof |
US5290785A (en) * | 1988-09-27 | 1994-03-01 | Fujisawa Pharmaceutical Co., Ltd. | Therapeutic agent for ischemic diseases |
US5173493A (en) * | 1988-09-27 | 1992-12-22 | Fujisawa Pharmaceutical Company, Ltd. | Pyridoindole derivatives and processes for preparation thereof |
FR2639944B1 (en) * | 1988-12-06 | 1991-01-18 | Adir | NEW INDOLE DERIVATIVES, THEIR PREPARATION PROCESS AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
CA2004911A1 (en) * | 1988-12-22 | 1990-06-22 | Mitsuaki Ohta | 4,5,6,7-tetrahydrobenzimidazole derivatives |
US5223625A (en) * | 1988-12-22 | 1993-06-29 | Duphar International Research B.V. | Annelated indolo [3,2,-C]lactams |
EP0377238A1 (en) * | 1988-12-22 | 1990-07-11 | Duphar International Research B.V | New annelated indolo (3,2-c)-lactams |
CA2012092A1 (en) * | 1989-03-13 | 1990-09-13 | Tadao Okegawa | 5-ht3 receptor antagonist |
DK0422154T3 (en) * | 1989-04-21 | 1994-03-07 | Sandoz Ag | Therapeutic use of 5-HT3 receptor antagonists |
GB8914804D0 (en) * | 1989-06-28 | 1989-08-16 | Glaxo Group Ltd | Process |
GB8917557D0 (en) * | 1989-08-01 | 1989-09-13 | Glaxo Group Ltd | Medicaments |
US5276050A (en) * | 1989-08-01 | 1994-01-04 | Glaxo Group Limited | Medicaments |
US5126343A (en) * | 1989-09-11 | 1992-06-30 | G. D. Searle & Co. | N-azabicyclo [3.3.0]octane amides of aromatic acids |
GB2236751B (en) | 1989-10-14 | 1993-04-28 | Wyeth John & Brother Ltd | Heterocyclic compounds |
GB8928837D0 (en) * | 1989-12-21 | 1990-02-28 | Beecham Group Plc | Pharmaceuticals |
US5187166A (en) * | 1990-07-31 | 1993-02-16 | Nisshin Flour Milling Co., Ltd. | Azabicyclo derivatives and their use as antiemetics |
EP1022025A3 (en) * | 1991-06-26 | 2002-06-05 | Sepracor, Inc. | Method and compositions for treating emesis nausea and other disorders using optically pure R(+) ondansetron |
JPH05310732A (en) * | 1992-03-12 | 1993-11-22 | Mitsubishi Kasei Corp | Cinnoline-3-carboxylic acid derivative |
ES2043535B1 (en) * | 1992-03-13 | 1994-08-01 | Vita Invest Sa | PROCEDURE FOR OBTAINING 1,2,3,9-TETRAHYDRO-9-METHYL-3- (2-METHYL-1H-IMIDAZOL-1-IL) METHYL * -4H-CARBAZOL-4-ONA. |
CA2106642C (en) * | 1992-10-14 | 2005-08-16 | Peter Bod | Carbazolone derivatives and process for preparing the same |
HU212934B (en) | 1992-10-14 | 1996-12-30 | Richter Gedeon Vegyeszet | Process for producing novel alkoxalylated carbazolone derivatives |
KR960700711A (en) * | 1993-03-08 | 1996-02-24 | 후지야마 아키라 | Medicine for treating or preventing cerebrovascular diseases |
GB9310756D0 (en) * | 1993-05-25 | 1993-07-14 | Glaxo Lab Sa | Compositions |
GB2325408B (en) * | 1994-06-28 | 1999-01-27 | Kenneth Francis Prendergast | Chewing gum formulation comprising ondansetron |
GB9423588D0 (en) * | 1994-11-22 | 1995-01-11 | Glaxo Wellcome Inc | Compositions |
AU702594B2 (en) * | 1995-10-13 | 1999-02-25 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
US6365743B1 (en) | 1995-10-13 | 2002-04-02 | Duphar International Research B.V. | Process for the preparation of enantiomerically pure imidazolyl compounds |
US5969137A (en) * | 1996-09-19 | 1999-10-19 | Virginia Commonwealth University | Benzylamidine derivatives with serotonin receptor binding activity |
CA2371822A1 (en) | 1999-03-01 | 2000-09-08 | Sepracor Inc. | Methods for treating apnea and apnea disorders using optically pure r(+)ondansetron |
EP1207160A1 (en) * | 2000-11-20 | 2002-05-22 | Hanmi Pharm. Co., Ltd. | Process for the preparation of 1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)-methyl)-4H-carbazol-4-one |
KR20040104654A (en) | 2002-04-29 | 2004-12-10 | 비오갈 기오기스제르갸르 알티. | Process for preparing 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1h-imidazol-1-yl)methyl]-4h-carbazol-4-one |
FI6164U1 (en) * | 2003-01-09 | 2004-03-15 | Synthon Bv | Ondansetronformer |
GB2398071B (en) * | 2003-01-24 | 2006-06-07 | Synthon Bv | Process for making ondansetron and intermediate thereof |
ES2238001B1 (en) * | 2004-01-21 | 2006-11-01 | Vita Cientifica, S.L. | NEW POLYMORPHIC FORMS OF ONDANSETRON, PROCEDURES FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USE AS ANANTIMETICS. |
WO2005108392A2 (en) | 2004-05-07 | 2005-11-17 | Taro Pharmaceutical Industries Ltd. | Process for preparing ondansetron hydrochloride dihydrate having a defined particle size |
US20090170872A1 (en) * | 2005-07-05 | 2009-07-02 | Orchid Research Laboratories Limited | Compounds and Their Pharmaceutical Use |
ES2432618T3 (en) | 2009-05-20 | 2013-12-04 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit |
DK2432467T3 (en) | 2009-05-20 | 2018-04-16 | Inst Nat Sante Rech Med | SEROTONIN 5-HT3 RECEPTOR ANTAGONISTS FOR USE IN TREATMENT OF VESTIBULAR DAMAGE LESSONS |
CN115611864A (en) * | 2022-11-01 | 2023-01-17 | 常州兰陵制药有限公司 | Ondansetron compound and preparation method and application thereof |
GB202301322D0 (en) | 2023-01-30 | 2023-03-15 | Therakind Ltd | Antiemetic pharmaceutical compositions for nasal delivery |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3740404A (en) * | 1969-05-09 | 1973-06-19 | American Cyanamid Co | Piperidinomethylenedihydrocarbazolones |
US3634420A (en) * | 1969-05-09 | 1972-01-11 | American Cyanamid Co | 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones |
DE3680123D1 (en) * | 1985-01-23 | 1991-08-14 | Glaxo Group Ltd | Tetrahydrocarbazolonderivate. |
-
1985
- 1985-01-25 KR KR1019850000454A patent/KR920003064B1/en not_active IP Right Cessation
- 1985-01-25 NZ NZ210940A patent/NZ210940A/en unknown
- 1985-01-25 DE DE19853502508 patent/DE3502508A1/en active Granted
- 1985-01-25 ES ES539852A patent/ES8609309A1/en not_active Expired
- 1985-01-25 CH CH346/85A patent/CH664152A5/en not_active IP Right Cessation
- 1985-01-25 FI FI850323A patent/FI84349C/en not_active IP Right Cessation
- 1985-01-25 LU LU85743A patent/LU85743A1/en active Protection Beyond IP Right Term
- 1985-01-25 PT PT79890A patent/PT79890B/en unknown
- 1985-01-25 PH PH31770A patent/PH22672A/en unknown
- 1985-01-25 IT IT47600/85A patent/IT1182150B/en active Protection Beyond IP Right Term
- 1985-01-25 HU HU85296A patent/HU193592B/en unknown
- 1985-01-25 DK DK035785A patent/DK169521B1/en not_active IP Right Cessation
- 1985-01-25 IE IE187/85A patent/IE57809B1/en not_active IP Right Cessation
- 1985-01-25 AT AT204/85A patent/AT392276B/en not_active IP Right Cessation
- 1985-01-25 BE BE0/214394A patent/BE901576A/en not_active IP Right Cessation
- 1985-01-25 DE DE1993175046 patent/DE19375046I2/en active Active
- 1985-01-25 NL NLAANVRAGE8500202,A patent/NL190373C/en not_active IP Right Cessation
- 1985-01-25 GB GB08501889A patent/GB2153821B/en not_active Expired
- 1985-01-25 GR GR850219A patent/GR850219B/el active IP Right Revival
- 1985-01-25 AU AU38097/85A patent/AU579132B2/en not_active Expired
- 1985-01-25 LU LU88268C patent/LU88268I2/xx unknown
- 1985-01-25 IL IL74165A patent/IL74165A/en not_active IP Right Cessation
- 1985-01-25 FR FR8501056A patent/FR2561244B1/en not_active Expired
- 1985-01-25 SE SE8500368A patent/SE460359B/en not_active IP Right Cessation
- 1985-01-25 NO NO850300A patent/NO164025C/en not_active IP Right Cessation
- 1985-01-25 CA CA000472888A patent/CA1252793A/en not_active Expired
- 1985-10-31 ES ES548430A patent/ES8708224A1/en not_active Expired
-
1986
- 1986-06-16 ES ES556101A patent/ES8801247A1/en not_active Expired
-
1989
- 1989-02-09 SG SG70/89A patent/SG7089G/en unknown
- 1989-04-20 HK HK331/89A patent/HK33189A/en not_active IP Right Cessation
- 1989-07-21 CY CY1479A patent/CY1479A/en unknown
-
1991
- 1991-12-23 CZ CS914043A patent/CZ404391A3/en unknown
- 1991-12-23 SK SK4043-91A patent/SK404391A3/en unknown
-
1994
- 1994-05-31 NL NL940009C patent/NL940009I2/en unknown
- 1994-11-09 NO NO1994022C patent/NO1994022I1/en unknown
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