IE850187L - Imidazoles - Google Patents

Imidazoles

Info

Publication number
IE850187L
IE850187L IE850187A IE18785A IE850187L IE 850187 L IE850187 L IE 850187L IE 850187 A IE850187 A IE 850187A IE 18785 A IE18785 A IE 18785A IE 850187 L IE850187 L IE 850187L
Authority
IE
Ireland
Prior art keywords
phenyl
hydrogen
3alkyl
cycloalkyl
alkenyl
Prior art date
Application number
IE850187A
Other versions
IE57809B1 (en
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848401888A external-priority patent/GB8401888D0/en
Priority claimed from GB848425959A external-priority patent/GB8425959D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of IE850187L publication Critical patent/IE850187L/en
Publication of IE57809B1 publication Critical patent/IE57809B1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Compounds of formula (I). <IMAGE> [wherein R<1> is hydrogen C1-10 alkyl, C3-7 cycloalkyl, C3-6 alkenyl, phenyl or phenyl-C1-3alkyl, and one of the groups represented by R<2>, R<3> and R<4> is hydrogen, C1-6 alkyl, C3-7 cycloalkyl, C2-6 alkenyl or phenyl-C1-3alkyl and each of the other two groups, which may be the same or different, is hydrogen or C1-6alkyl; and physiologically acceptable salts and solvates, e.g. hydrates, thereof] are potent selective antagonists at "neuronal" 5-hydroxytryptamine receptors and are useful in the treatment of migraine and psychotic disorders such as schizophrenia. [GB2153821A]
IE187/85A 1984-01-25 1985-01-25 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives IE57809B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848401888A GB8401888D0 (en) 1984-01-25 1984-01-25 Heterocyclic compounds
GB848425959A GB8425959D0 (en) 1984-10-15 1984-10-15 Heterocyclic compounds

Publications (2)

Publication Number Publication Date
IE850187L true IE850187L (en) 1985-07-25
IE57809B1 IE57809B1 (en) 1993-04-21

Family

ID=26287221

Family Applications (1)

Application Number Title Priority Date Filing Date
IE187/85A IE57809B1 (en) 1984-01-25 1985-01-25 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives

Country Status (29)

Country Link
KR (1) KR920003064B1 (en)
AT (1) AT392276B (en)
AU (1) AU579132B2 (en)
BE (1) BE901576A (en)
CA (1) CA1252793A (en)
CH (1) CH664152A5 (en)
CY (1) CY1479A (en)
CZ (1) CZ404391A3 (en)
DE (2) DE3502508A1 (en)
DK (1) DK169521B1 (en)
ES (3) ES8609309A1 (en)
FI (1) FI84349C (en)
FR (1) FR2561244B1 (en)
GB (1) GB2153821B (en)
GR (1) GR850219B (en)
HK (1) HK33189A (en)
HU (1) HU193592B (en)
IE (1) IE57809B1 (en)
IL (1) IL74165A (en)
IT (1) IT1182150B (en)
LU (2) LU85743A1 (en)
NL (2) NL190373C (en)
NO (2) NO164025C (en)
NZ (1) NZ210940A (en)
PH (1) PH22672A (en)
PT (1) PT79890B (en)
SE (1) SE460359B (en)
SG (1) SG7089G (en)
SK (1) SK404391A3 (en)

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US5225431A (en) * 1987-10-23 1993-07-06 Burroughs Wellcome Co. Therapeutic substituted indole compounds and compositions thereof
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JPH0256485A (en) * 1988-04-27 1990-02-26 Glaxo Group Ltd Lactam derivative
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US5173493A (en) * 1988-09-27 1992-12-22 Fujisawa Pharmaceutical Company, Ltd. Pyridoindole derivatives and processes for preparation thereof
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HU212934B (en) 1992-10-14 1996-12-30 Richter Gedeon Vegyeszet Process for producing novel alkoxalylated carbazolone derivatives
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Also Published As

Publication number Publication date
IT1182150B (en) 1987-09-30
NO1994022I1 (en) 1994-11-09
CY1479A (en) 1989-07-21
SK277923B6 (en) 1995-08-09
SE460359B (en) 1989-10-02
DK169521B1 (en) 1994-11-21
HU193592B (en) 1987-11-30
SE8500368D0 (en) 1985-01-25
ES556101A0 (en) 1987-12-16
GB8501889D0 (en) 1985-02-27
KR850005439A (en) 1985-08-26
NO164025C (en) 1990-08-22
FI850323A0 (en) 1985-01-25
ATA20485A (en) 1990-08-15
KR920003064B1 (en) 1992-04-13
SG7089G (en) 1989-06-09
PH22672A (en) 1988-11-14
LU88268I2 (en) 1994-02-03
CZ404391A3 (en) 1993-04-14
PT79890A (en) 1985-02-01
IL74165A (en) 1988-11-15
LU85743A1 (en) 1986-08-04
DK35785A (en) 1985-07-26
NO850300L (en) 1985-07-26
FR2561244B1 (en) 1988-03-04
ES539852A0 (en) 1986-07-16
CH664152A5 (en) 1988-02-15
HUT37784A (en) 1986-02-28
NL190373B (en) 1993-09-01
FI84349C (en) 1991-11-25
IT8547600A0 (en) 1985-01-25
GB2153821B (en) 1988-01-20
DE3502508C2 (en) 1990-05-03
NL8500202A (en) 1985-08-16
AU579132B2 (en) 1988-11-17
FI84349B (en) 1991-08-15
DE3502508A1 (en) 1985-08-14
ES548430A0 (en) 1987-10-01
DK35785D0 (en) 1985-01-25
NO164025B (en) 1990-05-14
DE19375046I2 (en) 2002-10-10
ES8801247A1 (en) 1987-12-16
NZ210940A (en) 1989-08-29
HK33189A (en) 1989-04-28
AU3809785A (en) 1985-08-01
FR2561244A1 (en) 1985-09-20
NL940009I1 (en) 1994-07-18
FI850323L (en) 1985-07-26
GR850219B (en) 1985-05-23
AT392276B (en) 1991-02-25
ES8708224A1 (en) 1987-10-01
GB2153821A (en) 1985-08-29
NL940009I2 (en) 1999-05-03
ES8609309A1 (en) 1986-07-16
NL190373C (en) 1994-02-01
PT79890B (en) 1987-02-03
BE901576A (en) 1985-07-25
SE8500368L (en) 1985-07-26
CA1252793A (en) 1989-04-18
SK404391A3 (en) 1995-08-09
IE57809B1 (en) 1993-04-21

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