ES2008360A6 - Tetrahydro carbazolone intermediates - Google Patents

Tetrahydro carbazolone intermediates

Info

Publication number
ES2008360A6
ES2008360A6 ES8703405A ES8703405A ES2008360A6 ES 2008360 A6 ES2008360 A6 ES 2008360A6 ES 8703405 A ES8703405 A ES 8703405A ES 8703405 A ES8703405 A ES 8703405A ES 2008360 A6 ES2008360 A6 ES 2008360A6
Authority
ES
Spain
Prior art keywords
carbazolone
tetrahydro
intermediates
compounds
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8703405A
Other languages
Spanish (es)
Inventor
Ian Harold Coates
John Bradshaw
James Angus Bell
David Cedric Humber
George Blanch Ewan
William Leonard Mitchell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB868628473A external-priority patent/GB8628473D0/en
Priority claimed from GB878726537A external-priority patent/GB8726537D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ES2008360A6 publication Critical patent/ES2008360A6/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

The invention relates to compounds of the general formula (I): < IMAGE > (I) wherein Im represents an imidazolyl group of the formula: < IMAGE > and the various substituents are defined hereinbelow. The compounds are potent and selective antagonists of the effect of 5-HT at 5-HT3 receptors and are useful, for example, in the treatment of psychotic disorders, anxiety, and nausea and vomiting.
ES8703405A 1986-11-28 1987-11-27 Tetrahydro carbazolone intermediates Expired ES2008360A6 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868628473A GB8628473D0 (en) 1986-11-28 1986-11-28 Chemical compounds
GB878726537A GB8726537D0 (en) 1987-11-12 1987-11-12 Tricyclic ketones

Publications (1)

Publication Number Publication Date
ES2008360A6 true ES2008360A6 (en) 1989-07-16

Family

ID=26291603

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8703405A Expired ES2008360A6 (en) 1986-11-28 1987-11-27 Tetrahydro carbazolone intermediates

Country Status (24)

Country Link
US (1) US4822881A (en)
AT (1) AT396933B (en)
AU (1) AU605805B2 (en)
BE (1) BE1001004A4 (en)
CA (1) CA1326032C (en)
CH (1) CH676120A5 (en)
CZ (1) CZ404591A3 (en)
DE (1) DE3740352A1 (en)
DK (1) DK169675B1 (en)
ES (1) ES2008360A6 (en)
FI (1) FI92062C (en)
FR (1) FR2611366B1 (en)
GB (1) GB2202530B (en)
GR (1) GR871809B (en)
HK (1) HK51591A (en)
IE (1) IE61510B1 (en)
IL (1) IL84635A (en)
IT (1) IT1211936B (en)
NL (1) NL8702851A (en)
NO (1) NO172581C (en)
NZ (1) NZ222725A (en)
PH (1) PH30436A (en)
SE (1) SE467255B (en)
SG (1) SG46591G (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8518742D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8812002D0 (en) * 1988-05-20 1988-06-22 Glaxo Group Ltd Chemical compounds
US5202343A (en) * 1986-11-28 1993-04-13 Glaxo Group Limited Tricyclic ketones useful as HT3 -receptor antagonists
DE3822792C2 (en) * 1987-07-11 1997-11-27 Sandoz Ag New use of 5HT¶3¶ antagonists
US5360800A (en) * 1987-09-03 1994-11-01 Glaxo Group Limited Tetrahydro-1H-pyrido[4,3-b]indol-1-one derivatives
GB8720693D0 (en) * 1987-09-03 1987-10-07 Glaxo Group Ltd Chemical compounds
JPH01258673A (en) * 1987-10-22 1989-10-16 Glaxo Group Ltd Ketone derivative
JPH0249772A (en) * 1988-04-07 1990-02-20 Glaxo Group Ltd Imidazole derivative
DK185489A (en) * 1988-04-22 1989-10-23 Duphar Int Res IMIDAZOLYLMETHYL-CYCLOALKANOEBAA INDOLONES, THEIR PREPARATION AND USE
EP0339959A3 (en) * 1988-04-27 1991-03-20 Glaxo Group Limited Lactam derivatives
GB8812636D0 (en) * 1988-05-27 1988-06-29 Glaxo Group Ltd Chemical compounds
EP0350129A1 (en) * 1988-07-07 1990-01-10 Duphar International Research B.V New annelated indoleketones with an imidazolylalkyl substituent
DE68926553T2 (en) * 1988-08-02 1996-10-17 Glaxo Group Ltd., London Lactam derivatives
HU207078B (en) * 1988-08-02 1993-03-01 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising such compounds
US5008272A (en) * 1988-08-15 1991-04-16 Glaxo Group Limited Lactam derivatives
US4997831A (en) * 1988-09-01 1991-03-05 Glaxo Group Limited Lactam derivatives
GB8820653D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820651D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
GB8820650D0 (en) * 1988-09-01 1988-10-05 Glaxo Group Ltd Medicaments
AU627221B2 (en) * 1988-09-27 1992-08-20 Fujisawa Pharmaceutical Co., Ltd. Pyridoindole derivatives and processes for preparation thereof
GB8823980D0 (en) * 1988-10-13 1988-11-23 Glaxo Group Ltd Chemical compounds
US5223625A (en) * 1988-12-22 1993-06-29 Duphar International Research B.V. Annelated indolo [3,2,-C]lactams
HU204049B (en) * 1989-02-28 1991-11-28 Glaxo Group Ltd Process for producing lactam derivatives and pharmaceutical compositions comprising same
GB8904552D0 (en) 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical process
GB8904551D0 (en) * 1989-02-28 1989-04-12 Glaxo Group Ltd Chemical compounds
WO1990012569A1 (en) 1989-04-21 1990-11-01 Sandoz Ag Therapeutic use of 5-ht3 receptor antagonists
GB8928208D0 (en) * 1989-12-13 1990-02-14 Glaxo Group Ltd Medicaments
HU211081B (en) * 1990-12-18 1995-10-30 Sandoz Ag Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same
KR100368895B1 (en) * 2000-03-30 2003-01-24 하나제약 주식회사 A process for preparing 1,2,3,9-tetrahydro-9-methyl-3- [(2-methyl-1H-imidazol-1-yl)methyl]-4H-carbazol-4-one
WO2003061657A1 (en) * 2002-01-18 2003-07-31 Aryx Therapeutics 5-ht3 receptor antagonists and methods of use
ES2432618T3 (en) 2009-05-20 2013-12-04 Inserm (Institut National De La Santé Et De La Recherche Medicale) Serotonin 5-HT3 receptor antagonists for use in the treatment or prevention of a pathology of the inner ear with vestibular deficit
US8580730B2 (en) 2009-05-20 2013-11-12 (Inserm) Institut National De La Sante Et De La Recherche Medicale Methods of treating lesional vestibular disorders by administering serotonin 5-HT3 receptor antagonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740404A (en) * 1969-05-09 1973-06-19 American Cyanamid Co Piperidinomethylenedihydrocarbazolones
US3634420A (en) * 1969-05-09 1972-01-11 American Cyanamid Co 3(morpholinomethyl)-2 3-dihydro-carbazol-4(1h)-ones
GB1365296A (en) * 1970-10-30 1974-08-29 Unilever Ltd Dentifrice compositions
US4176230A (en) * 1977-08-04 1979-11-27 Hoffmann-La Roche Inc. 5-(6-Alkylindol-3-ylmethylene)-1,3-dimethyl-2-(methylimino)-4-imidazolidinones
MC1286A1 (en) * 1978-11-01 1980-07-22 Wellcome Found PREPARATION OF HETEROCYCLIC COMPOUNDS FOR USE IN PHARMACY AND MEDICINES CONTAINING THESE COMPOUNDS
DK151884C (en) * 1979-03-07 1988-06-13 Pfizer METHOD OF ANALOGUE FOR THE PREPARATION OF 3- (1-IMIDAZOLYLALKYL) INCIDENTAL OR PHARMACEUTICAL ACCEPTABLE ACID ADDITION SALTS THEREOF
IE57809B1 (en) * 1984-01-25 1993-04-21 Glaxo Group Ltd 1,2,3,9-tetrahydro-3-(imidazol-1-ylmethyl)-4h-carbazol-4 one derivatives
US4695578A (en) * 1984-01-25 1987-09-22 Glaxo Group Limited 1,2,3,9-tetrahydro-3-imidazol-1-ylmethyl-4H-carbazol-4-ones, composition containing them, and method of using them to treat neuronal 5HT function disturbances
AU583343B2 (en) * 1985-01-23 1989-04-27 Glaxo Group Limited Heterocyclic compounds
GB8518741D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Process
GB8518745D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds
GB8518743D0 (en) * 1985-07-24 1985-08-29 Glaxo Group Ltd Heterocyclic compounds

Also Published As

Publication number Publication date
GB2202530B (en) 1990-04-18
GR871809B (en) 1988-03-07
FR2611366B1 (en) 1990-03-16
US4822881A (en) 1989-04-18
SE8704746L (en) 1988-05-29
NO172581B (en) 1993-05-03
SE467255B (en) 1992-06-22
IE61510B1 (en) 1994-11-16
FI875235A (en) 1988-05-29
ATA312487A (en) 1993-05-15
PH30436A (en) 1997-05-09
NZ222725A (en) 1990-08-28
DE3740352A1 (en) 1988-06-09
FI92062C (en) 1994-09-26
AU605805B2 (en) 1991-01-24
DK624887D0 (en) 1987-11-27
IL84635A0 (en) 1988-04-29
SE8704746D0 (en) 1987-11-27
NL8702851A (en) 1988-06-16
SG46591G (en) 1991-07-26
GB2202530A (en) 1988-09-28
GB8727835D0 (en) 1987-12-31
DK169675B1 (en) 1995-01-09
CA1326032C (en) 1994-01-11
IE873232L (en) 1988-05-28
IT8748642A0 (en) 1987-11-27
NO874959D0 (en) 1987-11-27
NO172581C (en) 1993-08-11
IL84635A (en) 1993-01-31
NO874959L (en) 1988-05-30
AU8184587A (en) 1988-06-02
CH676120A5 (en) 1990-12-14
BE1001004A4 (en) 1989-06-06
FI92062B (en) 1994-06-15
FR2611366A1 (en) 1988-09-02
DK624887A (en) 1988-05-29
HK51591A (en) 1991-07-12
FI875235A0 (en) 1987-11-27
CZ404591A3 (en) 1993-08-11
IT1211936B (en) 1989-11-08
AT396933B (en) 1993-12-27

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2007-11-27