ATA284985A - Verfahren zur herstellung von neuen carbapenemderivaten - Google Patents
Verfahren zur herstellung von neuen carbapenemderivatenInfo
- Publication number
- ATA284985A ATA284985A AT0284985A AT284985A ATA284985A AT A284985 A ATA284985 A AT A284985A AT 0284985 A AT0284985 A AT 0284985A AT 284985 A AT284985 A AT 284985A AT A284985 A ATA284985 A AT A284985A
- Authority
- AT
- Austria
- Prior art keywords
- carbapene
- derivatives
- producing new
- producing
- new
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D477/00—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring
- C07D477/10—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
- C07D477/12—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6
- C07D477/16—Heterocyclic compounds containing 1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbapenicillins, thienamycins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulphur-containing hetero ring with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 4, and with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached in position 6 with hetero atoms or carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 3
- C07D477/20—Sulfur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT0341587A AT396473B (de) | 1984-10-02 | 1987-12-23 | Verfahren zur herstellung von neuen carbapenemderivaten |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/656,838 US4683301A (en) | 1982-04-08 | 1984-10-02 | Carbapenem antibiotics |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ATA284985A true ATA284985A (de) | 1992-02-15 |
| AT395151B AT395151B (de) | 1992-10-12 |
Family
ID=24634788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT0284985A AT395151B (de) | 1984-10-02 | 1985-10-02 | Verfahren zur herstellung von neuen carbapenemderivaten |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US4683301A (de) |
| JP (1) | JPS6187682A (de) |
| KR (1) | KR910009270B1 (de) |
| AT (1) | AT395151B (de) |
| AU (1) | AU575432B2 (de) |
| BE (1) | BE903353A (de) |
| CA (1) | CA1260945A (de) |
| CH (1) | CH665640A5 (de) |
| DE (1) | DE3535196A1 (de) |
| DK (1) | DK446685A (de) |
| ES (2) | ES8703880A1 (de) |
| FI (1) | FI79317C (de) |
| FR (1) | FR2571054B1 (de) |
| GB (1) | GB2165247B (de) |
| GR (1) | GR852336B (de) |
| HU (1) | HU194240B (de) |
| IL (1) | IL76539A0 (de) |
| IT (1) | IT1190396B (de) |
| LU (1) | LU86105A1 (de) |
| NL (1) | NL8502681A (de) |
| OA (1) | OA08113A (de) |
| PT (1) | PT81236B (de) |
| SE (1) | SE466202B (de) |
| ZA (1) | ZA857581B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4732977A (en) * | 1982-09-28 | 1988-03-22 | Bristol Myers Company | Carbapenem antibiotics |
| US5116833A (en) * | 1990-10-19 | 1992-05-26 | Bristol-Myers Squibb Company | Antibiotic c-3 dithioacetal-substituted carbapenem compounds, compositions, and methods of use thereof |
| AR002507A1 (es) * | 1995-06-28 | 1998-03-25 | Merck & Co Inc | Proceso mejorado para sintetizar intermediarios de carbapenem |
| US5823718A (en) * | 1996-07-25 | 1998-10-20 | Alnet (Proprietary) Limited | Pillar bag |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3950357A (en) * | 1974-11-25 | 1976-04-13 | Merck & Co., Inc. | Antibiotics |
| US4235920A (en) * | 1975-11-21 | 1980-11-25 | Merck & Co., Inc. | N-Alkylated derivatives of thienamycin |
| AU531084B2 (en) * | 1977-10-19 | 1983-08-11 | Merck & Co., Inc. | Azetidine derivatives |
| AU4061378A (en) * | 1977-10-19 | 1980-04-17 | Merck & Co., Inc. | 1-azabicyclo (3.2.0) hept-2-enes |
| US4218463A (en) * | 1977-12-28 | 1980-08-19 | Merck & Co., Inc. | 3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid |
| US4174316A (en) * | 1978-08-14 | 1979-11-13 | Merck & Co., Inc. | 4-Iodomethylazetidin-2-one |
| DE2966497D1 (en) * | 1978-10-24 | 1984-01-26 | Merck & Co Inc | 6-, 1- and 2-substituted-1-carbapen-2-em-3-carboxylic acids, processes for the preparation of such compounds and pharmaceutical composition comprising such compounds |
| US4208422A (en) * | 1978-10-24 | 1980-06-17 | Merck & Co., Inc. | 1-Substituted-pen-2-em-3-carboxylic acids |
| US4232036A (en) * | 1978-10-24 | 1980-11-04 | Merck & Co., Inc. | 6-, 1- and 2-Substituted-1-carbadethiapen-2-em-3-carboxylic acids |
| US4318912A (en) * | 1979-01-02 | 1982-03-09 | Merck & Co., Inc. | 6-(1-Hydroxyethyl)-3-substituted-1-azabicyclo(3.2.0)-hept-2-en-7-one-2-carboxylic acid |
| DK165280A (da) * | 1979-04-19 | 1980-10-20 | Merck & Co Inc | Fremgangsmaade til fremstilling af 2- og 6-substituerede 1-carbadethiapen-2-em-3-carboxylsyrer og mellemprodukter til brug ved udoevelse af fremgangsmaaden |
| US4376774A (en) * | 1979-05-29 | 1983-03-15 | Merck & Co., Inc. | Antibiotic N-heterocyclyl thienamycin |
| EP0055990B1 (de) * | 1979-08-10 | 1986-06-11 | Beecham Group Plc | Beta-Lactam-Antibiotika, ihre Herstellung und Verwendung |
| US4309346A (en) * | 1980-03-27 | 1982-01-05 | Merck & Co., Inc. | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates |
| IE52147B1 (en) * | 1980-03-27 | 1987-07-08 | Merck & Co Inc | 4-(3-carboxy-2-oxopropyl)-azetidin-2-ones and process for their preparation |
| EP0037082B1 (de) * | 1980-03-27 | 1985-03-20 | Merck & Co. Inc. | Verfahren zur Herstellung von 1-Carbapenem-Derivaten und von Zwischenprodukten via silyl-substituierter Dithioacetale |
| EP0038869A1 (de) * | 1980-04-30 | 1981-11-04 | Merck & Co. Inc. | Verfahren zur Herstellung von 1-Carbapenemen und Zwischenprodukte für ihre Herstellung |
| JPS56161393A (en) * | 1980-05-16 | 1981-12-11 | Sanraku Inc | Beta-lactam compound |
| US4378315A (en) * | 1980-05-29 | 1983-03-29 | Merck & Co., Inc. | Process for the preparation of thienamycin and intermediates |
| US4350631A (en) * | 1980-12-18 | 1982-09-21 | Merck & Co., Inc. | 6- and 4-Substituted-1-azabicyclo[3.2.0]heptan-3,7-dione-2-carboxylates |
| ES514240A0 (es) * | 1981-08-03 | 1984-04-16 | Merck & Co Inc | Un procedimiento para la prepracion de nuevos derivados de acidos 2-carbamimidoil-1-,carbadestiapen-2-en-3-carboxilados. |
| EP0074599A1 (de) * | 1981-09-09 | 1983-03-23 | Takeda Chemical Industries, Ltd. | 5,6-Cis-Carbapenem-Derivate, ihre Herstellung und Verwendung |
| US4640915A (en) * | 1982-03-29 | 1987-02-03 | Fujisawa Pharmaceutical Co., Ltd. | 1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid derivatives |
| CA1198440A (en) * | 1982-04-08 | 1985-12-24 | Choung U. Kim | Carbapenem antibiotics |
| US4536335A (en) * | 1982-06-18 | 1985-08-20 | Bristol-Myers Company | Carbapenem antibiotics |
| EP0113101A1 (de) * | 1982-12-30 | 1984-07-11 | Merck & Co. Inc. | 6-(1-Hydroxyäthyl)-2-SR8-1-methyl-1-carbadethiapen-2-em-3-carbonsäureester |
| AR241016A1 (es) * | 1983-03-08 | 1991-04-30 | Bristol Myeres Squibb Company | "derivados de aminotiol cuaternario, procedimiento para prepararlos y procedimiento para preparar compuestos de carbapenem a partir de dichos derivados". |
-
1984
- 1984-10-02 US US06/656,838 patent/US4683301A/en not_active Expired - Fee Related
-
1985
- 1985-09-18 CA CA000491072A patent/CA1260945A/en not_active Expired
- 1985-09-25 GR GR852336A patent/GR852336B/el unknown
- 1985-09-27 FI FI853748A patent/FI79317C/fi not_active IP Right Cessation
- 1985-09-28 KR KR1019850007200A patent/KR910009270B1/ko not_active IP Right Cessation
- 1985-09-30 AU AU48102/85A patent/AU575432B2/en not_active Ceased
- 1985-09-30 ES ES547438A patent/ES8703880A1/es not_active Expired
- 1985-09-30 FR FR8514442A patent/FR2571054B1/fr not_active Expired
- 1985-10-01 SE SE8504538A patent/SE466202B/sv not_active IP Right Cessation
- 1985-10-01 JP JP60219030A patent/JPS6187682A/ja active Pending
- 1985-10-01 NL NL8502681A patent/NL8502681A/nl not_active Application Discontinuation
- 1985-10-01 LU LU86105A patent/LU86105A1/fr unknown
- 1985-10-01 BE BE0/215665A patent/BE903353A/fr not_active IP Right Cessation
- 1985-10-01 IL IL76539A patent/IL76539A0/xx not_active IP Right Cessation
- 1985-10-01 GB GB08524125A patent/GB2165247B/en not_active Expired
- 1985-10-01 IT IT22317/85A patent/IT1190396B/it active
- 1985-10-01 CH CH4235/85A patent/CH665640A5/de not_active IP Right Cessation
- 1985-10-01 HU HU853808A patent/HU194240B/hu not_active IP Right Cessation
- 1985-10-01 ZA ZA857581A patent/ZA857581B/xx unknown
- 1985-10-01 DK DK446685A patent/DK446685A/da not_active Application Discontinuation
- 1985-10-02 DE DE19853535196 patent/DE3535196A1/de not_active Ceased
- 1985-10-02 OA OA58695A patent/OA08113A/xx unknown
- 1985-10-02 AT AT0284985A patent/AT395151B/de not_active IP Right Cessation
- 1985-10-02 PT PT81236A patent/PT81236B/pt not_active IP Right Cessation
-
1986
- 1986-04-01 ES ES553605A patent/ES8800223A1/es not_active Expired
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ELJ | Ceased due to non-payment of the annual fee |